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DNA polymerase II large subunit (DPB1) [uncultured marine group II/III euryarchaeote AD1000_42_B01]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
PRK04023 super family
cl35239 DNA polymerase II large subunit; Validated
19-1323
0e+00
DNA polymerase II large subunit; Validated
PRK04023 :Pssm-ID: 235202 [Multi-domain]
Cd Length: 1121
Bit Score: 1250.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 19 E R E A Y QNW L DRRAE E V Y R IA AT A KA KGLD FE DEVEIP RTA D L A S R T E K L LD ey LD G ms IEDDL R D L LRTSD RE T AA I EIA 98
Cdd:PRK04023 4 E M E D Y FER L EKELD E L Y E IA EK A RS KGLD PS DEVEIP LAK D M A E R V E G L VG -- IK G -- VAERI R E L EKEMS RE E AA L EIA 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 99 LDV A RRMHARTSDIAT A I D SGL R VG LA V LTE A V LV APLEGI GE V R I MN N A DG S E F L S I D YAGPIR A AGGTAQAL G VL I GD 178
Cdd:PRK04023 80 KEI A EGKVGEFDSKEE A A D QAV R TA LA I LTE G V VA APLEGI AK V K I KK N D DG T E Y L A I Y YAGPIR S AGGTAQAL S VL V GD 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 179 MI RR E LG VG RY V PT TR E V ER VK EE FG LY - R V - GM QY K P PP EEI EV IVR AC PV M I N GE E TE KL E C SG Y kev R NI -- V NS N g 254
Cdd:PRK04023 160 YV RR K LG LD RY K PT DD E I ER YV EE IE LY k E V t SL QY S P SD EEI RL IVR NI PV E I D GE P TE DE E V SG H --- R DL er V ET N - 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 255 tart RIRGG V LLV IG EG LC LKAPKI Q K HTQR L DVP GW DFIAQFVGKD K AGA E S E DDI K rre I PKVSR Y ME DIIAGRPVF G 334
Cdd:PRK04023 236 ---- RIRGG M LLV LA EG IA LKAPKI L K YVDK L KID GW EWLEELISGK K EKE E E E EKK K --- I KPKDK Y LR DIIAGRPVF S 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 335 E P CEP GGFRLRYGRSR AS G L A A AG VN P VS M EA L GG F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VSTI EE 414
Cdd:PRK04023 309 H P SRK GGFRLRYGRSR NT G F A T AG IH P AT M YL L DD F IA VGTQ L KVERPGKA AC V V P VDS I E GPTV R L K NG DVV R IDDV EE 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 415 WSGCA D R V LS I W D S GEIL SGF G E F N ENN KD L V PS A Y NRD WW AAD L TD A LDHP E KMDRFVEL lgvsrdalppglpfngaie 494
Cdd:PRK04023 389 AKEIR D D V EE I L D L GEIL INY G D F L ENN HP L L PS S Y CEE WW IQE L EA A GAEY E PEFDLENP ------------------- 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 495 rggesslernwrqrdwylflrdmelgw G Q SR A V -- AQ E F G TAVP P PWNLW W S D mpmsfaptvidalvast VDD EE IRL L g 572
Cdd:PRK04023 450 --------------------------- S Q EE A L ki SE E Y G VPLH P KYTYL W H D ----------------- ISK EE LEA L - 484
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 573 aa R EWSPK G H I DDI G L pppstgtwprw TEVHSHGIL K SA L MT LG IE H HHDGDD IVI P t HWEG L VEG LGL E rygnafrvan 652
Cdd:PRK04023 485 -- R NALAG G G I LEE G V ----------- LVLDLSEGV K RI L EK LG VP H RVRDGK IVI E - EAYP L LYS LGL D ---------- 540
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 653 eagphiedrvsgiraatdmiaqdvgrq E EL E grravvrmraetaarqegfgiqetdeagava AE K IE D P G P N DP EA LR aa 732
Cdd:PRK04023 541 --------------------------- E LE E ------------------------------- LK K KL D D G S N VL EA VN -- 560
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 733 rvlldehsverslwltr R LS SLRWEDSV P C R V G S RMGRPEKA GT R E MKP M VH A L Y PI AEN GG PQ R LLGL AA - G KG V I R V Q 811
Cdd:PRK04023 561 ----------------- E LS GFEIRPKA P T R I G A RMGRPEKA KE R K MKP P VH V L F PI GNA GG ST R DINK AA k Y KG T I E V E 623
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 812 M G P R V C DK CG Q E SPHL RC HN rltrgeave CG GR T QMKK R R ----------- SNNMR R RLG -- LRTSVP L E E IVEVKRRA L 878
Cdd:PRK04023 624 I G R R K C PS CG K E TFYR RC PF --------- CG TH T EPVY R C prcgieveede CEKCG R EPT py SKRKID L K E LYDRALEN L 694
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 879 KLDRIP D RI K A VKGL I S VKQT PEP I EKGILRAKH G V S VF R DGT S RYDM S D V PLTHFRP S EIG TPWNV L F ELGY K HDI F G E 958
Cdd:PRK04023 695 GERKNF D EV K G VKGL T S KDKI PEP L EKGILRAKH D V Y VF K DGT V RYDM T D L PLTHFRP R EIG VSVEK L R ELGY T HDI Y G N 774
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 959 E L S S DE Q LL EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY EAGDER DLIGHL A IGLAPHTS G GV LC RIIG W T T 1038
Cdd:PRK04023 775 P L E S ED Q IV EL KV QD VII S RD A AEY LL RVAK F I DDLL EKY YG LEP FY NVEKRE DLIGHL V IGLAPHTS A GV VG RIIG F T K 854
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1039 A SA GYAHP L FHAAKRRNCDGDED SL M M LLDGLLNFSRS I LP AG RGG R MDAPLVL S T Q I IA KE I D K EA L N V D CS W A Y TRA F 1118
Cdd:PRK04023 855 A NV GYAHP Y FHAAKRRNCDGDED CV M L LLDGLLNFSRS Y LP DK RGG Q MDAPLVL T T R I DP KE V D D EA H N M D VV W R Y PLE F 934
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1119 YEAT KSRPH P N EV GGLV D LAG DR I G SIGEVR G YGW THD SGQPD AGP VN S S YKTL ET M KD KM L AQL A L GQQL RAV SAQR VA 1198
Cdd:PRK04023 935 YEAT LEGAD P K EV EDIM D TVE DR L G TPEQYE G FMF THD TSDIA AGP KV S A YKTL GS M EE KM E AQL E L ARKI RAV DERD VA 1014
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1199 SQ VI E SHFLPDL R GNL M AF T RQ KV RC V KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CGGN VV LTV SE G A V R KY I 1278
Cdd:PRK04023 1015 ER VI S SHFLPDL I GNL R AF S RQ EF RC T KC GAK YRR P PL S GKC PK ------------------ CGGN LI LTV HK G S V E KY L 1076
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*
gi 663503224 1279 E ITREVI E N YGV D DYTKQR V E WMTDSAD SLF ND D TVTVMT L D DF V 1323
Cdd:PRK04023 1077 E VSKKLA E E YGV S DYTKQR L E LLERGIK SLF EN D KSKQSG L S DF F 1121
Name
Accession
Description
Interval
E-value
PRK04023
PRK04023 DNA polymerase II large subunit; Validated
19-1323
0e+00
DNA polymerase II large subunit; Validated
Pssm-ID: 235202 [Multi-domain]
Cd Length: 1121
Bit Score: 1250.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 19 E R E A Y QNW L DRRAE E V Y R IA AT A KA KGLD FE DEVEIP RTA D L A S R T E K L LD ey LD G ms IEDDL R D L LRTSD RE T AA I EIA 98
Cdd:PRK04023 4 E M E D Y FER L EKELD E L Y E IA EK A RS KGLD PS DEVEIP LAK D M A E R V E G L VG -- IK G -- VAERI R E L EKEMS RE E AA L EIA 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 99 LDV A RRMHARTSDIAT A I D SGL R VG LA V LTE A V LV APLEGI GE V R I MN N A DG S E F L S I D YAGPIR A AGGTAQAL G VL I GD 178
Cdd:PRK04023 80 KEI A EGKVGEFDSKEE A A D QAV R TA LA I LTE G V VA APLEGI AK V K I KK N D DG T E Y L A I Y YAGPIR S AGGTAQAL S VL V GD 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 179 MI RR E LG VG RY V PT TR E V ER VK EE FG LY - R V - GM QY K P PP EEI EV IVR AC PV M I N GE E TE KL E C SG Y kev R NI -- V NS N g 254
Cdd:PRK04023 160 YV RR K LG LD RY K PT DD E I ER YV EE IE LY k E V t SL QY S P SD EEI RL IVR NI PV E I D GE P TE DE E V SG H --- R DL er V ET N - 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 255 tart RIRGG V LLV IG EG LC LKAPKI Q K HTQR L DVP GW DFIAQFVGKD K AGA E S E DDI K rre I PKVSR Y ME DIIAGRPVF G 334
Cdd:PRK04023 236 ---- RIRGG M LLV LA EG IA LKAPKI L K YVDK L KID GW EWLEELISGK K EKE E E E EKK K --- I KPKDK Y LR DIIAGRPVF S 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 335 E P CEP GGFRLRYGRSR AS G L A A AG VN P VS M EA L GG F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VSTI EE 414
Cdd:PRK04023 309 H P SRK GGFRLRYGRSR NT G F A T AG IH P AT M YL L DD F IA VGTQ L KVERPGKA AC V V P VDS I E GPTV R L K NG DVV R IDDV EE 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 415 WSGCA D R V LS I W D S GEIL SGF G E F N ENN KD L V PS A Y NRD WW AAD L TD A LDHP E KMDRFVEL lgvsrdalppglpfngaie 494
Cdd:PRK04023 389 AKEIR D D V EE I L D L GEIL INY G D F L ENN HP L L PS S Y CEE WW IQE L EA A GAEY E PEFDLENP ------------------- 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 495 rggesslernwrqrdwylflrdmelgw G Q SR A V -- AQ E F G TAVP P PWNLW W S D mpmsfaptvidalvast VDD EE IRL L g 572
Cdd:PRK04023 450 --------------------------- S Q EE A L ki SE E Y G VPLH P KYTYL W H D ----------------- ISK EE LEA L - 484
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 573 aa R EWSPK G H I DDI G L pppstgtwprw TEVHSHGIL K SA L MT LG IE H HHDGDD IVI P t HWEG L VEG LGL E rygnafrvan 652
Cdd:PRK04023 485 -- R NALAG G G I LEE G V ----------- LVLDLSEGV K RI L EK LG VP H RVRDGK IVI E - EAYP L LYS LGL D ---------- 540
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 653 eagphiedrvsgiraatdmiaqdvgrq E EL E grravvrmraetaarqegfgiqetdeagava AE K IE D P G P N DP EA LR aa 732
Cdd:PRK04023 541 --------------------------- E LE E ------------------------------- LK K KL D D G S N VL EA VN -- 560
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 733 rvlldehsverslwltr R LS SLRWEDSV P C R V G S RMGRPEKA GT R E MKP M VH A L Y PI AEN GG PQ R LLGL AA - G KG V I R V Q 811
Cdd:PRK04023 561 ----------------- E LS GFEIRPKA P T R I G A RMGRPEKA KE R K MKP P VH V L F PI GNA GG ST R DINK AA k Y KG T I E V E 623
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 812 M G P R V C DK CG Q E SPHL RC HN rltrgeave CG GR T QMKK R R ----------- SNNMR R RLG -- LRTSVP L E E IVEVKRRA L 878
Cdd:PRK04023 624 I G R R K C PS CG K E TFYR RC PF --------- CG TH T EPVY R C prcgieveede CEKCG R EPT py SKRKID L K E LYDRALEN L 694
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 879 KLDRIP D RI K A VKGL I S VKQT PEP I EKGILRAKH G V S VF R DGT S RYDM S D V PLTHFRP S EIG TPWNV L F ELGY K HDI F G E 958
Cdd:PRK04023 695 GERKNF D EV K G VKGL T S KDKI PEP L EKGILRAKH D V Y VF K DGT V RYDM T D L PLTHFRP R EIG VSVEK L R ELGY T HDI Y G N 774
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 959 E L S S DE Q LL EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY EAGDER DLIGHL A IGLAPHTS G GV LC RIIG W T T 1038
Cdd:PRK04023 775 P L E S ED Q IV EL KV QD VII S RD A AEY LL RVAK F I DDLL EKY YG LEP FY NVEKRE DLIGHL V IGLAPHTS A GV VG RIIG F T K 854
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1039 A SA GYAHP L FHAAKRRNCDGDED SL M M LLDGLLNFSRS I LP AG RGG R MDAPLVL S T Q I IA KE I D K EA L N V D CS W A Y TRA F 1118
Cdd:PRK04023 855 A NV GYAHP Y FHAAKRRNCDGDED CV M L LLDGLLNFSRS Y LP DK RGG Q MDAPLVL T T R I DP KE V D D EA H N M D VV W R Y PLE F 934
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1119 YEAT KSRPH P N EV GGLV D LAG DR I G SIGEVR G YGW THD SGQPD AGP VN S S YKTL ET M KD KM L AQL A L GQQL RAV SAQR VA 1198
Cdd:PRK04023 935 YEAT LEGAD P K EV EDIM D TVE DR L G TPEQYE G FMF THD TSDIA AGP KV S A YKTL GS M EE KM E AQL E L ARKI RAV DERD VA 1014
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1199 SQ VI E SHFLPDL R GNL M AF T RQ KV RC V KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CGGN VV LTV SE G A V R KY I 1278
Cdd:PRK04023 1015 ER VI S SHFLPDL I GNL R AF S RQ EF RC T KC GAK YRR P PL S GKC PK ------------------ CGGN LI LTV HK G S V E KY L 1076
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*
gi 663503224 1279 E ITREVI E N YGV D DYTKQR V E WMTDSAD SLF ND D TVTVMT L D DF V 1323
Cdd:PRK04023 1077 E VSKKLA E E YGV S DYTKQR L E LLERGIK SLF EN D KSKQSG L S DF F 1121
polC
TIGR00354 DNA polymerase, archaeal type II, large subunit; This model represents the large subunit, DP2, ...
23-1322
0e+00
DNA polymerase, archaeal type II, large subunit; This model represents the large subunit, DP2, of a two subunit novel Archaeal replicative DNA polymerase first characterized for Pyrococcus furiosus. Structure of DP2 appears to be organized as a ~950 residue component separated from a ~300 residue component by a ~150 residue intein. The other subunit, DP1, has sequence similarity to the eukaryotic DNA polymerase delta small subunit. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273031 [Multi-domain]
Cd Length: 1095
Bit Score: 944.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 23 Y QNW L DRRAEEV YRIA AT A KA KGLD F E DE VEIP RTA D L A S R T E K L LD ey LD G ms IEDDLRD L LRTSD RE TA A IE IA LDVA 102
Cdd:TIGR00354 6 Y FES L MVELDRI YRIA EA A RK KGLD P E LS VEIP LAK D M A E R V E G L VG -- PQ G -- LAKRIME L EGGLG RE LI A FK IA DEIV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 103 RRMHART s D IAT A I D SGL R VG LA V LTE A V LV APLEGI GE VRI MN N A D G S EF L SID YAGPIR A AGGTAQAL G VL IG D MI RR 182
Cdd:TIGR00354 82 EGKFGEM - D KEK A A D QAV R TA LA I LTE G V VA APLEGI AR VRI KR N F D K S NY L AVY YAGPIR S AGGTAQAL S VL VA D YV RR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 183 EL G VG RY V PT TR E V ER VK EE FG LY R --- VGM QY K P PPE EI EVI V RAC P VM I N GE E T EKL E C SG YKEVRN i V NS N gtart R 259
Cdd:TIGR00354 161 AA G LD RY K PT EE E I ER YV EE VE LY K sev ANL QY L P SDD EI RLA V SNI P IE I T GE P T DSV E V SG HRDLPR - V ET N ----- R 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 260 I RGG V LLVI G EG LC LKAPK IQ K HTQR L DVP GWD FIAQFV - GK DKA G A E S E DDIK rre I PKVSR Y ME DIIAGRPV FGE P CE 338
Cdd:TIGR00354 235 V RGG A LLVI V EG VA LKAPK LL K MVDE L GIE GWD WLDALI k GK GDK G S E G E EKVV --- I KAKDK Y LS DIIAGRPV LAH P SR 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 339 P GGFRLRYGR S R AS G L A AA GV N P VS M EA L G g F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VS T I EE WSGC 418
Cdd:TIGR00354 312 K GGFRLRYGR A R NT G F A TV GV H P AT M YL L E - F VA VGTQ L KVERPGKA GC V V P VDT I E GPTV K L K NG DVI R IN T L EE AKAV 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 419 ADR V LS I WDS G E IL SGF G E F N ENN KD L V P SAYNRD WW AAD ltdaldhpekmdrfvellgvsrdalppglpfnga I E RGGE 498
Cdd:TIGR00354 391 RGE V EE I LFL G D IL VNY G D F L ENN HP L I P ASWCEE WW IQE ---------------------------------- A E KANL 436
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 499 S S L ERNW R qrdwylflrdm ELGWGQSRAVAQ EF GTAVP P PWNLW W S D mpmsfaptvidalvast V DD E EI R L L gaa R E W s 578
Cdd:TIGR00354 437 S Y L RGDY R ----------- KISEEEALKLCD EF HVPLH P RYTYL W H D ----------------- V SV E DY R Y L --- R N W - 484
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 579 pkghiddiglpppstgtwprwtevhshgilks ALMTLGI E HH H DGD D IVI P thweglveglglerygnafrvaneagphi 658
Cdd:TIGR00354 485 -------------------------------- LSDNGKL E GK H GKS D LLL P ----------------------------- 503
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 659 ED R vsgiraatdmiaq D V G R QE E LE G RRAV VR mraetaarq E G F GIQ ET DE A GAVAAEKI E dpgpndpeal RAAR VL lde 738
Cdd:TIGR00354 504 ED S ------------- R V K R IL E AL G LEHK VR --------- E S F VVI ET WR A FIRCLGLD E ---------- KLSK VL --- 548
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 739 HSVERS L WLTRRL S SLRWEDSVPCRV G S RMGRPEKA GT R E M K P MV H A L Y PI AEN GG PQ R LLGL A AGKG - V I R V QMGP R V C 817
Cdd:TIGR00354 549 EVSKDV L EIVNGI S PIKVRPKALSYI G A RMGRPEKA KE R K M S P PP H I L F PI GMA GG NT R DIKN A INYT k E I E V EIAI R K C 628
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 818 DK CG Q ES PH L R C HN rltrgeave CG GR T QM kkrr SNNMR R RLG LR tsvpleeiv E VKRR A LKL -- DRIP D R IK A VKG LI S 895
Cdd:TIGR00354 629 PQ CG K ES FW L K C PV --------- CG EL T EQ ---- LYYGK R KVD LR --------- E LYEE A IAN lg EYKF D T IK G VKG MT S 686
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 896 VKQT PEP I EKGILRAK H GV S VF R DGT S R Y D MS D V P L THF R P S EIG TPWNV L F ELGY KH D IF G E EL SSDE Q LL EL L PQD FV 975
Cdd:TIGR00354 687 KTKI PEP L EKGILRAK N GV Y VF K DGT A R F D AT D L P I THF K P A EIG VSVEK L R ELGY ER D YY G A EL KDEN Q IV EL K PQD VI 766
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 976 PSI S AKGQ L LAICG F V DDLL VR FY G M DA FY EAGDER DLIGHL A IGLAPHTS G GVL C RIIG W T T A S AGYAHP L FHAAKRRN 1055
Cdd:TIGR00354 767 IPE S CAEY L VRVAN F I DDLL EK FY K M ER FY NVKSVE DLIGHL V IGLAPHTS A GVL G RIIG F T D A L AGYAHP Y FHAAKRRN 846
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1056 CDGDEDS L M M LLD G LLNFS RSI LP AG RGG R MDAPLVL S T QIIAK E I DKE AL N V D CSWA Y TRA FYEAT KSR P H P N EV GGL V 1135
Cdd:TIGR00354 847 CDGDEDS F M L LLD A LLNFS KKF LP DK RGG Q MDAPLVL T T IVDPR E V DKE VH N M D TMER Y PLE FYEAT MRF P S P K EV EDY V 926
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1136 DLAG DR I G SIGEVR G YGW THD SGQP DAGP VNSS YK T L E TM KD K MLA Q LA L GQQL RAV SAQR VA SQ VI E SHFLPD LR GNL M 1215
Cdd:TIGR00354 927 EKVE DR L G KPEQYC G LFF THD TSRI DAGP KVCA YK S L K TM QE K VYS Q ME L ARKI RAV DERD VA ER VI N SHFLPD II GNL R 1006
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1216 AF T RQ K VRC V KC AHS YRRIPL A GKC IQ nistsgglsggrgdggvl CG G N VV LTVS E G A V R KY I E ITREVI ENY G V DD YTK 1295
Cdd:TIGR00354 1007 AF S RQ E VRC T KC NTK YRRIPL V GKC LK ------------------ CG N N LT LTVS K G S V M KY L E LSKFLA ENY N V SS YTK 1068
1290 1300
....*....|....*....|....*..
gi 663503224 1296 QR VEWMTDSAD S L F NDD T VTVMT L D DF 1322
Cdd:TIGR00354 1069 QR LMILEQGIN S M F ENG T SKQVS L S DF 1095
PolC_DP2
pfam03833 DNA polymerase II large subunit DP2;
22-1055
0e+00
DNA polymerase II large subunit DP2;
Pssm-ID: 427537
Cd Length: 866
Bit Score: 940.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 22 A Y QNW L DRRAE E V Y R IA AT A KAK GLD FED EVEIP RTA DLA S R T EKLL D ey LD G ms IEDDL R D L LR T SD RE T AA I EIA LDV 101
Cdd:pfam03833 1 E Y FER L EKELD E A Y E IA EK A RSR GLD PSP EVEIP LAK DLA D R V EKLL G -- IK G -- VAERI R E L EK T MS RE E AA L EIA KEI 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 102 A RRMHARTSDIAT A I D SGL R VG LA V LTE A V LV APLEGI GE V R I MN N A DG S E F LS ID YAGPIR A AGGTAQAL G VL IG D MI R 181
Cdd:pfam03833 77 A EGKVGDFDSKEE A L D QAV R TA LA I LTE G V VA APLEGI AR V K I KK N D DG T E Y LS VY YAGPIR S AGGTAQAL S VL VA D YV R 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 182 R E LG VG RY V P TTR E V ER VK EE FG LY - RV - GM QY K P PP EEI EV IVR A CPV M I N GE E TE KL E C SG YKEVRN i V NS N gtart R 259
Cdd:pfam03833 157 R L LG ID RY K P RDE E I ER YV EE IE LY k RV t HL QY S P SD EEI RL IVR N CPV C I D GE P TE DE E V SG HRDLER - V ET N ----- R 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 260 I RGG VL LV IG EG LC LKAPKI Q KH TQR L DVP GW DFIAQFVGK DKA GAES E DDI K R R EI PK v SR Y ME D I IAGRPVF GE P CE P 339
Cdd:pfam03833 231 V RGG MC LV LA EG IA LKAPKI L KH VKK L GID GW EWLDELIKG DKA EKTG E EEE K P R VK PK - DK Y LR D L IAGRPVF SH P SR P 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 340 GGFRLRYGRSR AS G L A A AG VN P VS M EA L GG F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VSTI EE WSGCA 419
Cdd:pfam03833 310 GGFRLRYGRSR NT G F A T AG IH P AT M HI L DD F IA VGTQ L KVERPGKA AG V V P VDS I E GPTV R L K NG DVV R IDDV EE ALEIR 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 420 DR V LS I W D S GEIL SGF G E F N ENN KD LVPS A Y NRD WW AAD L TD A LDHPEKMD rfvellgvsrdalppglpfngai ERGG E S 499
Cdd:pfam03833 390 ND V EE I L D L GEIL INY G D F L ENN HP LVPS S Y CEE WW IQE L EA A GADVQALE ----------------------- DPTA E E 446
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 500 S LE rnwrqrdwylflrdmelgwgqsra VAQ E F G TAVP P PWNLW W S D mpmsfaptvidalvast VDD EE IRL L gaa REWSP 579
Cdd:pfam03833 447 A LE ------------------------ ISK E Y G VPLH P DYTYL W H D ----------------- ISV EE LNA L --- ADAVA 482
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 580 KG HIDDIG L PP P STGT wprwtevhshgi L K SA L MT L GIE H HHDGDD I V I P t H W EG L VEG LGL - E RY G NAFRVANEAGPHI 658
Cdd:pfam03833 483 KG GKIGGV L VL P LDPE ------------ I K RI L EK L LVP H KVRDGK I I I D - D W YP L LRC LGL d E DL G KLSKEERKDALEA 549
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 659 EDRV SG I raatdmiaqdvgrqeelegrra V VR M RA etaarqegfgiqetdeagavaaekiedpgpndpealraarvllde 738
Cdd:pfam03833 550 VNEL SG F ---------------------- K VR A RA --------------------------------------------- 562
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 739 hsverslwltrrlsslrwedsv P C R V G S RMGRPEK AGT R E MKP M VH A L Y PI A E N GG PQ R LLGL AA ---- G KG V I R V QM G P 814
Cdd:pfam03833 563 ---------------------- P T R I G A RMGRPEK SKE R K MKP P VH V L F PI G E A GG SR R DIAE AA kyae N KG E I E V EI G R 620
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 815 R V C DK CG Q E SPHL RC H nrltrgeav E CG GR T Q ----- M K KRRSNNMRR -- RL G LRTSVPLEEIVEV K --- RRAL K ---- L 880
Cdd:pfam03833 621 R R C PN CG K E TFEN RC P --------- D CG AH T E pvyvc P K CGIEVEDEK cp KC G REATCVSKIKIDL K key RRAL E nlge R 691
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 881 DRIP D RI K A VKGL I S VKQ TPEP I EKGILRAKHGVSVF R DGT S RYDM S D V PLTHFRP S EIG TPWNV L F ELGY K HDI F G EE L 960
Cdd:pfam03833 692 ENAL D EL K G VKGL T S KDK TPEP L EKGILRAKHGVSVF K DGT V RYDM T D L PLTHFRP R EIG VSVEK L R ELGY T HDI Y G KP L 771
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 961 S S DE Q LL EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY EAG D ER DLIGHL A IGLAPHTS G GVL C RIIG W T T AS 1040
Cdd:pfam03833 772 E S ED Q IV EL KV QD IIL S ED A AEY LL KVAK F I DDLL EKY YG LEP FY NVE D RE DLIGHL V IGLAPHTS A GVL G RIIG F T K AS 851
1050
....*....|....*
gi 663503224 1041 A GYAHP L FHAAKRRN 1055
Cdd:pfam03833 852 V GYAHP Y FHAAKRRN 866
PolC
COG1933 Archaeal DNA polymerase II, large subunit [Replication, recombination and repair];
254-1322
0e+00
Archaeal DNA polymerase II, large subunit [Replication, recombination and repair];
Pssm-ID: 441536 [Multi-domain]
Cd Length: 1075
Bit Score: 686.61
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 254 GTARTRIR G GVLLVIGEG L CL K APKIQ K HTQRLDVPGWDFI A QFVGKDK A GA E SEDDIKR re IPKVSRYMEDIIA G RPVF 333
Cdd:COG1933 22 AELGAERA G EARAGLAAE L EA K VRAVL K LLEAAAALEAGID A EAGAGAL A LT E GVVAAAG -- QGAEAAAIKAAGG G AVEG 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 334 GEPCEP GG F R L R Y G RSRASG LA AAGVNP V SMEALGGF LS VGTQMKV E RPGKACAVTPCIDIDGPT V LLDNGTFRRVSTI E 413
Cdd:COG1933 100 SIVRRG GG G R V R G G EAEEEA LA GEVRRK V LEIEDYDR LS EVDEEVR E EELLLAEEEDEEEEEEEE V EDEEADEVEEDDE E 179
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 414 E WSGCADRVLSIWDS G EI L SGFGEFNE N NKDLVPSAYNRDWW aa D LTDALDHP E KMDRF V ELLGVSRDAL P PG lpfn G AI 493
Cdd:COG1933 180 E GGLGLELRALVLVV G RD L KADKAEGG N VLLTDLDGEGEEGE -- D DEGDEGKD E DGEEA V LRDEGGGPLE P LV ---- G GR 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 494 ERGGESSLERNWRQR -- DWYLF L RDME LG W G QSRAVAQEFGTA V P - P P WNLWWSDMPMSFAPTVIDA LV AST V DDEEIRL 570
Cdd:COG1933 254 VGDLAREKGGTLAAL va GGGRI L AGLL LG D G AVTLGEALGVAV V G g A P SEGGGVGLEGVVVVLRGGS LV VLG V VAAVKIT 333
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 571 LGAAR E WSP K GHI D DIGLPPPSTGTWPRWT E ---- VHSHGILKSALMT L GI E HHHDGDDIVIPTH -- W E GLV EG LGL E RY 644
Cdd:COG1933 334 GRVEE E IVV K EED D LDEREIDLDDELLGPG E peel LVAELLEEPDGEE L SG E VEEEEEELDELEE ea E E SRE EG DED E EE 413
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 645 GNA f R VANEAGPHI E DRVSGIRAA T DMIAQDVGRQ EEL EGRRAVVRMRA E TAARQEGFGIQ E TD E AGAVAAEKIE D PGPN 724
Cdd:COG1933 414 LTE - R EEDALSLKL E LERELEGLL T EEEEELLELL EEL LLELLDEELED E LILELLILLEE E EE E ELILDLLLEL D LSEL 492
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 725 DPEALRAARVLLDEHSV E RSLWLTRRLSSL R WEDSVPCRVGS R MGRP E K AG TREMKPMVHA L y PIAENG G PQRLLGLA A G 804
Cdd:COG1933 493 KKGLKLLSDREVAPFDL E SGGLVALKSRMV R PRRRERRDLSD R RRTL E P AG EVGPPIGDVG L - LGRGLR G AADTDLKE A A 571
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 805 KGVIRVQMGP R VCDKCGQ E SP --- HLR C HNRLTRGEAVE C GGRTQMKKRRSNNMR R RLGLRTSVPLEEIVEVKRRALKL - 880
Cdd:COG1933 572 GVGLFKEPIL R LECCECG E PS cei CIE C GLEKPYCLICC C PDESGRDECPCCGCG R EPSTSSRKDFPLKKRLAAAEENG r 651
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 881 D R IP D RI K A VKGL I S VKQ TPEP I EKGILRAKH G VSVF R DGT S RYDM S D V PLTHFRPSEIG TPWNV L F ELGY KH DI F G EE L 960
Cdd:COG1933 652 E R AL D PL K G VKGL T S RDK TPEP L EKGILRAKH D VSVF K DGT V RYDM T D L PLTHFRPSEIG VTVEK L R ELGY TE DI L G KP L 731
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 961 S S DE QL L EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY E A G D ER DLIGHL A IGLAPHTS G GV LC RIIG W T T A S 1040
Cdd:COG1933 732 E S ED QL V EL KV QD III S ED A AEY LL RVAK F I DDLL EKY YG LEP FY N A E D RE DLIGHL V IGLAPHTS A GV VG RIIG F T L A V 811
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1041 A GYAHP L FHAAKRRNCDGDED SL M M LLDGLLNFSRS I LP AG RGG R MDAPLVL STQ I IAK EID K EA L N V D CSWA Y TRA FYE 1120
Cdd:COG1933 812 V GYAHP Y FHAAKRRNCDGDED CV M L LLDGLLNFSRS F LP DK RGG L MDAPLVL TSR I DPS EID D EA H N M D VVSR Y PLE FYE 891
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1121 AT KSRPH P N EV GG L V D LAG DR I G SI G EVR G Y G W THD SGQPD AGP VN S S YKTL ET M K DKM L AQL A L GQQL RAV SAQR VA SQ 1200
Cdd:COG1933 892 AT LEMAD P K EV ED L I D IVE DR L G TD G QYE G F G F THD TSDIA AGP DL S A YKTL GS M M DKM D AQL E L ARKI RAV DETD VA ER 971
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1201 VIESHFLPDL R GNL M AF T RQ KV RC V KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CGGNV V LTV S EG A V R KY I E I 1280
Cdd:COG1933 972 VIESHFLPDL I GNL R AF S RQ EF RC L KC GAK YRR M PL T GKC RK ------------------ CGGNV I LTV H EG S V N KY L E T 1033
1050 1060 1070 1080
....*....|....*....|....*....|....*....|..
gi 663503224 1281 TRE V I E N Y G V D DYTKQR V E WMTD S AD SLF ND D TVTVMT L D DF 1322
Cdd:COG1933 1034 AKK V A E E Y D V R DYTKQR L E ILER S IE SLF EN D KNKQSG L A DF 1075
Name
Accession
Description
Interval
E-value
PRK04023
PRK04023 DNA polymerase II large subunit; Validated
19-1323
0e+00
DNA polymerase II large subunit; Validated
Pssm-ID: 235202 [Multi-domain]
Cd Length: 1121
Bit Score: 1250.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 19 E R E A Y QNW L DRRAE E V Y R IA AT A KA KGLD FE DEVEIP RTA D L A S R T E K L LD ey LD G ms IEDDL R D L LRTSD RE T AA I EIA 98
Cdd:PRK04023 4 E M E D Y FER L EKELD E L Y E IA EK A RS KGLD PS DEVEIP LAK D M A E R V E G L VG -- IK G -- VAERI R E L EKEMS RE E AA L EIA 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 99 LDV A RRMHARTSDIAT A I D SGL R VG LA V LTE A V LV APLEGI GE V R I MN N A DG S E F L S I D YAGPIR A AGGTAQAL G VL I GD 178
Cdd:PRK04023 80 KEI A EGKVGEFDSKEE A A D QAV R TA LA I LTE G V VA APLEGI AK V K I KK N D DG T E Y L A I Y YAGPIR S AGGTAQAL S VL V GD 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 179 MI RR E LG VG RY V PT TR E V ER VK EE FG LY - R V - GM QY K P PP EEI EV IVR AC PV M I N GE E TE KL E C SG Y kev R NI -- V NS N g 254
Cdd:PRK04023 160 YV RR K LG LD RY K PT DD E I ER YV EE IE LY k E V t SL QY S P SD EEI RL IVR NI PV E I D GE P TE DE E V SG H --- R DL er V ET N - 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 255 tart RIRGG V LLV IG EG LC LKAPKI Q K HTQR L DVP GW DFIAQFVGKD K AGA E S E DDI K rre I PKVSR Y ME DIIAGRPVF G 334
Cdd:PRK04023 236 ---- RIRGG M LLV LA EG IA LKAPKI L K YVDK L KID GW EWLEELISGK K EKE E E E EKK K --- I KPKDK Y LR DIIAGRPVF S 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 335 E P CEP GGFRLRYGRSR AS G L A A AG VN P VS M EA L GG F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VSTI EE 414
Cdd:PRK04023 309 H P SRK GGFRLRYGRSR NT G F A T AG IH P AT M YL L DD F IA VGTQ L KVERPGKA AC V V P VDS I E GPTV R L K NG DVV R IDDV EE 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 415 WSGCA D R V LS I W D S GEIL SGF G E F N ENN KD L V PS A Y NRD WW AAD L TD A LDHP E KMDRFVEL lgvsrdalppglpfngaie 494
Cdd:PRK04023 389 AKEIR D D V EE I L D L GEIL INY G D F L ENN HP L L PS S Y CEE WW IQE L EA A GAEY E PEFDLENP ------------------- 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 495 rggesslernwrqrdwylflrdmelgw G Q SR A V -- AQ E F G TAVP P PWNLW W S D mpmsfaptvidalvast VDD EE IRL L g 572
Cdd:PRK04023 450 --------------------------- S Q EE A L ki SE E Y G VPLH P KYTYL W H D ----------------- ISK EE LEA L - 484
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 573 aa R EWSPK G H I DDI G L pppstgtwprw TEVHSHGIL K SA L MT LG IE H HHDGDD IVI P t HWEG L VEG LGL E rygnafrvan 652
Cdd:PRK04023 485 -- R NALAG G G I LEE G V ----------- LVLDLSEGV K RI L EK LG VP H RVRDGK IVI E - EAYP L LYS LGL D ---------- 540
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 653 eagphiedrvsgiraatdmiaqdvgrq E EL E grravvrmraetaarqegfgiqetdeagava AE K IE D P G P N DP EA LR aa 732
Cdd:PRK04023 541 --------------------------- E LE E ------------------------------- LK K KL D D G S N VL EA VN -- 560
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 733 rvlldehsverslwltr R LS SLRWEDSV P C R V G S RMGRPEKA GT R E MKP M VH A L Y PI AEN GG PQ R LLGL AA - G KG V I R V Q 811
Cdd:PRK04023 561 ----------------- E LS GFEIRPKA P T R I G A RMGRPEKA KE R K MKP P VH V L F PI GNA GG ST R DINK AA k Y KG T I E V E 623
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 812 M G P R V C DK CG Q E SPHL RC HN rltrgeave CG GR T QMKK R R ----------- SNNMR R RLG -- LRTSVP L E E IVEVKRRA L 878
Cdd:PRK04023 624 I G R R K C PS CG K E TFYR RC PF --------- CG TH T EPVY R C prcgieveede CEKCG R EPT py SKRKID L K E LYDRALEN L 694
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 879 KLDRIP D RI K A VKGL I S VKQT PEP I EKGILRAKH G V S VF R DGT S RYDM S D V PLTHFRP S EIG TPWNV L F ELGY K HDI F G E 958
Cdd:PRK04023 695 GERKNF D EV K G VKGL T S KDKI PEP L EKGILRAKH D V Y VF K DGT V RYDM T D L PLTHFRP R EIG VSVEK L R ELGY T HDI Y G N 774
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 959 E L S S DE Q LL EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY EAGDER DLIGHL A IGLAPHTS G GV LC RIIG W T T 1038
Cdd:PRK04023 775 P L E S ED Q IV EL KV QD VII S RD A AEY LL RVAK F I DDLL EKY YG LEP FY NVEKRE DLIGHL V IGLAPHTS A GV VG RIIG F T K 854
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1039 A SA GYAHP L FHAAKRRNCDGDED SL M M LLDGLLNFSRS I LP AG RGG R MDAPLVL S T Q I IA KE I D K EA L N V D CS W A Y TRA F 1118
Cdd:PRK04023 855 A NV GYAHP Y FHAAKRRNCDGDED CV M L LLDGLLNFSRS Y LP DK RGG Q MDAPLVL T T R I DP KE V D D EA H N M D VV W R Y PLE F 934
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1119 YEAT KSRPH P N EV GGLV D LAG DR I G SIGEVR G YGW THD SGQPD AGP VN S S YKTL ET M KD KM L AQL A L GQQL RAV SAQR VA 1198
Cdd:PRK04023 935 YEAT LEGAD P K EV EDIM D TVE DR L G TPEQYE G FMF THD TSDIA AGP KV S A YKTL GS M EE KM E AQL E L ARKI RAV DERD VA 1014
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1199 SQ VI E SHFLPDL R GNL M AF T RQ KV RC V KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CGGN VV LTV SE G A V R KY I 1278
Cdd:PRK04023 1015 ER VI S SHFLPDL I GNL R AF S RQ EF RC T KC GAK YRR P PL S GKC PK ------------------ CGGN LI LTV HK G S V E KY L 1076
1290 1300 1310 1320
....*....|....*....|....*....|....*....|....*
gi 663503224 1279 E ITREVI E N YGV D DYTKQR V E WMTDSAD SLF ND D TVTVMT L D DF V 1323
Cdd:PRK04023 1077 E VSKKLA E E YGV S DYTKQR L E LLERGIK SLF EN D KSKQSG L S DF F 1121
PRK14714
PRK14714 DNA-directed DNA polymerase II large subunit;
19-1322
0e+00
DNA-directed DNA polymerase II large subunit;
Pssm-ID: 237798 [Multi-domain]
Cd Length: 1337
Bit Score: 1073.55
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 19 E R E A Y QNW L D R RAEEV Y RI A AT A K A K GLD FED EVEIP RTA D L A S R T E K LL D ey L DG ms IEDDL R D L LRTSD RE T AA IE I A 98
Cdd:PRK14714 6 E M E R Y FER L E R ELDKA Y EV A EA A R A R GLD PSP EVEIP IAR D M A D R V E N LL G -- I DG -- VAERI R E L EGEMS RE E AA LK I V 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 99 L D VARRMHARTSDIATAIDSGL R VGL A V LTE A V LV AP L EGI GE V R I MN N A DG S E F L SID YAGPIR A AGGTAQAL G VL I GD 178
Cdd:PRK14714 82 D D FVEGKFGDYDTKEGKAEGAV R TAV A L LTE G V VA AP I EGI AR V E I KK N D DG T E Y L AVY YAGPIR S AGGTAQAL S VL V GD 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 179 MI R RE LG VG RY V P TTR E V ER VK EE FG LY R -- V G M QY K P PPE EI EV I VRA CP V MI N GE E T EKL E C SG YKEVRN i V NS N gta 256
Cdd:PRK14714 162 YV R AK LG ID RY K P REE E I ER YA EE ID LY D se T G L QY S P SEK EI RL I AEN CP I MI D GE A T GDE E V SG HRDLER - V ET N --- 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 257 rt RI RGG VL LV IG EG LC LKAPKIQK H T QRLDVP GWD FIAQFV - G KDKAGAESEDDIKRR E I ----------- P KVS --- R 321
Cdd:PRK14714 238 -- SL RGG MC LV LA EG IA LKAPKIQK Y T RKMKEE GWD WLQELI d G TIEGKSDAGEEGEEE E L stdadeyekgp P RIA psd K 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 322 Y ME D I I A GRPVF GE P CEP GGFRLRYGRSR AS G L A A AGV N P VS M EALGG FL S VGTQMK V ERPGKA CA V T P CID I D GPTV L L 401
Cdd:PRK14714 316 Y LR D L I G GRPVF SH P SRN GGFRLRYGRSR NT G F A T AGV H P AT M HLVDD FL A VGTQMK T ERPGKA AG V V P VDT I E GPTV K L 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 402 D NG TF RRV STI EE WSGCADR V LS I W D S GE I L SGF GEF N ENN KD L V P SA Y NRD WW AAD L TD A LDHPEKMDRFVELLGVSRD 481
Cdd:PRK14714 396 A NG DV RRV DDP EE ALEVRNG V EE I L D V GE Y L VNY GEF V ENN HP L L P AS Y CEE WW IQE L VK A GADVQALEDKPFVDLTRPT 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 482 A lppglpfngaierggesslernwrqrdwylflr DMELG W gqsrav A Q E F G TAVP P PWNLW W S D mpmsfaptvidalvas 561
Cdd:PRK14714 476 V --------------------------------- EEAAH W ------ A T E Y G APLH P YYTYL W H D ---------------- 500
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 562 t VDD E EI R L L GA A --- R E WSPK G HI DD IG L PP P S T G T wprwtevhshgi L K SA L MT L GIE H HHDG D D I V IP T h W EG L VEG 638
Cdd:PRK14714 501 - ISV E QV R A L AD A vad A E TRGI G FA DD GV L VL P L T P T ------------ V K RT L EL L LVP H TVRE D R I R IP D - W RP L LRS 566
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 639 LGL E rygnafr VAN EA GPHI E DRVSGIRA A T D M I aqdvgrq E EL EGRR av VR M RA etaarqegfgiqetdeagavaaeki 718
Cdd:PRK14714 567 LGL D ------- LSS EA ALEW E FAPKDGHN A I D L I ------- N EL APFK -- VR E RA ------------------------- 605
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 719 edpgpndpealraarvlldehsverslwltrrlsslrwedsv P C R V G S RMGRPEK AGT R E MKP M VH A L Y PI A E N GG P QR L 798
Cdd:PRK14714 606 ------------------------------------------ P T R I G N RMGRPEK SKP R K MKP P VH T L F PI G E A GG A QR D 643
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 799 LGL AA GK -------- GVI R V QM G P R V C DK CG Q E SPHL RC HNRL T RG E A V ECGGRTQMKKRRSNNM R RRLG l R TS V P L EEI 870
Cdd:PRK14714 644 VAK AA KH apdmsdeg GVI E V EV G R R R C PS CG T E TYEN RC PDCG T HT E P V YVCPDCGAEVPPDESG R VECP - R CD V E L TPY 722
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 871 VEVK ------- R R AL K ---- LDRIP D RI K A VKGL I S VKQT PEP I EKGILRAKH G V S VF R DGT S RYDM S D V P L THFRP S EI 939
Cdd:PRK14714 723 QRRT invkeey R S AL E nvge RENAF D LL K G VKGL T S REKI PEP L EKGILRAKH D V Y VF K DGT V RYDM T D L P V THFRP R EI 802
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 940 G TPWNV L F ELGY KH DI F G EE L SSDE Q LL EL LP QD F V P S IS A KGQ LL AICG FVDDLL VR FYG MDA FY EAGDER DL I GHL A I 1019
Cdd:PRK14714 803 G VSVEK L R ELGY TQ DI H G DP L VHED Q VV EL KV QD I V L S DG A AEY LL KVAK FVDDLL EK FYG LPR FY NVEKRE DL V GHL V I 882
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1020 GLAPHTS G GV LC RIIG W T T A SA GYAHP L FHAAKRRN -------------------------------------------- 1055
Cdd:PRK14714 883 GLAPHTS A GV VG RIIG F T S A NV GYAHP Y FHAAKRRN cfhgdtrilvqddggwhrdpirifveerldledpgyddfgtvyq 962
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 --------------------------------------------------------------------------------
Cdd:PRK14714 963 kpkrdvkvysvdengkvvltditsvskhpapdhlirfetergrsltvtpdhamlvwdggylekkrafevkegdavpvpeg 1042
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1056 --------------------------------------------- CDGDED SL M M LLDGLLNFS R S I LP AG RGG R MDAPL 1090
Cdd:PRK14714 1043 veetgvvladevvsieyvesdddfvycltvaeyhtvvangiftgq CDGDED CV M L LLDGLLNFS K S F LP EK RGG K MDAPL 1122
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1091 VL STQ I IAK EID K EA L N V D CSWA Y TRA FYEAT KSRPH P NE V GG L VDLAG DR I G SIGEVR G Y G W THD SGQPDA GP VN S S YK 1170
Cdd:PRK14714 1123 VL TSR I DPS EID D EA H N M D VVRY Y PLE FYEAT LEMAD P KD V ED L IERVE DR L G TPEQYE G F G F THD TSDIAL GP KL S A YK 1202
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1171 TL ET M K DKM L AQL A L GQQL RAV SAQR VA SQ VI ES HF L PDL R GNL M AF T RQ KV RC V KC AHS YRR I PLAGKC IQ nistsggl 1250
Cdd:PRK14714 1203 TL GS M L DKM D AQL E L ARKI RAV DEHD VA ER VI NY HF I PDL I GNL R AF S RQ EF RC L KC GTK YRR M PLAGKC RK -------- 1274
1450 1460 1470 1480 1490 1500 1510
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 663503224 1251 sggrgdggvl CGG NVV LTV S EG A V R KY IEITRE V IEN Y G V DD YTKQR V E WMTDSAD SLF ND D TVTVMT L D DF 1322
Cdd:PRK14714 1275 ---------- CGG RII LTV H EG S V E KY LDTAKM V ATE Y N V RE YTKQR L E VLDRDIE SLF EN D KNKQSG L A DF 1336
polC
TIGR00354 DNA polymerase, archaeal type II, large subunit; This model represents the large subunit, DP2, ...
23-1322
0e+00
DNA polymerase, archaeal type II, large subunit; This model represents the large subunit, DP2, of a two subunit novel Archaeal replicative DNA polymerase first characterized for Pyrococcus furiosus. Structure of DP2 appears to be organized as a ~950 residue component separated from a ~300 residue component by a ~150 residue intein. The other subunit, DP1, has sequence similarity to the eukaryotic DNA polymerase delta small subunit. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273031 [Multi-domain]
Cd Length: 1095
Bit Score: 944.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 23 Y QNW L DRRAEEV YRIA AT A KA KGLD F E DE VEIP RTA D L A S R T E K L LD ey LD G ms IEDDLRD L LRTSD RE TA A IE IA LDVA 102
Cdd:TIGR00354 6 Y FES L MVELDRI YRIA EA A RK KGLD P E LS VEIP LAK D M A E R V E G L VG -- PQ G -- LAKRIME L EGGLG RE LI A FK IA DEIV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 103 RRMHART s D IAT A I D SGL R VG LA V LTE A V LV APLEGI GE VRI MN N A D G S EF L SID YAGPIR A AGGTAQAL G VL IG D MI RR 182
Cdd:TIGR00354 82 EGKFGEM - D KEK A A D QAV R TA LA I LTE G V VA APLEGI AR VRI KR N F D K S NY L AVY YAGPIR S AGGTAQAL S VL VA D YV RR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 183 EL G VG RY V PT TR E V ER VK EE FG LY R --- VGM QY K P PPE EI EVI V RAC P VM I N GE E T EKL E C SG YKEVRN i V NS N gtart R 259
Cdd:TIGR00354 161 AA G LD RY K PT EE E I ER YV EE VE LY K sev ANL QY L P SDD EI RLA V SNI P IE I T GE P T DSV E V SG HRDLPR - V ET N ----- R 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 260 I RGG V LLVI G EG LC LKAPK IQ K HTQR L DVP GWD FIAQFV - GK DKA G A E S E DDIK rre I PKVSR Y ME DIIAGRPV FGE P CE 338
Cdd:TIGR00354 235 V RGG A LLVI V EG VA LKAPK LL K MVDE L GIE GWD WLDALI k GK GDK G S E G E EKVV --- I KAKDK Y LS DIIAGRPV LAH P SR 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 339 P GGFRLRYGR S R AS G L A AA GV N P VS M EA L G g F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VS T I EE WSGC 418
Cdd:TIGR00354 312 K GGFRLRYGR A R NT G F A TV GV H P AT M YL L E - F VA VGTQ L KVERPGKA GC V V P VDT I E GPTV K L K NG DVI R IN T L EE AKAV 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 419 ADR V LS I WDS G E IL SGF G E F N ENN KD L V P SAYNRD WW AAD ltdaldhpekmdrfvellgvsrdalppglpfnga I E RGGE 498
Cdd:TIGR00354 391 RGE V EE I LFL G D IL VNY G D F L ENN HP L I P ASWCEE WW IQE ---------------------------------- A E KANL 436
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 499 S S L ERNW R qrdwylflrdm ELGWGQSRAVAQ EF GTAVP P PWNLW W S D mpmsfaptvidalvast V DD E EI R L L gaa R E W s 578
Cdd:TIGR00354 437 S Y L RGDY R ----------- KISEEEALKLCD EF HVPLH P RYTYL W H D ----------------- V SV E DY R Y L --- R N W - 484
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 579 pkghiddiglpppstgtwprwtevhshgilks ALMTLGI E HH H DGD D IVI P thweglveglglerygnafrvaneagphi 658
Cdd:TIGR00354 485 -------------------------------- LSDNGKL E GK H GKS D LLL P ----------------------------- 503
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 659 ED R vsgiraatdmiaq D V G R QE E LE G RRAV VR mraetaarq E G F GIQ ET DE A GAVAAEKI E dpgpndpeal RAAR VL lde 738
Cdd:TIGR00354 504 ED S ------------- R V K R IL E AL G LEHK VR --------- E S F VVI ET WR A FIRCLGLD E ---------- KLSK VL --- 548
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 739 HSVERS L WLTRRL S SLRWEDSVPCRV G S RMGRPEKA GT R E M K P MV H A L Y PI AEN GG PQ R LLGL A AGKG - V I R V QMGP R V C 817
Cdd:TIGR00354 549 EVSKDV L EIVNGI S PIKVRPKALSYI G A RMGRPEKA KE R K M S P PP H I L F PI GMA GG NT R DIKN A INYT k E I E V EIAI R K C 628
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 818 DK CG Q ES PH L R C HN rltrgeave CG GR T QM kkrr SNNMR R RLG LR tsvpleeiv E VKRR A LKL -- DRIP D R IK A VKG LI S 895
Cdd:TIGR00354 629 PQ CG K ES FW L K C PV --------- CG EL T EQ ---- LYYGK R KVD LR --------- E LYEE A IAN lg EYKF D T IK G VKG MT S 686
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 896 VKQT PEP I EKGILRAK H GV S VF R DGT S R Y D MS D V P L THF R P S EIG TPWNV L F ELGY KH D IF G E EL SSDE Q LL EL L PQD FV 975
Cdd:TIGR00354 687 KTKI PEP L EKGILRAK N GV Y VF K DGT A R F D AT D L P I THF K P A EIG VSVEK L R ELGY ER D YY G A EL KDEN Q IV EL K PQD VI 766
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 976 PSI S AKGQ L LAICG F V DDLL VR FY G M DA FY EAGDER DLIGHL A IGLAPHTS G GVL C RIIG W T T A S AGYAHP L FHAAKRRN 1055
Cdd:TIGR00354 767 IPE S CAEY L VRVAN F I DDLL EK FY K M ER FY NVKSVE DLIGHL V IGLAPHTS A GVL G RIIG F T D A L AGYAHP Y FHAAKRRN 846
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1056 CDGDEDS L M M LLD G LLNFS RSI LP AG RGG R MDAPLVL S T QIIAK E I DKE AL N V D CSWA Y TRA FYEAT KSR P H P N EV GGL V 1135
Cdd:TIGR00354 847 CDGDEDS F M L LLD A LLNFS KKF LP DK RGG Q MDAPLVL T T IVDPR E V DKE VH N M D TMER Y PLE FYEAT MRF P S P K EV EDY V 926
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1136 DLAG DR I G SIGEVR G YGW THD SGQP DAGP VNSS YK T L E TM KD K MLA Q LA L GQQL RAV SAQR VA SQ VI E SHFLPD LR GNL M 1215
Cdd:TIGR00354 927 EKVE DR L G KPEQYC G LFF THD TSRI DAGP KVCA YK S L K TM QE K VYS Q ME L ARKI RAV DERD VA ER VI N SHFLPD II GNL R 1006
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1216 AF T RQ K VRC V KC AHS YRRIPL A GKC IQ nistsgglsggrgdggvl CG G N VV LTVS E G A V R KY I E ITREVI ENY G V DD YTK 1295
Cdd:TIGR00354 1007 AF S RQ E VRC T KC NTK YRRIPL V GKC LK ------------------ CG N N LT LTVS K G S V M KY L E LSKFLA ENY N V SS YTK 1068
1290 1300
....*....|....*....|....*..
gi 663503224 1296 QR VEWMTDSAD S L F NDD T VTVMT L D DF 1322
Cdd:TIGR00354 1069 QR LMILEQGIN S M F ENG T SKQVS L S DF 1095
PolC_DP2
pfam03833 DNA polymerase II large subunit DP2;
22-1055
0e+00
DNA polymerase II large subunit DP2;
Pssm-ID: 427537
Cd Length: 866
Bit Score: 940.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 22 A Y QNW L DRRAE E V Y R IA AT A KAK GLD FED EVEIP RTA DLA S R T EKLL D ey LD G ms IEDDL R D L LR T SD RE T AA I EIA LDV 101
Cdd:pfam03833 1 E Y FER L EKELD E A Y E IA EK A RSR GLD PSP EVEIP LAK DLA D R V EKLL G -- IK G -- VAERI R E L EK T MS RE E AA L EIA KEI 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 102 A RRMHARTSDIAT A I D SGL R VG LA V LTE A V LV APLEGI GE V R I MN N A DG S E F LS ID YAGPIR A AGGTAQAL G VL IG D MI R 181
Cdd:pfam03833 77 A EGKVGDFDSKEE A L D QAV R TA LA I LTE G V VA APLEGI AR V K I KK N D DG T E Y LS VY YAGPIR S AGGTAQAL S VL VA D YV R 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 182 R E LG VG RY V P TTR E V ER VK EE FG LY - RV - GM QY K P PP EEI EV IVR A CPV M I N GE E TE KL E C SG YKEVRN i V NS N gtart R 259
Cdd:pfam03833 157 R L LG ID RY K P RDE E I ER YV EE IE LY k RV t HL QY S P SD EEI RL IVR N CPV C I D GE P TE DE E V SG HRDLER - V ET N ----- R 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 260 I RGG VL LV IG EG LC LKAPKI Q KH TQR L DVP GW DFIAQFVGK DKA GAES E DDI K R R EI PK v SR Y ME D I IAGRPVF GE P CE P 339
Cdd:pfam03833 231 V RGG MC LV LA EG IA LKAPKI L KH VKK L GID GW EWLDELIKG DKA EKTG E EEE K P R VK PK - DK Y LR D L IAGRPVF SH P SR P 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 340 GGFRLRYGRSR AS G L A A AG VN P VS M EA L GG F LS VGTQ M KVERPGKA CA V T P CID I D GPTV L L D NG TFR R VSTI EE WSGCA 419
Cdd:pfam03833 310 GGFRLRYGRSR NT G F A T AG IH P AT M HI L DD F IA VGTQ L KVERPGKA AG V V P VDS I E GPTV R L K NG DVV R IDDV EE ALEIR 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 420 DR V LS I W D S GEIL SGF G E F N ENN KD LVPS A Y NRD WW AAD L TD A LDHPEKMD rfvellgvsrdalppglpfngai ERGG E S 499
Cdd:pfam03833 390 ND V EE I L D L GEIL INY G D F L ENN HP LVPS S Y CEE WW IQE L EA A GADVQALE ----------------------- DPTA E E 446
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 500 S LE rnwrqrdwylflrdmelgwgqsra VAQ E F G TAVP P PWNLW W S D mpmsfaptvidalvast VDD EE IRL L gaa REWSP 579
Cdd:pfam03833 447 A LE ------------------------ ISK E Y G VPLH P DYTYL W H D ----------------- ISV EE LNA L --- ADAVA 482
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 580 KG HIDDIG L PP P STGT wprwtevhshgi L K SA L MT L GIE H HHDGDD I V I P t H W EG L VEG LGL - E RY G NAFRVANEAGPHI 658
Cdd:pfam03833 483 KG GKIGGV L VL P LDPE ------------ I K RI L EK L LVP H KVRDGK I I I D - D W YP L LRC LGL d E DL G KLSKEERKDALEA 549
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 659 EDRV SG I raatdmiaqdvgrqeelegrra V VR M RA etaarqegfgiqetdeagavaaekiedpgpndpealraarvllde 738
Cdd:pfam03833 550 VNEL SG F ---------------------- K VR A RA --------------------------------------------- 562
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 739 hsverslwltrrlsslrwedsv P C R V G S RMGRPEK AGT R E MKP M VH A L Y PI A E N GG PQ R LLGL AA ---- G KG V I R V QM G P 814
Cdd:pfam03833 563 ---------------------- P T R I G A RMGRPEK SKE R K MKP P VH V L F PI G E A GG SR R DIAE AA kyae N KG E I E V EI G R 620
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 815 R V C DK CG Q E SPHL RC H nrltrgeav E CG GR T Q ----- M K KRRSNNMRR -- RL G LRTSVPLEEIVEV K --- RRAL K ---- L 880
Cdd:pfam03833 621 R R C PN CG K E TFEN RC P --------- D CG AH T E pvyvc P K CGIEVEDEK cp KC G REATCVSKIKIDL K key RRAL E nlge R 691
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 881 DRIP D RI K A VKGL I S VKQ TPEP I EKGILRAKHGVSVF R DGT S RYDM S D V PLTHFRP S EIG TPWNV L F ELGY K HDI F G EE L 960
Cdd:pfam03833 692 ENAL D EL K G VKGL T S KDK TPEP L EKGILRAKHGVSVF K DGT V RYDM T D L PLTHFRP R EIG VSVEK L R ELGY T HDI Y G KP L 771
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 961 S S DE Q LL EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY EAG D ER DLIGHL A IGLAPHTS G GVL C RIIG W T T AS 1040
Cdd:pfam03833 772 E S ED Q IV EL KV QD IIL S ED A AEY LL KVAK F I DDLL EKY YG LEP FY NVE D RE DLIGHL V IGLAPHTS A GVL G RIIG F T K AS 851
1050
....*....|....*
gi 663503224 1041 A GYAHP L FHAAKRRN 1055
Cdd:pfam03833 852 V GYAHP Y FHAAKRRN 866
PolC
COG1933 Archaeal DNA polymerase II, large subunit [Replication, recombination and repair];
254-1322
0e+00
Archaeal DNA polymerase II, large subunit [Replication, recombination and repair];
Pssm-ID: 441536 [Multi-domain]
Cd Length: 1075
Bit Score: 686.61
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 254 GTARTRIR G GVLLVIGEG L CL K APKIQ K HTQRLDVPGWDFI A QFVGKDK A GA E SEDDIKR re IPKVSRYMEDIIA G RPVF 333
Cdd:COG1933 22 AELGAERA G EARAGLAAE L EA K VRAVL K LLEAAAALEAGID A EAGAGAL A LT E GVVAAAG -- QGAEAAAIKAAGG G AVEG 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 334 GEPCEP GG F R L R Y G RSRASG LA AAGVNP V SMEALGGF LS VGTQMKV E RPGKACAVTPCIDIDGPT V LLDNGTFRRVSTI E 413
Cdd:COG1933 100 SIVRRG GG G R V R G G EAEEEA LA GEVRRK V LEIEDYDR LS EVDEEVR E EELLLAEEEDEEEEEEEE V EDEEADEVEEDDE E 179
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 414 E WSGCADRVLSIWDS G EI L SGFGEFNE N NKDLVPSAYNRDWW aa D LTDALDHP E KMDRF V ELLGVSRDAL P PG lpfn G AI 493
Cdd:COG1933 180 E GGLGLELRALVLVV G RD L KADKAEGG N VLLTDLDGEGEEGE -- D DEGDEGKD E DGEEA V LRDEGGGPLE P LV ---- G GR 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 494 ERGGESSLERNWRQR -- DWYLF L RDME LG W G QSRAVAQEFGTA V P - P P WNLWWSDMPMSFAPTVIDA LV AST V DDEEIRL 570
Cdd:COG1933 254 VGDLAREKGGTLAAL va GGGRI L AGLL LG D G AVTLGEALGVAV V G g A P SEGGGVGLEGVVVVLRGGS LV VLG V VAAVKIT 333
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 571 LGAAR E WSP K GHI D DIGLPPPSTGTWPRWT E ---- VHSHGILKSALMT L GI E HHHDGDDIVIPTH -- W E GLV EG LGL E RY 644
Cdd:COG1933 334 GRVEE E IVV K EED D LDEREIDLDDELLGPG E peel LVAELLEEPDGEE L SG E VEEEEEELDELEE ea E E SRE EG DED E EE 413
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 645 GNA f R VANEAGPHI E DRVSGIRAA T DMIAQDVGRQ EEL EGRRAVVRMRA E TAARQEGFGIQ E TD E AGAVAAEKIE D PGPN 724
Cdd:COG1933 414 LTE - R EEDALSLKL E LERELEGLL T EEEEELLELL EEL LLELLDEELED E LILELLILLEE E EE E ELILDLLLEL D LSEL 492
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 725 DPEALRAARVLLDEHSV E RSLWLTRRLSSL R WEDSVPCRVGS R MGRP E K AG TREMKPMVHA L y PIAENG G PQRLLGLA A G 804
Cdd:COG1933 493 KKGLKLLSDREVAPFDL E SGGLVALKSRMV R PRRRERRDLSD R RRTL E P AG EVGPPIGDVG L - LGRGLR G AADTDLKE A A 571
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 805 KGVIRVQMGP R VCDKCGQ E SP --- HLR C HNRLTRGEAVE C GGRTQMKKRRSNNMR R RLGLRTSVPLEEIVEVKRRALKL - 880
Cdd:COG1933 572 GVGLFKEPIL R LECCECG E PS cei CIE C GLEKPYCLICC C PDESGRDECPCCGCG R EPSTSSRKDFPLKKRLAAAEENG r 651
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 881 D R IP D RI K A VKGL I S VKQ TPEP I EKGILRAKH G VSVF R DGT S RYDM S D V PLTHFRPSEIG TPWNV L F ELGY KH DI F G EE L 960
Cdd:COG1933 652 E R AL D PL K G VKGL T S RDK TPEP L EKGILRAKH D VSVF K DGT V RYDM T D L PLTHFRPSEIG VTVEK L R ELGY TE DI L G KP L 731
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 961 S S DE QL L EL LP QD FVP S IS A KGQ LL AICG F V DDLL VRF YG MDA FY E A G D ER DLIGHL A IGLAPHTS G GV LC RIIG W T T A S 1040
Cdd:COG1933 732 E S ED QL V EL KV QD III S ED A AEY LL RVAK F I DDLL EKY YG LEP FY N A E D RE DLIGHL V IGLAPHTS A GV VG RIIG F T L A V 811
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1041 A GYAHP L FHAAKRRNCDGDED SL M M LLDGLLNFSRS I LP AG RGG R MDAPLVL STQ I IAK EID K EA L N V D CSWA Y TRA FYE 1120
Cdd:COG1933 812 V GYAHP Y FHAAKRRNCDGDED CV M L LLDGLLNFSRS F LP DK RGG L MDAPLVL TSR I DPS EID D EA H N M D VVSR Y PLE FYE 891
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1121 AT KSRPH P N EV GG L V D LAG DR I G SI G EVR G Y G W THD SGQPD AGP VN S S YKTL ET M K DKM L AQL A L GQQL RAV SAQR VA SQ 1200
Cdd:COG1933 892 AT LEMAD P K EV ED L I D IVE DR L G TD G QYE G F G F THD TSDIA AGP DL S A YKTL GS M M DKM D AQL E L ARKI RAV DETD VA ER 971
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1201 VIESHFLPDL R GNL M AF T RQ KV RC V KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CGGNV V LTV S EG A V R KY I E I 1280
Cdd:COG1933 972 VIESHFLPDL I GNL R AF S RQ EF RC L KC GAK YRR M PL T GKC RK ------------------ CGGNV I LTV H EG S V N KY L E T 1033
1050 1060 1070 1080
....*....|....*....|....*....|....*....|..
gi 663503224 1281 TRE V I E N Y G V D DYTKQR V E WMTD S AD SLF ND D TVTVMT L D DF 1322
Cdd:COG1933 1034 AKK V A E E Y D V R DYTKQR L E ILER S IE SLF EN D KNKQSG L A DF 1075
PRK14715
PRK14715 DNA-directed DNA polymerase II large subunit;
19-1070
0e+00
DNA-directed DNA polymerase II large subunit;
Pssm-ID: 237799 [Multi-domain]
Cd Length: 1627
Bit Score: 622.25
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 19 E RE AY QNWLD R RAEEV Y R IA ATAK AKG L D FE D E VEIP RTA D L A S R T E K L LDE yldg MSIEDDL R D L LRTSDR E T AA I E I A 98
Cdd:PRK14715 9 E MK AY FENIQ R EVDRI Y K IA EKCR AKG K D PS D D VEIP LAT D M A D R V E G L VGP ---- KGVAERI R E L VKELGK E P AA L E V A 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 99 LDVARRMHART S DIAT A i DSGL R VG LA V LTE AVLV APLEGI GE V R I MN N A DGSE F L S I D YAGPIR A AGGTAQAL G VL I GD 178
Cdd:PRK14715 85 KEIVEGKFGDL S KEKY A - EQAV R TA LA I LTE GIVA APLEGI AD V K I KR N E DGSE Y L A I Y YAGPIR S AGGTAQAL S VL V GD 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 179 MI R REL G VG RY V P TTR E V ER VK EE FG LY R --- VGM QY K P PPE EI EVIV R AC P VM I N GEET EKL E C SG YKEV rnivns NGT 255
Cdd:PRK14715 164 YV R KKM G LD RY K P SED E I ER YV EE VD LY Q sev GRF QY S P EAD EI RTAM R NI P IE I T GEET DDV E V SG HRDL ------ PRV 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 256 ARTRI RGG V LLV IG EG LC LKAPKI QK H TQR L DVP GWD FIAQFVG K --------- DKAGA E SE D DIKRR E ----------- 315
Cdd:PRK14715 238 ETNHL RGG A LLV LV EG VL LKAPKI LR H VDK L GIE GWD WLKELKE K keekdeeks EEVKT E EV D EEFEE E ekgfyyelyek 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 316 -- I PKVSRYMEDI IAGRPVF GE P CEP GGFRLRYGRSR AS G L A AA G VN P VS M EALGG F LSV GTQ M K V ERPGKA CA V T P CID 393
Cdd:PRK14715 318 vn I EANKKFIKEV IAGRPVF AH P STN GGFRLRYGRSR NT G F A TW G FH P AL M YLVDE F MAI GTQ L K T ERPGKA TC V V P VDS 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 394 I DG P T V L L D NG TFR RV S TIE EWSGCAD RV LS I WDS G EI L SGF G E F N ENN KD L V PS AYNRD W WAAD L td ALDHP E KMDR F V 473
Cdd:PRK14715 398 I EP P I V K L K NG SVV RV D TIE KAIEVRN RV EE I LFL G DA L VNY G D F L ENN HT L L PS NWCEE W YEQE L -- IAKNI E YDPE F I 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 474 E llgvsrdalppglpf N GAI E RGGESS L ERN wrqrdwylflrdmelgwgqsravaqefg T AVP P PWNLW W S D mpmsfapt 553
Cdd:PRK14715 476 N --------------- N PTP E EAIHFA L VTD ---------------------------- T PLH P RYTYY W H D -------- 504
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 554 vidalvast V DD EEI R LL gaa R E W SPK G HIDDI glp PPSTGT W PRWTEVHSHGIL K SA L MTL G IE H hhdgddivipthwe 633
Cdd:PRK14715 505 --------- V SK EEI E LL --- R K W LLG G KEEWF --- EGKKNV W AVKVVLEDDKKI K RI L ELI G CP H -------------- 555
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 634 glveglglerygnafrvaneagphiedrvsgiraatdmiaqdvg R Q E EL E G R RA V VRMRAETA - ARQE G FGI qetdeaga 712
Cdd:PRK14715 556 -------------------------------------------- R V E RS E N R NK V IVIEEYYP l LYSL G TDL -------- 583
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 713 vaa E KIE D PGP N DP E ALRAARVLLD ehsverslw LTRR LS SLRWEDSVPCRV G S RMGRPEKA GT R E MKP M V HA L Y PI AEN 792
Cdd:PRK14715 584 --- E NLK D LVQ N WE E KAKPFKNVIH --------- FINL LS RFELRRRGYSYI G A RMGRPEKA AP R K MKP P V NV L F PI GNA 651
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 793 GG PQ RL LGL A AGKG - VIRVQMGPRV C D KCG QESPHLR C hnrltrgea VE CG G R TQM K KRR snnmrrrlgl R TSV P LEEIV 871
Cdd:PRK14715 652 GG QV RL INK A VEEN k TDDIEIAFFK C P KCG KVGLYHV C --------- PF CG T R VEL K PYA ---------- R REI P PKDYW 712
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 872 EVKRRA LK LDR i P DRI K AV KG LI S VKQTP EP I EKGILRAK HG V S VF R DGT S R Y D MS DVP L THF R PSEI GTPWNV L F ELGY 951
Cdd:PRK14715 713 YAALEN LK INK - P GDV K CI KG MT S KYKIV EP L EKGILRAK ND V Y VF K DGT I R F D CT DVP I THF K PSEI NVSVEK L R ELGY 791
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 952 KH DI F G EE L SS D E Q L LEL LP QD FVPSISAKGQL L AICG F V DDLL VR FY GM D A FY EAGDER DLIGHL A IG L APHTS G G VLC 1031
Cdd:PRK14715 792 DK DI E G KP L ER D D Q I LEL KV QD VIIPYNCAEYF L KVAR F I DDLL EK FY KL D R FY NVKKKE DLIGHL V IG M APHTS A G MVG 871
1050 1060 1070
....*....|....*....|....*....|....*....
gi 663503224 1032 RIIG WTT A SA GYAHP L FHAAKRRNC DGDEDSLMMLL DG L 1070
Cdd:PRK14715 872 RIIG YSD A LV GYAHP Y FHAAKRRNC FPGDTRILVNI DG N 910
PRK14715
PRK14715 DNA-directed DNA polymerase II large subunit;
1055-1322
6.72e-73
DNA-directed DNA polymerase II large subunit;
Pssm-ID: 237799 [Multi-domain]
Cd Length: 1627
Bit Score: 268.25
E-value: 6.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1055 N CDGDED SLMM LLD GL LNFS RSI LP AG RGG R MDAPLVL S T QIIA KE I D K E AL N V D CS W A Y TRA FYE A T KSR P H P N EV GGL 1134
Cdd:PRK14715 1376 Q CDGDED AVFL LLD AF LNFS KYF LP DK RGG Q MDAPLVL T T RLDP KE V D G E VH N M D TM W Y Y PLE FYE K T LEM P S P K EV KEF 1455
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1135 VDLAG DR I G SIGEVR G Y G W TH DSGQPDA GP VNSS YKTL ET M KD K MLA QLA LGQQL RA VSAQR VA SQ VI E SHF L PDL R GNL 1214
Cdd:PRK14715 1456 IETVE DR L G KPEQYE G I G Y TH ETDDIGL GP KICA YKTL GS M LE K TAR QLA VAEKI RA TDERD VA EK VI Q SHF V PDL I GNL 1535
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663503224 1215 M AF T RQ KV RC v KC AHS YRR I PL A GKC IQ nistsgglsggrgdggvl CG GNVV LTVS E GAV R KY IEITREVI E N Y G V D DYT 1294
Cdd:PRK14715 1536 R AF S RQ EF RC - KC GAK YRR V PL K GKC PK ------------------ CG SKLI LTVS K GAV E KY MPVAKMMA E K Y N V N DYT 1596
250 260
....*....|....*....|....*...
gi 663503224 1295 KQR VEWMTDSAD SLF ND D TVTVMT LDDF 1322
Cdd:PRK14715 1597 KQR LCIIKEGIK SLF EN D KRKQVK LDDF 1624
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
