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Conserved domains on  [gi|641457734|gb|AIA62249|]
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membrane glycoprotein [BtMr-AlphaCoV/SAX2011]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 5-222 2.19e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


:

Pssm-ID: 394850  Cd Length: 218  Bit Score: 366.20  E-value: 2.19e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   5 STVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIF 84
Cdd:cd21564    1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  85 MLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIE 164
Cdd:cd21564   81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 641457734 165 ALPQYVTVAKATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMTESEK 222
Cdd:cd21564  161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
 
Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 5-222 2.19e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394850  Cd Length: 218  Bit Score: 366.20  E-value: 2.19e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   5 STVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIF 84
Cdd:cd21564    1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  85 MLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIE 164
Cdd:cd21564   81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 641457734 165 ALPQYVTVAKATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMTESEK 222
Cdd:cd21564  161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
CoV_M pfam01635
Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins ...
 14-221 9.05e-102

Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The membrane (M) protein is the most abundant structural protein and defines the shape of the viral envelope, being the central organizer of coronavirus assembly. M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many CoVs requires only the M and envelope (E) proteins for efficient virion assembly. Interaction of spike (S) with M is necessary for retention of S in the ER-Golgi intermediate compartment (ERGIC)/Golgi complex and its incorporation into new virions; binding of M to nucleocapsid (N) proteins stabilizes the nucleocapsid. Together, M and E protein make up the viral envelope and their interaction is sufficient for the production and release of virus-like particles (VLPs).


Pssm-ID: 460275  Cd Length: 208  Bit Score: 293.42  E-value: 9.05e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   14 EHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIFMLVVTLVLW 93
Cdd:pfam01635   1 SHLREWNFAWSIILTLLIVVLQYGYASRSRFLYVLKMILLWLLWPLTLALSIFNAVASYNVNYVYFGFSIIFAVVTFVLW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   94 IMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIEALPQYVTVA 173
Cdd:pfam01635  81 LMYFVNSIRLYRRTGSWWSFNPETNALLCVSVLGRTVTRPLDEDPTGITLTLLSGTLYVEGQKLARGVSVESLPNYVTVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 641457734  174 KATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMTESE 221
Cdd:pfam01635 161 KPSTTIHYLKKGKSDNVGSNTGWAIYVRSKAGNYSLPSTTTGKLEESA 208
 
Name Accession Description Interval E-value
alphaCoV_M cd21564
alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 5-222 2.19e-130

alphacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of alphacoronaviruses including human coronaviruses (HCoVs), HCoV-229E and HCoV-NL63. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394850  Cd Length: 218  Bit Score: 366.20  E-value: 2.19e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   5 STVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIF 84
Cdd:cd21564    1 GCIPVGEVIWHLRNWNFSWNIILTIFIVVLQYGHYKYSWFLYGLKMLILWLLWPLVLALSIFDAWASFQVNWVFFAFSIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  85 MLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIE 164
Cdd:cd21564   81 MACITLVLWIMYFVNSIRLYRRTHSWWSFNPETNAILCVSVLGRSYCLPVLGAPTGVTLTLLSGTLLVEGFKVATGVQVD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 641457734 165 ALPQYVTVAKATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMTESEK 222
Cdd:cd21564  161 QLPKYVTVAKPSTTIVYTRVGRSLNASSATGWAFYVRSKHGDYSAVANPTDNLSESEK 218
CoV_M pfam01635
Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins ...
 14-221 9.05e-102

Coronavirus M matrix/glycoprotein; This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The membrane (M) protein is the most abundant structural protein and defines the shape of the viral envelope, being the central organizer of coronavirus assembly. M proteins play a critical role in protein-protein interactions (as well as protein-RNA interactions) since virus-like particle (VLP) formation in many CoVs requires only the M and envelope (E) proteins for efficient virion assembly. Interaction of spike (S) with M is necessary for retention of S in the ER-Golgi intermediate compartment (ERGIC)/Golgi complex and its incorporation into new virions; binding of M to nucleocapsid (N) proteins stabilizes the nucleocapsid. Together, M and E protein make up the viral envelope and their interaction is sufficient for the production and release of virus-like particles (VLPs).


Pssm-ID: 460275  Cd Length: 208  Bit Score: 293.42  E-value: 9.05e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   14 EHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIFMLVVTLVLW 93
Cdd:pfam01635   1 SHLREWNFAWSIILTLLIVVLQYGYASRSRFLYVLKMILLWLLWPLTLALSIFNAVASYNVNYVYFGFSIIFAVVTFVLW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   94 IMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIEALPQYVTVA 173
Cdd:pfam01635  81 LMYFVNSIRLYRRTGSWWSFNPETNALLCVSVLGRTVTRPLDEDPTGITLTLLSGTLYVEGQKLARGVSVESLPNYVTVA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 641457734  174 KATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMTESE 221
Cdd:pfam01635 161 KPSTTIHYLKKGKSDNVGSNTGWAIYVRSKAGNYSLPSTTTGKLEESA 208
CoV_M cd21529
coronavirus Membrane (or Matrix) protein; This family contains the Membrane (M) protein of ...
 12-209 6.72e-55

coronavirus Membrane (or Matrix) protein; This family contains the Membrane (M) protein of coronaviruses (CoVs) including three highly pathogenic human CoVs such as Middle East respiratory syndrome (MERS)-related CoV, severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394849 [Multi-domain]  Cd Length: 198  Bit Score: 174.23  E-value: 6.72e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  12 VIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNWAYFGISIFMLVVTLV 91
Cdd:cd21529    1 SVSLLEWWNLVLIIILLALIAILQFGYATRSRMIYIIKLIVLWLLWPLTLAVTIWAAVYHGNSKDAVFIISIIMAVLTFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  92 LWIMYFVNSFRLYRRTRSFWAFNPETDSI-IVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIEALPQYV 170
Cdd:cd21529   81 MWLKYWIDSFRLFMRTRSAWSFNPESNALaGIMDPMGQWRCIPIDHMPPVISPVIKHGVLYLHGQELATGVSVHSLPKGI 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 641457734 171 TVAKATTTIVFHRVGKAVNErTQTGWLFFVRSGYGDYAA 209
Cdd:cd21529  161 TVATPSTTFIYTLVKRIEST-NDRGFAVYIYVKHGASNA 198
betaCoV_M cd21565
betacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein ...
 12-207 2.57e-43

betacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of betacoronaviruses including the M proteins from three highly pathogenic human coronaviruses (CoVs) such as Middle East respiratory syndrome (MERS)-related CoV, severe acute respiratory syndrome (SARS) CoV, and SARS-CoV-2, also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394851  Cd Length: 208  Bit Score: 144.83  E-value: 2.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  12 VIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISIFMLVVTLV 91
Cdd:cd21565    1 IIAIIKDWNFAWSIIFLLITIVLQYGYPSRSMTVYVIKMFVLWLLWPLSIALSVFAAV--YPINLVSQGISGIFAAISAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  92 LWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGvRIEALPQYVT 171
Cdd:cd21565   79 MWLSYFVQSIRLFRRTGSWWSFNPETNCLLNVPIGGTTVVRPLVEDSTSITAVVTRGHLKMAGMHLGRC-DYDRLPNEVT 157

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 641457734 172 VAKATTTIVFhRVGKAVNERTQTGWLFFVRSGYGDY 207
Cdd:cd21565  158 VAKPNVLIAY-KMVKRQRYGTNSGVAIYHRYKAGNY 192
HCoV-like_M cd21568
Membrane (or Matrix) protein from human coronavirus and related betacoronaviruses in the A ...
 13-218 2.42e-39

Membrane (or Matrix) protein from human coronavirus and related betacoronaviruses in the A lineage; This group contains the Membrane (M) protein of human coronaviruses (HCoVs), HCoV-OC43 and HCoV-HKU1, and similar proteins from betacoronaviruses in the embecovirus subgenera (A lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394854  Cd Length: 220  Bit Score: 134.92  E-value: 2.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  13 IEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISIFMLVVTLVL 92
Cdd:cd21568   13 IKFLKEWNFSLGIILLFITIILQFGYTSRSMFVYVIKMIILWLMWPLTIILTIFNCV--YALNNVYLGFSIVFTIVSIIM 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  93 WIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIEALPQYVTV 172
Cdd:cd21568   91 WIVYFVNSIRLFIRTGSWWSFNPETNNLMCIDMKGTMYVRPIIEDYHTLTATIIRGHLYIQGVKLGTGYSLSDLPAYVTV 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 641457734 173 AKaTTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTGQMT 218
Cdd:cd21568  171 AK-VSHLCTYKRAFLDKIDDTSGFAVYVKSKVGNYRLPSNKGSGMD 215
MERS-like-CoV_M cd21567
Membrane (or Matrix) protein from Middle East respiratory syndrome-related coronavirus and ...
 4-207 1.47e-31

Membrane (or Matrix) protein from Middle East respiratory syndrome-related coronavirus and related betacoronaviruses in the C lineage; This group contains the Membrane (M) protein of Middle East respiratory syndrome (MERS)-related CoV, bat-CoV HKU5, and similar proteins from betacoronaviruses in the merbecovirus subgenera (C lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394853  Cd Length: 216  Bit Score: 114.99  E-value: 1.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   4 NSTVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISI 83
Cdd:cd21567    2 NMTLTTEQIIAIIKDWNFAWSIIFLLITIVLQYGYPSRSMTVYVFKMFVLWLLWPSSMALSIFSAV--YPIDLASQIISG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  84 FMLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATgVRI 163
Cdd:cd21567   80 ILAAISAMMWISYFVQSIRLFMRTGSWWSFNPETNCLLNVPIGGTTVVRPLVEDSTSVTAVVTNGYLKMAGMHFGA-CDY 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 641457734 164 EALPQYVTVAKATTTIVFHRVgKAVNERTQTGWLFFVRSGYGDY 207
Cdd:cd21567  159 DRLPNEVTVAKPNVLIALKMV-KRQSYGTNSGVAIYHRYKAGNY 201
batCoV_HKU9-like_M cd21570
Membrane (or Matrix) protein from bat coronavirus HKU9 and related betacoronaviruses in the D ...
 4-177 1.29e-26

Membrane (or Matrix) protein from bat coronavirus HKU9 and related betacoronaviruses in the D lineage; This group contains the Membrane (M) protein of Rousettus bat coronavirus HKU9, and similar proteins from betacoronaviruses in the nobecovirus subgenera (D lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394856  Cd Length: 217  Bit Score: 101.85  E-value: 1.29e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   4 NSTVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISI 83
Cdd:cd21570    1 NSTFSREEVFAAVKDWNFAVSVLLLFITILLQWGYPSRCKPLWVVKMFILWLLWPLSIAAAVFAAV--YPINKVAFGFAI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  84 FMLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATgVRI 163
Cdd:cd21570   79 AFACISGLMWLSYFISSFRLLCRTGSAWSFMPETNMLLNVPLLGRTVTRPILADSPAIQFLLLRGEIQFDGFKLGR-CDP 157

                        170
                 ....*....|....
gi 641457734 164 EALPQYVTVAKATT 177
Cdd:cd21570  158 GEMPDIVTVAKPAS 171
SARS-like-CoV_M cd21569
Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, ...
 4-215 1.16e-25

Membrane (or Matrix) protein from Severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, and related betacoronaviruses in the B lineage; This group contains the Membrane (M) protein of Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2 (also known as 2019 novel CoV (2019-nCoV) or COVID-19 virus), and related proteins from betacoronaviruses in the sarbecovirus subgenera (B lineage). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394855  Cd Length: 218  Bit Score: 99.69  E-value: 1.16e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734   4 NSTVPVADVIEHLRNWSFAWNILLTLLIALLQYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISI 83
Cdd:cd21569    1 NGTITVEELKQLLEQWNLVIGFLFLAWIMLLQFAYSNRNRFLYIIKLVFLWLLWPVTLACFVLAAV--YRINWVTGGIAI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  84 FMLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSIIVFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATgVRI 163
Cdd:cd21569   79 AMACIVGLMWLSYFVASFRLFARTRSMWSFNPETNILLNVPLRGTILTRPLMESELVIGAVIIRGHLRMAGHSLGR-CDI 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 641457734 164 EALPQYVTVAkATTTIVFHRVGKAVNERTQTGWLFFVRSGYGDYAAHSTGTG 215
Cdd:cd21569  158 KDLPKEITVA-TSRTLSYYKLGASQRVGTDSGFAAYNRYRIGNYKLNTDHSG 208
gammaCoV_M cd21566
gammacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 35-186 6.22e-17

gammacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of gammacoronavirus including avian infectious bronchitis virus (IBV). There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394852  Cd Length: 212  Bit Score: 76.32  E-value: 6.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  35 QYGNFKYSKLLYGLKMAMLWLLWPCVIALSITNAWadFNVNWAYFGISIFMLVVTLVLWIMYFVNSFRLYRRTRSFWAFN 114
Cdd:cd21566   31 QYGYATRSRFIYILKMIVLWCFWPLNIAVGVISCI--YPPNTGGLVAAIILTVFACLSFVGYWIQSIRLFKRCRSWWSFN 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 641457734 115 PETDSIIVFSVY-GTTYSIPVIQAPQGITFTVLSGTLLVDGIKVAtgvRIEA--LPQYVTVAKATTTIVFHRVGK 186
Cdd:cd21566  109 PESNAVGSILLTnGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLA---KCEPdhLPKDIFVCTPDRRNIYRMVQK 180
deltaCoV_M cd21594
deltacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) ...
 42-182 1.02e-12

deltacoronavirus Membrane (or Matrix) protein; This subfamily contains the Membrane (M) protein of deltacoronaviruses including porcine deltacoronavirus and Bulbul coronavirus HKU11. There are five essential genes in CoVs that result in the following gene products: Spike (S) protein, Membrane (M) glycoprotein, Nucleocapsid (N), Envelope (E) protein, and the Orf1ab (a large polyprotein known as replicase/protease); all are required to produce a structurally complete viral particle. The M protein, a triple-spanning membrane protein, is the most abundant protein in the virion. It plays a central role in virion assembly and morphogenesis, and it defines the shape of the viral envelope. It is regarded as the central organizer of CoV assembly, interacting with all other major coronaviral structural proteins and turning cellular membranes into workshops where virus and host factors come together to make new virus particles. While homotypic interactions between the M proteins are the major driving force behind virion envelope formation, it needs to interact with other coronaviral structural proteins for complete virion formation. The interaction of the Spike protein with M is not required for the assembly process. However, binding of M to N protein stabilizes the nucleocapsid (N protein-RNA complex), as well as the internal core of virions, and thereby promotes completion of viral assembly. Thus, the M protein, and its interactions with other structural proteins, is necessary for the production and release of virus-like particles.


Pssm-ID: 394857  Cd Length: 217  Bit Score: 64.77  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 641457734  42 SKLLYGLKMAMLWLLWPCVIALSITNAWADFNVNW-AYFGISIFMLVVTLVLWIMYFVNSFRLYRRTRSFWAFNPETDSI 120
Cdd:cd21594   31 NRMIYVIKLILLWLLQPFTLVVTIWTAVDNGSKKTdAVFIISIIFAVLTFVSWLKYWYDSIRLVMKTKSAWSFSPESRLL 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 641457734 121 I-VFSVYGTTYSIPVIQAPQGITFTVLSGTLLVDGIKVATGVRIEALPQYVTVAKATTTivFH 182
Cdd:cd21594  111 AgIMDPMGNWRCIPIDHMAPILTPVVKHGKLKLHGQELATGISVTSPPKDMVVVSPSDT--FH 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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