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Conserved domains on  [gi|663429560|ref|NP_001287675|]
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transmembrane protein 53 isoform 2 [Homo sapiens]

Protein Classification

DUF829 domain-containing protein( domain architecture ID 1282)

DUF829 domain-containing protein similar to Homo sapiens transmembrane protein 53 (TMEM53) that inhibits bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF829 super family cl05328
Eukaryotic protein of unknown function (DUF829); This family consists of several ...
 7-198 9.85e-36

Eukaryotic protein of unknown function (DUF829); This family consists of several uncharacterized eukaryotic proteins.


The actual alignment was detected with superfamily member pfam05705:

Pssm-ID: 461719  Cd Length: 241  Bit Score: 125.55  E-value: 9.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560    7 SLGIPSLRV--LAQKLLELLFDYEI-EKEPLLFHVFSNGGVMLYRYVLELLQTR-RFCRL--RVVGTIFDSAPGDSNLVG 80
Cdd:pfam05705  39 DLLWRTKRLapALDKLLELLSESQRsEYWPILFHVFSNGGGFLYLALLKALQEQySFKKPlpKIKGIVFDSAPGIGHFLQ 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560   81 ALRALAAILERRAAMLRLLLLVAFALVVVLFHVLLAPITAL-----FHTHFYDRLQDAGSRWPELYLYSRADEVVLARDI 155
Cdd:pfam05705 119 NAKAFSAALPKSSSVWSSHKLRSLLALALALTLLVLLILFLpsvasYSRKALNDLATGPLPCPQLYLYSKADRVIPWRDV 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 663429560  156 ERMVEARLARRVLARSVDFVSSAHVSHLRDYPTYYTSLCVDFM 198
Cdd:pfam05705 199 ESFADEARQRGVSVDAVCFEDSPHVGHMRSHPERYWPKVVEFW 241
 
Name Accession Description Interval E-value
DUF829 pfam05705
Eukaryotic protein of unknown function (DUF829); This family consists of several ...
 7-198 9.85e-36

Eukaryotic protein of unknown function (DUF829); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 461719  Cd Length: 241  Bit Score: 125.55  E-value: 9.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560    7 SLGIPSLRV--LAQKLLELLFDYEI-EKEPLLFHVFSNGGVMLYRYVLELLQTR-RFCRL--RVVGTIFDSAPGDSNLVG 80
Cdd:pfam05705  39 DLLWRTKRLapALDKLLELLSESQRsEYWPILFHVFSNGGGFLYLALLKALQEQySFKKPlpKIKGIVFDSAPGIGHFLQ 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560   81 ALRALAAILERRAAMLRLLLLVAFALVVVLFHVLLAPITAL-----FHTHFYDRLQDAGSRWPELYLYSRADEVVLARDI 155
Cdd:pfam05705 119 NAKAFSAALPKSSSVWSSHKLRSLLALALALTLLVLLILFLpsvasYSRKALNDLATGPLPCPQLYLYSKADRVIPWRDV 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 663429560  156 ERMVEARLARRVLARSVDFVSSAHVSHLRDYPTYYTSLCVDFM 198
Cdd:pfam05705 199 ESFADEARQRGVSVDAVCFEDSPHVGHMRSHPERYWPKVVEFW 241
 
Name Accession Description Interval E-value
DUF829 pfam05705
Eukaryotic protein of unknown function (DUF829); This family consists of several ...
 7-198 9.85e-36

Eukaryotic protein of unknown function (DUF829); This family consists of several uncharacterized eukaryotic proteins.


Pssm-ID: 461719  Cd Length: 241  Bit Score: 125.55  E-value: 9.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560    7 SLGIPSLRV--LAQKLLELLFDYEI-EKEPLLFHVFSNGGVMLYRYVLELLQTR-RFCRL--RVVGTIFDSAPGDSNLVG 80
Cdd:pfam05705  39 DLLWRTKRLapALDKLLELLSESQRsEYWPILFHVFSNGGGFLYLALLKALQEQySFKKPlpKIKGIVFDSAPGIGHFLQ 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429560   81 ALRALAAILERRAAMLRLLLLVAFALVVVLFHVLLAPITAL-----FHTHFYDRLQDAGSRWPELYLYSRADEVVLARDI 155
Cdd:pfam05705 119 NAKAFSAALPKSSSVWSSHKLRSLLALALALTLLVLLILFLpsvasYSRKALNDLATGPLPCPQLYLYSKADRVIPWRDV 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 663429560  156 ERMVEARLARRVLARSVDFVSSAHVSHLRDYPTYYTSLCVDFM 198
Cdd:pfam05705 199 ESFADEARQRGVSVDAVCFEDSPHVGHMRSHPERYWPKVVEFW 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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