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Conserved domains on  [gi|659106911|ref|XP_008453467|]
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actin-interacting protein 1-2 [Cucumis melo]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 17591517)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
37-354 1.37e-48

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 1.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  37 NGRSVMILNLDNPLEVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLkKEFKVLSGRIDDLQWSPDGMR 116
Cdd:COG2319   98 ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 117 IVACGEGKGksfVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCL 196
Cdd:COG2319  177 LASGSDDGT---VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 197 RFSPDGSKFITVSSDKKGIIYDAKTGDKMGELssdDGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTL 276
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTL 326

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 659106911 277 TSHgTGGVDDmlVGCLWQNQHLVTVSLGGTISLFSASDLdKSPVILSGHMKNVTSlVVLKSDPKVILSTSYDGVIIKW 354
Cdd:COG2319  327 TGH-TGAVRS--VAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSADGTVRLW 399
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 535-608 4.03e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 4.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659106911 535 HTARINCLAWSPDNTKVATGSLDTCVIIYEIDKPASNRlTIKGaHLGGVYGLAFTDDF-SVVSSGEDACVRVWKL 608
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGtYLASGSSDKTIRLWDL 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 488-521 6.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 6.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 659106911   488 TLEKHRGAISVIRYSPDLSMFASGDLNREAVVWD 521
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
37-354 1.37e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 1.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  37 NGRSVMILNLDNPLEVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLkKEFKVLSGRIDDLQWSPDGMR 116
Cdd:COG2319   98 ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 117 IVACGEGKGksfVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCL 196
Cdd:COG2319  177 LASGSDDGT---VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 197 RFSPDGSKFITVSSDKKGIIYDAKTGDKMGELssdDGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTL 276
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTL 326

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 659106911 277 TSHgTGGVDDmlVGCLWQNQHLVTVSLGGTISLFSASDLdKSPVILSGHMKNVTSlVVLKSDPKVILSTSYDGVIIKW 354
Cdd:COG2319  327 TGH-TGAVRS--VAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-354 3.80e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 3.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  51 EVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLKKeFKVLSGRIDDLQWSPDGMRIVACGEGKgksFVR 130
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDK---TIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 131 AFMWDSGTNVGEFDGHSRRVLSCAFKPTRPFrIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGsKFITVSS 210
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 211 -DKKGIIYDAKTGDKMGELSsddGHKGSIYAVSWSSDGKRVLTVSADKTAKVWEISDagnGKLEKTLTSHgTGGVDDMLV 289
Cdd:cd00200  155 qDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---GKCLGTLRGH-ENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659106911 290 gcLWQNQHLVTVSLGGTISLFSASDLDKSPViLSGHMKNVTSLVVLKsDPKVILSTSYDGVIIKW 354
Cdd:cd00200  228 --SPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 535-608 4.03e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 4.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659106911 535 HTARINCLAWSPDNTKVATGSLDTCVIIYEIDKPASNRlTIKGaHLGGVYGLAFTDDF-SVVSSGEDACVRVWKL 608
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGtYLASGSSDKTIRLWDL 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 232-263 4.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 659106911   232 DGHKGSIYAVSWSSDGKRVLTVSADKTAKVWE 263
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-263 1.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 659106911  232 DGHKGSIYAVSWSSDGKRVLTVSADKTAKVWE 263
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 139-266 1.69e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 139 NVGEFDGHSRRVLSCAFKPTRPFRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYD 218
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 659106911 219 AKTGDKMGELSSDDGHKgSIYAVsWSSDGKRVLTVSADKT----AKVWEISD 266
Cdd:PTZ00421 197 PRDGTIVSSVEAHASAK-SQRCL-WAKRKDLIITLGCSKSqqrqIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 535-564 4.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.94e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 659106911   535 HTARINCLAWSPDNTKVATGSLDTCVIIYE 564
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
535-564 2.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.69e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 659106911  535 HTARINCLAWSPDNTKVATGSLDTCVIIYE 564
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 488-521 6.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 6.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 659106911   488 TLEKHRGAISVIRYSPDLSMFASGDLNREAVVWD 521
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
37-354 1.37e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 1.37e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  37 NGRSVMILNLDNPLEVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLkKEFKVLSGRIDDLQWSPDGMR 116
Cdd:COG2319   98 ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 117 IVACGEGKGksfVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCL 196
Cdd:COG2319  177 LASGSDDGT---VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 197 RFSPDGSKFITVSSDKKGIIYDAKTGDKMGELssdDGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTL 276
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTL 326

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 659106911 277 TSHgTGGVDDmlVGCLWQNQHLVTVSLGGTISLFSASDLdKSPVILSGHMKNVTSlVVLKSDPKVILSTSYDGVIIKW 354
Cdd:COG2319  327 TGH-TGAVRS--VAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
38-395 5.41e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 5.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  38 GRSVMILNLDNPLEVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLkKEFKVLSGRIDDLQWSPDGMRI 117
Cdd:COG2319   57 DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 118 VACGEGKGksfVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLR 197
Cdd:COG2319  136 ASGSADGT---VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 198 FSPDGSKFITVSSDKKGIIYDAKTGDKMGELssdDGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTLT 277
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGELLRTLT 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 278 SHgTGGVDDmlVGCLWQNQHLVTVSLGGTISLFSASDlDKSPVILSGHMKNVTSlVVLKSDPKVILSTSYDGVIIKW-IQ 356
Cdd:COG2319  286 GH-SGGVNS--VAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSPDGKTLASGSDDGTVRLWdLA 360

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 659106911 357 GIGYSGKLQRRENSqIKCFAALEDE--LVTSGFDN--KVWRVS 395
Cdd:COG2319  361 TGELLRTLTGHTGA-VTSVAFSPDGrtLASGSADGtvRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-354 3.80e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 3.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  51 EVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGFVLKKeFKVLSGRIDDLQWSPDGMRIVACGEGKgksFVR 130
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDK---TIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 131 AFMWDSGTNVGEFDGHSRRVLSCAFKPTRPFrIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGsKFITVSS 210
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 211 -DKKGIIYDAKTGDKMGELSsddGHKGSIYAVSWSSDGKRVLTVSADKTAKVWEISDagnGKLEKTLTSHgTGGVDDMLV 289
Cdd:cd00200  155 qDGTIKLWDLRTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---GKCLGTLRGH-ENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659106911 290 gcLWQNQHLVTVSLGGTISLFSASDLDKSPViLSGHMKNVTSLVVLKsDPKVILSTSYDGVIIKW 354
Cdd:cd00200  228 --SPDGYLLASGSEDGTIRVWDLRTGECVQT-LSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
129-608 9.54e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 9.54e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 129 VRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGSKFITV 208
Cdd:COG2319   18 LALLAAALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 209 SSDKKGIIYDAKTGdkmGELSSDDGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTLTSHgTGGVDDml 288
Cdd:COG2319   97 SADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGH-SGAVTS-- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 289 VGCLWQNQHLVTVSLGGTISLFSASDlDKSPVILSGHMKNVTSLVVLkSDPKVILSTSYDGVIikwiqgigysgklqrre 368
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFS-PDGKLLASGSADGTV----------------- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 369 nsqikcfaaledelvtsgfdnKVWRVsiKDGQCgeaeaidvgsqpkdltlaalspelalvsidsgVVLLRGSSivstinl 448
Cdd:COG2319  229 ---------------------RLWDL--ATGKL--------------------------------LRTLTGHS------- 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 449 gFTVTASVLAPDGSEAIIGGQDGKLHIYSINGDSLTEevTLEKHRGAISVIRYSPDLSMFASGDLNREAVVWDRASREVk 528
Cdd:COG2319  247 -GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL- 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 529 LKNMLYHTARINCLAWSPDNTKVATGSLDTCVIIYEIDKPAsnRLTIKGAHLGGVYGLAFTDDFS-VVSSGEDACVRVWK 607
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWD 400


                 .
gi 659106911 608 L 608
Cdd:COG2319  401 L 401
WD40 COG2319
WD40 repeat [General function prediction only];
68-566 2.77e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 2.77e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  68 SPNGEWIASADVSGTVRIWGTHSGFVLKkEFKVLSGRIDDLQWSPDGMRIVACGEGKGksfVRAFMWDSGTNVGEFDGHS 147
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLL-LLLGLAAAVASLAASPDGARLAAGAGDLT---LLLLDAAAGALLATLLGHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 148 RRVLSCAFKPTRPfRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYDAKTGDKMGE 227
Cdd:COG2319   79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 228 LSsddGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeisDAGNGKLEKTLTSHGTGgvddmlVGCLW---QNQHLVTVSLG 304
Cdd:COG2319  158 LT---GHSGAVTSVAFSPDGKLLASGSDDGTVRLW---DLATGKLLRTLTGHTGA------VRSVAfspDGKLLASGSAD 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 305 GTISLFSASDlDKSPVILSGHMKNVTSLVVLkSDPKVILSTSYDGVIikwiqgigysgklqrrensqikcfaaledelvt 384
Cdd:COG2319  226 GTVRLWDLAT-GKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTV--------------------------------- 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 385 sgfdnKVWRVSikDGQCgeaeaidvgsqpkdltlaalspelalvsidsgVVLLRGSSivstinlgFTVTASVLAPDGSEA 464
Cdd:COG2319  271 -----RLWDLA--TGEL--------------------------------LRTLTGHS--------GGVNSVAFSPDGKLL 303

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 465 IIGGQDGKLHIYSINGDSLTeeVTLEKHRGAISVIRYSPDLSMFASGDLNREAVVWDRASREVkLKNMLYHTARINCLAW 544
Cdd:COG2319  304 ASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAF 380

                        490       500
                 ....*....|....*....|..
gi 659106911 545 SPDNTKVATGSLDTCVIIYEID 566
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-564 4.94e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 4.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 186 LRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYDAKTGDKMGELSsddGHKGSIYAVSWSSDGKRVLTVSADKTAKVWeis 265
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 266 DAGNGKLEKTLTSHgtggvDDMLVGCLWQNQH--LVTVSLGGTISLFSASDLDKSPViLSGHMKNVTSLVVLkSDPKVIL 343
Cdd:cd00200   79 DLETGECVRTLTGH-----TSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFS-PDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 344 STSYDGVIIKWiqgigysgklqrrENSQIKCFAALEdelvtsGFDNKVWRVSIkdgqcgeaeaidvgsqpkdltlaalsp 423
Cdd:cd00200  152 SSSQDGTIKLW-------------DLRTGKCVATLT------GHTGEVNSVAF--------------------------- 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 424 elalvsidsgvvllrgssivstinlgftvtasvlAPDGSEAIIGGQDGKLHIYSINGDSLTEevTLEKHRGAISVIRYSP 503
Cdd:cd00200  186 ----------------------------------SPDGEKLLSSSSDGTIKLWDLSTGKCLG--TLRGHENGVNSVAFSP 229

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 659106911 504 DLSMFASGDLNREAVVWDRASREvkLKNMLY-HTARINCLAWSPDNTKVATGSLDTCVIIYE 564
Cdd:cd00200  230 DGYLLASGSEDGTIRVWDLRTGE--CVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-266 3.72e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 3.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911  37 NGRSVMILNLDNPLEVSVYAEHGYPATVARYSPNGEWIASADVSGTVRIWGTHSGfVLKKEFKVLSGRIDDLQWSPDGMR 116
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPDGKL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 117 IVACGEGKGksfVRAFMWDSGTNVGEFDGHSRRVLSCAfkptrpfriatcgedflvnfyegppfrfklslrdhsnfvncl 196
Cdd:COG2319  303 LASGSDDGT---VRLWDLATGKLLRTLTGHTGAVRSVA------------------------------------------ 337

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 197 rFSPDGSKFITVSSDKKGIIYDAKTGDKMGELSsddGHKGSIYAVSWSSDGKRVLTVSADKTAKVWEISD 266
Cdd:COG2319  338 -FSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 535-608 4.03e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 4.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 659106911 535 HTARINCLAWSPDNTKVATGSLDTCVIIYEIDKPASNRlTIKGaHLGGVYGLAFTDDF-SVVSSGEDACVRVWKL 608
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKG-HTGPVRDVAASADGtYLASGSSDKTIRLWDL 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 232-263 4.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 659106911   232 DGHKGSIYAVSWSSDGKRVLTVSADKTAKVWE 263
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-263 1.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.59e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 659106911  232 DGHKGSIYAVSWSSDGKRVLTVSADKTAKVWE 263
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 139-266 1.69e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659106911 139 NVGEFDGHSRRVLSCAFKPTRPFRIATCGEDFLVNFYEGPPFRFKLSLRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYD 218
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 659106911 219 AKTGDKMGELSSDDGHKgSIYAVsWSSDGKRVLTVSADKT----AKVWEISD 266
Cdd:PTZ00421 197 PRDGTIVSSVEAHASAK-SQRCL-WAKRKDLIITLGCSKSqqrqIMLWDTRK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 2.74e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 659106911   179 PFRFKLSLRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 535-564 4.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.94e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 659106911   535 HTARINCLAWSPDNTKVATGSLDTCVIIYE 564
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
535-564 2.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.69e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 659106911  535 HTARINCLAWSPDNTKVATGSLDTCVIIYE 564
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
185-218 9.96e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.96e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 659106911  185 SLRDHSNFVNCLRFSPDGSKFITVSSDKKGIIYD 218
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-86 2.76e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 659106911    52 VSVYAEHGYPATVARYSPNGEWIASADVSGTVRIW 86
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 488-521 6.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 6.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 659106911   488 TLEKHRGAISVIRYSPDLSMFASGDLNREAVVWD 521
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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