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Conserved domains on  [gi|664278166|ref|WP_030808338|]
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MULTISPECIES: polyphosphate--glucose phosphotransferase [Streptomyces]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 3-242 4.71e-132

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 371.90  E-value: 4.71e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERHKVLTPHPATPKGVADGVAEVVGHFDWSGPVGITFPGVVTDGITRTAANVDKG 82
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  83 WIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLTFGTGIGSAVFTDGKLVPNTELGHLELHGHDAE 162
Cdd:cd24058   81 WIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 163 KHASTKAKEDEDLSWQHWAHRVQKYLLHVEMLFSPELFIIGGGVSRKAEKFLPLIeKVRAELVPAQLQNNAGIVGAAMAA 242
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLL-DVKTPVVPAVLRNDAGIVGAALLA 239
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 3-242 4.71e-132

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 371.90  E-value: 4.71e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERHKVLTPHPATPKGVADGVAEVVGHFDWSGPVGITFPGVVTDGITRTAANVDKG 82
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  83 WIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLTFGTGIGSAVFTDGKLVPNTELGHLELHGHDAE 162
Cdd:cd24058   81 WIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 163 KHASTKAKEDEDLSWQHWAHRVQKYLLHVEMLFSPELFIIGGGVSRKAEKFLPLIeKVRAELVPAQLQNNAGIVGAAMAA 242
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLL-DVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-242 3.62e-42

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 145.42  E-value: 3.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDrGDLaRERHKVLTPHPATPKGVADGVAEVVGHFDWSGP--------VGITFPGVV--TDGI 72
Cdd:COG1940    7 VIGIDIGGTKIKAALVDLD-GEV-LARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPVdpETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  73 TRTAANVDkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT--- 149
Cdd:COG1940   85 VLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRG-ADNVVYLTLGTGIGGGIVINGKLLRGAngn 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 --ELGHLELHGHDA----------EKHASTKA--------KEDEDLS------------------WQHWAHRVQKYLLHV 191
Cdd:COG1940  163 agEIGHMPVDPDGPlcgcgnrgclETYASGPAllrrarelGGAEKLTaeelfaaaragdplalevLDEAARYLGIGLANL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278166 192 EMLFSPELFIIGGGVSRKAEKFLPLIEK-----------VRAELVPAQLQNNAGIVGAAMAA 242
Cdd:COG1940  243 INLLDPEVIVLGGGVSAAGDLLLEPIREalakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 5-239 3.27e-29

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 111.28  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166    5 GVDIGGSGIKGAPVDLDRGDLARERhkVLTPHPATPKGVADGVAEVV----GHFDWSGPVGITFPGVVTDGITRTAANVD 80
Cdd:pfam00480   2 GIDIGGTKIAAALFDEEGEILARER--VPTPTTTTEETLVDAIAFFVdsaqRKFGELIAVGIGSPGLISPKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   81 KGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLV-----PNTELGHLE 155
Cdd:pfam00480  80 IGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIGHIQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  156 LHGHDA----------EKHASTKA------KEDEDLS------------------WQHWAHRVQKYLLHVEMLFSPELFI 201
Cdd:pfam00480 159 LDPNGPkcgcgnhgclETIASGRAlekryqQKGEDLEgkdiivlaeqgdevaeeaVERLARYLAKAIANLINLFDPQAIV 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 664278166  202 IGGGVSrKAEKFLPLIEKVRA------------ELVPAQLQNNAGIVGAA 239
Cdd:pfam00480 239 LGGGVS-NADGLLEAIRSLVKkylngylpvppvIIVAASLGDNAGALGAA 287
PRK09557 PRK09557
fructokinase; Reviewed
 5-207 4.84e-13

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 66.97  E-value: 4.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKgaPVDLDRGDLARERHKVLTP---HPATPKGVADGVAEVVGHFDWSGPVGITFPGVVTDgITRTAANVDK 81
Cdd:PRK09557   4 GIDLGGTKIE--VIALDDAGEELFRKRLPTPrddYQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISP-YTGLVKNANS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  82 GWI-----DTDartlLGERIGQPVTILNDADAAGVAEMTFGAGKGRtGTVILLTFGTGIGSAVFTDGKLVPNT-----EL 151
Cdd:PRK09557  81 TWLngqplDKD----LSARLNREVRLANDANCLAVSEAVDGAAAGK-QTVFAVIIGTGCGAGVAINGRVHIGGngiagEW 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 152 GHLELHGHDAEKH-------------------------------ASTKAKEDED-------------LSWQHWAHRVQKY 187
Cdd:PRK09557 156 GHNPLPWMDEDELryrnevpcycgkqgcietfisgtgfatdyrrLSGKALKGSEiirlveegdpvaeLAFRRYEDRLAKS 235

                        250       260
                 ....*....|....*....|
gi 664278166 188 LLHVEMLFSPELFIIGGGVS 207
Cdd:PRK09557 236 LAHVINILDPDVIVLGGGMS 255
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 3-242 4.71e-132

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 371.90  E-value: 4.71e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERHKVLTPHPATPKGVADGVAEVVGHFDWSGPVGITFPGVVTDGITRTAANVDKG 82
Cdd:cd24058    1 ILGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  83 WIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLTFGTGIGSAVFTDGKLVPNTELGHLELHGHDAE 162
Cdd:cd24058   81 WIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 163 KHASTKAKEDEDLSWQHWAHRVQKYLLHVEMLFSPELFIIGGGVSRKAEKFLPLIeKVRAELVPAQLQNNAGIVGAAMAA 242
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLL-DVKTPVVPAVLRNDAGIVGAALLA 239
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 5-240 5.45e-43

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 145.68  E-value: 5.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGAPVDLDRGDLARERHKvlTPHPATPKGVADGVAEVVGHFDWSGP-------VGITFPGVV--TDGITRT 75
Cdd:cd23763    2 GIDIGGTKIRAALVDLDGEILARERVP--TPAEEGPEAVLDRIAELIEELLAEAGvrerilgIGIGVPGPVdpETGIVLF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  76 AANVdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT-----E 150
Cdd:cd23763   80 APNL-PWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRG-VRNFVYITLGTGIGGGIIIDGKLYRGAngaagE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 151 LGHLELhghdaekhastkakededlsWQHWAHRVQKYLLHVEMLFSPELFIIGGGVSRKAEKFLPLIEKVRA-------- 222
Cdd:cd23763  158 IGHITV--------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRrralpplr 217

                        250       260
                 ....*....|....*....|.
gi 664278166 223 ---ELVPAQLQNNAGIVGAAM 240
Cdd:cd23763  218 rrvRIVPSELGDDAGLLGAAA 238
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 3-242 3.62e-42

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 145.42  E-value: 3.62e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDrGDLaRERHKVLTPHPATPKGVADGVAEVVGHFDWSGP--------VGITFPGVV--TDGI 72
Cdd:COG1940    7 VIGIDIGGTKIKAALVDLD-GEV-LARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPVdpETGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  73 TRTAANVDkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT--- 149
Cdd:COG1940   85 VLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRG-ADNVVYLTLGTGIGGGIVINGKLLRGAngn 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 --ELGHLELHGHDA----------EKHASTKA--------KEDEDLS------------------WQHWAHRVQKYLLHV 191
Cdd:COG1940  163 agEIGHMPVDPDGPlcgcgnrgclETYASGPAllrrarelGGAEKLTaeelfaaaragdplalevLDEAARYLGIGLANL 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 664278166 192 EMLFSPELFIIGGGVSRKAEKFLPLIEK-----------VRAELVPAQLQNNAGIVGAAMAA 242
Cdd:COG1940  243 INLLDPEVIVLGGGVSAAGDLLLEPIREalakyalpparEDPRIVPASLGDDAGLLGAAALA 304
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 3-239 2.76e-34

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 124.59  E-value: 2.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDlDRGDLArERHKVLTPHPATPKGVADGV----AEVVGHFDWSGpVGITFPGVV---TDGITRT 75
Cdd:cd24068    2 ILGIDIGGTKIKYGLVD-ADGEIL-EKDSVPTPASKGGDAILERLleiiAELKEKYDIEG-IGISSAGQVdpkTGEVIYA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  76 AANVdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT-----E 150
Cdd:cd24068   79 TDNL-PGWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKG-LDDFLCLTLGTGIGGAIILDGRLYRGAngsagE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 151 LGHLELHGHDA----------EKHAST--------KAKEDEDLSWQ------------------HWAHRVQKYLLHVEML 194
Cdd:cd24068  157 LGHMVVDPGGRpcccggkgclEQYASGtalvrrvaEALGEPGIDGReifdladagdplakevveEFAEDLATGLANLVHI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664278166 195 FSPELFIIGGGVSRKAEKFLPLIEK-----------VRAELVPAQLQNNAGIVGAA 239
Cdd:cd24068  237 FDPEVIVIGGGISAQGELFLEELREelrkllmppllDATKIEPAKLGNDAGLLGAA 292
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 5-239 9.92e-30

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 112.83  E-value: 9.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGAPVDLDRGDLARERhkvlTPHPATPKGVADGVAEVV----GHFDWSGpVGITFPGVVTD--GITRTAAN 78
Cdd:cd24061    3 GVDIGGTKIAAGVVDEEGEILATER----VPTPPTADGIVDAIVEAVeelrEGHDVSA-VGVAAAGFVDAdrATVLFAPN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  79 VdkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLVPNT-----ELGH 153
Cdd:cd24061   78 I--AWRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTD-DMVMITVGTGLGGGIVIGGKLLRGAfgiagEFGH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 154 LEL--HGHDA--------EKHASTKA----------------------KEDEDLSWQHWA--------------HRVQKY 187
Cdd:cd24061  155 IRVvpDGLLCgcgsrgcwEQYASGRAlvryakeaanatpegaavlladGSVDGITGKHISeaaragdpvaldalRELARW 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 664278166 188 L----LHVEMLFSPELFIIGGGVSRKAEKFLPLIEKV------------RAELVPAQLQNNAGIVGAA 239
Cdd:cd24061  235 LgaglASLAALLDPELFVIGGGVSDAGDLLLDPIREAferwlpgrgwrpIPRLRTAQLGNDAGLIGAA 302
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 3-240 2.46e-29

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 111.51  E-value: 2.46e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDrGDLArERHKVltPHPATPKG-----VADGVAEVVGHFDwsgPVGITFPGVVTD--GITRT 75
Cdd:cd24152    2 YLVFDIGGTFIKYALVDEN-GNII-KKGKI--PTPKDSLEefldyIKKIIKRYDEEID---GIAISAPGVIDPetGIIYG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  76 AANVDKgWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLVPNT-----E 150
Cdd:cd24152   75 GGALPY-LKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIK-NGAVIVLGTGIGGAIIIDGKLYRGShffagE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 151 LGHLELHGHDA---------------EKHASTKAKEDEDL----------------SWQHWAHRVQKYLLHVEMLFSPEL 199
Cdd:cd24152  153 FSYLLTDDDDKdllffsglasmfglvKRYNKAKGLEPLDGeeifekyakgdeaakkILDEYIRNLAKLIYNIQYILDPEV 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664278166 200 FIIGGGVSRkAEKFLPLIEK-------------VRAELVPAQLQNNAGIVGAAM 240
Cdd:cd24152  233 IVIGGGISE-QPLFIEDLKKevneilanrpgsiPKPEIKACKFGNDANLLGALY 285
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 5-239 3.27e-29

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 111.28  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166    5 GVDIGGSGIKGAPVDLDRGDLARERhkVLTPHPATPKGVADGVAEVV----GHFDWSGPVGITFPGVVTDGITRTAANVD 80
Cdd:pfam00480   2 GIDIGGTKIAAALFDEEGEILARER--VPTPTTTTEETLVDAIAFFVdsaqRKFGELIAVGIGSPGLISPKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   81 KGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLV-----PNTELGHLE 155
Cdd:pfam00480  80 IGWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIGHIQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  156 LHGHDA----------EKHASTKA------KEDEDLS------------------WQHWAHRVQKYLLHVEMLFSPELFI 201
Cdd:pfam00480 159 LDPNGPkcgcgnhgclETIASGRAlekryqQKGEDLEgkdiivlaeqgdevaeeaVERLARYLAKAIANLINLFDPQAIV 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 664278166  202 IGGGVSrKAEKFLPLIEKVRA------------ELVPAQLQNNAGIVGAA 239
Cdd:pfam00480 239 LGGGVS-NADGLLEAIRSLVKkylngylpvppvIIVAASLGDNAGALGAA 287
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 3-241 3.47e-22

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 92.39  E-value: 3.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDldRGDLArerHKVLTPHPATP-KGVADGVAEVV----GHFDWSGPVGITFPGVVT--DGITRT 75
Cdd:cd24065    2 TIGLDLGGTKIAAGVVD--GGRIL---SRLVVPTPREGgEAVLDALARAVealqAEAPGVEAVGLGVPGPLDfrRGRVRF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  76 AANVdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT-----E 150
Cdd:cd24065   77 APNI-PGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARG-TESSVYVTISTGIGGGLVLGGRVLRGRhgqagE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 151 LGHLEL--HG----------------------------------HDAEKHASTKAKEDEDLSWQHwAHRVQKYLLHVEML 194
Cdd:cd24065  155 IGHTTVlpGGpmcgcglvgclealasgralardasfaygrpmstAELFELAQQGEPKALRIVEQA-AAHLGIGLANLQKA 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 664278166 195 FSPELFIIGGGVSRKAEKFL-PLIEKVR--------AELVPAQLQNNAGIVGAAMA 241
Cdd:cd24065  234 LDPEVFVLGGGVAQVGDYYLlPVQEAARrytegwhaPPLRLAHLGTDAGVIGAALA 289
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 3-239 1.62e-20

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 88.12  E-value: 1.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDrGDLArERHKVLTP----HPATPKGVADGVAEVV--GHFDWSGPVGITF--PGVVT--DGI 72
Cdd:cd24062    2 IVGIDVGGTTIKMAFLTQE-GEIV-QKWEIPTNklegGENIITDIAESIQQLLeeLGYSKEDLIGIGVgvPGPVDveTGT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  73 TRTAANVdkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT--- 149
Cdd:cd24062   80 VEVAVNL--GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQG-AKDLVFITLGTGVGGGVIANGKIVHGAnga 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 --ELGH-----------------------------------------------LELHGHDAEKHASTKAKEDEDLSwQHW 180
Cdd:cd24062  157 agEIGHitvnpeggapcncgktgcletvasatgivriareeleegkgssalriLALGGELTAKDVFEAAKAGDELA-LAV 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664278166 181 AHRVQKYL----LHVEMLFSPELFIIGGGVSRKAEKFLPLIEKV-----------RAELVPAQLQNNAGIVGAA 239
Cdd:cd24062  236 VDTVARYLglalANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYfdrftfprvrqDTEIVLATLGNDAGVIGAA 309
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 5-242 2.61e-19

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 84.54  E-value: 2.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGAPVDLDrGDLaRERHKVLTPHPATPKGVADGVAEVVGHF------DWSGPVGITF--PGVV--TDGITR 74
Cdd:cd24076    5 GVELGVDYITVVVTDLA-GEV-LWRREVPLPASDDPDEVLAQLAALIREAlaaapdSPLGILGIGVgvPGLVdsEDGVVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  75 TAANVdkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT----- 149
Cdd:cd24076   83 LAPNL--GWRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRG-VSDLVYLSAGVGIGAGIILDGELYRGAsgfag 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 ELGHLELHGHDA----------EKHASTKA-----KEDEDLSWQHWAHRVQK-------------------------YLL 189
Cdd:cd24076  160 EIGHMTVDPDGPpcscgnrgcwETYASERAllraaGRLGAGGEPLSLAELVEaaragdpaalaaleevgeylgiglaNLV 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 664278166 190 HvemLFSPELFIIGGGVSRKAEKFLPLIEKV-----------RAELVPAQLQNNAGIVGAAMAA 242
Cdd:cd24076  240 N---TFNPELVVLGGALAPLGPWLLPPLRAEvarralpaparDVRIVVSRLGEDAAALGAAALA 300
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 3-241 1.02e-16

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 77.66  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERhkVLTPH---PATPKGVADGVAEVVGHFDWSGPVGITFPGVV--TDGITrTAA 77
Cdd:cd24057    2 YYGFDIGGTKIEFAVFDEALQLVWTKR--VPTPTddyAAFLAAIAELVAEADARFGVKGPVGIGIPGVIdpEDGTL-ITA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  78 NVDKgwidTDARTL---LGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLVPNT----- 149
Cdd:cd24057   79 NIPA----AKGRPLradLSARLGRPVRIDNDANCFALSEAWDGAGRGYP-SVFGLILGTGVGGGLVVNGRLVGGRsgiag 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 ELGHLEL------HGHDA-------------EKHASTKAKE-------DEDLSWQHW--------AHRVQKYLLHVEML- 194
Cdd:cd24057  154 EWGHGPLpadallLGYDLpvlrcgcgqtgclETYLSGRGLErlyahlyGEELDAPEIiaawaagdPQAVAHVDRWLDLLa 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664278166 195 ---------FSPELFIIGGGVSRKAEKFLPLIEKVRAEL---------VPAQLQNNAGIVGAAMA 241
Cdd:cd24057  234 gclaniltaLDPDVVVLGGGLSNFPALIAELPAALPAHLlsgartpriVPARHGDAGGVRGAAFL 298
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 3-239 1.87e-16

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 76.77  E-value: 1.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERH--KVLTPHPATPKGVADGVAEVVGHFDWSGpVGITFPGVV--TDGITRTAAN 78
Cdd:cd24064    1 VIGIDLGGTDTKIGIVDENGDILKKKTIdtKVENGKEDVINRIAETVNELIEEMELLG-IGIGSPGSIdrENGIVRFSPN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  79 VdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPN-----TELGH 153
Cdd:cd24064   80 F-PDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKG-SNHIIGLTLGTGVGSGVICHGQLLTGydgiaAELGH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 154 LEL-----------HG----------------HDAEKHASTKAKEDEDLSWQHW--------------AHRVQKYL---- 188
Cdd:cd24064  158 VIVepngpicgcgnRGcveafasataiiryarESRKRYPDSLAGESEKINAKHVfdaarkndplatmvFRRVVDALaiai 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 664278166 189 ---LHVemlFSPELFIIGGGVSRKAEKFL-PLIEKVR----------AELVPAQLQNNAGIVGAA 239
Cdd:cd24064  238 ggfVHI---FNPEIIIIGGGISRAGSFLLdPIREKTKkyvmlsfqdtYSIELSNLVEDAGILGAA 299
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 5-154 1.89e-16

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 76.82  E-value: 1.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGAPVDLDRGDLARERHKVLTPHPATpkgVADGVAEVVGHFDWSGP--------VGITFPGVVT--DGITR 74
Cdd:cd24073    5 GVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEA---VAEAIAEAVAELLAQAGlspdrllgIGVGLPGLVDaeTGICR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  75 TAANVdkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNT----- 149
Cdd:cd24073   82 WSPLL--GWRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRG-LDNFAVVTIGRGIGCGLVVDGRLYRGAhggag 158


                 ....*
gi 664278166 150 ELGHL 154
Cdd:cd24073  159 EIGHT 163
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 3-239 1.75e-15

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 74.16  E-value: 1.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERHKvlTPHPATPKGVADGVAEVVGHF-DWSGP------VGITFPG--VVTDGIT 73
Cdd:cd24059    3 VIGVEIGRDLLSAVLCDLSGNILAREKYP--LDEKENPEEVLEKLYELIDRLlEKENIkskilgIGIGAPGplDVEKGII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  74 RTAANVdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLTfGTGIGSAVFTDGKLVPN----- 148
Cdd:cd24059   81 LNPPNF-PGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILA-DEGIGAGIIINGKLYRGvdgya 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 149 TELGH-----------------LEL-----------------HGHDAEKHASTKAKEDEDLSWQhwAHRVQKYL----LH 190
Cdd:cd24059  159 GEIGHtsidingprcscgnrgcLELyasipaiekkarsalgsGRSFQLDIVEALQKGDPIADEV--IEEAAKYLgiglVN 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 191 VEMLFSPELFIIGGGVSRKAEKFLPLIEKV-----------RAELVPAQLQNNAGIVGAA 239
Cdd:cd24059  237 LINLLNPEAIIIGGELIYLGERYLEPIEKEvnsrlfgrnarEVRILKSSLGEDAPLLGAA 296
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 4-240 4.64e-15

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 72.70  E-value: 4.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   4 FGVDIGGSGIKGAPVDldrGDLARERHKVLTPHPATPKGVADGVAEVVG-HFDWSGPVGITFPGVVTDGITrTAANVDK- 81
Cdd:cd24069    1 LAIDIGGTKIAAALIG---NGQIIDRRQIPTPRSGTPEALADALASLLAdYQGQFDRVAVASTGIIRDGVL-TALNPKNl 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  82 -GWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLV--PNTELGHL--EL 156
Cdd:cd24069   77 gGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEG-VGNLVFITVSTGVGGGLVLNGQLLtgPNGLAGHIghTL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 157 HGHD-------------------AEKHASTK-------AKEDEDLSWQH--WAHRVQKYLLHV--------EMLFSPELF 200
Cdd:cd24069  156 ADPPgpvcgcgrrgcveaiasgtAIAAAASEilgepvdAKDVFERARSGdeEAARLIDRAARAladliadlKATLDLDCV 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 664278166 201 IIGGGVSRkAEKFLPLIEK--------VRAELVPAQLQNNAGIVGAAM 240
Cdd:cd24069  236 VIGGSVGL-AEGFLERVEQyladepaiFRVSLEPARLGQDAGLLGAAL 282
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 81-240 4.97e-15

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 72.58  E-value: 4.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  81 KGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFGTGIGSAVFTDGKLVP---NTELGHLEL- 156
Cdd:cd24067   80 PGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLD-SLAYITVGTGIGVGLVVNGKPVHgllHPEMGHIRVp 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 157 --------------HGHDAEKHASTKA------KEDEDLS-----WQHWAHRVQKYLLHVEMLFSPELFIIGGGVSRKAe 211
Cdd:cd24067  159 rhpdddgfpgvcpfHGDCLEGLASGPAiaarwgIPAEELPddhpaWDLEAYYLAQACANLTLTLSPERIVLGGGVMQRP- 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 664278166 212 kflPLIEKVRAEL---------------------VPAQLQNNAGIVGAAM 240
Cdd:cd24067  238 ---GLFPRIREKFrkllngylevprllpdideyiVPPALGNDAGILGALA 284
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 5-240 3.34e-14

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 70.45  E-value: 3.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGAPVDLDRGDLARERHKvlTPHPATPKGVADGVAEVVGHFdWSGP-------VGITFPG--VVTDGITRT 75
Cdd:cd24063    4 AVDIGGTWIRAGLVDEDGRILLKIRQP--TPKTGDPGTVSEQVLGLIETL-LSKAgkdsiegIGVSSAGplDLRKGTIVN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  76 AANVDKGWIDTdaRTLLGERIGQPVTILNDADAAGVAEMTFGAGKGrTGTVILLTFGTGIGSAVFTDGKLVPNTE----- 150
Cdd:cd24063   81 SPNIKGKEIPL--VEPLKEEFNIPVALLNDAVAAALGEHLFGAGRG-TSNLVYITISTGIGGGVIVDGRLLLGKNgnaae 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 151 ------------------LGHLE------------------------LHGHDAEKHASTkAKE------DEDLSWQHWAH 182
Cdd:cd24063  158 vghlvvdtesglkcgcggYGHWEafasgrgiprfarewaegfssrtsLKLRNPGGEGIT-AKEvfsaarKGDPLALKIIE 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664278166 183 RVQKY----LLHVEMLFSPELFIIGGGVSRKAEKFL-PLIEKV--------RAELVPAQLQNNAGIVGAAM 240
Cdd:cd24063  237 KLARYngrgIANVINAYDPELIVIGGSVFNNNKDILdPLIEYLeknpaiskGPEIVLSELGDDVGLIGALA 307
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 3-219 3.54e-13

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 67.70  E-value: 3.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDrGDLaRERHKVLTPHPATP----KGVADGVAEVVGHFDWSGP---VGITFPGVV--TDGIT 73
Cdd:cd24071    3 IIGVKIEEGYLVLALTDLK-GKI-LEKTRIPFDHETDPekviELIAENIKKLIKNKHVEKKllgIGIAVSGLVdsKKGIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  74 RTAANVdkGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVIlLTFGTGIGSAVFTDGKLVPNT---- 149
Cdd:cd24071   81 IRSTIL--GWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFIC-VTVGAGIGSSLVIDGKLYTGNfgga 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 150 -ELGHLELHGHDA----------EKHAS-----------------TKAKEDEDLSWQH----------WAHRV-QKY--- 187
Cdd:cd24071  158 gEIGHMTIQPDGRkcycgqkgclEAYASfealvneikeltesyplSLLKELEDFEIEKvreaaeegdsVATELfKKAgey 237

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 664278166 188 ----LLHVEMLFSPELFIIGGGVSRKAEKFLPLIEK 219
Cdd:cd24071  238 lgigIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIE 273
PRK09557 PRK09557
fructokinase; Reviewed
 5-207 4.84e-13

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 66.97  E-value: 4.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKgaPVDLDRGDLARERHKVLTP---HPATPKGVADGVAEVVGHFDWSGPVGITFPGVVTDgITRTAANVDK 81
Cdd:PRK09557   4 GIDLGGTKIE--VIALDDAGEELFRKRLPTPrddYQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISP-YTGLVKNANS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  82 GWI-----DTDartlLGERIGQPVTILNDADAAGVAEMTFGAGKGRtGTVILLTFGTGIGSAVFTDGKLVPNT-----EL 151
Cdd:PRK09557  81 TWLngqplDKD----LSARLNREVRLANDANCLAVSEAVDGAAAGK-QTVFAVIIGTGCGAGVAINGRVHIGGngiagEW 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 152 GHLELHGHDAEKH-------------------------------ASTKAKEDED-------------LSWQHWAHRVQKY 187
Cdd:PRK09557 156 GHNPLPWMDEDELryrnevpcycgkqgcietfisgtgfatdyrrLSGKALKGSEiirlveegdpvaeLAFRRYEDRLAKS 235

                        250       260
                 ....*....|....*....|
gi 664278166 188 LLHVEMLFSPELFIIGGGVS 207
Cdd:PRK09557 236 LAHVINILDPDVIVLGGGMS 255
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 5-239 5.74e-13

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 66.84  E-value: 5.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   5 GVDIGGSGIKGapVDLDRGDLARERHKVLTPHP---ATPKGVADGVAEVVGHFDWSGPVGITFPGVVtDGITRTAANVDK 81
Cdd:cd24066    3 GIDLGGTKIEG--IALDRAGRELLRRRVPTPRGdyeATLDAIADLVEEAEEELGAPATVGIGTPGSI-SPRTGLVKNANS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  82 GW-----IDTDartlLGERIGQPVTILNDADAAGVAEMTFGAGKGRtGTVILLTFGTGIGSAVFTDGKLVPNT-----EL 151
Cdd:cd24066   80 TWlngkpLKAD----LEARLGRPVRIENDANCFALSEATDGAGAGA-GVVFGVILGTGVGGGIVVNGRVLTGAngiagEW 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 152 GHLELH--------------------------------------GHDAEKHASTKAKEDEDLS---WQHWAHRVQKYLLH 190
Cdd:cd24066  155 GHNPLPwpdedelpgppcycgkrgcvetflsgpalerdyarltgKTLSAEEIVALARAGDAAAvatLDRFLDRLGRALAN 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 664278166 191 VEMLFSPELFIIGGGVSRKAEKFLPLIEKVRA---------ELVPAQLQNNAGIVGAA 239
Cdd:cd24066  235 VINILDPDVIVLGGGLSNIDELYTEGPAALARyvfsdevetPIVKNKHGDSSGVRGAA 292
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 3-244 2.37e-11

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 62.18  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLARERHKV--LTPHPATPKGVADGVAEVVGHFDWS-GPVGITFPGVV---TDGITRTA 76
Cdd:cd24070    3 VLGIDIGGTNIRIGLVDEDGKLLDFEKVPSkdLLRAGDPVEVLADLIREYIEEAGLKpAAIVIGVPGTVdkdRRTVISTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  77 aNVdKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRtGTVILLTFGTGIGSAVFTDGKLVPNT-----EL 151
Cdd:cd24070   83 -NI-PGLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDDE-GVVLGFYIGTGIGNAILINGKPLRGKngvagEL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 152 GH-----------------LELH--GHDAEKHASTKAKEDEDLSW-QHWAH--RVQKYLLHVEM-------LFSPELFII 202
Cdd:cd24070  160 GHipvygngkpcgcgntgcLETYasGRALEEIAEEHYPDTPILDIfVDHGDepELDEFVEDLALaiateinILDPDAVIL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 664278166 203 GGGVSRKA----EKFLPLIEK-VRA-------ELVPAQLQNNAGIVGAAMAAAG 244
Cdd:cd24070  240 GGGVIDMKgfprETLEEYIRKhLRKpypadnlKIIYAELGPEAGVIGAAIYAFD 293
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 60-154 1.34e-10

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 60.12  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  60 VGITFPGVVT--DGITRTAANVDKGWIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLTfGTGIGS 137
Cdd:cd24060   63 VGISTGGRVNprEGIVLHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVIT-GTGIGG 141

                         90       100
                 ....*....|....*....|..
gi 664278166 138 AVFTDGKLVPNT-----ELGHL 154
Cdd:cd24060  142 GIILNHELIHGSsfcaaELGHI 163
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 62-231 6.65e-10

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 58.09  E-value: 6.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  62 ITFPGVVtdgitrtaaNVDKGWI----DTDARTL-----LGERIGQPVTILNDADAAGVAEMTFGAGKGRTgTVILLTFG 132
Cdd:cd24074   68 ITLPGII---------DPESGIVhrlpFYDIKNLplgeaLEQHTGLPVYVQHDISAWTLAERFFGAAKGAK-NIIQIVID 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 133 TGIGSAVFTDGKLV-PNT----ELGHLELHGHD----------AEKHASTKAKED----------------EDLSWQHW- 180
Cdd:cd24074  138 DDIGAGVITDGQLLhAGSsrlgELGHTQIDPYGkrcycgnhgcLETVASIPAILEqanqlleqspdsmlhgQPISIESLc 217

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664278166 181 -----------------AHRVQKYLLHVEMLFSPELFIIGGGVSRKAEKFLPLIEK-VRAELVPAQLQN 231
Cdd:cd24074  218 qaalagdplaqdiiiqvGRHLGRILAILVNLFNPEKILIGSPLNNAAEILFPALSQsIRQQSLPAYSQH 286
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 4-164 3.94e-08

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 52.68  E-value: 3.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   4 FGVDIGGSGIKGAPVDLDRGDLARERhkVLTPHPATPK---GVADGVAEVVGHFDWSGPVGITFPGVV-TDGITRTAANV 79
Cdd:PRK13310   3 YGFDIGGTKIELGVFNEKLELQWEER--VPTPRDSYDAfldAVCELVAEADQRFGCKGSVGIGIPGMPeTEDGTLYAANV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  80 DKGwidtDARTL---LGERIGQPVTILNDADAAGVAEmTFGAGKGRTGTVILLTFGTGIGSAVFTDGKLVPNT-----EL 151
Cdd:PRK13310  81 PAA----SGKPLradLSARLGRDVRLDNDANCFALSE-AWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGRsyitgEF 155

                        170
                 ....*....|...
gi 664278166 152 GHLELHgHDAEKH 164
Cdd:PRK13310 156 GHMRLP-VDALTL 167
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 83-159 5.83e-08

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 52.42  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  83 WIDTDARTLLGERIGQPVTILNDADAAGVAEMTFGAGKGRTGTVILLtFGTGIGSAVFTDGKLVPNT-----ELGHLELH 157
Cdd:cd24072   86 WRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVIN-LDYGIGSAIVIDNKLYIGAssgsgEIGHTKVN 164


                 ..
gi 664278166 158 GH 159
Cdd:cd24072  165 PD 166
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 1-244 6.24e-07

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 49.14  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   1 MEIFGVDIGGSGIKGAPVDLDrGDLaRERHKVLTPHPATPKGVADGVAEVV----GHFDWsgpVGITFPGVVTDGITrTA 76
Cdd:PRK05082   1 MTTLAIDIGGTKIAAALVGED-GQI-RQRRQIPTPASQTPEALRQALSALVsplqAQADR---VAVASTGIINDGIL-TA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  77 ANVDK--GWIDTDARTLLGERIGQPVTILNDADAAGVAEmtFGAGKGRTGTVILLTFGTGIGSAVFTDGKLV--PNTELG 152
Cdd:PRK05082  75 LNPHNlgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIRNMVFITVSTGVGGGIVLNGKLLtgPGGLAG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 153 HLelhGHD----------------AEKHASTKAKEDEDLSW------------------------QHWAHRVQKYLLHVE 192
Cdd:PRK05082 153 HI---GHTladphgpvcgcgrrgcVEAIASGRAIAAAAQGWlagcdaktiferagqgdeqaqaliNRSAQAIARLIADLK 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166 193 MLFSPELFIIGGGVSRkAEKFLPLIEKV--------RAELVPAQLQNNAGIVGAAMAAAG 244
Cdd:PRK05082 230 ATLDCQCVVLGGSVGL-AEGYLELVQAYlaqepaiyHVPLLAAHYRHDAGLLGAALWAQG 288
ASKHA_NBD_HK cd24000
nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) ...
 2-153 9.29e-05

nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). It can catalyze this reaction on glucose, fructose, sorbitol and glucosamine, and as such is the first step in a number of metabolic pathways. Hexokinase contains two structurally similar domains. Some members of the family have two copies of each of these domains. Hexokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466850 [Multi-domain]  Cd Length: 357  Bit Score: 43.03  E-value: 9.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166   2 EIFGVDIGGSGIKGAPVDLD-RGDLARERHKVLTPHPATPKG-------VADGVAEVVGHFDWS--GPVGITFP-----G 66
Cdd:cd24000   44 EFLAIDLGGTNLRVALVSLDgKGIEVTISKKYEIPDEIKTASaeeffdfIADCIAEFLKENGLKkpLPLGFTFSfpleqT 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664278166  67 VVTDGI--TRTAANVDKGWIDTDARTLLGE---RIGQPV---TILNDAdaagVAemTFGAGKGRTGTVIL-LTFGTGIGS 137
Cdd:cd24000  124 SLNDGKllSWTKGFKIPGVEGKDVGELLNDalkKRGLPVkvvAVLNDT----VA--TLLAGAYKDPDCRIgLILGTGTNA 197

                        170       180
                 ....*....|....*....|....*
gi 664278166 138 AVF---------TDGKLVpNTELGH 153
Cdd:cd24000  198 AYLeptsnillgDGGMII-NTEWGN 221
ASKHA_NBD_FGGY_SHK cd07777
nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1. ...
 3-50 1.97e-03

nucleotide-binding domain (NBD) of sedoheptulokinase (SHK) and similar proteins; SHK (EC 2.7.1.14), also called heptulokinase, or carbohydrate kinase-like protein (CARKL), is encoded by the carbohydrate kinase-like (CARKL/SHPK) gene. It acts as a modulator of macrophage activation through control of glucose metabolism. SHK catalyzes the ATP-dependent phosphorylation of sedoheptulose to produce sedoheptulose 7-phosphate and ADP. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subfamily belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.


Pssm-ID: 466796 [Multi-domain]  Cd Length: 436  Bit Score: 38.74  E-value: 1.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 664278166   3 IFGVDIGGSGIKGAPVDLDRGDLArerHKVLTPHPATPKGVADGVAEV 50
Cdd:cd07777    2 VLGIDIGTTSIKAALLDLESGRIL---ESVSRPTPAPISSDDPGRSEQ 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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