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Conserved domains on  [gi|66346713|ref|NP_001018024|]
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cx9C motif-containing protein 4 [Homo sapiens]

Protein Classification

MTCP1 domain-containing protein( domain architecture ID 10557070)

MTCP1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MTCP1 pfam08991
Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with ...
6-58 7.62e-14

Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilization of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype.


:

Pssm-ID: 430360  Cd Length: 58  Bit Score: 58.85  E-value: 7.62e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 66346713    6 PCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPK-----GRSVVCSGFEKEEE 58
Cdd:pfam08991  1 PCKPEACAIQDCLQRNNYNESKCQKVIDALYECCKKFYKengddARSVSCPKPSLLRL 58
 
Name Accession Description Interval E-value
MTCP1 pfam08991
Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with ...
6-58 7.62e-14

Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilization of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype.


Pssm-ID: 430360  Cd Length: 58  Bit Score: 58.85  E-value: 7.62e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 66346713    6 PCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPK-----GRSVVCSGFEKEEE 58
Cdd:pfam08991  1 PCKPEACAIQDCLQRNNYNESKCQKVIDALYECCKKFYKengddARSVSCPKPSLLRL 58
 
Name Accession Description Interval E-value
MTCP1 pfam08991
Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with ...
6-58 7.62e-14

Mature-T-Cell Proliferation I type; Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilization of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype.


Pssm-ID: 430360  Cd Length: 58  Bit Score: 58.85  E-value: 7.62e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 66346713    6 PCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPK-----GRSVVCSGFEKEEE 58
Cdd:pfam08991  1 PCKPEACAIQDCLQRNNYNESKCQKVIDALYECCKKFYKengddARSVSCPKPSLLRL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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