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Conserved domains on  [gi|67470874|ref|XP_651399|]
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dolichol monophosphate mannose synthase, putative [Entamoeba histolytica HM-1:IMSS]

Protein Classification

DPM1_like and GtrA domain-containing protein( domain architecture ID 10157757)

DPM1_like and GtrA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-222 6.38e-105

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 307.15  E-value: 6.38e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKGN 85
Cdd:cd06442   1 IIIPTYNERENIPELIERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAARGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  86 VVLVMDADLQHPVSVVPKLYEAIKN-GAEVAVGSRHCPGGGIENWAFHRRVISWGAALLARP--FTSVSDPMSGFFAVKS 162
Cdd:cd06442  81 VIVVMDADLSHPPEYIPELLEAQLEgGADLVIGSRYVEGGGVEGWGLKRKLISRGANLLARLllGRKVSDPTSGFRAYRR 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67470874 163 SILKR--SKLEAKGYKILLEVLVKTGAKN--VVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSL 222
Cdd:cd06442 161 EVLEKliDSLVSKGYKFQLELLVRARRLGyrIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 231-353 2.61e-22

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


:

Pssm-ID: 441847  Cd Length: 133  Bit Score: 91.04  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874 231 LLKFIVVGGLGTIIDILIFTLLVSI-GLPGGFAQTLSFIAALCNNFFLNSLWTFpQNVDVNEKKKQFIKFGVVSCVAFII 309
Cdd:COG2246  10 LLRFGLVGGLGTLVDLGVFYLLVELlGLPPLLANVIAFVVAVIVNFLLNRRWTF-RSRGGRSRLREFLRFLLVSLVGLAL 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 67470874 310 RSLLFKLGRMYVPdeFPYIqMLLFVVIGTVTIINFIGSKLIVFA 353
Cdd:COG2246  89 NLGLLALLVYVLG--LPYL-LAKLIGIVVGTVFNFLLSRRWVFR 129
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-222 6.38e-105

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 307.15  E-value: 6.38e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKGN 85
Cdd:cd06442   1 IIIPTYNERENIPELIERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAARGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  86 VVLVMDADLQHPVSVVPKLYEAIKN-GAEVAVGSRHCPGGGIENWAFHRRVISWGAALLARP--FTSVSDPMSGFFAVKS 162
Cdd:cd06442  81 VIVVMDADLSHPPEYIPELLEAQLEgGADLVIGSRYVEGGGVEGWGLKRKLISRGANLLARLllGRKVSDPTSGFRAYRR 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67470874 163 SILKR--SKLEAKGYKILLEVLVKTGAKN--VVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSL 222
Cdd:cd06442 161 EVLEKliDSLVSKGYKFQLELLVRARRLGyrIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 1-223 6.54e-44

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 151.39  E-value: 6.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    1 MTDLTIIVPTYNEAENIEQLIIQLEDTLKDI-NFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENR--GLSPAVIE 77
Cdd:PLN02726   8 AMKYSIIVPTYNERLNIALIVYLIFKALQDVkDFEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGklGLGTAYIH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   78 GFGIAKGNVVLVMDADLQHPVSVVPKLYEAIK-NGAEVAVGSRHCPGGGIENWAFHRRVISWGAALLARPF--TSVSDPM 154
Cdd:PLN02726  88 GLKHASGDFVVIMDADLSHHPKYLPSFIKKQReTGADIVTGTRYVKGGGVHGWDLRRKLTSRGANVLAQTLlwPGVSDLT 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67470874  155 SGFFAVKSSILKR--SKLEAKGYKILLEVLVKTGAKN--VVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSLF 223
Cdd:PLN02726 168 GSFRLYKRSALEDlvSSVVSKGYVFQMEIIVRASRKGyrIEEVPITFVDRVYGESKLGGSEIVQYLKGLLYLL 240
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-208 9.18e-39

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 137.14  E-value: 9.18e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   1 MTDLTIIVPTYNEAENIEQLIIQLEDTLkDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFG 80
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLEEALESLLAQT-YPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  81 IAKGNVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGSRHCPGGGIenwaFHRRVISWGAAlLARPFTSVSDPMSGFFA 159
Cdd:COG0463  80 AARGDYIAFLDADDQLDPEKLEELVAALeEGPADLVYGSRLIREGES----DLRRLGSRLFN-LVRLLTNLPDSTSGFRL 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 67470874 160 VKSSILKRSKLEaKGYKILLEVL--VKTGAKnVVEVPIIFTtrvHGESKLT 208
Cdd:COG0463 155 FRREVLEELGFD-EGFLEDTELLraLRHGFR-IAEVPVRYR---AGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-167 8.79e-30

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 112.10  E-value: 8.79e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874     5 TIIVPTYNEAENIEQLIiqleDTLKDI---NFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGI 81
Cdd:pfam00535   1 SVIIPTYNEEKYLLETL----ESLLNQtypNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    82 AKGNVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGSRHCPGGGIENWAFHRRV---ISWGAALLARPFTSVSDPMSGF 157
Cdd:pfam00535  77 ATGDYIAFLDADDEVPPDWLEKLVEALeEDGADVVVGSRYVIFGETGEYRRASRItlsRLPFFLGLRLLGLNLPFLIGGF 156

                         170
                  ....*....|
gi 67470874   158 FAVKSSILKR 167
Cdd:pfam00535 157 ALYRREALEE 166
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 231-353 2.61e-22

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 91.04  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874 231 LLKFIVVGGLGTIIDILIFTLLVSI-GLPGGFAQTLSFIAALCNNFFLNSLWTFpQNVDVNEKKKQFIKFGVVSCVAFII 309
Cdd:COG2246  10 LLRFGLVGGLGTLVDLGVFYLLVELlGLPPLLANVIAFVVAVIVNFLLNRRWTF-RSRGGRSRLREFLRFLLVSLVGLAL 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 67470874 310 RSLLFKLGRMYVPdeFPYIqMLLFVVIGTVTIINFIGSKLIVFA 353
Cdd:COG2246  89 NLGLLALLVYVLG--LPYL-LAKLIGIVVGTVFNFLLSRRWVFR 129
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 233-352 1.38e-21

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 88.37  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   233 KFIVVGGLGTIIDILIFTLLVSI-GLPGGFAQTLSFIAALCNNFFLNSLWTFPQNVDVneKKKQFIKFGVVSCVAFIIRS 311
Cdd:pfam04138   1 RFLLVGVLGTLVDLAVFLLLLELfGLSYLLANAIAFVVAILVNFLLNRRWTFRDRRSG--SLRELLRFFLVSLAGLLLNL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 67470874   312 LLFKLGRMYVPDEFPYIQmllFVVIGTVTIINFIGSKLIVF 352
Cdd:pfam04138  79 LLLWLLVDGLGLPPLLAK---LVGIAVGTVVNFLLSRFFVF 116
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 4-115 1.43e-09

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 57.52  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874     4 LTIIVPTYNEAENIEQLIIQLEDTLKDInfDILVMDDNSPDKTgekVQRLKSEGHKcdvVIRTE-------NRGLSpavi 76
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRGDA--EVIVVDGGSTDGT---VEIARSLGAK---VIHSPkgrarqmNAGAA---- 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 67470874    77 egfgIAKGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVA 115
Cdd:TIGR04283  69 ----LAKGDILLFLHADTRLPKDFLEAIRRALAKPGYVA 103
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-222 6.38e-105

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 307.15  E-value: 6.38e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKGN 85
Cdd:cd06442   1 IIIPTYNERENIPELIERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAARGD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  86 VVLVMDADLQHPVSVVPKLYEAIKN-GAEVAVGSRHCPGGGIENWAFHRRVISWGAALLARP--FTSVSDPMSGFFAVKS 162
Cdd:cd06442  81 VIVVMDADLSHPPEYIPELLEAQLEgGADLVIGSRYVEGGGVEGWGLKRKLISRGANLLARLllGRKVSDPTSGFRAYRR 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 67470874 163 SILKR--SKLEAKGYKILLEVLVKTGAKN--VVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSL 222
Cdd:cd06442 161 EVLEKliDSLVSKGYKFQLELLVRARRLGyrIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-184 1.17e-53

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 174.68  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTL-KDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKG 84
Cdd:cd04179   1 VVIPAYNEEENIPELVERLLAVLeEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRAGFKAARG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  85 NVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGSRHCPGGGiENWAFHRRVISWGAALLARPFT--SVSDPMSGFFAVK 161
Cdd:cd04179  81 DIVVTMDADLQHPPEDIPKLLEKLlEGGADVVIGSRFVRGGG-AGMPLLRRLGSRLFNFLIRLLLgvRISDTQSGFRLFR 159

                       170       180
                ....*....|....*....|....*
gi 67470874 162 SSILK--RSKLEAKGYKILLEVLVK 184
Cdd:cd04179 160 REVLEalLSLLESNGFEFGLELLVG 184
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 1-223 6.54e-44

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 151.39  E-value: 6.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    1 MTDLTIIVPTYNEAENIEQLIIQLEDTLKDI-NFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENR--GLSPAVIE 77
Cdd:PLN02726   8 AMKYSIIVPTYNERLNIALIVYLIFKALQDVkDFEIIVVDDGSPDGTQDVVKQLQKVYGEDRILLRPRPGklGLGTAYIH 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   78 GFGIAKGNVVLVMDADLQHPVSVVPKLYEAIK-NGAEVAVGSRHCPGGGIENWAFHRRVISWGAALLARPF--TSVSDPM 154
Cdd:PLN02726  88 GLKHASGDFVVIMDADLSHHPKYLPSFIKKQReTGADIVTGTRYVKGGGVHGWDLRRKLTSRGANVLAQTLlwPGVSDLT 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 67470874  155 SGFFAVKSSILKR--SKLEAKGYKILLEVLVKTGAKN--VVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSLF 223
Cdd:PLN02726 168 GSFRLYKRSALEDlvSSVVSKGYVFQMEIIVRASRKGyrIEEVPITFVDRVYGESKLGGSEIVQYLKGLLYLL 240
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-208 9.18e-39

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 137.14  E-value: 9.18e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   1 MTDLTIIVPTYNEAENIEQLIIQLEDTLkDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFG 80
Cdd:COG0463   1 MPLVSVVIPTYNEEEYLEEALESLLAQT-YPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  81 IAKGNVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGSRHCPGGGIenwaFHRRVISWGAAlLARPFTSVSDPMSGFFA 159
Cdd:COG0463  80 AARGDYIAFLDADDQLDPEKLEELVAALeEGPADLVYGSRLIREGES----DLRRLGSRLFN-LVRLLTNLPDSTSGFRL 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 67470874 160 VKSSILKRSKLEaKGYKILLEVL--VKTGAKnVVEVPIIFTtrvHGESKLT 208
Cdd:COG0463 155 FRREVLEELGFD-EGFLEDTELLraLRHGFR-IAEVPVRYR---AGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-167 8.79e-30

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 112.10  E-value: 8.79e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874     5 TIIVPTYNEAENIEQLIiqleDTLKDI---NFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGI 81
Cdd:pfam00535   1 SVIIPTYNEEKYLLETL----ESLLNQtypNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    82 AKGNVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGSRHCPGGGIENWAFHRRV---ISWGAALLARPFTSVSDPMSGF 157
Cdd:pfam00535  77 ATGDYIAFLDADDEVPPDWLEKLVEALeEDGADVVVGSRYVIFGETGEYRRASRItlsRLPFFLGLRLLGLNLPFLIGGF 156

                         170
                  ....*....|
gi 67470874   158 FAVKSSILKR 167
Cdd:pfam00535 157 ALYRREALEE 166
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 6-166 6.38e-27

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 104.87  E-value: 6.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLKDI--NFDILVMDDNSPDKTGEKVQRLkSEGHKCDVVIR-TENRGLSPAVIEGFGIA 82
Cdd:cd04187   1 IVVPVYNEEENLPELYERLKAVLESLgyDYEIIFVDDGSTDRTLEILREL-AARDPRVKVIRlSRNFGQQAALLAGLDHA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  83 KGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVAVG---SRHcpgggiENWafHRRVISWGAALLARPFTSVSDPM--SGF 157
Cdd:cd04187  80 RGDAVITMDADLQDPPELIPEMLAKWEEGYDVVYGvrkNRK------ESW--LKRLTSKLFYRLINKLSGVDIPDngGDF 151


                ....*....
gi 67470874 158 FAVKSSILK 166
Cdd:cd04187 152 RLMDRKVVD 160
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 231-353 2.61e-22

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 91.04  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874 231 LLKFIVVGGLGTIIDILIFTLLVSI-GLPGGFAQTLSFIAALCNNFFLNSLWTFpQNVDVNEKKKQFIKFGVVSCVAFII 309
Cdd:COG2246  10 LLRFGLVGGLGTLVDLGVFYLLVELlGLPPLLANVIAFVVAVIVNFLLNRRWTF-RSRGGRSRLREFLRFLLVSLVGLAL 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 67470874 310 RSLLFKLGRMYVPdeFPYIqMLLFVVIGTVTIINFIGSKLIVFA 353
Cdd:COG2246  89 NLGLLALLVYVLG--LPYL-LAKLIGIVVGTVFNFLLSRRWVFR 129
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 233-352 1.38e-21

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 88.37  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   233 KFIVVGGLGTIIDILIFTLLVSI-GLPGGFAQTLSFIAALCNNFFLNSLWTFPQNVDVneKKKQFIKFGVVSCVAFIIRS 311
Cdd:pfam04138   1 RFLLVGVLGTLVDLAVFLLLLELfGLSYLLANAIAFVVAILVNFLLNRRWTFRDRRSG--SLRELLRFFLVSLAGLLLNL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 67470874   312 LLFKLGRMYVPDEFPYIQmllFVVIGTVTIINFIGSKLIVF 352
Cdd:pfam04138  79 LLLWLLVDGLGLPPLLAK---LVGIAVGTVVNFLLSRFFVF 116
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 6-195 3.57e-20

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 87.24  E-value: 3.57e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLKDI---NFDILVMDDNSPDKTGEKVQRLkSEGHKCDVVI--RTENRGLSPAVIEGFG 80
Cdd:cd04188   1 VVIPAYNEEKRLPPTLEEAVEYLEERpsfSYEIIVVDDGSKDGTAEVARKL-ARKNPALIRVltLPKNRGKGGAVRAGML 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  81 IAKGNVVLVMDADLQHPVSVVPKLYEAIKN-GAEVAVGSRHCPGGG-IENWAFHRRVISWGAALLARPFT--SVSDPMSG 156
Cdd:cd04188  80 AARGDYILFADADLATPFEELEKLEEALKTsGYDIAIGSRAHLASAaVVKRSWLRNLLGRGFNFLVRLLLglGIKDTQCG 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 67470874 157 FFAVKSSILKR--SKLEAKGYKILLEVLV---KTGAKnVVEVPI 195
Cdd:cd04188 160 FKLFTRDAARRlfPRLHLERWAFDVELLVlarRLGYP-IEEVPV 202
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-287 2.62e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 84.02  E-value: 2.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   1 MTDLTIIVPTYNEAENIEQLIIQLED-TLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGF 79
Cdd:COG1215  28 LPRVSVIIPAYNEEAVIEETLRSLLAqDYPKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  80 GIAKGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVAVGSrhcpgggieNWAFHRRVISwgAALLARPFTSVSDPMSGFfa 159
Cdd:COG1215 108 KAARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGASGA---------NLAFRREALE--EVGGFDEDTLGEDLDLSL-- 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874 160 vkssilkrsKLEAKGYKILL--EVLVKTgaknvvEVPIIFTTRVHGESKLTGGVMTNYLLH-------LFSLFCYPGTCP 230
Cdd:COG1215 175 ---------RLLRAGYRIVYvpDAVVYE------EAPETLRALFRQRRRWARGGLQLLLKHrpllrprRLLLFLLLLLLP 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 67470874 231 LLKFIVVGGLGTIIDILIFTLLVSIGLPGGFAQTLSFIAALCNNFFLNSLWTFPQNV 287
Cdd:COG1215 240 LLLLLLLLALLALLLLLLPALLLALLLALRRRRLLLPLLHLLYGLLLLLAALRGKKV 296
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-136 4.02e-17

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 77.55  E-value: 4.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDtLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKGN 85
Cdd:cd00761   1 VIIPAYNEEPYLERCLESLLA-QTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGE 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 67470874  86 VVLVMDADLQHPVSVVPKLYEAIKNGAEVAVGSRHCpgggieNWAFHRRVI 136
Cdd:cd00761  80 YILFLDADDLLLPDWLERLVAELLADPEADAVGGPG------NLLFRRELL 124
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 6-167 1.00e-16

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 76.88  E-value: 1.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIiqleDTLKDI---NFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRT-ENRGLSPAVIEGFGI 81
Cdd:cd06423   1 IIVPAYNEEAVIERTI----ESLLALdypKLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDkENGGKAGALNAGLRH 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  82 AKGNVVLVMDADlqhpvSVVPK--LYEAIKNGAE----VAVGSRHCPGGGIENWAFHRRVIS-WGAALLARPFTSVSD-- 152
Cdd:cd06423  77 AKGDIVVVLDAD-----TILEPdaLKRLVVPFFAdpkvGAVQGRVRVRNGSENLLTRLQAIEyLSIFRLGRRAQSALGgv 151

                       170
                ....*....|....*..
gi 67470874 153 -PMSG-FFAVKSSILKR 167
Cdd:cd06423 152 lVLSGaFGAFRREALRE 168
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-93 1.27e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 65.78  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   1 MTDLTIIVPTYNEAENIEQLIIQLEDtLKDINFDILVMDDNSPDKTGEKVQRLKSEGhkCDVVIRTENRGLSPAVIEGFG 80
Cdd:COG1216   2 RPKVSVVIPTYNRPELLRRCLESLLA-QTYPPFEVIVVDNGSTDGTAELLAALAFPR--VRVIRNPENLGFAAARNLGLR 78

                        90
                ....*....|...
gi 67470874  81 IAKGNVVLVMDAD 93
Cdd:COG1216  79 AAGGDYLLFLDDD 91
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-117 4.44e-11

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 62.25  E-value: 4.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   5 TIIVPTYNEAENIEQLIIQLE--DTLKDiNFDILVMDDNSPDKTGEKVQRLKSEgHKCDVVIRTENRGLSPAVIEGFGIA 82
Cdd:cd02525   3 SIIIPVRNEEKYIEELLESLLnqSYPKD-LIEIIVVDGGSTDGTREIVQEYAAK-DPRIRLIDNPKRIQSAGLNIGIRNS 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 67470874  83 KGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVAVG 117
Cdd:cd02525  81 RGDIIIRVDAHAVYPKDYILELVEALKRTGADNVG 115
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 4-270 1.44e-10

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 61.68  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    4 LTIIVPTYNEAENIEQLIIQLEDTLKDIN--FDILVMDDNSPDKTGEK-VQRLKSEGHKCDVVIRTENRGLSPAVIEGFG 80
Cdd:PRK10714   8 VSVVIPVYNEQESLPELIRRTTAACESLGkeYEILLIDDGSSDNSAEMlVEAAQAPDSHIVAILLNRNYGQHSAIMAGFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   81 IAKGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVaVGSRHcpgggienwafHRRVISW----GAALLARPFTSVSDPMSG 156
Cdd:PRK10714  88 HVTGDLIITLDADLQNPPEEIPRLVAKADEGYDV-VGTVR-----------QNRQDSWfrktASKMINRLIQRTTGKAMG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  157 FFAVKSSILKRSKLEA----KGYKILLEVLVKTGAKNVVEVPIIFTTRVHGESKLTGGVMTNYLLHLFSLFCypgTCPLL 232
Cdd:PRK10714 156 DYGCMLRAYRRHIVDAmlhcHERSTFIPILANTFARRAIEIPVHHAEREFGDSKYSFMRLINLMYDLVTCLT---TTPLR 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 67470874  233 KFIVVGGLGTIIDILIFTLLVSIGLPGG-----------FAQTLSFIAA 270
Cdd:PRK10714 233 LLSLLGSIIAIGGFSLAVLLVVLRLTFGpqwaaegvfmlFAVLFTFIGA 281
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-161 1.35e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 57.68  E-value: 1.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLED-TLKDINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTENRGLSP---AVIEGFGI 81
Cdd:cd04192   1 VVIAARNEAENLPRLLQSLSAlDYPKEKFEVILVDDHSTDGTVQILEFAAAKPNFQLKILNNSRVSISGkknALTTAIKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  82 AKGNVVLVMDADLQHPVSVVPKLYEAI-KNGAEVAVGsrhcPGGGIENWAF--HRRVISW--------GAALLARPFTSV 150
Cdd:cd04192  81 AKGDWIVTTDADCVVPSNWLLTFVAFIqKEQIGLVAG----PVIYFKGKSLlaKFQRLDWlsllgliaGSFGLGKPFMCN 156

                       170
                ....*....|....*
gi 67470874 151 SDPM----SGFFAVK 161
Cdd:cd04192 157 GANMayrkEAFFEVG 171
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 4-115 1.43e-09

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 57.52  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874     4 LTIIVPTYNEAENIEQLIIQLEDTLKDInfDILVMDDNSPDKTgekVQRLKSEGHKcdvVIRTE-------NRGLSpavi 76
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRGDA--EVIVVDGGSTDGT---VEIARSLGAK---VIHSPkgrarqmNAGAA---- 68

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 67470874    77 egfgIAKGNVVLVMDADLQHPVSVVPKLYEAIKNGAEVA 115
Cdd:TIGR04283  69 ----LAKGDILLFLHADTRLPKDFLEAIRRALAKPGYVA 103
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 5-93 2.99e-09

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 56.82  E-value: 2.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   5 TIIVPTYNEAENIEQliiQLEDTL-----KDiNFDILVMDDNSPDKTGEKVQRLKSEGHKcdVVIRTENRGLSPAVIEGF 79
Cdd:cd06439  32 TIIIPAYNEEAVIEA---KLENLLaldypRD-RLEIIVVSDGSTDGTAEIAREYADKGVK--LLRFPERRGKAAALNRAL 105

                        90
                ....*....|....
gi 67470874  80 GIAKGNVVLVMDAD 93
Cdd:cd06439 106 ALATGEIVVFTDAN 119
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 3-119 5.73e-09

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 56.70  E-value: 5.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    3 DLTIIVPTYNEAENIEQLiiqLEDTLK----------DINFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIR----TEN 68
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKM---LKETIKylesrsrkdpKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNIDIRllslLRN 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 67470874   69 RGLSPAVIEGFGIAKGNVVLVMDADLQHPVSVVPKLYEAI----KNGAEVAVGSR 119
Cdd:PTZ00260 148 KGKGGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMlkieQNGLGIVFGSR 202
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 4-93 8.54e-09

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 55.27  E-value: 8.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   4 LTIIVPTYNEAENIEQLIIQLEdTLKDINFDILVMDDNSPDKTGEKVQRLkseghkcDVVIRTENRGLSPAVIEGFGIAK 83
Cdd:cd02522   1 LSIIIPTLNEAENLPRLLASLR-RLNPLPLEIIVVDGGSTDGTVAIARSA-------GVVVISSPKGRARQMNAGAAAAR 72

                        90
                ....*....|
gi 67470874  84 GNVVLVMDAD 93
Cdd:cd02522  73 GDWLLFLHAD 82
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-124 1.08e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 51.02  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLIIQLEDTLkDINFDILVMDDNSPDKTgekVQRLKSEGHKCDVVIRTENRGLSPAVIEGFGIAKGN 85
Cdd:cd04186   1 IIIVNYNSLEYLKACLDSLLAQT-YPDFEVIVVDNASTDGS---VELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGD 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 67470874  86 VVLVM--DADLQHPvsVVPKLYEAIKNGAEVA-VGSRhCPGG 124
Cdd:cd04186  77 YVLLLnpDTVVEPG--ALLELLDAAEQDPDVGiVGPK-VSGA 115
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 4-93 2.15e-06

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 47.58  E-value: 2.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   4 LTIIVPTYNEAEN-----IEQLIIQLEDtlkdiNFDILVMDDNSPD-KTGEKVQRLKSEGHKCDVVIRTENRGLSPAVIE 77
Cdd:cd04184   3 ISIVMPVYNTPEKylreaIESVRAQTYP-----NWELCIADDASTDpEVKRVLKKYAAQDPRIKVVFREENGGISAATNS 77

                        90
                ....*....|....*.
gi 67470874  78 GFGIAKGNVVLVMDAD 93
Cdd:cd04184  78 ALELATGEFVALLDHD 93
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 4-93 3.15e-05

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 44.59  E-value: 3.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   4 LTIIVPTYNEAENIEQLIiqleDTLKDINFDILVMDDNSPDKTGEKVQRLKSEghkcdvVIRTENRGLSPAVIEGFGIAK 83
Cdd:cd02511   2 LSVVIITKNEERNIERCL----ESVKWAVDEIIVVDSGSTDRTVEIAKEYGAK------VYQRWWDGFGAQRNFALELAT 71

                        90
                ....*....|
gi 67470874  84 GNVVLVMDAD 93
Cdd:cd02511  72 NDWVLSLDAD 81
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 4-115 4.25e-05

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 44.65  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    4 LTIIVPTYNEAENIEQLIIQLED-TLKdiNFDILVMDDNSPDKTGEKVQRLKSEgHKCDVVIRTENRGLSPAVIEGFGIA 82
Cdd:PRK10073   8 LSIIIPLYNAGKDFRAFMESLIAqTWT--ALEIIIVNDGSTDNSVEIAKHYAEN-YPHVRLLHQANAGVSVARNTGLAVA 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 67470874   83 KGNVVLVMDADlqhpVSVVPKLYE-----AIKNGAEVA 115
Cdd:PRK10073  85 TGKYVAFPDAD----DVVYPTMYEtlmtmALEDDLDVA 118
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 5-93 4.47e-05

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 43.69  E-value: 4.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   5 TIIVPTYNEAENIEQLI----IQledtlKDINFDILVMDDNSPDKTgekVQRLKSEGHKCDVVIRTENRGLSPAVIEGFG 80
Cdd:cd06433   1 SIITPTYNQAETLEETIdsvlSQ-----TYPNIEYIVIDGGSTDGT---VDIIKKYEDKITYWISEPDKGIYDAMNKGIA 72

                        90
                ....*....|...
gi 67470874  81 IAKGNVVLVMDAD 93
Cdd:cd06433  73 LATGDIIGFLNSD 85
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 3-167 5.39e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 43.90  E-value: 5.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874     3 DLTIIVPTYNEAENIEQliiQLEDTLKD--INFDILVMDDNSPDKTGEKVQRLKSE-GHKCDVVIRTEN----RGLSPAV 75
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGR---VLEAILAQpyPPVEVVVVVNPSDAETLDVAEEIAARfPDVRLRVIRNARllgpTGKSRGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874    76 IEGFGIAKGNVVLVMDADlqhpvSVVPKlyEAIKNGAEVAVGSRHCPGGGIENWAFHRRVIS-WGAALLARPFTSVS--- 151
Cdd:pfam13641  80 NHGFRAVKSDLVVLHDDD-----SVLHP--GTLKKYVQYFDSPKVGAVGTPVFSLNRSTMLSaLGALEFALRHLRMMslr 152

                         170       180
                  ....*....|....*....|..
gi 67470874   152 -----DPMSG-FFAVKSSILKR 167
Cdd:pfam13641 153 lalgvLPLSGaGSAIRREVLKE 174
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 3-143 5.83e-05

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 43.78  E-value: 5.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   3 DLTIIVPTYNEAENIeqliiqLEDTL------KDINFdILVMDDnspDKTGEKVQRLKSEGHKCDVVIRTENRGLSPAVI 76
Cdd:cd06434   1 DVTVIIPVYDEDPDV------FRECLrsilrqKPLEI-IVVTDG---DDEPYLSILSQTVKYGGIFVITVPHPGKRRALA 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874  77 EGFGIAKGNVVLVMDADLQHPVSVVP---KLYEAIKNGaevAVGSRhcpgggIENWAFHRRVISWGAALL 143
Cdd:cd06434  71 EGIRHVTTDIVVLLDSDTVWPPNALPemlKPFEDPKVG---GVGTN------QRILRPRDSKWSFLAAEY 131
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 5-97 1.94e-04

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 42.30  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   5 TIIVPTYNEAENIEQLIiqleDTLKDINF-----DILVMDDNSPD---KTGEKVQRLKSEGHKCDVVIRTENRGL-SPAV 75
Cdd:cd06437   4 TVQLPVFNEKYVVERLI----EAACALDYpkdrlEIQVLDDSTDEtvrLAREIVEEYAAQGVNIKHVRRADRTGYkAGAL 79

                        90       100
                ....*....|....*....|..
gi 67470874  76 IEGFGIAKGNVVLVMDADLQHP 97
Cdd:cd06437  80 AEGMKVAKGEYVAIFDADFVPP 101
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-70 2.30e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 41.85  E-value: 2.30e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67470874   5 TIIVPTYNEAENI-EQLIIQLEDTLKdiNFDILVMDDNSPDKTGEKVQRLKSEGHKCDVVIRTE-NRG 70
Cdd:cd04196   1 AVLMATYNGEKYLrEQLDSILAQTYK--NDELIISDDGSTDGTVEIIKEYIDKDPFIIILIRNGkNLG 66
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 231-283 2.40e-04

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 40.22  E-value: 2.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 67470874   231 LLKFIVVGGLGTIIDILIFTLLVS-IGLPGGFAQTLSFIAALCNNFFLNSLWTF 283
Cdd:pfam04138  63 LLRFFLVSLAGLLLNLLLLWLLVDgLGLPPLLAKLVGIAVGTVVNFLLSRFFVF 116
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 6-93 2.02e-03

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 38.74  E-value: 2.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67470874   6 IIVPTYNEAENIEQLI--IQLEDTLKDInFDILVMDDNSPDKTGEKVqrlksEGHKCDVVIRT--ENRGLSPAVIEGFGI 81
Cdd:cd06438   1 ILIPAHNEEAVIGNTVrsLKAQDYPREL-YRIFVVADNCTDDTAQVA-----RAAGATVLERHdpERRGKGYALDFGFRH 74

                        90
                ....*....|....*..
gi 67470874  82 AKG-----NVVLVMDAD 93
Cdd:cd06438  75 LLNladdpDAVVVFDAD 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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