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Conserved domains on  [gi|663511210|gb|AIF01813|]
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hypothetical protein [uncultured marine group II/III euryarchaeote KM3_14_H03]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
42-179 3.44e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210  42 GIEGAAVDPAGERVIVYGADSYMELLDASDPQIRIELVwNGEGDLHAGDFHPGGQTALIVGESGEVLRYARDDHSVTdag 121
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--- 323

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210 122 GNLEFGNVDLRSVAWNPGGSWAYVGGSDG--WLWRmraaADGGAEVHLLEGRGGSdVTAI 179
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGtvRLWD----LATGELLRTLTGHTGA-VTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
42-179 3.44e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210  42 GIEGAAVDPAGERVIVYGADSYMELLDASDPQIRIELVwNGEGDLHAGDFHPGGQTALIVGESGEVLRYARDDHSVTdag 121
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--- 323

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210 122 GNLEFGNVDLRSVAWNPGGSWAYVGGSDG--WLWRmraaADGGAEVHLLEGRGGSdVTAI 179
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGtvRLWD----LATGELLRTLTGHTGA-VTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
42-179 3.44e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210  42 GIEGAAVDPAGERVIVYGADSYMELLDASDPQIRIELVwNGEGDLHAGDFHPGGQTALIVGESGEVLRYARDDHSVTdag 121
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--- 323

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210 122 GNLEFGNVDLRSVAWNPGGSWAYVGGSDG--WLWRmraaADGGAEVHLLEGRGGSdVTAI 179
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGtvRLWD----LATGELLRTLTGHTGA-VTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
2-251 7.49e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210   2 ASSGARVLSVLLVSVMLLPHAHADSAVELDTIVSLAPVDLGIEGAAVDPAGERVIVYGADSYMELLDASDPQIRIELvWN 81
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL-TG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210  82 GEGDLHAGDFHPGGQTALIVGESGEVLRYARDDhsvTDAGGNLEFGNVDLRSVAWNPGGSWAYVGGSDG--WLWRmraaA 159
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT---GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtvRLWD----L 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663511210 160 DGGAEVHLLEGRGGSdVTAIDCH--GTQmlcVVTSVVDG-IGVINRD--HSIFWIGGTGYPWQDVFCPPDdtGQCVAV-S 233
Cdd:COG2319  192 ATGKLLRTLTGHTGA-VRSVAFSpdGKL---LASGSADGtVRLWDLAtgKLLRTLTGHSGSVRSVAFSPD--GRLLASgS 265

                        250
                 ....*....|....*...
gi 663511210 234 DDRNVGIIDLDSEHPMTT 251
Cdd:COG2319  266 ADGTVRLWDLATGELLRT 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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