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Conserved domains on  [gi|67540562|ref|XP_664055|]
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hypothetical protein [Aspergillus nidulans FGSC A4]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 93-520 4.40e-110

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 332.23  E-value: 4.40e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:cd17323   3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSyLEWRWTAWITMI 252
Cdd:cd17323  83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 253 MAAAAGLIGLFVLpetyapvllqrkaarlrletknwalhakldespitigsvitrylsrplvmllrePILQLITLYMTFI 332
Cdd:cd17323 162 ISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVGLV 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 333 YGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAY----IFYFTRTRIRQtfvSTGRIRPEDRLYPMIPGAF 408
Cdd:cd17323 188 YAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIggrlSDYYYRRLKKK---NGGKPEPEARLPPAFIGAF 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 409 LLPLGQFWFAWTSFPSISPWPQILAGVPIGAGIQIIYLQGLAYLVDVYLVNANSAISANAIVRSTVAAGFTMFATPMYHR 488
Cdd:cd17323 265 LFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNN 344

                       410       420       430
                ....*....|....*....|....*....|..
gi 67540562 489 LGVRCASSLLGFLGVAFIPIPIVFYIYGERVR 520
Cdd:cd17323 345 LGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 93-520 4.40e-110

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 332.23  E-value: 4.40e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:cd17323   3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSyLEWRWTAWITMI 252
Cdd:cd17323  83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 253 MAAAAGLIGLFVLpetyapvllqrkaarlrletknwalhakldespitigsvitrylsrplvmllrePILQLITLYMTFI 332
Cdd:cd17323 162 ISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVGLV 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 333 YGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAY----IFYFTRTRIRQtfvSTGRIRPEDRLYPMIPGAF 408
Cdd:cd17323 188 YAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIggrlSDYYYRRLKKK---NGGKPEPEARLPPAFIGAF 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 409 LLPLGQFWFAWTSFPSISPWPQILAGVPIGAGIQIIYLQGLAYLVDVYLVNANSAISANAIVRSTVAAGFTMFATPMYHR 488
Cdd:cd17323 265 LFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNN 344

                       410       420       430
                ....*....|....*....|....*....|..
gi 67540562 489 LGVRCASSLLGFLGVAFIPIPIVFYIYGERVR 520
Cdd:cd17323 345 LGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
132-268 3.44e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 111.97  E-value: 3.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   132 LFIAGFAAGPLLFGPLSEL----YGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562   208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPET 268
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-456 1.13e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.61  E-value: 1.13e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  83 PPWKKWVYANIIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYA 162
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 163 VFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLE 242
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 243 WRWTAWITMIMAAAAGLIGLFVLPETYAPVllqrkaarlrletknwalhakldespitigsviTRYLSRPLVMLLREPIL 322
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAA---------------------------------RARLRGSLRELLRRPRL 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 323 QLITLYMTFIYGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFTRTRirqtfvstgrirpeDRLYP 402
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRRRL 275

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 67540562 403 MIPGAFLLPLGQFWFAWTSfpsiSPWPQILAGVPIGAGIQIIYLQGLAYLVDVY 456
Cdd:COG2814 276 LLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
MFS_1 pfam07690
Major Facilitator Superfamily;
99-445 2.93e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 97.87  E-value: 2.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    99 LVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIE 178
Cdd:pfam07690   7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   179 TLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITqSYLEWRWTAWITMIMAAAAG 258
Cdd:pfam07690  87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   259 LIGLFVLPETYAPVLLQRKAARLRLETknwalhakldespitigsvitrylsrPLVMLLREPILQLITLYmtFIYGFIYL 338
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIV--------------------------AWKALLRDPVLWLLLAL--LLFGFAFF 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   339 LFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFTRtrirqtfvstgRIRPEDRLYPMIPGAFLLPLGQFWFA 418
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-----------RLGRRRRLLLALLLLILAALGLLLLS 286

                         330       340
                  ....*....|....*....|....*..
gi 67540562   419 WTSFPSISPWPQILAGVPIGAGIQIIY 445
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALN 313
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
116-289 1.07e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 81.88  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  116 AEEFGV--GRQVTTLgtALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASG 193
Cdd:PRK11102  18 AADFGVsaGSVQMTL--SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  194 PLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPETYAPVl 273
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETLPKE- 173

                        170
                 ....*....|....*.
gi 67540562  274 lQRKAARLRLETKNWA 289
Cdd:PRK11102 174 -RRQPFHLRTTIRNFA 188
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 93-520 4.40e-110

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 332.23  E-value: 4.40e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:cd17323   3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSyLEWRWTAWITMI 252
Cdd:cd17323  83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 253 MAAAAGLIGLFVLpetyapvllqrkaarlrletknwalhakldespitigsvitrylsrplvmllrePILQLITLYMTFI 332
Cdd:cd17323 162 ISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVGLV 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 333 YGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAY----IFYFTRTRIRQtfvSTGRIRPEDRLYPMIPGAF 408
Cdd:cd17323 188 YAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIggrlSDYYYRRLKKK---NGGKPEPEARLPPAFIGAF 264

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 409 LLPLGQFWFAWTSFPSISPWPQILAGVPIGAGIQIIYLQGLAYLVDVYLVNANSAISANAIVRSTVAAGFTMFATPMYHR 488
Cdd:cd17323 265 LFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNN 344

                       410       420       430
                ....*....|....*....|....*....|..
gi 67540562 489 LGVRCASSLLGFLGVAFIPIPIVFYIYGERVR 520
Cdd:cd17323 345 LGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
132-268 3.44e-29

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 111.97  E-value: 3.44e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   132 LFIAGFAAGPLLFGPLSEL----YGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562   208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPET 268
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-456 1.13e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.61  E-value: 1.13e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  83 PPWKKWVYANIIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYA 162
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 163 VFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLE 242
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 243 WRWTAWITMIMAAAAGLIGLFVLPETYAPVllqrkaarlrletknwalhakldespitigsviTRYLSRPLVMLLREPIL 322
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAA---------------------------------RARLRGSLRELLRRPRL 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 323 QLITLYMTFIYGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFTRTRirqtfvstgrirpeDRLYP 402
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRRRL 275

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 67540562 403 MIPGAFLLPLGQFWFAWTSfpsiSPWPQILAGVPIGAGIQIIYLQGLAYLVDVY 456
Cdd:COG2814 276 LLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 93-486 3.38e-26

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 109.97  E-value: 3.38e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:cd17320   3 LLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFItQSYLEWRWTAWITMI 252
Cdd:cd17320  83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL-LLFFGWRAIFVFLAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 253 MAAAAGLIGLFVLPETyapvllqrkaarlrletknwalhAKLDESPITIGSVITRYLSrplvmLLREPILQLITLYMTFI 332
Cdd:cd17320 162 LGLLLLLLVLLFLPET-----------------------LPEEKRKPLLSSLLRAYKR-----VLKNRRFLGYALALGLS 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 333 YGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSayifYFTRTRIRqtfvstgRIRPEDRLYPMIPGAFLLPL 412
Cdd:cd17320 214 FAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGS----LLNGRLVR-------RFGPRRLLRLGLLLLLAAAL 282

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67540562 413 GQFWFAWTSFPSIspWPQILAGVPIGAGIQIIYLQGLAYLVDVYLVNANSAISANAIVRSTVAAGFTMFATPMY 486
Cdd:cd17320 283 VLLLAALLGGLSL--WPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 78-372 1.95e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 97.57  E-value: 1.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  78 NPQNLPPWKKWVYANIIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPL 157
Cdd:COG0477   3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 158 IAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFIT 237
Cdd:COG0477  83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 238 QsYLEWRWTAWItMIMAAAAGLIGLFVLPETYAPVLLQRKAARLRLETKNWALHAKLDESPITIGSVITRYLSRPLVMLL 317
Cdd:COG0477 163 A-ALGWRWIFLI-NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 67540562 318 REPILQLITLYMTFIYGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLG 372
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_1 pfam07690
Major Facilitator Superfamily;
99-445 2.93e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 97.87  E-value: 2.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    99 LVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIE 178
Cdd:pfam07690   7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   179 TLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITqSYLEWRWTAWITMIMAAAAG 258
Cdd:pfam07690  87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   259 LIGLFVLPETYAPVLLQRKAARLRLETknwalhakldespitigsvitrylsrPLVMLLREPILQLITLYmtFIYGFIYL 338
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIV--------------------------AWKALLRDPVLWLLLAL--LLFGFAFF 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   339 LFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFTRtrirqtfvstgRIRPEDRLYPMIPGAFLLPLGQFWFA 418
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-----------RLGRRRRLLLALLLLILAALGLLLLS 286

                         330       340
                  ....*....|....*....|....*..
gi 67540562   419 WTSFPSISPWPQILAGVPIGAGIQIIY 445
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALN 313
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 93-433 4.84e-20

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 92.06  E-value: 4.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:TIGR00710   9 LLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMI 252
Cdd:TIGR00710  89 LSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILV-WLSWHAIFAFLSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   253 MAAAAGLIGLFVLPETyapvLLQRKAARLRLETKNWALhakldespitigsvitrylsrplvmLLREPILQLITLYMTFI 332
Cdd:TIGR00710 168 AGILLSALIFFILPET----LPYEARIQISTYFETFLL-------------------------LLKSKMFWGYALIYGAS 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   333 YGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFtrtrirqtfvstGRIRPEDRLYPMipGAFLLPL 412
Cdd:TIGR00710 219 FGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRF------------IKKWGAKSLLRM--GLILFAV 284

                         330       340
                  ....*....|....*....|.
gi 67540562   413 GQFWFAWTSFPSISPWPQILA 433
Cdd:TIGR00710 285 SAVLLEITAILGLGSWAMIIG 305
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 116-266 1.49e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 87.22  E-value: 1.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 116 AEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPL 195
Cdd:cd17324  26 ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFW 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562 196 SIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLP 266
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLLP 175
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 106-257 6.50e-18

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 84.92  E-value: 6.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 106 SVFSAATGVTAEEFGVGRQVTTLGTALFIAgFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRF 185
Cdd:cd17502  13 TIVATALPTIVAEFGGLSLVSWVGTAYLLT-STAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRA 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67540562 186 IGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAA 257
Cdd:cd17502  92 IQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD-HLSWRWCFYINLPIGGLA 162
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 97-508 7.39e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 7.39e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  97 LSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARN 176
Cdd:cd06174   4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 177 IETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFI-TQSYLEWRWTAWITMIMAA 255
Cdd:cd06174  84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLIAAALAL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 256 AAGLIGLFVLPETYAPVLLQRKAARlrletknwalhakldespitigsviTRYLSRPLVMLLREPILQLITLYMTFIYGF 335
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEEAS-------------------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLA 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 336 IYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGSAYIFYFTRTRIRqtfvstgrirpedRLYPMIPGAFLLPLGQF 415
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-------------RKPLLLIGLLLMALGLA 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 416 WFAWTSFPSISPWPQILAGVPIGAGIQIIYLQGLAYLVDVYLVNANSAisANAIVRSTVAAGFTMFATPMYHRLGVRCAS 495
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL--LNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363

                       410
                ....*....|...
gi 67540562 496 SLLGFLGVAFIPI 508
Cdd:cd06174 364 LVLAVLLLLAAIL 376
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 99-265 8.81e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 84.92  E-value: 8.81e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  99 LVVTFATSVFSAATGVTAEEFGV---GRQVTTLGTALFIAGFAagpLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVAR 175
Cdd:cd17321   6 FLAALDVTIVNVALPTIARDLGAspsQLQWVVNAYLLAFAALL---LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 176 NIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITM-IMA 254
Cdd:cd17321  83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-LFGWRWIFLINVpIGL 161

                       170
                ....*....|.
gi 67540562 255 AAAGLIGLFVL 265
Cdd:cd17321 162 VALLLARTFSG 172
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
116-289 1.07e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 81.88  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  116 AEEFGV--GRQVTTLgtALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASG 193
Cdd:PRK11102  18 AADFGVsaGSVQMTL--SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  194 PLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPETYAPVl 273
Cdd:PRK11102  96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETLPKE- 173

                        170
                 ....*....|....*.
gi 67540562  274 lQRKAARLRLETKNWA 289
Cdd:PRK11102 174 -RRQPFHLRTTIRNFA 188
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 125-294 1.09e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.85  E-value: 1.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 125 VTTLGTALFIAGFAAGPLLF----GPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGG 200
Cdd:cd17325  28 ASVAQIGLIVAAYALAQLLFsppaGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMA 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 201 YFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAAAAGLIGLFVLPETYAPVLLQRKAAR 280
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAA 186

                       170
                ....*....|....
gi 67540562 281 LRLETKNWALHAKL 294
Cdd:cd17325 187 RLRSGLRLLLRDRR 200
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
93-279 2.27e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.00  E-value: 2.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFAT-SVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPV 171
Cdd:COG2223   8 LLATLAFFLAFGVwYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 172 GVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITM 251
Cdd:COG2223  88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-GWRNAFLILG 166

                       170       180
                ....*....|....*....|....*...
gi 67540562 252 IMAAAAGLIGLFVLPETYAPVLLQRKAA 279
Cdd:COG2223 167 ILLLVVAVLAWLFLRDPPAGAAAAAKAS 194
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
93-265 2.38e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 77.60  E-value: 2.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFA---TSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQI 169
Cdd:COG2271  11 ILALLFLAYFLNyldRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 170 PVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWI 249
Cdd:COG2271  91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRAAFLI 169

                       170
                ....*....|....*.
gi 67540562 250 TMIMAAAAGLIGLFVL 265
Cdd:COG2271 170 LGLPGLLLALLRFWLL 185
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 117-267 6.61e-15

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 76.51  E-value: 6.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 117 EEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLS 196
Cdd:cd17328  27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSP 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562 197 IAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFVLPE 267
Cdd:cd17328 107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVRE 177
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 93-283 4.29e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 73.76  E-value: 4.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGR-QVTTLGTALFIAGFAAGPLLfGPLSELYGRKRPLIAGYAVFVVFQIPV 171
Cdd:cd17474   3 AVFFATLLAVLGVSIVDPILPAIAEALGASPaQVGLLITAFTLPAAVLMPVA-GVLADRFGRKKVLLPGLLLFGIGGLLC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 172 GVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYleWRWTAWITM 251
Cdd:cd17474  82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS--WRYPFFLLA 159

                       170       180       190
                ....*....|....*....|....*....|..
gi 67540562 252 IMAAAAGLIGLFVLPETYAPVLLQRKAARLRL 283
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDL 191
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 105-267 2.10e-13

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 72.41  E-value: 2.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   105 TSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCR 184
Cdd:TIGR00711  18 STIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   185 FIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAAAAGLIGLFV 264
Cdd:TIGR00711  98 VIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY-HWRWIFLINVPIGIIVVVVAFFI 176


                  ...
gi 67540562   265 LPE 267
Cdd:TIGR00711 177 LPR 179
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 99-260 5.74e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 70.30  E-value: 5.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  99 LVVTFATSVFSAATGVTAEEFGV-GRQVTTLGTALFIAGFAAGPLlFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNI 177
Cdd:cd17504   6 LAVMLVETMLSPALPTIQREFGTsAAAVSWVLTAYLLVGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 178 ETLILCRFIGGVA-ASGPLSIAggYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAA 256
Cdd:cd17504  85 PVLIAGRALQGIGgAVFPLAFA--LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-HLGWRWIFWTAAPVAVL 161


                ....
gi 67540562 257 AGLI 260
Cdd:cd17504 162 LAAL 165
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 147-266 5.85e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 70.30  E-value: 5.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 147 LSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGP 226
Cdd:cd17503  54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 67540562 227 IVGPILGGFITqSYLEWRWTAWITMIMaaaaGLIGLFVLP 266
Cdd:cd17503 134 AIGPTLGGWLT-DNLSWRWIFYINLPI----GILALLLAP 168
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 121-266 1.25e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 69.14  E-value: 1.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 121 VGRQVTTLGTALFIAGFAAGPLLfGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGvAASGPLSIAGG 200
Cdd:cd17330  32 SGYYVGLLQSSYSLGQFLASPLW-GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDG-LTGGNVSVAQA 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67540562 201 YFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEwRWTAWITMIMAAAAGLIGLFVLP 266
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALLNLVLVLFFLP 174
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 142-274 2.81e-12

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 68.06  E-value: 2.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 142 LLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDP-VQRGLALAIFSG 220
Cdd:cd17476  51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGA 130

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 67540562 221 TTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPETYAPVLL 274
Cdd:cd17476 131 TAPLGFALGGVFGGLFAQ-LAWWPWIFWFLAILAAIVAVAAIFWTSPSFIAVLL 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 100-275 9.25e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 66.44  E-value: 9.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 100 VVTFATSVFSAATGVTAEEFGvgrqvttLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIET 179
Cdd:cd17319  21 NISVAAPTIMKDLGLSPTQYG-------LIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 180 LILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITqSYLEWRWTAWITMIMAAAAGL 259
Cdd:cd17319  94 LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-LLFGWRWAFIIEGLLGLLLAV 172

                       170
                ....*....|....*.
gi 67540562 260 IGLFVLPETYAPVLLQ 275
Cdd:cd17319 173 LWWFYLRQVWGLALGY 188
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 94-260 1.48e-11

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 65.70  E-value: 1.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  94 IGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGV 173
Cdd:cd17316   6 LGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 174 ARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLE---WRWTAWIT 250
Cdd:cd17316  86 LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgWRILFLIG 165

                       170
                ....*....|
gi 67540562 251 MIMAAAAGLI 260
Cdd:cd17316 166 ALPALLALLL 175
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 93-263 1.99e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.68  E-value: 1.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEE-FGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPV 171
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 172 GVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITM 251
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAA 361

                       170
                ....*....|..
gi 67540562 252 IMAAAAGLIGLF 263
Cdd:cd17325 362 ALLLLAAVLFLL 373
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
116-269 3.14e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 3.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 116 AEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGR--KRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASG 193
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67540562 194 PLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAAAAGLIGLFVLPETY 269
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRETR 362
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
132-269 3.27e-10

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 61.96  E-value: 3.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  132 LFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQR 211
Cdd:PRK10473  46 VYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRR 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 67540562  212 GLALAIFSGTTLVGPIVGPILgGFITQSYLEWRWTAWITMIMAAAAGLIGLFVLPETY 269
Cdd:PRK10473 126 AKVLSLLNGITCIIPVLAPVL-GHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETR 182
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 102-265 8.44e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 61.10  E-value: 8.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 102 TFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLlFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLI 181
Cdd:cd06179  11 LFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPI-VGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLI 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 182 LCRFIGGVAAsGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLE-WRWTAWITMIMAAAAgLI 260
Cdd:cd06179  90 GGQALIGIGA-GTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWRWIFYINAIFNALA-LI 167


                ....*
gi 67540562 261 GLFVL 265
Cdd:cd06179 168 LLFFF 172
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 93-266 1.58e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 59.52  E-value: 1.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVT-FATSVFSAATGVTAEEFGVGR-QVTTLGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIP 170
Cdd:cd17365   2 ALCFLIIVLDgFDLAVMGFVAPALAQDWGLSPaQLGPVGSAALF-GMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 171 VGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWtawit 250
Cdd:cd17365  81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-GWRS----- 154

                       170
                ....*....|....*.
gi 67540562 251 miMAAAAGLIGLFVLP 266
Cdd:cd17365 155 --VFLLGGVPPLILLP 168
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
117-268 1.71e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 59.95  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  117 EEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAasgpLS 196
Cdd:PRK15402  41 EDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG----LC 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  197 IAG--GYFAdffdpVQRGLA-------LAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAgLIGLF-VLP 266
Cdd:PRK15402 117 FIGavGYAA-----IQESFEeadaikiTALMANVALLAPLLGPLVGAALIH-VLPWRGMFVLFAALAALS-FFGLWrAMP 189


                 ..
gi 67540562  267 ET 268
Cdd:PRK15402 190 ET 191
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 99-373 4.43e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 58.52  E-value: 4.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    99 LVVTFATSVFSAATGVTAEEFGvgrqvtTLGTALfIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIE 178
Cdd:TIGR00895  34 AAMGFAAPAISAEWGLDPVQLG------FLFSAG-LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   179 TLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALaifsGTTLVGPIVGPILGGFITQ---SYLEWRWTAWITMIMAA 255
Cdd:TIGR00895 107 QLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAV----GLMFCGYPIGAAVGGFLAGwliPVFGWRSLFYVGGIAPL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   256 AAGLIGLFVLPETYAPVLLQR-KAARLRLETKNWALHAKLDESPITIGSVITRylSRPLVMLLREPILQLITLYMTFIYG 334
Cdd:TIGR00895 183 LLLLLLMRFLPESIDFLVSKRpETVRRIVNAIAPQMQAEAQSALPEQKSTQGT--KRSVFKALFQGKTARITVLLWLLYF 260

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 67540562   335 F----IYLLFEAYPVsFIEERGYSLGVGALPFLSIGVGVVLGS 373
Cdd:TIGR00895 261 MllvgVYFLTNWLPK-LMVELGFSLSLAATGGALFNFGGVIGS 302
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 103-280 2.40e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 56.16  E-value: 2.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 103 FATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLIL 182
Cdd:cd17371  13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 183 CRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLE---WRWTAWITMIMAAAAGL 259
Cdd:cd17371  93 LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPeiaWRVLFLLGALPALLVLF 172

                       170       180
                ....*....|....*....|.
gi 67540562 260 IGLFVlPETyaPVLLQRKAAR 280
Cdd:cd17371 173 IRRFV-KEP--PQWQAARAAR 190
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 105-268 2.51e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 56.04  E-value: 2.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 105 TSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCR 184
Cdd:cd17359  17 TGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIAR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 185 FIGGVAASGPLSIAGGYFADFFDPVQRGLA-----LAIFSGtTLVGPIVGPILGGFITQSYLE---WRWTAWITMIMAAA 256
Cdd:cd17359  97 IIGGLAVGGASALVPMYIAEVAPAEIRGRLvslnqLMIVFG-QLLAYIVNYLIANAGGADWLGaegWRWMLGLEAIPAIL 175

                       170
                ....*....|..
gi 67540562 257 AgLIGLFVLPET 268
Cdd:cd17359 176 F-LLGMLFIPES 186
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 94-277 2.55e-08

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 56.04  E-value: 2.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  94 IGWLSLVVTFATSVFSAATGVTAEEFGvgrqvtTLGTALFIAGfAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGV 173
Cdd:cd17358  18 VGWSSPALPSLMSDNSLSLPLTVAQFS------WFGSLLTLGA-LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAF 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 174 ARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGpivgpILGGFITQSYLEWRWTAWITMIM 253
Cdd:cd17358  91 AKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIG-----ILLGYVLGSFLPWRTLALIGAIP 165

                       170       180
                ....*....|....*....|....
gi 67540562 254 AAAAgLIGLFVLPETyaPVLLQRK 277
Cdd:cd17358 166 PVVF-LILLFFIPES--PRWLAKK 186
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 99-262 3.16e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 3.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  99 LVVTFATSVFSAATGVTAEEfgvgrqvTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIE 178
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPAT-------SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGS 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 179 --TLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAA 256
Cdd:cd17316 268 ptLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347


                ....*.
gi 67540562 257 AGLIGL 262
Cdd:cd17316 348 ALIVAL 353
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 105-270 3.40e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 55.66  E-value: 3.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 105 TSVFSAATGVTAEEFGVGRQVTTLG--TALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLIL 182
Cdd:cd17315  13 LGVINGALLYIAKDLGFGLSTSLQGlvVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 183 CRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILG-GFITQSYLEWRWTAWITmIMAAAAGLIG 261
Cdd:cd17315  93 GRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGlALSLSPPGWWRLMFALA-AVPALLQLLL 171


                ....*....
gi 67540562 262 LFVLPETYA 270
Cdd:cd17315 172 MFFLPESRA 180
Sugar_tr pfam00083
Sugar (and other) transporter;
126-268 5.73e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 54.97  E-value: 5.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   126 TTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVA---RNIETLILCRFIGGVAASGPLSIAGGYF 202
Cdd:pfam00083  48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYI 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67540562   203 ADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFI--TQSYLEWRWTAWITMIMaAAAGLIGLFVLPET 268
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnkTSNSDGWRIPLGLQLVP-ALLLIIGLLFLPES 194
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 131-249 6.90e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 6.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 131 ALFIAGFAagpLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQ 210
Cdd:cd17473  45 ALFIALFA---PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 67540562 211 RGLALAIFSGTTLVGPIVGPILGGFITQsyLEWRWTAWI 249
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALAE--IGWRAPFLV 158
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 98-271 2.03e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.95  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  98 SLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNI 177
Cdd:cd17477   5 VALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 178 ETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAA 257
Cdd:cd17477  85 WVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVP 164

                       170
                ....*....|....
gi 67540562 258 GLIGLFVLPETYAP 271
Cdd:cd17477 165 LLLTRRAAPEIEEA 178
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 140-264 4.04e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 52.23  E-value: 4.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 140 GPLLfGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAaSGPLSIAGGYFADFFDPVQRGLALAIFS 219
Cdd:cd17390  48 SPLV-GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIF-KHTQSLCKAYLSDLVSEQERSRVLGRFN 125

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 67540562 220 GTTLVGPIVGPILGGFITQSYLEWRWTAWIT-MIMAAAAGLIGLFV 264
Cdd:cd17390 126 AASSLGFILGPVVGGHLAETDGGFYYVALLCsAIFILNAGLVWFLL 171
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
76-370 4.23e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.18  E-value: 4.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  76 PLNPQNLPPWKKWVYANIIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKR 155
Cdd:COG2807   5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 156 PLIAGYAVFVVFQIPVGVARNIETLILCRFIGGV--AASGPL--SIAGGYFADffdpvQRGLALAIFSGTTLVGPIVGPI 231
Cdd:COG2807  85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAgiAVGNVLlpGLIKRWFPD-----RVGLMTGLYTAAMGLGAALAAG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 232 LGGFITQSyLEWRWTAWITMIMAAAAGLIGLFVLPETYAPVLLQRKAARLRLetknwalhakldespitigsvitrylsr 311
Cdd:COG2807 160 LTVPLAAA-LGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS---------------------------- 210

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 312 plvmLLREPILQLITLYMtFIYGFIYLLFEAYPVSFIEERGYSLGV-GALPFLSIGVGVV 370
Cdd:COG2807 211 ----LWRSPLAWLLTLFF-GLQSLLYYAVVAWLPPILRDAGLSAATaGLLLSLFQLAGIP 265
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
132-305 5.19e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.82  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  132 LFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPvqr 211
Cdd:PRK11043  49 LFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPA--- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  212 GLALAIFSGTT-LVG--PIVGPILGGFITQSYlEWRwtawitMIMAAAAGlIGLFVLpetyAPVLLQRKAARLRLETKNW 288
Cdd:PRK11043 126 QKANRVFATIMpLVAlsPALAPLLGAWLLNHF-GWQ------AIFATLFA-ITLLLI----LPTLRLKPSKKARKQSQDA 193

                        170
                 ....*....|....*..
gi 67540562  289 ALHAKLDESPITIGSVI 305
Cdd:PRK11043 194 LTFKQLLKSKTYLGNVL 210
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 130-282 8.12e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.06  E-value: 8.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 130 TALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPV 209
Cdd:cd17489  37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPS 116

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67540562 210 QRGLALAIFSGTTLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLIGLFVLPETYAPVLLQRKAARLR 282
Cdd:cd17489 117 RRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
93-264 1.75e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 1.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSA-ATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPV 171
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSwLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 172 GVAR-NIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWIT 250
Cdd:COG2223 289 ALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVF 368

                       170
                ....*....|....
gi 67540562 251 MIMAAAAGLIGLFV 264
Cdd:COG2223 369 AVLALVALVLTLLL 382
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 127-250 1.92e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.89  E-value: 1.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 127 TLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFF 206
Cdd:cd17317  28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 67540562 207 DPVQRGLALAIFSGTTLVGPIVGPILGGFITQsyleWRWTAWIT 250
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALLAYLIRD----WRWLQLAI 147
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 132-265 2.12e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 50.01  E-value: 2.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 132 LFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFdPVQR 211
Cdd:cd17333  39 SQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESS 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 67540562 212 GLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFVL 265
Cdd:cd17333 118 ATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTL 171
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 126-288 2.41e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 50.05  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   126 TTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAAsGPLSIAGGYFADF 205
Cdd:pfam06609  80 QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAA-GPAGASPLFIGEL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   206 FDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAA-AAGLIGLFVLPETYAPVLLQRKAARLRLE 284
Cdd:pfam06609 159 MSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQG-NWRWIFYIYIIMSAiAVLLIIIWYHPPSFAQLHGKKARKRDELA 237


                  ....
gi 67540562   285 TKNW 288
Cdd:pfam06609 238 KLDW 241
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
131-268 2.49e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 49.82  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  131 ALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQ 210
Cdd:PRK15403  58 SLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTK 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 67540562  211 RGLALAIFSGTTLVGPIVGPiLGGFITQSYLEWRWTAWITMIMAAAAGLIGLFVLPET 268
Cdd:PRK15403 138 GIKLMAIITSIVLVAPIIGP-LSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 144-267 3.89e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.14  E-value: 3.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 144 FGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAggYFADFFDPVQRGLALAI----FS 219
Cdd:cd17472  52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--LLADLTREENRTKAMALigasIG 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 67540562 220 GTTLVGPIVGPILGGFITQSYLewrwtAWITMIMAAAAGLIGLFVLPE 267
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGL-----FLITAILSLVSLLILLFFVPD 172
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 86-260 7.62e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 7.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  86 KKWVYANIIGWLSLVVTFATSVFSAAtgVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSE-LYGRKRPLIAGYAVF 164
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPL--FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLM 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 165 VVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWR 244
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360

                       170
                ....*....|....*.
gi 67540562 245 WTAWITMIMAAAAGLI 260
Cdd:cd06174 361 GAFLVLAVLLLLAAIL 376
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 142-260 1.36e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 47.54  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 142 LLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFdPVQRGLALAIFSGT 221
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNA 331

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 67540562 222 TLVGPIVGPILGGFITQsYLEWRWTAWITMIMAAAAGLI 260
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQ-YFGYRAVFLVCAVLALLALVL 369
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 131-271 1.56e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 47.25  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 131 ALFIAGFAAGPLLFGP----LSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGV-AASGplSIAGGYFADF 205
Cdd:cd17388  41 GVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGItGATG--AVAAAYIADV 118

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67540562 206 FDPVQRGLALAIFSGTTLVGPIVGPILGGFItqsylewrWTAWITMIMAAAAG------LIGLFVLPETYAP 271
Cdd:cd17388 119 TPPEQRARNFGLLGAAFGLGFIAGPALGGLL--------GEISPRAPFLVAAGlnglnfLLGLFVLPESLPP 182
emrD PRK11652
multidrug transporter EmrD;
142-268 2.10e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 46.82  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  142 LLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGV--AASGPLSiaggyfadffdpvqRGLALAIFS 219
Cdd:PRK11652  61 LFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLgtGVGGVMA--------------RTLPRDLYE 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562  220 GTTL------------VGPIVGPILGGFITqSYLEWRWTAWITMIMAAAAGLIGLFVLPET 268
Cdd:PRK11652 127 GTQLrhansllnmgilVSPLLAPLIGGLLT-TLFGWRACYLFLLLLGAGVTFSMARWMPET 186
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 180-330 2.45e-05

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 47.03  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   180 LILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEW---------------R 244
Cdd:TIGR00805 174 FLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTgsvntedliitptdpR 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   245 WTA--WITMIMAAAAGL---IGLFVLPETYaPVLLQRKAARLrleTKNWALHAKLDESPiTIGSVITRYLSRPLVMLLRE 319
Cdd:TIGR00805 254 WIGawWIGFLVCGFVALltsIPLFFFPKTL-PKEGKRVNVDV---HEAEKLEKSRGEDR-KKNSGITKDFPKFIKRLLCN 328

                         170
                  ....*....|.
gi 67540562   320 PILQLITLYMT 330
Cdd:TIGR00805 329 KIYMLVILAQV 339
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-265 3.42e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 3.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  83 PPWKKWVYANIIGWLSLVVTFATSVFsaatgVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYA 162
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLY-----YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 163 VFVVFQIPVGVAR--NIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQ-------RGLALAIFSGTTLVGPIVGPILG 233
Cdd:COG2211 303 LAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALA 382

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 67540562 234 GFI----------TQSYLEWRWTAWITMIMAAAAGLIGLFVL 265
Cdd:COG2211 383 GLLlalfgyvagaAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 128-268 3.70e-05

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 46.45  E-value: 3.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 128 LGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:cd17438  39 LGLIVYL-GMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLA 117

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67540562 208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQSY-------LEWRWTAW----ITMIMAAAAGLIGLFVLPET 268
Cdd:cd17438 118 REKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYgwgfsmgTNYHFHSWrvfvIICALPCIASIIALKFMPES 189
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 105-268 4.23e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 45.72  E-value: 4.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 105 TSVFSAATGVTAEEFGVGRQVT---TLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLI 181
Cdd:cd17360  13 TGVISGALLYIKDDLGEVVLSTgwqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 182 LCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMImAAAAGLIG 261
Cdd:cd17360  93 VGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAV-PAVLQFIG 171


                ....*..
gi 67540562 262 LFVLPET 268
Cdd:cd17360 172 LLFLPES 178
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 107-263 4.78e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 45.60  E-value: 4.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 107 VFSAATGVTAeeFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIP----VGVARNIETLIL 182
Cdd:cd17369 249 TFALSYATQT--LGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPffwlLDTGSTWLIVLA 326

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 183 CRFIGGVAASGPLSIAGGYFADFFDPVQR--GLALAIFSGTTLVGPIVgPILGGFITQSYLEWRWTAWITMIMAAAAGLI 260
Cdd:cd17369 327 AVVVLGVLHGMMYGPQAAFLAELFPTRVRytGASLGYQLGAILGGGFA-PLIATALVAATGSWWPVALYLAALAVISLVA 405


                ...
gi 67540562 261 GLF 263
Cdd:cd17369 406 ALF 408
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 108-265 5.14e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 45.73  E-value: 5.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 108 FSAATGVTAEEFGVGR-QVTTLGTALFIAgFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFI 186
Cdd:cd17312  22 FSVAKPPIVEEIGLSKdDLGIIGSAFLIA-YAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67540562 187 GGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAAAAGLIGLFVL 265
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY-GWRAAFLVPGIVGLVVAIILFFFL 178
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 81-268 5.93e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 45.36  E-value: 5.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  81 NLPPWKKW-VYAniigwlSLVVTFATSVFSAATGVTAeefgvgrqvtTLGT-ALFIAGFAAGPL---LFGPLSELYGRKR 155
Cdd:cd17367   8 NLVEWYDWyVYA------AFALYFAPQFFPSGDPTVA----------LLSTaAVFAVGFLMRPIggwLFGRLADRIGRRA 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 156 PLIA-----GYAVFVVFQIP----VGVARNIeTLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLAlAIFSGTTLVGP 226
Cdd:cd17367  72 ALTLsvslmAAGSLVIAVTPtyatIGIWAPI-ILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFY-SSFQYVTLIGG 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 67540562 227 IVGPILGGFITQSYL------EWRWTawITMIMAAAAGLIGLFV---LPET 268
Cdd:cd17367 150 QLLALGVLLVLQHTLgedqmaAWGWR--IPFLLGGVLAVVVLWLrrgLEET 198
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
93-268 6.66e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 6.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  93 IIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVG 172
Cdd:COG0738  12 AIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 173 VARNIETLILCRFIGGVAASGPLSIAGGYFADFFdPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYL--EWRWTAWIT 250
Cdd:COG0738  92 LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslSWHLPYLIL 170

                       170
                ....*....|....*....
gi 67540562 251 MIMAAAAGLIGLFV-LPET 268
Cdd:COG0738 171 AVLLLLLALLFLRSkLPEI 189
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 127-236 1.05e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.65  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   127 TLGTALFIAGFAAGPLLFGPLSELYGRkRPLIAGYAVFVVFQIPVGVARNIETLILCR-FIGGVAASGPLSIAGGYFADF 205
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRLGP-RVTALLLLLGAVFAVLVGSTLFSPTLLLLLgAIAGFFVNGGQSGLYALMALF 366

                          90       100       110
                  ....*....|....*....|....*....|.
gi 67540562   206 FDPVQRGLALAIFSGTTLVGPIVGPILGGFI 236
Cdd:TIGR00895 367 YPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 139-267 1.41e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 44.27  E-value: 1.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 139 AGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIF 218
Cdd:cd17362  54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLK 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 67540562 219 SGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGlIGLFVLPE 267
Cdd:cd17362 134 ELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLG-IGMWFLPP 181
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 128-240 1.64e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   128 LGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:TIGR01299 207 LGLIVYL-GMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLA 285

                          90       100       110
                  ....*....|....*....|....*....|...
gi 67540562   208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQSY 240
Cdd:TIGR01299 286 QEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHY 318
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 128-268 1.94e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 43.80  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 128 LGTALFIAGFAAGPLlFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVaASGPLSIAGGYFADFFD 207
Cdd:cd17389  69 IGSLFSLLQFLSSPI-TGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAIVADVTS 146

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67540562 208 PVQRGLALAI----FSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFV-LPET 268
Cdd:cd17389 147 PKKRSKGMALigvaFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLALADLLFIFFfLPET 212
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 126-282 2.10e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 2.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 126 TTLGTALFIAGFAA--GPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFA 203
Cdd:cd17329  35 SIVGLVLALSAVAGivASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67540562 204 DFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLewRWTAWITMIMAAAAGLIGLFVLPETYAPVLLQRKAARLR 282
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 132-237 2.14e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 43.74  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 132 LFIAGFAAGPLLFGPL-----SELYGRKRPLIAGYAVFVVFQIPVGVARNIET-----LILCRFIGGVAAsGPLSIAGGY 201
Cdd:cd17326  40 WVVAAYSLGQLVFSPVfgywsNKTSSVKEPLIVSILIAIVGNILYALAEYFPSnrkyvMLVARFLIGVGA-GNVAVLRAY 118

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 67540562 202 FADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFIT 237
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT 154
PRK12307 PRK12307
MFS transporter;
124-389 2.18e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 43.76  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  124 QVTTLGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFA 203
Cdd:PRK12307  54 EGAFLATAAFI-GRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  204 DFFDPVQRGLALAIFsgttLVGPIVGPILGGFITQSYLE---WRwtawitmimaaAAGLIGLFvlpetyaPVLLQRKAAR 280
Cdd:PRK12307 133 ESWPKHLKSKASAFL----VSGFGIGNIIAAYFMPSFAEaygWR-----------AAFFVGLL-------PVLLVIYIRA 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  281 LRLETKNWaLHAKLDESPITIGSVITRYLSRPLVMLLRE--PILQLITLYMTFIYGFIYLLFEAYPvSFIEERGYSLGVG 358
Cdd:PRK12307 191 RAPESKEW-EEAKLSGKGKHSQSAWSVFSLSMKGLFNRAqfPLTLCVFIVLFSIFGANWPIFGLLP-TYLAGEGFDTGVV 268

                        250       260       270
                 ....*....|....*....|....*....|..
gi 67540562  359 ALPFLSIGVGVVLGSAYI-FYFTRTRIRQTFV 389
Cdd:PRK12307 269 SNLMTAAAFGTVLGNIVWgLCADRIGLKKTFS 300
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 128-268 3.78e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 43.10  E-value: 3.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 128 LGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:cd17439  39 LGLIVYL-GMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLA 117

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67540562 208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQSY-------LEWRWTAWITMIMAAA----AGLIGLFVLPET 268
Cdd:cd17439 118 QEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYgwsfqmgSAYQFHSWRVFVLVCAfpsvFAIGALTTMPES 189
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 109-193 4.77e-04

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 42.46  E-value: 4.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 109 SAATGVTAEEFGVGRQV--TTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFI 186
Cdd:cd17377  22 SSFTSIVSEWFLVGNAAykVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFL 101


                ....*..
gi 67540562 187 GGVAASG 193
Cdd:cd17377 102 VGVMNGG 108
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 128-212 6.15e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 42.48  E-value: 6.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 128 LGTALFIaGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:cd17363  39 LGLIVYL-GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLA 117


                ....*
gi 67540562 208 PVQRG 212
Cdd:cd17363 118 REKRG 122
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 95-373 7.33e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.87  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  95 GWLSLVVTFATSVFSAATGVTA--------EEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVV 166
Cdd:cd17355   1 GWVVLAVTFLILILSWGIRYYFgvfiipiiAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 167 FQIPVGVARNIETLILCRFIGGVAASGPLSIAGG-YFADFFDPVQRGLALAI-FSGTTLVGPIVGPILGGFITQsyLEWR 244
Cdd:cd17355  81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGIlTAGGGLGSLVFLPLGAALIEA--FGWR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 245 WTawitmiMAAAAGLIGLFVLPetyAPVLLQRKAARLrletknwALHAKLDESPITIGSVITRYLSRPLVMLLREPIlql 324
Cdd:cd17355 159 TA------LLVLALLALLVLVP---VLLLLRRRPADL-------ALRAYDDASPASPGSTLKEALRSASFWLLALAF--- 219

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 67540562 325 itlymtFIYGFIYLLFEAYPVSFIEERGYSLGVGALPFLSIGVGVVLGS 373
Cdd:cd17355 220 ------FLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGR 262
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 136-341 7.97e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 41.79  E-value: 7.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 136 GFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLAL 215
Cdd:cd17433  53 GAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLG 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 216 AIFSGTTLVGpivgpILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFvLPETYAPVLLQRK----AARLRLEtknWALH 291
Cdd:cd17433 133 SCVQLMVVIG-----IMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCF-MPETPRFLLTQHRrqeaMAALRFL---RGPD 203

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 67540562 292 AKLDESPITIGSVITRYLSRPLVMLLREPilqliTLYMTFIYGFIYLLFE 341
Cdd:cd17433 204 QGWEWECIGIEQSFHLEEQSFSLALLKQP-----GIYKPLIIGVSLMAFQ 248
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 130-276 8.56e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 41.85  E-value: 8.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 130 TALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVV-FQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDP 208
Cdd:cd17356  51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPK 130

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67540562 209 VQRGLALAIFSGTTLVGPIVGPILgGFITQSYL---EWRwTAWITMIMAAAAGLIGLFVLPETyaPVLLQR 276
Cdd:cd17356 131 HIRGTLVSLYQLAITIGILVAYCI-NYGTHKLDgsaQWR-IPLGLQIVWGLLLLIGMFFLPES--PRWLYR 197
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 108-373 1.32e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.21  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   108 FSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIG 187
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   188 GVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFVLPE 267
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   268 TYAPVLLqRKAARLRLETKNWALHAKLDE-SPITIGsvitrylsrpLVMLLREPILQLITLYMTFIYGFIYLLFEAYPVS 346
Cdd:TIGR00881 174 SPQSCGL-PPAEEMPNEEPDGDAEKKEEElTKKQIF----------LQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLY 242

                         250       260
                  ....*....|....*....|....*..
gi 67540562   347 FIEERGYSLGVGALPFLSIGVGVVLGS 373
Cdd:TIGR00881 243 LTQEKGFSKEKASWAFTLYELGGLVGT 269
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 132-225 1.36e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 40.91  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 132 LFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAasgplsIAGGYFA------DF 205
Cdd:cd17445  44 CFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAA------LAGVYLTlyltrlEL 117

                        90       100
                ....*....|....*....|
gi 67540562 206 FDPVQRgLALAIFSGTTLVG 225
Cdd:cd17445 118 CDPPQR-LLVAMAGGLTMVG 136
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 130-277 1.67e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 41.09  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 130 TALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVV---FQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFF 206
Cdd:cd17357  55 VSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVsslLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEIS 134

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67540562 207 DPVQRGlALAIFSGTTLVGPIVgpiLGGFITQSYL-----EWRWTAWITMIMAAAAGLIgLFVLPETYAPVLLQRK 277
Cdd:cd17357 135 PSELRG-ALGSLTQIGVTLGIL---LGQVFGLPSVlgtetLWPYLLFFPGIPALLQLAA-LPFFPESPKFLLISKG 205
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 111-217 1.83e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  111 ATGVTA----EEFGVGrqVTTLGTALFIA--GFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCR 184
Cdd:PRK11551  33 SAGVAAprmaQEFGLD--VAQMGWAFSAGilGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVAR 110

                         90       100       110
                 ....*....|....*....|....*....|...
gi 67540562  185 FIGGVAASGPLSIAGGYFADFFDPVQRGLALAI 217
Cdd:PRK11551 111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVSL 143
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 123-245 2.80e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.21  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 123 RQVTTLGTALFiAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGpLSIAGGYF 202
Cdd:cd17372  34 WQVALITSVVF-AGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGG-GPQLASWY 111

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 67540562 203 ADFFDPVQRGLALAIFSGTTLVGPIVGPILGGFITQSyLEWRW 245
Cdd:cd17372 112 LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR-LGWRW 153
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 133-264 4.00e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 4.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 133 FIAGFAAGpLLFGPLSELYG---RKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPV 209
Cdd:cd17319 225 FLAGAIGM-ILGGRLSDRLLrgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGE 303

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 67540562 210 QRGLALAIFSGTTLVGPIVGPILGGFITQSYLEWRWTAWITMIMAAAAGLIGLFV 264
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 128-265 4.23e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 4.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 128 LGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARN-IETLILCRFIGGVAASGPLSIAGGYFADFF 206
Cdd:cd17365 210 TITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFLAGACVNGAQVGLYALAARFY 289

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 67540562 207 DPVQRGLALAIFSGTTLVGPIVGPILGGFITQSYLEwrwTAWITMIMAAAAGLIGLFVL 265
Cdd:cd17365 290 PTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLG---PESVFLALAIPAALGALAVL 345
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-262 4.47e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 4.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  82 LPPWKKWVYANIIGWLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGY 161
Cdd:cd17478 188 STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 162 AVFVVFQIPVGVARNIETLILCrFIGGVAASGPLSIAGGYFADFFdPVQRGLALAIFSGTTL-VGPIVGPILGGFITQSY 240
Cdd:cd17478 268 LLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFgLGGIGAPVLGALADAFG 345

                       170       180
                ....*....|....*....|..
gi 67540562 241 LEwrWTAWITMIMAAAAGLIGL 262
Cdd:cd17478 346 LE--SVLLILALLPLLGALLAF 365
MFS_1 pfam07690
Major Facilitator Superfamily;
96-230 5.01e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    96 WLSLVVTFATSVFSAATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVAR 175
Cdd:pfam07690 207 LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 67540562   176 NIETLILCR---FIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGP 230
Cdd:pfam07690 287 LTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 133-328 7.12e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.78  E-value: 7.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 133 FIAGFAAGPLlFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAaSGPLSIAGGYFADFFDPVQRG 212
Cdd:cd17391  46 FLVSAIFSPI-WGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSG 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 213 LALAIFSGTTLVGPIVGPILGGFITQSYlEWRWTAWITMIMAAAAGLIGLFVLPETYAPVllQRKAARLRLETKNWALHA 292
Cdd:cd17391 124 WALGTLSTGVVAGTLIGPLLGGFLADLF-GIRNVFFITGGLLFLAFLLTLFFVKEDFKPV--EKKKMVSTKEVWNSVPNP 200

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 67540562 293 KLdespitigsVITRYLSRPLVMLLREPILQLITLY 328
Cdd:cd17391 201 SL---------LISLFVTTFIIQLANQSIEPILTLY 227
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 97-340 8.35e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 38.44  E-value: 8.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562    97 LSLVVTFATSVFsaATGVTAEEFGVGRQVTTLGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVA-R 175
Cdd:TIGR00886  12 LSFLVWFAFSPL--AVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   176 NIETLILCRFIggvaasgpLSIAGGYFA-------DFFDPVQRGLALAIFSG--------TTLVGP-IVGPILGGFITQS 239
Cdd:TIGR00886  90 SYSVLLLIRLF--------IGIAGGSFAscmpwisFFFPKKIQGTALGLAAGwgnmgggvAQFVMPpIIGSLIFGGGQPA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   240 YLEWRWTAWITMIMAAAAGLIGLFVL-----PETYAPVLLQRKAARLRLETKNWALHAKLdeSPITIGSVITryLSRPLV 314
Cdd:TIGR00886 162 HLAWGWAFVIVPAGILLLPALLIFFVgadtpPGKPATGKLSFKEALKVFGNRHTWILALL--YSVTFGSFLG--VSSIFA 237

                         250       260
                  ....*....|....*....|....*...
gi 67540562   315 MLLRE--PILQLITLYMTFIYGFIYLLF 340
Cdd:TIGR00886 238 MLFKDqfGLSKVQAGAYASLGGFLGSLA 265
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 130-245 8.39e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 38.56  E-value: 8.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 130 TALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFDPV 209
Cdd:cd17447  41 ATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIE 120

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 67540562 210 QRGLALAIFSGTTLVGPIVGPILGGFITqsylEWRW 245
Cdd:cd17447 121 HRTVAGVLISLFWTVGNMLLALVAYLIR----DWRW 152
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 131-193 8.50e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 8.50e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67540562 131 ALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASG 193
Cdd:cd17374  42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSG 104
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 88-269 9.00e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 38.37  E-value: 9.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562  88 WVYANIIGWLSLVVTFATSVFSAATGVTAEEFgvgrQVTTLGTALFIAGFAAGPLLFGPLSELYGRK--RPLIAGYAVFV 165
Cdd:cd17336   2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRF----GLSSSQSGLILSANDIGQLLAVLLVSYFGGRghRPRWIGIGSIL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562 166 ------VFQIPvgvarniETLILCRFIGGVAASGPLSIAGGYFADFFDPVQRGLALAIFSGTTLVGPIVGPILGGF---- 235
Cdd:cd17336  78 mglgcfLLALP-------HFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFllri 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 67540562 236 ----------ITQSYLEWRWTAWITMIMAAAAGLIG---LFVLPETY 269
Cdd:cd17336 151 yvdfsrvplgITPDDPRWIGAWWLGFLILGILLLIVsipLFFFPPIF 197
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 128-267 9.28e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 38.46  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67540562   128 LGTALFIAGFAAGPLLFGPLSELYGRKRPLIAGYAVFVVFQIPVGVARNIETLILCRFIGGVAASGPLSIAGGYFADFFD 207
Cdd:TIGR00898 131 LTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLP 210

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67540562   208 PVQRGLALAIFSGTTLVGPIVGPILGGFITQsyleWRWtawiTMIMAAAAGLIGL---FVLPE 267
Cdd:TIGR00898 211 KKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD----WRW----LQLAVSLPTFLFFllsWFVPE 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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