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Conserved domains on  [gi|663523379|gb|AIF13634|]
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putative phospholipase C (plcA) [uncultured marine group II/III euryarchaeote KM3_63_C07]

Protein Classification

RmlC family protein( domain architecture ID 10008288)

RmlC family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RmlC COG4101
Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];
15-143 2.03e-37

Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];


:

Pssm-ID: 443277  Cd Length: 146  Bit Score: 124.69  E-value: 2.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  15 TDEGGIWSLRQLEKVRSWND--------IEYAPGLSGKNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHE 86
Cdd:COG4101    2 STLTIDWAHAGVRVVRPGLDattagkqgLDYFEGISAETVGSTGLWMGLVTIPPGARAKAHHHGEHETAIYVLSGRAETR 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 663523379  87 YGPGCRKSVVHSAGDMFYIEPDLPHEVFNCSDSEWVHAVVSRSDASEWQNIEPYDRD 143
Cdd:COG4101   82 YGERLEHRVVTEPGDFIFIPPGVPHQEINLSDTEPAVAVIARTDPNEQESVVNLPEL 138
 
Name Accession Description Interval E-value
RmlC COG4101
Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];
15-143 2.03e-37

Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];


Pssm-ID: 443277  Cd Length: 146  Bit Score: 124.69  E-value: 2.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  15 TDEGGIWSLRQLEKVRSWND--------IEYAPGLSGKNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHE 86
Cdd:COG4101    2 STLTIDWAHAGVRVVRPGLDattagkqgLDYFEGISAETVGSTGLWMGLVTIPPGARAKAHHHGEHETAIYVLSGRAETR 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 663523379  87 YGPGCRKSVVHSAGDMFYIEPDLPHEVFNCSDSEWVHAVVSRSDASEWQNIEPYDRD 143
Cdd:COG4101   82 YGERLEHRVVTEPGDFIFIPPGVPHQEINLSDTEPAVAVIARTDPNEQESVVNLPEL 138
cupin_BLR2406-like cd02210
Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes ...
 41-134 4.92e-30

Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380340 [Multi-domain]  Cd Length: 98  Bit Score: 104.13  E-value: 4.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  41 LSGKNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGPGCRKSVVHSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:cd02210    1 ISAETVGAKGLWMGVVTIPPGARTGAHHHGEHETAIYVLSGRAETRYGDRLEHRAEAGPGDFIYIPPGVPHQEVNLSDDE 80

                         90
                 ....*....|....
gi 663523379 121 WVHAVVSRSDASEW 134
Cdd:cd02210   81 PAVAVVARSDPEEQ 94
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 28-122 4.04e-10

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 54.21  E-value: 4.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379    28 KVRSWNDIEYaPGLSGkntpsTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYG-PGCRKSVVH--SAGDMFY 104
Cdd:smart00835  13 RLREADPTNF-PALNG-----LGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVdPNGNKVYDArlREGDVFV 86

                           90       100
                   ....*....|....*....|
gi 663523379   105 IEPDLPHEVFN--CSDSEWV 122
Cdd:smart00835  87 VPQGHPHFQVNsgDENLEFV 106
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 58-120 9.84e-08

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 46.48  E-value: 9.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379   58 IPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGpGCRKSVvhSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:pfam07883   5 LPPGESSPPHRHPGEDEFFYVLEGEGELTVD-GEEVVL--KAGDSVYFPAGVPHRFRNTGDEP 64
 
Name Accession Description Interval E-value
RmlC COG4101
Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];
15-143 2.03e-37

Uncharacterized conserved protein, RmlC-like cupin domain [General function prediction only];


Pssm-ID: 443277  Cd Length: 146  Bit Score: 124.69  E-value: 2.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  15 TDEGGIWSLRQLEKVRSWND--------IEYAPGLSGKNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHE 86
Cdd:COG4101    2 STLTIDWAHAGVRVVRPGLDattagkqgLDYFEGISAETVGSTGLWMGLVTIPPGARAKAHHHGEHETAIYVLSGRAETR 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 663523379  87 YGPGCRKSVVHSAGDMFYIEPDLPHEVFNCSDSEWVHAVVSRSDASEWQNIEPYDRD 143
Cdd:COG4101   82 YGERLEHRVVTEPGDFIFIPPGVPHQEINLSDTEPAVAVIARTDPNEQESVVNLPEL 138
cupin_BLR2406-like cd02210
Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes ...
 41-134 4.92e-30

Bradyrhizobium japonicum BLR2406 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLR2406, a Bradyrhizobium japonicum protein of unknown function with a cupin beta barrel domain. Proteins in this subfamily appear to align closest to RmlC carbohydrate epimerase which is involved in dTDP-L-rhamnose production, and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380340 [Multi-domain]  Cd Length: 98  Bit Score: 104.13  E-value: 4.92e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  41 LSGKNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGPGCRKSVVHSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:cd02210    1 ISAETVGAKGLWMGVVTIPPGARTGAHHHGEHETAIYVLSGRAETRYGDRLEHRAEAGPGDFIYIPPGVPHQEVNLSDDE 80

                         90
                 ....*....|....
gi 663523379 121 WVHAVVSRSDASEW 134
Cdd:cd02210   81 PAVAVVARSDPEEQ 94
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
46-126 3.50e-11

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 56.01  E-value: 3.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  46 TPSTGLSMNRAYIPPGGVAKAHIHvDFDVMVYLLQGSVRHEYGpgcRKSVVHSAGDMFYIEPDLPHEVFNCSDSEWVHAV 125
Cdd:COG1917   18 DGEDELEVVRVTFEPGARTPWHSH-PGEELIYVLEGEGEVEVG---GEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLV 93


                 .
gi 663523379 126 V 126
Cdd:COG1917   94 V 94
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 28-122 4.04e-10

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 54.21  E-value: 4.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379    28 KVRSWNDIEYaPGLSGkntpsTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYG-PGCRKSVVH--SAGDMFY 104
Cdd:smart00835  13 RLREADPTNF-PALNG-----LGISAARVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVdPNGNKVYDArlREGDVFV 86

                           90       100
                   ....*....|....*....|
gi 663523379   105 IEPDLPHEVFN--CSDSEWV 122
Cdd:smart00835  87 VPQGHPHFQVNsgDENLEFV 106
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 53-127 7.46e-09

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 49.40  E-value: 7.46e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 663523379  53 MNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGPGcrKSVVHSAGDMFYIEPDLPHEVFNCSDSEWVHAVVS 127
Cdd:cd02208    1 ISVVTLPPGTSSPPHWHPEQDEIFYVLSGEGELTLDDG--ETVELKAGDIVLIPPGVPHSFVNTSDEPAVFLVVS 73
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 58-120 9.84e-08

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 46.48  E-value: 9.84e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379   58 IPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGpGCRKSVvhSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:pfam07883   5 LPPGESSPPHRHPGEDEFFYVLEGEGELTVD-GEEVVL--KAGDSVYFPAGVPHRFRNTGDEP 64
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 29-120 4.61e-07

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 46.17  E-value: 4.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379   29 VRSWNDIEYaPGLSGkntpsTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEY-GPGCRKSVVH---SAGDMFY 104
Cdd:pfam00190  17 VTTVNSKNL-PGLNT-----LGISAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFvVPGNGNRVFHkvlREGDVFV 90

                          90
                  ....*....|....*.
gi 663523379  105 IEPDLPHEVFNCSDSE 120
Cdd:pfam00190  91 VPQGLPHFQYNIGDEP 106
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
45-120 8.78e-07

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 44.75  E-value: 8.78e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663523379  45 NTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGPgcrKSVVHSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:COG0662   21 GEGGERLSVKRITVPPGAELSLHVHPHRDEFFYVLEGTGEVTIGD---EEVELKAGDSVYIPAGVPHRLRNPGDEP 93
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
43-120 1.16e-06

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 44.62  E-value: 1.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 663523379  43 GKNTPSTGLSMNRAYIPPGG-VAKAHIHVDFDVMVYLLQGSVRHEYGPGcrkSVVHSAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:COG3837   20 GDALGLTRLGVNLITLPPGAsSSPYHAHSAEEEFVYVLEGELTLRIGGE---EYVLEPGDSVGFPAGVPHRLRNRGDEP 95
cupin_BLR7677-like cd02234
Bradyrhizobium japonicum BLR7677 and related proteins, cupin domain; This family includes ...
 59-121 1.71e-06

Bradyrhizobium japonicum BLR7677 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLR7677, a Bradyrhizobium japonicum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380362 [Multi-domain]  Cd Length: 103  Bit Score: 43.65  E-value: 1.71e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663523379  59 PPGGVAKAHIHVDFdVMVYLLQGSVRHEYGPGcrKSVVHSAGDMFYIEPDLPHEVF-NCSDSEW 121
Cdd:cd02234   27 PPGAASPPHRHPGF-VFAYVLEGEVRSQVNGG--PPRVYKAGESFYEPPGAHHRVSrNASATEP 87
cupin_bxe_c0505 cd06980
uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial ...
 55-118 1.81e-06

uncharacterized protein bxe_c0505, cupin domain; This family includes mostly bacterial proteins homologous to bxe_c0505, a Burkholderia xenovorans protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380385 [Multi-domain]  Cd Length: 105  Bit Score: 43.71  E-value: 1.81e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663523379  55 RAYIPPGGVAKAHIH-VDFDvMVYLLQGSVRHEY-GPGcrkSVVHSAGDMFYIEPDLPHEVFNCSD 118
Cdd:cd06980   27 RATGGGEGPTGWHYHdCDFQ-MVYVLKGWVKFEFeGGG---EVRLEAGDCVYQPPGIRHNVLDYSD 88
cupin_KdgF cd02238
pectin degradation protein KdgF and related proteins, cupin domain; This family includes ...
 29-122 2.24e-06

pectin degradation protein KdgF and related proteins, cupin domain; This family includes bacterial and archaeal pectin degradation protein KdgF that catalyzes the linearization of unsaturated uronates from both pectin and alginate, which are polysaccharides found in the cell walls of plants and brown algae, respectively, and represent an important source of carbon. These polysaccharides, mostly consisting of chains of uronates, can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Pectin degradation is used by many plant-pathogenic bacteria during infection, and also, pectin and alginate can both represent abundant sources of carbohydrate for the production of biofuels. These proteins belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380366 [Multi-domain]  Cd Length: 104  Bit Score: 43.61  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  29 VRSWNDIEY---APGLSGKnTPSTG--LSMNRAYIPPGGVAKAHIHVdFDVMVYLLQGSVRHEYGPgcRKSVVHsAGDMF 103
Cdd:cd02238    1 FVKWDELPWeelGPGVRRK-ILAGGekLMLVEVRFEKGAVVPLHSHP-HEQIGYVLSGRFEFTIGG--ETRILK-PGDSY 75

                         90
                 ....*....|....*....
gi 663523379 104 YIEPDLPHEVFNCSDSEWV 122
Cdd:cd02238   76 YIPPNVPHGAEALEDSVLL 94
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 50-133 2.24e-06

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 43.80  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  50 GLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHE-YGPGCRKSVVH-SAGDMFYIEPDLPHEVFNCSDSEWVHAVVS 127
Cdd:COG2140    2 TLAGGLTVLEPGGVREEHWHPNAAEWYYVLSGEARMTvQDPPGRARTVDvGPGDVVYVPPGYGHYIINTGDEPLVFLAVF 81


                 ....*.
gi 663523379 128 RSDASE 133
Cdd:COG2140   82 DDDAGS 87
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 50-120 4.30e-06

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 43.73  E-value: 4.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379  50 GLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHE-YGPGCRKSVVH-SAGDMFYIEPDLPHEVFNCSDSE 120
Cdd:cd20306   33 GLSIYRLRLSPGGIREPHWHPNANELGYVISGEARVSiLDPTGSLDTFTvKPGQVVFIPQGWLHWIENVGDEE 105
cupin_CV2614-like cd02236
Chromobacterium violaceum CV2614 and related proteins, cupin domain; This family includes ...
 30-115 8.55e-06

Chromobacterium violaceum CV2614 and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to CV2614, a Chromobacterium violaceum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380364 [Multi-domain]  Cd Length: 102  Bit Score: 42.10  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663523379  30 RSWN--DIEYAPGlsgknTPStgLSMNRAYIPPGGVAKAHIHvDFDVMVYLLQGSVRHEYGPGcrKSVVHSAGDmFYIE- 106
Cdd:cd02236    6 TTWDgqPIPYPEG-----QPE--ITVLRITIPPGAELPWHTH-PVPNAGYVLSGELTVEYEDG--KKRTFKAGD-AFVEa 74


                 ....*....
gi 663523379 107 PDLPHEVFN 115
Cdd:cd02236   75 VNTWHRGRN 83
cupin_pirin-like_N cd20287
pirin-like, N-terminal cupin domain; This family contains the N-terminal cupin domain of pirin ...
 53-123 3.09e-04

pirin-like, N-terminal cupin domain; This family contains the N-terminal cupin domain of pirin and pirin-like proteins, including Escherichia coli YhhW and YhaK. Pirin functions as both a transcriptional cofactor and an apoptosis-related protein in mammals and is involved in seed germination and seedling development in plants. Proteins in this family have two tandem cupin-like folds but the C-terminal cupin fold has diverged considerably and does not have a metal binding site. The exact functions of pirins are unknown but they have quercitinase activity in Escherichia coli and are thought to play important roles in transcription and apoptosis. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380421 [Multi-domain]  Cd Length: 81  Bit Score: 37.57  E-value: 3.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379  53 MNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEygPGCRKSVVHSAGDMFYI--EPDLPHEVFNCSDSEWVH 123
Cdd:cd20287    4 FNEFVGGRGGGFPDHPHRGFEILSYLLEGS*EHE--DSCGNTGQ*NAGELQW*saGRGILHSE*NCSEDEPLH 74
cupin_OxOx cd02241
Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3. ...
 39-83 8.06e-04

Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3.4) catalyzes the manganese-dependent oxidative decarboxylation of oxalate to carbon dioxide and hydrogen peroxide (H2O2). It is widespread in fungi and various plant tissues and may play a role in plant signaling and defense. This enzyme has been employed in a widely used assay for detecting urinary oxalate levels. Also, the gene encoding OxOx from barley roots has been expressed in oilseed rape in order to provide a defense against externally supplied oxalic acid. In germin, the predominant protein produced during the early phase of wheat germination, it is believed that H2O2 production is employed as a defense mechanism in response to infection by pathogens. Germin is also a marker of growth onset in cell walls in germinating cereals. The H2O2 produced by OxOx, together with the Ca2+ released by degradation of calcium oxalate, are thought to mediate cell wall cross-linking at high concentrations. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380368  Cd Length: 191  Bit Score: 37.58  E-value: 8.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 663523379  39 PGLSGkntpsTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSV 83
Cdd:cd02241   63 PALNG-----LGISMARGDLAPCGVNPPHTHPRATELLYVVEGTL 102
cupin_OxDC cd02240
Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a ...
 48-118 8.62e-04

Oxalate decarboxylase (OxDC), cupin domain; Oxalate decarboxylase (OxDC; EC 4.1.1.2) is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds and both domains are included in this alignment. Each OxDC cupin domain contains one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380367 [Multi-domain]  Cd Length: 145  Bit Score: 37.46  E-value: 8.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379  48 STGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEY--GPGCRKSVVHSAGDMFYIEPDLPHEVFNCSD 118
Cdd:cd02240   24 SKDLSSALVRVAPGAMRELHWHPNTAEWQYVISGSARVTVfdEDGRFETFNLGAGDVGYVPSGSGHHIENIGD 96
cupin_HppE-like_C cd20489
hydroxypropylphosphonic acid epoxidase (HppE) and similar proteins, C-terminal cupin domain; ...
 75-111 1.15e-03

hydroxypropylphosphonic acid epoxidase (HppE) and similar proteins, C-terminal cupin domain; This family includes HppE (hydroxypropylphosphonic acid epoxidase or HPP epoxidase or 2-hydroxypropylphosphonic acid epoxidase; EC 1.11.1.23), a non-heme mononuclear iron-dependent enzyme that catalyzes a unique epoxidation reaction as part of the biosynthetic pathway of the clinically important oxirane antibiotic fosfomycin. HppE uses a facial triad with two histidine ligands and one aspartic acid or glutamic acid, His2(Glu/Asp), to catalyze a variety of different reactions, including DNA repair and antibiotic biosynthesis. The C-terminal catalytic domain of HppE has a cupin fold that binds a divalent cation, whereas the N-terminal domain carries a helix-turn-helix (HTH) motif with putative DNA-binding helices. HppE converts (S)-2-hydroxypropyl-1-phosphonate (S-HPP) to the antibiotic fosfomycin [(1R,2S)-epoxypropylphosphonate] in an unusual 1,3-dehydrogenation of a secondary alcohol to an epoxide; it uses H2O2 as a co-substrate to abstract hydrogen (Ho) from C1 of S-HPP to initiate epoxide ring closure, using an iron(IV)-oxo complex as the Ho abstractor. HppE belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization and its structure serves as a model for numerous proteins of unknown function, predicted to be transcription factors, containing an HTH motif at the N-terminus and a cupin domain at the C-terminus.


Pssm-ID: 380446 [Multi-domain]  Cd Length: 97  Bit Score: 36.07  E-value: 1.15e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 663523379  75 MVYLLQGSVRHEYG-PGCRKSVVHSAGDMFYIEPDLPH 111
Cdd:cd20489   42 FVYVLKGKVNMYWGdKGNPKEAVLNTGDSIYITPYVPH 79
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 53-115 1.51e-03

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 36.02  E-value: 1.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663523379  53 MNRAYIPPGGVAKAHIHVDfDVMVYLLQGSVrhEYGPGCRKSVVHSAGDMFYIEPDLPHEVFN 115
Cdd:cd02235   21 QVRVEIPPGAVAGRHTHPG-EESGYVLEGSL--ELEVDGQPPVTLKAGDSFFIPAGTVHNAKN 80
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 44-119 9.15e-03

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 33.64  E-value: 9.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 663523379  44 KNTPSTGLSMNRAYIPPGGVAKAHIHVDFDVMVYLLQGSVRHEYGpgcRKSVVHSAGDMFYIEPDLPHEVFNCSDS 119
Cdd:cd02214   12 DNDGDPRYSLAHARVPPGESTLPHRLKGSEEVYYILEGEGTMEID---GEPREVGPGDAVLIPPGAVQRIENTGEE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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