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Conserved domains on  [gi|663530566|gb|AIF20549|]
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putative transcriptional regulator [uncultured marine thaumarchaeote KM3_90_E04]

Protein Classification

transcriptional regulator( domain architecture ID 10006468)

HTH domain-containing transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AF0184 COG2522
Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];
1-105 8.14e-21

Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];


:

Pssm-ID: 442012 [Multi-domain]  Cd Length: 99  Bit Score: 80.64  E-value: 8.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663530566   1 MLLPAEIESKSLIPALRAILAKDLAKKhNIREDEISQMLGVTQAAVSNYIRGIRGDPKLIEKlleEKQVASMITEISDNL 80
Cdd:COG2522    1 MKLPCEIAVREVLPAIRALLAKELVER-GLSQSEIAKLLGITQAAVSQYLSGKRGASERIEF---DEEIKELIEELAEGL 76

                         90       100
                 ....*....|....*....|....*
gi 663530566  81 ASDNAYTplSLSKFIGLCNYIKSSL 105
Cdd:COG2522   77 ASGKPED--ALAEICRLCRELLKRG 99
 
Name Accession Description Interval E-value
AF0184 COG2522
Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];
1-105 8.14e-21

Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];


Pssm-ID: 442012 [Multi-domain]  Cd Length: 99  Bit Score: 80.64  E-value: 8.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663530566   1 MLLPAEIESKSLIPALRAILAKDLAKKhNIREDEISQMLGVTQAAVSNYIRGIRGDPKLIEKlleEKQVASMITEISDNL 80
Cdd:COG2522    1 MKLPCEIAVREVLPAIRALLAKELVER-GLSQSEIAKLLGITQAAVSQYLSGKRGASERIEF---DEEIKELIEELAEGL 76

                         90       100
                 ....*....|....*....|....*
gi 663530566  81 ASDNAYTplSLSKFIGLCNYIKSSL 105
Cdd:COG2522   77 ASGKPED--ALAEICRLCRELLKRG 99
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-65 3.72e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.65  E-value: 3.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 663530566    22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:smart00530   3 KELREEKGLTQEELAEKLGVSRSTLSRIENGKRKpSLETLKKLAK 47
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 22-65 6.01e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 33.28  E-value: 6.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 663530566   22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:pfam01381   2 KELREELGLSQEELAEKLGVSRSTISKIENGKREpSLETLKKLAE 46
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 22-65 8.83e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.91  E-value: 8.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 663530566  22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:cd00093    5 KELRKEKGLTQEELAEKLGVSRSTISRIENGKRNpSLETLEKLAK 49
 
Name Accession Description Interval E-value
AF0184 COG2522
Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];
1-105 8.14e-21

Predicted transcriptional regulator, contains XRE-type HTH domain [Transcription];


Pssm-ID: 442012 [Multi-domain]  Cd Length: 99  Bit Score: 80.64  E-value: 8.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663530566   1 MLLPAEIESKSLIPALRAILAKDLAKKhNIREDEISQMLGVTQAAVSNYIRGIRGDPKLIEKlleEKQVASMITEISDNL 80
Cdd:COG2522    1 MKLPCEIAVREVLPAIRALLAKELVER-GLSQSEIAKLLGITQAAVSQYLSGKRGASERIEF---DEEIKELIEELAEGL 76

                         90       100
                 ....*....|....*....|....*
gi 663530566  81 ASDNAYTplSLSKFIGLCNYIKSSL 105
Cdd:COG2522   77 ASGKPED--ALAEICRLCRELLKRG 99
MJ0558 COG1497
Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];
8-62 3.31e-03

Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];


Pssm-ID: 441106  Cd Length: 261  Bit Score: 35.98  E-value: 3.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 663530566   8 ESKSLIPALRaILAKDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRGDpKLIEK 62
Cdd:COG1497    5 RSKREATRFQ-ILVEIAERQPAVRQGEIADKLGVTPQAVSEYIKELVEE-GLVEK 57
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
22-65 3.72e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 33.65  E-value: 3.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 663530566    22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:smart00530   3 KELREEKGLTQEELAEKLGVSRSTLSRIENGKRKpSLETLKKLAK 47
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 22-65 6.01e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 33.28  E-value: 6.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 663530566   22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:pfam01381   2 KELREELGLSQEELAEKLGVSRSTISKIENGKREpSLETLKKLAE 46
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 22-65 8.83e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 32.91  E-value: 8.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 663530566  22 KDLAKKHNIREDEISQMLGVTQAAVSNYIRGIRG-DPKLIEKLLE 65
Cdd:cd00093    5 KELRKEKGLTQEELAEKLGVSRSTISRIENGKRNpSLETLEKLAK 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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