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Conserved domains on  [gi|6606564|gb|AAF19211|]
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vascular endothelial growth factor-A188 [Rattus norvegicus]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 11255541)

PDGF and VEGF_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 49-131 5.80e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 126.77  E-value: 5.80e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564      49 SYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCE 128
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 6606564     129 CRP 131
Cdd:smart00141  81 CRP 83
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 166-214 4.88e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 4.88e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6606564    166 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 214
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 49-131 5.80e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 126.77  E-value: 5.80e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564      49 SYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCE 128
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 6606564     129 CRP 131
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 49-132 6.98e-33

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 113.62  E-value: 6.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564   49 SYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPH--QSQHIGEMSFLQHSR 126
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                ....*.
gi 6606564  127 CECRPK 132
Cdd:cd00135  81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
51-129 3.85e-32

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 111.61  E-value: 3.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564     51 CRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIK---PHQSQHIGEMSFLQHSRC 127
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 6606564    128 EC 129
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-132 5.98e-27

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 100.47  E-value: 5.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564    22 KWSQAAPTteGEQKAHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNV 101
Cdd:PHA02661  21 PWCFSGST--GSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNV 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 6606564   102 TMQIM----RIKPHQSQHIGEMSFLQHSRCECRPK 132
Cdd:PHA02661  99 TVTVMltsvSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 166-214 4.88e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 4.88e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6606564    166 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 214
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 49-131 5.80e-38

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 126.77  E-value: 5.80e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564      49 SYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPHQSQHIGEMSFLQHSRCE 128
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 6606564     129 CRP 131
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 49-132 6.98e-33

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 113.62  E-value: 6.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564   49 SYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIKPH--QSQHIGEMSFLQHSR 126
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                ....*.
gi 6606564  127 CECRPK 132
Cdd:cd00135  81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
51-129 3.85e-32

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 111.61  E-value: 3.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564     51 CRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNVTMQIMRIK---PHQSQHIGEMSFLQHSRC 127
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 6606564    128 EC 129
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-132 5.98e-27

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 100.47  E-value: 5.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6606564    22 KWSQAAPTteGEQKAHEVVKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNV 101
Cdd:PHA02661  21 PWCFSGST--GSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSNV 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 6606564   102 TMQIM----RIKPHQSQHIGEMSFLQHSRCECRPK 132
Cdd:PHA02661  99 TVTVMltsvSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 166-214 4.88e-23

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 87.36  E-value: 4.88e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6606564    166 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 214
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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