BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847   20 LQNFFNKTDYCDLTLQFrDNSQLKVHRLVLSACTDYFNVL-EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLEFElK 98
Cdd:pfam00651   1 LNELREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALfSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISE-E 78

                          90       100
                  ....*....|....*....|....*..
gi 672886847   99 MYGKLLRTAKEMNMTVLLKLLEAHRRT 125
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  23 FFNKTDYCDLTLQFR-DNSQLKVHRLVLSACTDYFNVLEQtCEIVDDALIMPneFQADVVVPIVNFMYTGTLEFELKMYG 101
Cdd:PHA03098   3 SFELQKFCDESIIIVnGGGIIKVHKIILSSSSEYFKKMFK-NNFKENEINLN--IDYDSFNEVIKYIYTGKINITSNNVK 79

                 ....*..
gi 672886847 102 KLLRTAK 108
Cdd:PHA03098  80 DILSIAN 86

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847   20 LQNFFNKTDYCDLTLQFrDNSQLKVHRLVLSACTDYFNVL-EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLEFElK 98
Cdd:pfam00651   1 LNELREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALfSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISE-E 78

                          90       100
                  ....*....|....*....|....*..
gi 672886847   99 MYGKLLRTAKEMNMTVLLKLLEAHRRT 125
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  29 YCDLTLqFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRTAK 108
Cdd:cd18315    1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ...
gi 672886847 109 EMN 111
Cdd:cd18315   80 LLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  10 DNWGVFFLQKLQNFFNKTDYCDLTLQFRDNSqLKVHRLVLSACTDYFNVL------EQTCEIVDDALIMPNEFQAdvvvp 83
Cdd:cd18256    1 DKHASLILAQLNKLRGQHEFCDVQLQVGMEL-FSVHRLVLAASSPYFAALfaggmsESSKDVVQIHGVEPDIFHI----- 74

                         90
                 ....*....|.
gi 672886847  84 IVNFMYTGTLE 94
Cdd:cd18256   75 LLDFIYTGVVE 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  16 FLQkLQNFFNKTDYCDLTLQFRDNSqLKVHRLVLSACTDYF-NVLEQTCEIVDDALIMP-NEFQADVVVPIVNFMYTGTL 93
Cdd:cd18293    3 FLQ-LHRQQNSGVFCDVLLQAEGES-VPAHCCVLSACSPYLtERLSSEPPPAGQKVVLElQGLKAHTLLKLVDFLYTSEL 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 672886847  94 EFELKMYGKLLRTAKEMNMTVLLKL-LEAHRR 124
Cdd:cd18293   81 EVSSEEAQDVLAAARRLQISELESLcLEGGKL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  17 LQKLQNFFnktdyCDLTLQFrDNSQLKVHRLVLSACTDYFNVL--EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLE 94
Cdd:cd18202   12 QQRLNNQF-----CDVTLLI-EGEEYKAHKSVLAANSEYFRELfiEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYTSELT 85

                         90       100       110
                 ....*....|....*....|....*....|...
gi 672886847  95 FELKMYGKLLRTAKEMNMTVLLKLLEAHRRTME 127
Cdd:cd18202   86 FDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672886847  28 DYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEI---VDDALIMPneFQADVVVPIVNFMYT 90
Cdd:cd18302    4 DLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIeasSCSALTMP--IPSDILEIILDYLYT 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  30 CDLTLqFRDNSQLKVHRLVLSACTDYF------NVLEQTCEIVDDALIMPNEFQAdvvvpIVNFMYTGTLEFELKMYGKL 103
Cdd:cd18234    2 CDVIL-IAGDRRIPAHRLVLSAVSDYFaamftnDVREATEEEIKLKDVDPDALWT-----LVQYCYTGRLELKEDNVESL 75

                 ....
gi 672886847 104 LRTA 107
Cdd:cd18234   76 LATA 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  18 QKLQNFfnktdYCDLTLQFRDNsQLKVHRLVLSACTDYFNVL--EQTCEIVD-DALIMPNEFQAdvvvpIVNFMYTGTLE 94
Cdd:cd18290   21 QRLQGL-----YCDVSVVVKGH-AFKAHRAVLAASSSYFRDLfnSSRSAVVElPAAVQPQSFQQ-----ILSFCYTGRLS 89

                         90
                 ....*....|...
gi 672886847  95 FELKMYGKLLRTA 107
Cdd:cd18290   90 MNVGDQFLLMYTA 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  30 CDLTLQFRDnSQLKVHRLVLSACTDYFN--VLEQTCEIVDDALIMPnEFQADVVVPIVNFMYTGTLEF-ELKMYGKLLRT 106
Cdd:cd18223   19 CDVTIVVED-TKFKAHKNVLAASSLYFKnaFSSQEIWISSHVLELP-DLKAEVFAEILNFIYSSKVVVkRQETVTDLVAA 96

                         90
                 ....*....|....*...
gi 672886847 107 AKEMNMTVLLKLLEAHRR 124
Cdd:cd18223   97 GKKLGITFLENLTDQNFS 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  18 QKLQNFFnktdyCDLTLQFRDnSQLKVHRLVLSACTDYFNVLEQtcEIVDDALIMpnEFQADVVVP-----IVNFMYTGT 92
Cdd:cd18324   17 QRHQGFL-----CDCTVLVGD-AQFRAHRAVLASCSMYFHLFYK--DQLDKRDIV--HLNSDIVTApafalLLEFMYEGK 86

                         90       100
                 ....*....|....*....|....*.
gi 672886847  93 LEFELKMYGKLLRTAKEMNMTVLLKL 118
Cdd:cd18324   87 LQFKDLPIEDVLAAASYLHMYDIVKV 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847   6 SVKVdnwgvffLQKLQNFFNKTDYCDLTLQFrDNSQLKVHRLVLSACTDYFNVLEQTCEIVDdaLIMPNEFqADVVVPIV 85
Cdd:cd18232    2 SVKV-------LQALNKQREEGQYCDATLDV-GGRVFKAHWSVLACCSHFFQSLYGDGTSGS--VVLPESF-AEVFGLLL 70

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 672886847  86 NFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHR 123
Cdd:cd18232   71 DFFYTGELALTRENRDRVLLAAKELRVPEAVELCQRFQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  30 CDLTLqFRDNSQLKVHRLVLSACTDYF--NVLEQTCEivDDALIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRTA 107
Cdd:cd18278   32 CDVTL-IVEGKEFRAHRAVLAACSEYFlqALVGQTEN--DLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIQEVIRCA 108

                 ....*
gi 672886847 108 KEMNM 112
Cdd:cd18278  109 EFLRM 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672886847  30 CDLTLqFRDNSQLKVHRLVLSACTDYF--NVLEQTCEivDDALIMPNEFQADVVVPIVNFMYTGTL 93
Cdd:cd18955    2 CDVTI-VVEDQRFRAHRAVLAACSDYFlsRVVGQTDG--DLVITLPEEVTVKGFEPLLQFAYTAKL 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  30 CDLTLQFRDNsQLKVHRLVLSACTDYFNVLEQTCEIVDDalimPNEFQADVVVP-----IVNFMYTGTLEFELKMYGKLL 104
Cdd:cd18328   26 CDVVLIVQDQ-EYRTHRSVLAACSKYFKKLFTAGTLADQ----PYVYEIDFVTPealsaILEFAYTSTLTITTSNVKHIL 100

                         90
                 ....*....|....
gi 672886847 105 RTAKEMNMTVLLKL 118
Cdd:cd18328  101 NAAQMLEIQCIINV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  11 NWGVFFLQKLQNFFNKTDYCDLTLQFRDnSQLKVHRLVLSACTDYFNVL--EQTCEIVDdalIMPNEFQADVVVPIVNFM 88
Cdd:cd18193    3 NHGLILLQQLNAQREFGFLCDCTVAIGD-VYFKAHKSVLASFSNYFKMLfvHQTSECVR---LKPTDIQPDIFSYLLHLM 78

                 ....*....
gi 672886847  89 YTGTLEFEL 97
Cdd:cd18193   79 YTGKMAPQL 87

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  17 LQKLQNFFNKTDYCDLTLQfRDNSQLKVHRLVLSACTDYFNVL------EQTCEIVDDALIMPNEFQAdvvvpIVNFMYT 90
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLE-ADGSIFRVHRVILAAGSDYFRAMftsgmkESTQSVVQLPTIPAKDLRL-----LISFAYS 74

                 ...
gi 672886847  91 GTL 93
Cdd:cd18263   75 GIL 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672886847  29 YCDLTLQF--RDNSQLKVHRLVLSACTDYFNVL--EQTCEIVDDALIMPN-----EFQADVVVPIVNFMYTGTL 93
Cdd:cd18241   23 FCDITLAFggAGGREFRAHRSVLAAATEYFTPLlsGQFSESRSGRVEMRKwssepGPDPDTVEAVIQYMYTGRI 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  15 FFLQKLQNFFNKTDYCDLTLQFrDNSQLKVHRLVLSACTDYFNVL-------EQTCEIV--DDALImpnEFQAdvvvpIV 85
Cdd:cd18287    8 FLSEDIGALFLNEEYSDVTFVV-EEKRFPAHRVILAARSEYFRALlyggmreSQQSEIElkDTNAE---AFKA-----LL 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 672886847  86 NFMYTGTLEfelkmygklLRTAKEMNMTVLLKLleAHR 123
Cdd:cd18287   79 KYIYTGRLT---------LTDLKEDVLLDVLGL--AHQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  17 LQKLQNFFNKTDYCDLTLQFRDNSqLKVHRLVLSACTDYFNvleqtceivDDALIMPNEFQADVVVP------IVNFMYT 90
Cdd:cd18229    6 LETLNAQRLGGHFCDVTVRIHDAS-LRAHRCVLAAGSPFFH---------DKLLLGHSEIEVPPVVPaqtvrqLVEFMYS 75

                 ...
gi 672886847  91 GTL 93
Cdd:cd18229   76 GSL 78

hypothetical protein; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672886847  17 LQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPN--EFQADVVVPIVNFMY 89
Cdd:PHA02713  13 VSNISNLLDDDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNlqMFDKDAVKNIVQYLY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  29 YCDLTLQFRDNSqLKVHRLVLSACTDYFNVLeQTCEIVDDAliMPNEFQADVVVP-----IVNFMYTGTLEFELKMYGKL 103
Cdd:cd18207   27 FCDVLLRVGEES-FPAHRAVLAACSEYFESV-FSAQEGDGG--TPRELEMHTISSkvfgdILDFAYTSRIVVRLESFPEL 102

                         90
                 ....*....|....*..
gi 672886847 104 LRTAKEMNMTVLLKLLE 120
Cdd:cd18207  103 MTAAKFLLMRSVIDICQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  18 QKLQNFFnktdyCDLTLQFRDnSQLKVHRLVLSACTDYFNVLEQtcEIVDDALIMpnEFQADVVVP-----IVNFMYTGT 92
Cdd:cd18325   17 QRHQGFL-----CDCTVLVGE-AQFRAHRAVLASCSMYFHLFYR--DQLDKRDIV--HLNSDIVTApafslLLEFMYEGK 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 672886847  93 LEFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQR 134
Cdd:cd18325   87 LEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKELCSEEKI 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  17 LQKLQNFFNKTDYCDLTLQFrDNSQLKVHRLVLSACTDYFNVL--EQTCEIVDDALIMpNEFQADVVVPIVNFMYTGTLE 94
Cdd:cd18247    7 FPVMEEIRRQGKLCDVTLKV-GDQKFSAHRIVLAATIPYFHAMftHDMVESKQDEITM-QGIEPSALEALINFAYSGRIA 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  30 CDLTLqFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDAlimpNEFQADVVVPI-----VNFMYTGTLEFELKMYGKLL 104
Cdd:cd18261   29 CDITL-VAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEA----DEVNLHGVTSLglkqaLDFAYTGQILLEPGVIQDVL 103

                         90
                 ....*....|....
gi 672886847 105 RTAKEMNMTVLLKL 118
Cdd:cd18261  104 AAGSHLQLLELLSL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672886847  17 LQKLQNFFNKTDYCDLTLQFRDNSqLKVHRLVLSACTDYFNVL-EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLE 94
Cdd:cd18271   12 LSVLQNFREQNAFFDFNIIVKDET-IPCHRCVLAACSDFFRAMfEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAE 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  28 DYCDLTLQFRDnSQLKVHRLVLSACTDYFNVL-EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRT 106
Cdd:cd18240   16 KLCDVVIRVNG-VEFPAHRNILCACSPYFRALfTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPA 94

                         90
                 ....*....|.
gi 672886847 107 AKEMNMTVLLK 117
Cdd:cd18240   95 ADQFNIMGIVK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  17 LQKLQNFFNKTDYCDLTLQFRDNsQLKVHRLVLSACTDYF-----NVLEQTCEIvddaLIMPNEFQADVVVPIVNFMYTG 91
Cdd:cd18253    6 LQVFNEFRDSRLFTDVIICVEGR-EFPCHRAILSACSSYFramfcNDHRESREM----LVEINGILAEAMDCFLQYVYTG 80

                         90       100
                 ....*....|....*....|....
gi 672886847  92 TLEFELKMYGKLLRTAKEMNMTVL 115
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672886847  31 DLTLQFRDnSQLKVHRLVLSACTDYFNVL--EQTCEIVdDALIMPNEFQADVVVPIVNFMYTGTL 93
Cdd:cd18332   21 DVTLLVGG-TPLRAHKAVLIACSGFFYSIfsGRVGEGV-SVLTLPSGLEARGFQLLLDFMYTSRL 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847  18 QKLQNFFnktdyCDLTLQFRDnSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFqadVVVP----IVNFMYTGTL 93
Cdd:cd18194   17 QRSQGFL-----CDCTVLVGS-AQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDI---VTAPafglLLDFMYEGRL 87

                         90       100
                 ....*....|....*....|....*..
gi 672886847  94 EFELKMYGKLLRTAKEMNMTVLLKLLE 120
Cdd:cd18194   88 ALRDLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672886847  29 YCDLTLQFRDNsQLKVHRLVLSACTDYFNVLEQtceiVDDALIMPNEFQADVVVPIVNFMYTGTL 93
Cdd:cd18219   21 FCDVTVIVEDR-KFRAHKNILSASSTYFHQLFS----VAGQVVELNFIRADIFAEILNYIYSSKI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672886847   7 VKVDNWGVFFLQKLQNFFNKTDYCDLTLQFRdNSQLKVHRLVLSACTDYFnvlEQTCEIVDDALIMPNEFQADVVVPIVN 86
Cdd:cd18208    3 INLHNFSNSVLETLNEQRNRGHFCDVTVRIH-GSMLRAHRCVLAAGSPFF---QDKLLLGYSDIEIPSVVSVQSVQKLID 78

                 ....*..
gi 672886847  87 FMYTGTL 93
Cdd:cd18208   79 FMYSGVL 85