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Conserved domains on  [gi|6753390|ref|NP_034007|]
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cyclin-dependent kinase inhibitor 2A isoform p19ARF [Mus musculus]

Protein Classification

P19Arf_N domain-containing protein( domain architecture ID 10538381)

P19Arf_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P19Arf_N super family cl06435
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus ...
 4-45 1.21e-08

Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.


The actual alignment was detected with superfamily member pfam07392:

Pssm-ID: 462153  Cd Length: 51  Bit Score: 48.68  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6753390      4 RFLVTVRIQRAGRPLQERVFLVKFVRSRRPRTASCALAFVNM 45
Cdd:pfam07392   1 RFLVTVRIRRAGRPPQVRVFVVKIVRPAREWAAPGVRAAVAL 42
 
Name Accession Description Interval E-value
P19Arf_N pfam07392
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus ...
 4-45 1.21e-08

Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.


Pssm-ID: 462153  Cd Length: 51  Bit Score: 48.68  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6753390      4 RFLVTVRIQRAGRPLQERVFLVKFVRSRRPRTASCALAFVNM 45
Cdd:pfam07392   1 RFLVTVRIRRAGRPPQVRVFVVKIVRPAREWAAPGVRAAVAL 42
 
Name Accession Description Interval E-value
P19Arf_N pfam07392
Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus ...
 4-45 1.21e-08

Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus; This family represents the N-terminus (approximately 50 residues) of cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.


Pssm-ID: 462153  Cd Length: 51  Bit Score: 48.68  E-value: 1.21e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6753390      4 RFLVTVRIQRAGRPLQERVFLVKFVRSRRPRTASCALAFVNM 45
Cdd:pfam07392   1 RFLVTVRIRRAGRPPQVRVFVVKIVRPAREWAAPGVRAAVAL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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