NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|645229801|ref|XP_008221629|]
View 

PREDICTED: sphinganine C4-monooxygenase 1-like [Prunus mume]

Protein Classification

sterol desaturase family protein( domain architecture ID 10513792)

sterol desaturase family protein is an oxidoreductase, similar to C-5 sterol desaturase, which catalyzes a dehydrogenation reaction to introduce a C5-6 double bond into substrates such as lathosterol and the B ring of ergosterol

EC:  1.-.-.-
Gene Ontology:  GO:0006629|GO:0016491

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 96-232 8.83e-30

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


:

Pssm-ID: 397991  Cd Length: 134  Bit Score: 108.67  E-value: 8.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801   96 FVTAMIVLDTWQYFMHRYMHHNKFLYKHIHSQHHRLVVPYAFGALYNHPVEGLLLdTIGGALSFLLSGMSPRASIFFFSF 175
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRLPWLWRRFHKVHHSSEAPNALTALRFHPLEALLF-ALLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 645229801  176 ATIKTVDDHCGLWLPGNLFHVFFSNNTAYHDVHHqLYGSKYNFSqPFFVMWDRILGT 232
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLPWLLKRLLGTPRFHRLHH-SKNEEYNFG-VTFPLWDRLFGT 134
 
Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 96-232 8.83e-30

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 108.67  E-value: 8.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801   96 FVTAMIVLDTWQYFMHRYMHHNKFLYKHIHSQHHRLVVPYAFGALYNHPVEGLLLdTIGGALSFLLSGMSPRASIFFFSF 175
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRLPWLWRRFHKVHHSSEAPNALTALRFHPLEALLF-ALLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 645229801  176 ATIKTVDDHCGLWLPGNLFHVFFSNNTAYHDVHHqLYGSKYNFSqPFFVMWDRILGT 232
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLPWLLKRLLGTPRFHRLHH-SKNEEYNFG-VTFPLWDRLFGT 134
ERG3 COG3000
Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid ...
 95-236 7.39e-23

Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism];


Pssm-ID: 442238  Cd Length: 158  Bit Score: 91.15  E-value: 7.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801  95 QFVTAMIVLDTWQYFMHRYMHHNKFLYkHIHSQHHRLVVPYAFGALYNHPVEGLLLDTIGGALSFLLsGMSPRASIFFFS 174
Cdd:COG3000    1 QFLLAFLLLDFVYYWLHRLSHRVPLLW-RFHAVHHSSERMNLLTALRFHPLEILLSALLFLLPLALL-GFPPEAVLLYLA 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645229801 175 FATIKTVDDHCGLWLPGNLFHVFFSNNTAYHDVHHQlYGSKY---NFSQpFFVMWDRILGTHMPY 236
Cdd:COG3000   79 LNLLYQFFNHSNIRLPLDGPLEYVFVTPSHHRVHHS-RNPEYldkNYGG-ILSIWDRLFGTYRPE 141
PLN02869 PLN02869
fatty aldehyde decarbonylase
 108-232 2.63e-06

fatty aldehyde decarbonylase


Pssm-ID: 166510 [Multi-domain]  Cd Length: 620  Bit Score: 47.92  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801 108 YFMHRYMHHNkFLYKHIHSQHHRLVVPYAFGALYnHPVEGLLLDTIGGALSFLLSGMSPRASIFFFsFATIKTVD----- 182
Cdd:PLN02869 143 YWLHRALHHH-YLYSRYHSHHHSSIVTEPITSVI-HPFAEHIAYFLLFAIPLLTTIFTGTASIAAF-FGYISYIDfmnnm 219

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 645229801 183 DHCGLWL-PGNLFHVF-----FSNNTAYHDVHHQLYGSKYNFSQPFFvmwDRILGT 232
Cdd:PLN02869 220 GHCNFELiPKWLFSIFpplkyLMYTPSYHSLHHTQFRTNYSLFMPIY---DYIYGT 272
 
Name Accession Description Interval E-value
FA_hydroxylase pfam04116
Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol ...
 96-232 8.83e-30

Fatty acid hydroxylase; This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.


Pssm-ID: 397991  Cd Length: 134  Bit Score: 108.67  E-value: 8.83e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801   96 FVTAMIVLDTWQYFMHRYMHHNKFLYKHIHSQHHRLVVPYAFGALYNHPVEGLLLdTIGGALSFLLSGMSPRASIFFFSF 175
Cdd:pfam04116   1 VLLGLLLFDFLFYWVHRLLHRLPWLWRRFHKVHHSSEAPNALTALRFHPLEALLF-ALLVLLPLLLLGLPLLAFLLGLLL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 645229801  176 ATIKTVDDHCGLWLPGNLFHVFFSNNTAYHDVHHqLYGSKYNFSqPFFVMWDRILGT 232
Cdd:pfam04116  80 GTLWYLFIHSGLLFPLPWLLKRLLGTPRFHRLHH-SKNEEYNFG-VTFPLWDRLFGT 134
ERG3 COG3000
Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid ...
 95-236 7.39e-23

Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism];


Pssm-ID: 442238  Cd Length: 158  Bit Score: 91.15  E-value: 7.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801  95 QFVTAMIVLDTWQYFMHRYMHHNKFLYkHIHSQHHRLVVPYAFGALYNHPVEGLLLDTIGGALSFLLsGMSPRASIFFFS 174
Cdd:COG3000    1 QFLLAFLLLDFVYYWLHRLSHRVPLLW-RFHAVHHSSERMNLLTALRFHPLEILLSALLFLLPLALL-GFPPEAVLLYLA 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645229801 175 FATIKTVDDHCGLWLPGNLFHVFFSNNTAYHDVHHQlYGSKY---NFSQpFFVMWDRILGTHMPY 236
Cdd:COG3000   79 LNLLYQFFNHSNIRLPLDGPLEYVFVTPSHHRVHHS-RNPEYldkNYGG-ILSIWDRLFGTYRPE 141
PLN02869 PLN02869
fatty aldehyde decarbonylase
 108-232 2.63e-06

fatty aldehyde decarbonylase


Pssm-ID: 166510 [Multi-domain]  Cd Length: 620  Bit Score: 47.92  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645229801 108 YFMHRYMHHNkFLYKHIHSQHHRLVVPYAFGALYnHPVEGLLLDTIGGALSFLLSGMSPRASIFFFsFATIKTVD----- 182
Cdd:PLN02869 143 YWLHRALHHH-YLYSRYHSHHHSSIVTEPITSVI-HPFAEHIAYFLLFAIPLLTTIFTGTASIAAF-FGYISYIDfmnnm 219

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 645229801 183 DHCGLWL-PGNLFHVF-----FSNNTAYHDVHHQLYGSKYNFSQPFFvmwDRILGT 232
Cdd:PLN02869 220 GHCNFELiPKWLFSIFpplkyLMYTPSYHSLHHTQFRTNYSLFMPIY---DYIYGT 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH