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Conserved domains on  [gi|664800252|gb|AIF68485|]
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tRNA methyltransferase [Palaeococcus pacificus DY20341]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 4-253 1.97e-129

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 366.02  E-value: 1.97e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   4 EGDKVLLVDPRGKRYLLTVR-DEEFHTDLGILKLGELIGMEFGQSIKTHKEKEFKVLKPSIVDFLAKMKRGPQTIHPKDA 82
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEeGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  83 AQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEEN 162
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252 163 VSHIILDLPQPENVLEHAIKALKPGGFFVAYTPCANQVIRFYAKLKEYKghFSRPKTIECLVREQEVKENCFRPSTRMLA 242
Cdd:COG2519  161 VDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG--FTDIEAVETLLREWKVEGLAVRPEHRMVG 238

                        250
                 ....*....|.
gi 664800252 243 HTGYLTFMRKL 253
Cdd:COG2519  239 HTGFLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 4-253 1.97e-129

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 366.02  E-value: 1.97e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   4 EGDKVLLVDPRGKRYLLTVR-DEEFHTDLGILKLGELIGMEFGQSIKTHKEKEFKVLKPSIVDFLAKMKRGPQTIHPKDA 82
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEeGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  83 AQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEEN 162
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252 163 VSHIILDLPQPENVLEHAIKALKPGGFFVAYTPCANQVIRFYAKLKEYKghFSRPKTIECLVREQEVKENCFRPSTRMLA 242
Cdd:COG2519  161 VDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG--FTDIEAVETLLREWKVEGLAVRPEHRMVG 238

                        250
                 ....*....|.
gi 664800252 243 HTGYLTFMRKL 253
Cdd:COG2519  239 HTGFLVFARKL 249
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 75-252 8.38e-20

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 85.24  E-value: 8.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   75 QTIHPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNI 154
Cdd:pfam08704  22 QILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAREEFREHGIDQLVTVTHRDV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  155 -YDGIDEEnVSHII----LDLPQPENVLEHAIKALK-PGGFFVAYTPCANQVIRFYAKLKEYKghFSRPKTIECLVREQE 228
Cdd:pfam08704 102 cKEGFLTE-VSGKAdavfLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAELG--FTEISTLEVLLRVYD 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664800252  229 VKE----------------------------------------NCFRPSTRMLAHTGYLTFMRK 252
Cdd:pfam08704 179 VRTvslpvidlgidrekenertrteglsnddksednsgnsmlgTALKPMSEAVGHTGYLTFATK 242
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-191 3.85e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  97 IIEAGVGSGALTIFLANIVGKEgkIVSYEVREDFAKLAwRNIVWAGFDDRVEIKLKNIYDGIDEENVSH--IILDLPQ-- 172
Cdd:cd02440    2 VLDLGCGTGALALALASGPGAR--VTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPPEADESFdvIISDPPLhh 78

                         90       100
                 ....*....|....*....|...
gi 664800252 173 ----PENVLEHAIKALKPGGFFV 191
Cdd:cd02440   79 lvedLARFLEEARRLLKPGGVLV 101
arsM PRK11873
arsenite methyltransferase;
87-191 7.05e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 43.01  E-value: 7.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  87 AHAGISPGDFIIEAGVGSGaLTIFLA-NIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDrVEIKLKNIY-----DGIDE 160
Cdd:PRK11873  71 ALAELKPGETVLDLGSGGG-FDCFLAaRRVGPTGKVIGVDMTPEMLAKARANARKAGYTN-VEFRLGEIEalpvaDNSVD 148

                         90       100       110
                 ....*....|....*....|....*....|..
gi 664800252 161 ENVSHIILDL-PQPENVLEHAIKALKPGGFFV 191
Cdd:PRK11873 149 VIISNCVINLsPDKERVFKEAFRVLKPGGRFA 180
rADc smart00650
Ribosomal RNA adenine dimethylases;
82-131 8.01e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.11  E-value: 8.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 664800252    82 AAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVgkeGKIVSYEVREDFA 131
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERA---KRVTAIEIDPRLA 48
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 4-253 1.97e-129

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 366.02  E-value: 1.97e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   4 EGDKVLLVDPRGKRYLLTVR-DEEFHTDLGILKLGELIGMEFGQSIKTHKEKEFKVLKPSIVDFLAKMKRGPQTIHPKDA 82
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEeGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  83 AQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEEN 162
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252 163 VSHIILDLPQPENVLEHAIKALKPGGFFVAYTPCANQVIRFYAKLKEYKghFSRPKTIECLVREQEVKENCFRPSTRMLA 242
Cdd:COG2519  161 VDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG--FTDIEAVETLLREWKVEGLAVRPEHRMVG 238

                        250
                 ....*....|.
gi 664800252 243 HTGYLTFMRKL 253
Cdd:COG2519  239 HTGFLVFARKL 249
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 75-252 8.38e-20

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 85.24  E-value: 8.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   75 QTIHPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNI 154
Cdd:pfam08704  22 QILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAREEFREHGIDQLVTVTHRDV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  155 -YDGIDEEnVSHII----LDLPQPENVLEHAIKALK-PGGFFVAYTPCANQVIRFYAKLKEYKghFSRPKTIECLVREQE 228
Cdd:pfam08704 102 cKEGFLTE-VSGKAdavfLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAELG--FTEISTLEVLLRVYD 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664800252  229 VKE----------------------------------------NCFRPSTRMLAHTGYLTFMRK 252
Cdd:pfam08704 179 VRTvslpvidlgidrekenertrteglsnddksednsgnsmlgTALKPMSEAVGHTGYLTFATK 242
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 97-192 1.95e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 52.49  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  97 IIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEENVSHIilDL------ 170
Cdd:COG4122   20 ILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRLADGPF--DLvfidad 97

                         90       100
                 ....*....|....*....|...
gi 664800252 171 -PQPENVLEHAIKALKPGGFFVA 192
Cdd:COG4122   98 kSNYPDYLELALPLLRPGGLIVA 120
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 82-209 1.15e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.61  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  82 AAQIVAHAGISPGDFIIEAGVGSGALTIFLANivgKEGKIVSYEVREDFAKLAWRNIVWAGFddRVEIKLKNIYD-GIDE 160
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDlPFPD 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664800252 161 ENVSHIIL-----DLPQPENVLEHAIKALKPGGFFVAYTPCANQVIRFYAKLKE 209
Cdd:COG2226   86 GSFDLVISsfvlhHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 74-195 1.57e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.95  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  74 PQTIHPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFlANIVGkeGKIVSYEVREDFAKLAWRNIVWAGFDDrVEIKLKN 153
Cdd:COG1041    7 PGSLDPRLARALVNLAGAKEGDTVLDPFCGTGTILIE-AGLLG--RRVIGSDIDPKMVEGARENLEHYGYED-ADVIRGD 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 664800252 154 IYD-GIDEENVSHIILDLP--QP------------ENVLEHAIKALKPGGFFVAYTP 195
Cdd:COG1041   83 ARDlPLADESVDAIVTDPPygRSskisgeellelyEKALEEAARVLKPGGRVVIVTP 139
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 81-195 1.02e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 47.23  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  81 DAAQ------IVAHAGISPGDFIIEAGVGSGALTIFLANIVGkeGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNI 154
Cdd:COG2230   33 EEAQeakldlILRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADY 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 664800252 155 YDGIDEENVSHII-------LDLPQPENVLEHAIKALKPGGFFVAYTP 195
Cdd:COG2230  111 RDLPADGQFDAIVsigmfehVGPENYPAYFAKVARLLKPGGRLLLHTP 158
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
76-133 3.68e-06

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 46.97  E-value: 3.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 664800252   76 TIHPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVgkeGKIVSYEVREDFAKL 133
Cdd:pfam00398  13 LKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRA---KQVVAIEIDPRLAKL 67
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-191 3.85e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.73  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  97 IIEAGVGSGALTIFLANIVGKEgkIVSYEVREDFAKLAwRNIVWAGFDDRVEIKLKNIYDGIDEENVSH--IILDLPQ-- 172
Cdd:cd02440    2 VLDLGCGTGALALALASGPGAR--VTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPPEADESFdvIISDPPLhh 78

                         90       100
                 ....*....|....*....|...
gi 664800252 173 ----PENVLEHAIKALKPGGFFV 191
Cdd:cd02440   79 lvedLARFLEEARRLLKPGGVLV 101
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
89-191 5.81e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 46.18  E-value: 5.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  89 AGISPGDFIIEAGVGSGALTIFLANIVGKegKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEENVSHII- 167
Cdd:COG4076   31 RVVKPGDVVLDIGTGSGLLSMLAARAGAK--KVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIIs 108

                         90       100       110
                 ....*....|....*....|....*....|..
gi 664800252 168 -------LDLPQPEnVLEHAIKA-LKPGGFFV 191
Cdd:COG4076  109 emldtalLDEGQVP-ILNHARKRlLKPGGRII 139
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 87-191 9.25e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 45.52  E-value: 9.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  87 AHAGISPGDFIIEAGVGSGALTIFLANIVgKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIK---LKNIYDGIDEENV 163
Cdd:COG4123   31 AFAPVKKGGRVLDLGTGTGVIALMLAQRS-PGARITGVEIQPEAAELARRNVALNGLEDRITVIhgdLKEFAAELPPGSF 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 664800252 164 SHII---------------------------LDLpqpENVLEHAIKALKPGGFFV 191
Cdd:COG4123  110 DLVVsnppyfkagsgrkspdearaiarhedaLTL---EDLIRAAARLLKPGGRFA 161
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
90-206 1.59e-05

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 44.67  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   90 GISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFdDRVEIKLKNIYDGIDEENVSHIILD 169
Cdd:pfam01135  70 ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGL-ENVIVVVGDGRQGWPEFAPYDAIHV 148

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 664800252  170 LPQPENVLEHAIKALKPGGFFVA-YTPCANQVIRFYAK 206
Cdd:pfam01135 149 GAAAPEIPEALIDQLKEGGRLVIpVGPNGNQVLQQFDK 186
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 4-45 2.08e-05

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 40.94  E-value: 2.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 664800252    4 EGDKVLLVDPRGKRYLLT-VRDEEFHTDLGILKLGELIGMEFG 45
Cdd:pfam14801   6 AGDRVQLTDPKGRKHTITlEPGGEFHTHRGAIRHDDLIGRPEG 48
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 82-131 4.88e-05

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 43.58  E-value: 4.88e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 664800252  82 AAQIVAHAGISPGDFIIEAGVGSGALTIFLANivgKEGKIVSYEVREDFA 131
Cdd:COG0030   26 IRRIVDAAGITPGDTVLEIGPGLGALTRALLE---RAARVTAVEIDRRLA 72
arsM PRK11873
arsenite methyltransferase;
87-191 7.05e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 43.01  E-value: 7.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  87 AHAGISPGDFIIEAGVGSGaLTIFLA-NIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDrVEIKLKNIY-----DGIDE 160
Cdd:PRK11873  71 ALAELKPGETVLDLGSGGG-FDCFLAaRRVGPTGKVIGVDMTPEMLAKARANARKAGYTN-VEFRLGEIEalpvaDNSVD 148

                         90       100       110
                 ....*....|....*....|....*....|..
gi 664800252 161 ENVSHIILDL-PQPENVLEHAIKALKPGGFFV 191
Cdd:PRK11873 149 VIISNCVINLsPDKERVFKEAFRVLKPGGRFA 180
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 83-195 7.28e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.54  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  83 AQIVAHAGISPGDfIIEAGVGSGALTIFLAnivgKEG-KIVSYEVREDFAKLAWRNIVwagfDDRVEIKLKNIYDGIDEE 161
Cdd:COG2227   15 AALLARLLPAGGR-VLDVGCGTGRLALALA----RRGaDVTGVDISPEALEIARERAA----ELNVDFVQGDLEDLPLED 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 664800252 162 N------VSHIILDLPQPENVLEHAIKALKPGGFFVAYTP 195
Cdd:COG2227   86 GsfdlviCSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
rADc smart00650
Ribosomal RNA adenine dimethylases;
82-131 8.01e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.11  E-value: 8.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 664800252    82 AAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVgkeGKIVSYEVREDFA 131
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERA---KRVTAIEIDPRLA 48
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 91-192 1.21e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 41.93  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  91 ISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDrVEIKLKNIYDGIDEENVSHIILDL 170
Cdd:PRK13942  74 LKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKKLGYDN-VEVIVGDGTLGYEENAPYDRIYVT 152

                         90       100
                 ....*....|....*....|..
gi 664800252 171 PQPENVLEHAIKALKPGGFFVA 192
Cdd:PRK13942 153 AAGPDIPKPLIEQLKDGGIMVI 174
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 78-188 3.15e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 41.37  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  78 HPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKlKNIYDG 157
Cdd:PRK13943  65 QPSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRRLGIENVIFVC-GDGYYG 143

                         90       100       110
                 ....*....|....*....|....*....|.
gi 664800252 158 IDEENVSHIILDLPQPENVLEHAIKALKPGG 188
Cdd:PRK13943 144 VPEFAPYDVIFVTVGVDEVPETWFTQLKEGG 174
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 97-198 3.83e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.10  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   97 IIEAGVGSGaltIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIYDGIDEENVSHIILDlpqPENV 176
Cdd:pfam13489  26 VLDFGCGTG---IFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPD---PPAL 99

                          90       100
                  ....*....|....*....|..
gi 664800252  177 LEHAIKALKPGGFFVAYTPCAN 198
Cdd:pfam13489 100 LRQIAALLKPGGLLLLSTPLAS 121
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 91-197 7.46e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 38.94  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   91 ISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFdDRVEIKLKNI--------YDGIDEEN 162
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGF-DNVEFEQGDIeelpelleDDKFDVVI 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 664800252  163 VSHIILDLPQPENVLEHAIKALKPGGFFVAYTPCA 197
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDS 114
PRK08317 PRK08317
hypothetical protein; Provisional
 91-192 9.91e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.53  E-value: 9.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  91 ISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWR----NIVWAGF--DDRVEIKL-KNIYDGIDEENV 163
Cdd:PRK08317  17 VQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKEraagLGPNVEFvrGDADGLPFpDGSFDAVRSDRV 96

                         90       100       110
                 ....*....|....*....|....*....|
gi 664800252 164 -SHIildlPQPENVLEHAIKALKPGGFFVA 192
Cdd:PRK08317  97 lQHL----EDPARALAEIARVLRPGGRVVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 97-188 1.06e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 37.54  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   97 IIEAGVGSGALTIFLANIVGkeGKIVSYEVREDFAKLAWRNIVWAGFddRVEIKLKNIYD-GIDEENVSHII-------L 168
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDlPFPDGSFDLVVssgvlhhL 76

                          90       100
                  ....*....|....*....|
gi 664800252  169 DLPQPENVLEHAIKALKPGG 188
Cdd:pfam13649  77 PDPDLEAALREIARVLKPGG 96
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 98-190 2.04e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 36.58  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   98 IEAGVGSGALTIFLANiVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDRVEIKLKNIyDGIDEENVS-------HIILDL 170
Cdd:pfam08242   1 LEIGCGTGTLLRALLE-ALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQL-DLGELDPGSfdvvvasNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 664800252  171 PQPENVLEHAIKALKPGGFF 190
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
77-191 2.93e-03

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 37.80  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252   77 IHPKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGKEGKIVSYEVREDFAKLAWRNIVWAGFDDrVEI------K 150
Cdd:pfam01209  26 IHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEEGKYN-IEFlqgnaeE 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 664800252  151 LKNIYDGIDEENVSHIILDLPQPENVLEHAIKALKPGGFFV 191
Cdd:pfam01209 105 LPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 79-191 5.95e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 36.82  E-value: 5.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  79 PKDAAQIVAHAGISPGDFIIEAGVGSGALTIFLANIVGkeGKIVSYEVREDFAKLAWRNIVWAGFdDRVEIKLKNIYDGI 158
Cdd:COG0500   12 PGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELD 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 664800252 159 DEEN------VSHIILDLPQPEN---VLEHAIKALKPGGFFV 191
Cdd:COG0500   89 PLPAesfdlvVAFGVLHHLPPEEreaLLRELARALKPGGVLL 130
PRK14968 PRK14968
putative methyltransferase; Provisional
 89-171 7.66e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.42  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  89 AGISPGDFIIEAGVGSGALTIFLANivgKEGKIVSYEVREDFAKLAWRNIVWAGFDDR-VEIKLKNIYDGIDEENVSHII 167
Cdd:PRK14968  19 AVDKKGDRVLEVGTGSGIVAIVAAK---NGKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFEPFRGDKFDVIL 95


                 ....
gi 664800252 168 LDLP 171
Cdd:PRK14968  96 FNPP 99
iditol_2_DH_like cd08235
L-iditol 2-dehydrogenase; Putative L-iditol 2-dehydrogenase based on annotation of some ...
 89-190 9.52e-03

L-iditol 2-dehydrogenase; Putative L-iditol 2-dehydrogenase based on annotation of some members in this subgroup. L-iditol 2-dehydrogenase catalyzes the NAD+-dependent conversion of L-iditol to L-sorbose in fructose and mannose metabolism. This enzyme is related to sorbitol dehydrogenase, alcohol dehydrogenase, and other medium chain dehydrogenase/reductases. The zinc-dependent alcohol dehydrogenase (ADH-Zn)-like family of proteins is a diverse group of proteins related to the first identified member, class I mammalian ADH. This group is also called the medium chain dehydrogenases/reductase family (MDR) to highlight its broad range of activities and to distinguish from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal GroES-like catalytic domain. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.


Pssm-ID: 176197 [Multi-domain]  Cd Length: 343  Bit Score: 36.80  E-value: 9.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664800252  89 AGISPGDFIIEAGVG-SGALTIFLANIVGKEGKIVS--YEVREDFAKLawrnivwAGFDDRVEIKLKNIYDGIDEEN--- 162
Cdd:cd08235  161 AGIKPGDTVLVIGAGpIGLLHAMLAKASGARKVIVSdlNEFRLEFAKK-------LGADYTIDAAEEDLVEKVRELTdgr 233

                         90       100       110
                 ....*....|....*....|....*....|..
gi 664800252 163 -VSHIILDLPQPEnVLEHAIKALKPGG---FF 190
Cdd:cd08235  234 gADVVIVATGSPE-AQAQALELVRKGGrilFF 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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