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Conserved domains on  [gi|66775065|gb|AAY56126|]
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down-regulated in gastrointestinal cancer protein [Homo sapiens]

Protein Classification

PLAC8 family protein( domain architecture ID 2503)

PLAC8 family protein such as mammalian cornifelin, Arabidopsis plant cadmium resistance (PCR) proteins, and Zea mays cell number regulator proteins

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAC8 super family cl04722
PLAC8 family; This family includes the Placenta-specific gene 8 protein.
 24-108 6.32e-20

PLAC8 family; This family includes the Placenta-specific gene 8 protein.


The actual alignment was detected with superfamily member TIGR01571:

Pssm-ID: 471097  Cd Length: 104  Bit Score: 77.85  E-value: 6.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66775065    24 SNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNEC---CLCG----------------TSVAMRTLYRTRYGIPGSI 84
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFageCLCGgltaiamsalcgfcgcYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 66775065    85 CDDYMATLCCPHCTLCQIKRDINR 108
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
 
Name Accession Description Interval E-value
A_thal_Cys_rich TIGR01571
uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 ...
 24-108 6.32e-20

uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 residues. It is common in plants but found also in Homo sapiens, Dictyostelium, and Leishmania; at least 12 distinct members are found in Arabidopsis. Most members of this family contain more than 10 per cent Cys, but no Cys residue is invariant across the family.


Pssm-ID: 273697  Cd Length: 104  Bit Score: 77.85  E-value: 6.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66775065    24 SNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNEC---CLCG----------------TSVAMRTLYRTRYGIPGSI 84
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFageCLCGgltaiamsalcgfcgcYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 66775065    85 CDDYMATLCCPHCTLCQIKRDINR 108
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
PLAC8 pfam04749
PLAC8 family; This family includes the Placenta-specific gene 8 protein.
 26-101 7.86e-11

PLAC8 family; This family includes the Placenta-specific gene 8 protein.


Pssm-ID: 461417  Cd Length: 99  Bit Score: 54.26  E-value: 7.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66775065    26 WQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNE-------------------CCLCGTSVAMRTLYRTRYGIPGSICD 86
Cdd:pfam04749   1 WSTGLFDCFSDCGTCLLGCCCPCVLFGRNAERLDRgntscllagfaafcgltgcGLGWIYSCLQRGKIREKYGIEGSPCG 80

                          90
                  ....*....|....*
gi 66775065    87 DYMATLCCPHCTLCQ 101
Cdd:pfam04749  81 DCCVHCCCPCCALCQ 95
 
Name Accession Description Interval E-value
A_thal_Cys_rich TIGR01571
uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 ...
 24-108 6.32e-20

uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 residues. It is common in plants but found also in Homo sapiens, Dictyostelium, and Leishmania; at least 12 distinct members are found in Arabidopsis. Most members of this family contain more than 10 per cent Cys, but no Cys residue is invariant across the family.


Pssm-ID: 273697  Cd Length: 104  Bit Score: 77.85  E-value: 6.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66775065    24 SNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNEC---CLCG----------------TSVAMRTLYRTRYGIPGSI 84
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFageCLCGgltaiamsalcgfcgcYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 66775065    85 CDDYMATLCCPHCTLCQIKRDINR 108
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
PLAC8 pfam04749
PLAC8 family; This family includes the Placenta-specific gene 8 protein.
 26-101 7.86e-11

PLAC8 family; This family includes the Placenta-specific gene 8 protein.


Pssm-ID: 461417  Cd Length: 99  Bit Score: 54.26  E-value: 7.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66775065    26 WQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNE-------------------CCLCGTSVAMRTLYRTRYGIPGSICD 86
Cdd:pfam04749   1 WSTGLFDCFSDCGTCLLGCCCPCVLFGRNAERLDRgntscllagfaafcgltgcGLGWIYSCLQRGKIREKYGIEGSPCG 80

                          90
                  ....*....|....*
gi 66775065    87 DYMATLCCPHCTLCQ 101
Cdd:pfam04749  81 DCCVHCCCPCCALCQ 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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