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Conserved domains on  [gi|674571832|emb|CDS42250|]
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lipase maturation factor [Echinococcus multilocularis]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 119-555 4.91e-110

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 337.00  E-value: 4.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  119 WKWTSLLIEAGFLCFLLSIKLRKYSRS---ASMIVAWLIKWLLFREAVSTGFARLANDNYFWWDLSAMEHYFSTQISPTP 195
Cdd:pfam06762   3 FQWDSLLLETGFLAIFLAPLGLLRRLPkspPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  196 AAYYLSLAPSLVLRIISLFFIVMEIFIPFLFLIPVRELQIFSFFAKVMFHADLIVIGNHGIYNLLSIVLSFALL------ 269
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLddafly 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  270 -------PEPKRYKGSSVSHRFVSVATTvavlTVLFYGVWVFFGFQEGieamritilrkefidqakTVNYYTILIVSSFF 342
Cdd:pfam06762 163 fwtpesrKKPPRTRLLSVIETLLSLLVY----GLLIYGTVSLFGLKIS------------------ENGTFLRRVTLPSI 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  343 VLNLLAAMFRSLSTRGCMNRMLDFTGVALVGLMGGGLFAASLAPFsslvdssSVVPLPSFAYeltAALKPFHLANDYRFF 422
Cdd:pfam06762 221 VLGLVSLLSVPVCALLRSNKLIQSIQLAIVTLAAVLLFALSLVPF-------SVRNLLSRMN---ASFNPLHLVNSYGLF 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  423 HQkekdvllkVDRQRTVLVLEGAMNENGPWKELSFHHVPSTPEKMPSVIPGHLPVVDFEAALSGERTFENSPIVATLVYR 502
Cdd:pfam06762 291 GS--------MTGGRPEVVIEGSNDGEGPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYR 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 674571832  503 ILTKEKEVLALLEPSGFPI-GPKFVQIRKYTYEISRSING---PQWWKRKLQNIYLP 555
Cdd:pfam06762 363 LLQNDPEVLGLLDHNPFPDkPPKYVRAELYRYRFTTPGERratGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 119-555 4.91e-110

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 337.00  E-value: 4.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  119 WKWTSLLIEAGFLCFLLSIKLRKYSRS---ASMIVAWLIKWLLFREAVSTGFARLANDNYFWWDLSAMEHYFSTQISPTP 195
Cdd:pfam06762   3 FQWDSLLLETGFLAIFLAPLGLLRRLPkspPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  196 AAYYLSLAPSLVLRIISLFFIVMEIFIPFLFLIPVRELQIFSFFAKVMFHADLIVIGNHGIYNLLSIVLSFALL------ 269
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLddafly 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  270 -------PEPKRYKGSSVSHRFVSVATTvavlTVLFYGVWVFFGFQEGieamritilrkefidqakTVNYYTILIVSSFF 342
Cdd:pfam06762 163 fwtpesrKKPPRTRLLSVIETLLSLLVY----GLLIYGTVSLFGLKIS------------------ENGTFLRRVTLPSI 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  343 VLNLLAAMFRSLSTRGCMNRMLDFTGVALVGLMGGGLFAASLAPFsslvdssSVVPLPSFAYeltAALKPFHLANDYRFF 422
Cdd:pfam06762 221 VLGLVSLLSVPVCALLRSNKLIQSIQLAIVTLAAVLLFALSLVPF-------SVRNLLSRMN---ASFNPLHLVNSYGLF 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  423 HQkekdvllkVDRQRTVLVLEGAMNENGPWKELSFHHVPSTPEKMPSVIPGHLPVVDFEAALSGERTFENSPIVATLVYR 502
Cdd:pfam06762 291 GS--------MTGGRPEVVIEGSNDGEGPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYR 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 674571832  503 ILTKEKEVLALLEPSGFPI-GPKFVQIRKYTYEISRSING---PQWWKRKLQNIYLP 555
Cdd:pfam06762 363 LLQNDPEVLGLLDHNPFPDkPPKYVRAELYRYRFTTPGERratGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 119-555 4.91e-110

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 337.00  E-value: 4.91e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  119 WKWTSLLIEAGFLCFLLSIKLRKYSRS---ASMIVAWLIKWLLFREAVSTGFARLANDNYFWWDLSAMEHYFSTQISPTP 195
Cdd:pfam06762   3 FQWDSLLLETGFLAIFLAPLGLLRRLPkspPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  196 AAYYLSLAPSLVLRIISLFFIVMEIFIPFLFLIPVRELQIFSFFAKVMFHADLIVIGNHGIYNLLSIVLSFALL------ 269
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLddafly 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  270 -------PEPKRYKGSSVSHRFVSVATTvavlTVLFYGVWVFFGFQEGieamritilrkefidqakTVNYYTILIVSSFF 342
Cdd:pfam06762 163 fwtpesrKKPPRTRLLSVIETLLSLLVY----GLLIYGTVSLFGLKIS------------------ENGTFLRRVTLPSI 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  343 VLNLLAAMFRSLSTRGCMNRMLDFTGVALVGLMGGGLFAASLAPFsslvdssSVVPLPSFAYeltAALKPFHLANDYRFF 422
Cdd:pfam06762 221 VLGLVSLLSVPVCALLRSNKLIQSIQLAIVTLAAVLLFALSLVPF-------SVRNLLSRMN---ASFNPLHLVNSYGLF 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674571832  423 HQkekdvllkVDRQRTVLVLEGAMNENGPWKELSFHHVPSTPEKMPSVIPGHLPVVDFEAALSGERTFENSPIVATLVYR 502
Cdd:pfam06762 291 GS--------MTGGRPEVVIEGSNDGEGPWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYR 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 674571832  503 ILTKEKEVLALLEPSGFPI-GPKFVQIRKYTYEISRSING---PQWWKRKLQNIYLP 555
Cdd:pfam06762 363 LLQNDPEVLGLLDHNPFPDkPPKYVRAELYRYRFTTPGERratGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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