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Conserved domains on  [gi|652970169|ref|WP_027223062|]
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glycosyltransferase family 9 protein [Legionella pneumophila]

Protein Classification

glycosyltransferase family 9 protein( domain architecture ID 11436709)

glycosyltransferase family 9 protein may functions as a lipopolysaccharide heptosyltransferase involved in the biosynthesis of lipooligosaccharide (LOS)

CAZY:  GT9
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
1-287 3.57e-68

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440620  Cd Length: 336  Bit Score: 217.54  E-value: 3.57e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   1 MKILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASARAFIKFALQIRRQRY 80
Cdd:COG0859    5 MRILIIRLSALGDVLLATPALRALKRAYPDAEIDLLVEPRFAPLLELNPYVDEVIPFDKKRRKGLAELLKLLRQLRAERY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  81 DVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDNIPresvkVTQPGRMIDLKLLLIQPfLNDALPERSPKIYLSE 160
Cdd:COG0859   85 DLVIDLQGSLRSALLARLAGAPRRIGFDKELRSLLLNHRVP-----LPPDQHEVERYLALLAA-LGIPLPDPRPDLPLPE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 161 YEKQKAVFLFKKHGLPSKKNLMLNIVGSCPLKTYPLEYMATLVNQIAGQvNVNILFNFLPHQKDIAQKIYQLCNDeakkN 240
Cdd:COG0859  159 EDRAEARALLARLGLPGKPYIVLHPGASWPAKRWPAERFAELARALAAR-GLRVVLLGGPGERELAEEIAAALGP----P 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 652970169 241 IFFELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:COG0859  234 VINLAGKTSLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGP 280
 
Name Accession Description Interval E-value
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
1-287 3.57e-68

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 217.54  E-value: 3.57e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   1 MKILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASARAFIKFALQIRRQRY 80
Cdd:COG0859    5 MRILIIRLSALGDVLLATPALRALKRAYPDAEIDLLVEPRFAPLLELNPYVDEVIPFDKKRRKGLAELLKLLRQLRAERY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  81 DVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDNIPresvkVTQPGRMIDLKLLLIQPfLNDALPERSPKIYLSE 160
Cdd:COG0859   85 DLVIDLQGSLRSALLARLAGAPRRIGFDKELRSLLLNHRVP-----LPPDQHEVERYLALLAA-LGIPLPDPRPDLPLPE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 161 YEKQKAVFLFKKHGLPSKKNLMLNIVGSCPLKTYPLEYMATLVNQIAGQvNVNILFNFLPHQKDIAQKIYQLCNDeakkN 240
Cdd:COG0859  159 EDRAEARALLARLGLPGKPYIVLHPGASWPAKRWPAERFAELARALAAR-GLRVVLLGGPGERELAEEIAAALGP----P 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 652970169 241 IFFELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:COG0859  234 VINLAGKTSLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGP 280
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
2-341 2.24e-38

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 138.25  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASARAFIKFALQIRRQRYD 81
Cdd:cd03789    1 KILVIRLSALGDVVLTTPLLRALKKAYPDAKITVVVGPGYAELLELNPYIDEVIPDDKRRRAGLRGRRKLLRELRARKYD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  82 VVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDNIPresvkvtqpgrmidlKLLLIQPFlndalperspkiylsey 161
Cdd:cd03789   81 LVIDLHSSLRSALLLLLSGAPRRIGFDREKRRFLLNHPVK---------------PLVVIPPG----------------- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 162 ekqkavflfkkhglpskknlmlnivGSCPLKTYPLEYMATLVNQIAGQvNVNILFNFLPHQKDIAQKIYQLCNDEAkKNI 241
Cdd:cd03789  129 -------------------------ASGPAKRWPAERFAELADRLADE-GYRVVLFGGPAEEELAEEIAAALGARV-VNL 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 242 FFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSPwiCKHDWSTFEDDfYHAAVHLSDFKPDLYQNTPE 321
Cdd:cd03789  182 AGKTS---LRELAALLARADLVVGNDSGPMHLAAALGTPTVALFGP--TDPARTGPYGS-NHVVVRADLPCSPCCPKREC 255
                        330       340
                 ....*....|....*....|
gi 652970169 322 hlfKDRAFQLFKELKPELVW 341
Cdd:cd03789  256 ---PRGDHKCMRDITPEEVI 272
heptsyl_trn_II TIGR02195
lipopolysaccharide heptosyltransferase II; This family consists of examples of ADP-heptose:LPS ...
2-280 3.39e-19

lipopolysaccharide heptosyltransferase II; This family consists of examples of ADP-heptose:LPS heptosyltransferase II, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274026  Cd Length: 334  Bit Score: 87.05  E-value: 3.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169    2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRA-SARAFIKFALQIRRQRY 80
Cdd:TIGR02195   1 KILVIGPSWVGDMVMAQSLYRLLKKRYPQAVIDVLAPAWCRPLLERMPEIRQAIDMPLGHGAlELTERRRLGRSLREERY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   81 DVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDniPRESVKVTQPgrmidlklLLIQPFLNDA------LPERSP 154
Cdd:TIGR02195  81 DQAIVLPNSLKSALIPFFAGIPHRTGWRGEMRYGLLND--VRALDKERLP--------LMVERYIALAydkgqdLPQPLP 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  155 KIYLsEYEKQKAVFLFKKHGLPSKKnlmlNIVGSCP------LKTYPLEYMATLVNQIAGQVNVNILFNFlPHQKDIAQK 228
Cdd:TIGR02195 151 RPQL-QVSPAEQAAALAKFGLDTER----PIIAFCPgaefgpAKRWPHEHYAELAKRLIDQGYQVVLFGS-AKDHPAGNE 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 652970169  229 IYQLCNDEAkKNIFFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKP 280
Cdd:TIGR02195 225 IEALLPGEL-RNLAGETS---LDEAVDLIALAKAVVTNDSGLMHVAAALNRP 272
PRK10916 PRK10916
ADP-heptose--LPS heptosyltransferase RfaF;
1-287 1.49e-13

ADP-heptose--LPS heptosyltransferase RfaF;


Pssm-ID: 182835  Cd Length: 348  Bit Score: 70.86  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   1 MKILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASA----RafiKFALQIR 76
Cdd:PRK10916   1 MKILVIGPSWVGDMMMSQSLYRTLKARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEigerR---RLGHSLR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  77 RQRYDVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTD-------NIP---RESVKVTQPGRMIDLKLLLIQPFLn 146
Cdd:PRK10916  78 EKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDlrvldkeAFPlmvERYVALAYDKGVMRTAADLPQPLL- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 147 dalperSPKIYLSEYEKQKAVFLFkkhglpskkNLMLN--IVGSC------PLKTYPLEYMATLVNQIAGQVNVNILFNF 218
Cdd:PRK10916 157 ------WPQLQVSEGEKSETCAAF---------SLSSErpIIGFCpgaefgPAKRWPHYHYAELAQQLIDEGYQVVLFGS 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 652970169 219 lPHQKDIAQKIYQLCNDEAK---KNIFFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:PRK10916 222 -AKDHEAGNEILAALNTEQQawcRNLAGETQ---LEQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGP 289
Glyco_transf_9 pfam01075
Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to ...
70-287 1.44e-12

Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to glycosyltransferase family 9. Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.


Pssm-ID: 395853  Cd Length: 247  Bit Score: 66.58  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   70 KFALQIRRQRYDVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFlytdNIPRESVKVTQPG--RMIDLKLLLIQPFLND 147
Cdd:pfam01075   3 RLGKALRANAYDRVIDLQGLLKSALLVRFLKAPPRIGFDGESRRL----GSLFYSRKHDKPKgpHAVERNRALFAQALGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  148 ALPERSPKIYLSEYEKQKAVFLFKKhglpSKKNLMLNIVGSCPLKTYPLEYMATLVNqIAGQVNVNILFnfLPHQKDIAQ 227
Cdd:pfam01075  79 PKPESKPELGLSLPFRAAALDAAGA----GRPYIVFCPGASFDAKRWPEEHYAELAE-ALQERGYQVVL--FGGPEAHEE 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  228 KIYQLCNDEAKKNIFFELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:pfam01075 152 EIAERIAAGLEETCVNLLGKTSLEEAAALLAGADLVVGNDSGLMHLAAALDRPVIGLYGP 211
 
Name Accession Description Interval E-value
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
1-287 3.57e-68

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 217.54  E-value: 3.57e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   1 MKILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASARAFIKFALQIRRQRY 80
Cdd:COG0859    5 MRILIIRLSALGDVLLATPALRALKRAYPDAEIDLLVEPRFAPLLELNPYVDEVIPFDKKRRKGLAELLKLLRQLRAERY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  81 DVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDNIPresvkVTQPGRMIDLKLLLIQPfLNDALPERSPKIYLSE 160
Cdd:COG0859   85 DLVIDLQGSLRSALLARLAGAPRRIGFDKELRSLLLNHRVP-----LPPDQHEVERYLALLAA-LGIPLPDPRPDLPLPE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 161 YEKQKAVFLFKKHGLPSKKNLMLNIVGSCPLKTYPLEYMATLVNQIAGQvNVNILFNFLPHQKDIAQKIYQLCNDeakkN 240
Cdd:COG0859  159 EDRAEARALLARLGLPGKPYIVLHPGASWPAKRWPAERFAELARALAAR-GLRVVLLGGPGERELAEEIAAALGP----P 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 652970169 241 IFFELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:COG0859  234 VINLAGKTSLRELAALLARADLVVGNDTGPMHLAAALGTPTVALFGP 280
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
2-341 2.24e-38

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 138.25  E-value: 2.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASARAFIKFALQIRRQRYD 81
Cdd:cd03789    1 KILVIRLSALGDVVLTTPLLRALKKAYPDAKITVVVGPGYAELLELNPYIDEVIPDDKRRRAGLRGRRKLLRELRARKYD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  82 VVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDNIPresvkvtqpgrmidlKLLLIQPFlndalperspkiylsey 161
Cdd:cd03789   81 LVIDLHSSLRSALLLLLSGAPRRIGFDREKRRFLLNHPVK---------------PLVVIPPG----------------- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 162 ekqkavflfkkhglpskknlmlnivGSCPLKTYPLEYMATLVNQIAGQvNVNILFNFLPHQKDIAQKIYQLCNDEAkKNI 241
Cdd:cd03789  129 -------------------------ASGPAKRWPAERFAELADRLADE-GYRVVLFGGPAEEELAEEIAAALGARV-VNL 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 242 FFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSPwiCKHDWSTFEDDfYHAAVHLSDFKPDLYQNTPE 321
Cdd:cd03789  182 AGKTS---LRELAALLARADLVVGNDSGPMHLAAALGTPTVALFGP--TDPARTGPYGS-NHVVVRADLPCSPCCPKREC 255
                        330       340
                 ....*....|....*....|
gi 652970169 322 hlfKDRAFQLFKELKPELVW 341
Cdd:cd03789  256 ---PRGDHKCMRDITPEEVI 272
heptsyl_trn_II TIGR02195
lipopolysaccharide heptosyltransferase II; This family consists of examples of ADP-heptose:LPS ...
2-280 3.39e-19

lipopolysaccharide heptosyltransferase II; This family consists of examples of ADP-heptose:LPS heptosyltransferase II, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274026  Cd Length: 334  Bit Score: 87.05  E-value: 3.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169    2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRA-SARAFIKFALQIRRQRY 80
Cdd:TIGR02195   1 KILVIGPSWVGDMVMAQSLYRLLKKRYPQAVIDVLAPAWCRPLLERMPEIRQAIDMPLGHGAlELTERRRLGRSLREERY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   81 DVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTDniPRESVKVTQPgrmidlklLLIQPFLNDA------LPERSP 154
Cdd:TIGR02195  81 DQAIVLPNSLKSALIPFFAGIPHRTGWRGEMRYGLLND--VRALDKERLP--------LMVERYIALAydkgqdLPQPLP 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  155 KIYLsEYEKQKAVFLFKKHGLPSKKnlmlNIVGSCP------LKTYPLEYMATLVNQIAGQVNVNILFNFlPHQKDIAQK 228
Cdd:TIGR02195 151 RPQL-QVSPAEQAAALAKFGLDTER----PIIAFCPgaefgpAKRWPHEHYAELAKRLIDQGYQVVLFGS-AKDHPAGNE 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 652970169  229 IYQLCNDEAkKNIFFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKP 280
Cdd:TIGR02195 225 IEALLPGEL-RNLAGETS---LDEAVDLIALAKAVVTNDSGLMHVAAALNRP 272
PRK10916 PRK10916
ADP-heptose--LPS heptosyltransferase RfaF;
1-287 1.49e-13

ADP-heptose--LPS heptosyltransferase RfaF;


Pssm-ID: 182835  Cd Length: 348  Bit Score: 70.86  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   1 MKILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIYPEHRASA----RafiKFALQIR 76
Cdd:PRK10916   1 MKILVIGPSWVGDMMMSQSLYRTLKARYPQAIIDVMAPAWCRPLLSRMPEVNEAIPMPLGHGALEigerR---RLGHSLR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  77 RQRYDVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFLYTD-------NIP---RESVKVTQPGRMIDLKLLLIQPFLn 146
Cdd:PRK10916  78 EKRYDRAYVLPNSFKSALVPFFAGIPHRTGWRGEMRYGLLNDlrvldkeAFPlmvERYVALAYDKGVMRTAADLPQPLL- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169 147 dalperSPKIYLSEYEKQKAVFLFkkhglpskkNLMLN--IVGSC------PLKTYPLEYMATLVNQIAGQVNVNILFNF 218
Cdd:PRK10916 157 ------WPQLQVSEGEKSETCAAF---------SLSSErpIIGFCpgaefgPAKRWPHYHYAELAQQLIDEGYQVVLFGS 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 652970169 219 lPHQKDIAQKIYQLCNDEAK---KNIFFELSnydLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:PRK10916 222 -AKDHEAGNEILAALNTEQQawcRNLAGETQ---LEQAVILIAACKAIVTNDSGLMHVAAALNRPLVALYGP 289
Glyco_transf_9 pfam01075
Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to ...
70-287 1.44e-12

Glycosyltransferase family 9 (heptosyltransferase); Members of this family belong to glycosyltransferase family 9. Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.


Pssm-ID: 395853  Cd Length: 247  Bit Score: 66.58  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   70 KFALQIRRQRYDVVIDAYTKLESWLIVLLCGAKRRISYKKKYRAFlytdNIPRESVKVTQPG--RMIDLKLLLIQPFLND 147
Cdd:pfam01075   3 RLGKALRANAYDRVIDLQGLLKSALLVRFLKAPPRIGFDGESRRL----GSLFYSRKHDKPKgpHAVERNRALFAQALGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  148 ALPERSPKIYLSEYEKQKAVFLFKKhglpSKKNLMLNIVGSCPLKTYPLEYMATLVNqIAGQVNVNILFnfLPHQKDIAQ 227
Cdd:pfam01075  79 PKPESKPELGLSLPFRAAALDAAGA----GRPYIVFCPGASFDAKRWPEEHYAELAE-ALQERGYQVVL--FGGPEAHEE 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  228 KIYQLCNDEAKKNIFFELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:pfam01075 152 EIAERIAAGLEETCVNLLGKTSLEEAAALLAGADLVVGNDSGLMHLAAALDRPVIGLYGP 211
heptsyl_trn_I TIGR02193
lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS ...
2-287 6.33e-10

lipopolysaccharide heptosyltransferase I; This family consists of examples of ADP-heptose:LPS heptosyltransferase I, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274025  Cd Length: 319  Bit Score: 59.66  E-value: 6.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169    2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITI----YPEHRASA---RAFIKFALQ 74
Cdd:TIGR02193   1 RILIVKTSSLGDVIHTLPALTDIKRALPDVEIDWVVEEGFADIVRLHPAVDEVIPValrrWRKTLFSAatwREIKALRAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   75 IRRQRYDVVIDAYTKLESWLIVLLCGAKR----RISYKKKYRAFLY--TDNIPRESVKVTQPGRMIDLKL---------- 138
Cdd:TIGR02193  81 LRAERYDAVIDAQGLIKSALVARMARGPRhgfdWRSAREPLASLFYnkRVGISYQQHAVERNRKLFALALgypppiaeti 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169  139 -LLIQPFLNDALPERSPKiylseyeKQKAVFLfkkHGlPSKKNlmlnivgscplKTYPLEYMATLVNQIAGQvNVNIlfn 217
Cdd:TIGR02193 161 dYGLARRAAVAFLGHALP-------APYAVLL---HA-TSRDD-----------KTWPEERWRELARLLLAR-GLQI--- 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 652970169  218 FLP----HQKDIAQKIYqlCNDEAKKniffELSNYDLRTFILIMNQCDAIIGNEGGAIHIAKALNKPSFTIFSP 287
Cdd:TIGR02193 215 VLPwgndAEKQRAERIA--EALPGAV----VLPKMSLAEVAALLAGADAVVGVDTGLTHLAAALDKPTVTLYGA 282
PRK10422 PRK10422
lipopolysaccharide core biosynthesis protein; Provisional
2-112 1.45e-08

lipopolysaccharide core biosynthesis protein; Provisional


Pssm-ID: 182447  Cd Length: 352  Bit Score: 55.55  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652970169   2 KILVIQQKKIGDVLLSSVICNNLKKLIPNAEIHYLINQEALPVIEGNPNINQAITIyPEHRASARAFIKFALQIRRQ--- 78
Cdd:PRK10422   7 RILIIKMRFHGDMLLTTPVISSLKKNYPDAKIDVLLYQDTIPILSENPEINALYGI-KNKKAGASEKIKNFFSLIKVlra 85
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 652970169  79 -RYDVVIDAYTKLESWLIVLLCGAKRRISYKKKYR 112
Cdd:PRK10422  86 nKYDLIVNLTDQWMVALLVRLLNARVKISQDYHHR 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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