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Conserved domains on  [gi|640544886|ref|WP_024977037|]
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MULTISPECIES: response regulator transcription factor [Ralstonia]

Protein Classification

response regulator transcription factor( domain architecture ID 11468282)

response regulator transcription factor with a receiver domain and a helix-turn-helix DNA-binding domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 1-192 1.42e-82

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 242.13  E-value: 1.42e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAP 80
Cdd:COG4567    1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRL-----------GDGSGLDLIEA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  81 LRQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALqvgvSEAVAEQTMENPAPLSVARLEWEHIQRVL 160
Cdd:COG4567   70 LRERDPDARIVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAAL----ERAEGDAPAPPENPMSLDRLEWEHIQRVL 145

                        170       180       190
                 ....*....|....*....|....*....|..
gi 640544886 161 AEHGGNISATARALNMHRRTLQRKLGKRPVAK 192
Cdd:COG4567  146 AECDGNISATARALGMHRRTLQRKLAKRPPRR 177
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 1-192 1.42e-82

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 242.13  E-value: 1.42e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAP 80
Cdd:COG4567    1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRL-----------GDGSGLDLIEA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  81 LRQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALqvgvSEAVAEQTMENPAPLSVARLEWEHIQRVL 160
Cdd:COG4567   70 LRERDPDARIVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAAL----ERAEGDAPAPPENPMSLDRLEWEHIQRVL 145

                        170       180       190
                 ....*....|....*....|....*....|..
gi 640544886 161 AEHGGNISATARALNMHRRTLQRKLGKRPVAK 192
Cdd:COG4567  146 AECDGNISATARALGMHRRTLQRKLAKRPPRR 177
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 8-188 1.00e-55

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 173.94  E-value: 1.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAPLRQALPD 87
Cdd:NF033791   5 LIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRL-----------GDGNGLDVVEALRERRPD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQtmENPapLSVARLEWEHIQRVLAEHGGNI 167
Cdd:NF033791  74 ARIVVLTGYGNIATAVAAVKLGAVDYLAKPADADDVEAALLARPGEKPEPP--ENP--MSADRVRWEHIQRVYELCDRNV 149

                        170       180
                 ....*....|....*....|.
gi 640544886 168 SATARALNMHRRTLQRKLGKR 188
Cdd:NF033791 150 SETARRLNMHRRTLQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 7-127 4.41e-54

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 167.62  E-value: 4.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   7 FLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAPLRQALP 86
Cdd:cd17563    3 LLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRL-----------GGDSGLDLIPPLRALQP 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd17563   72 DARIVVLTGYASIATAVEAIKLGADDYLAKPADADEILAAL 112
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-128 2.86e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 65.64  E-value: 2.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886    8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPHggtDSGLHWIAPLRQALPD 87
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDI--------NMPG---MDGLELLKRIRRRDPT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 640544886   88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
8-156 2.19e-13

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 67.57  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhggTDSGLHWIAPLRQALPD 87
Cdd:PRK11361   8 LIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIR--------MP---EMDGIKALKEMRSHETR 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQvgvsEAVAEQTMENP-----APLSvARLEWEHI 156
Cdd:PRK11361  77 TPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQ----RALQLQSMKKEirhlhQALS-TSWQWGHI 145
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 8-142 1.31e-08

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 53.60  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886    8 LILDDDDVFAQTLARALtrRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkGLMPH-GGTDSGLHWIAPLRQALP 86
Cdd:TIGR02915   2 LIVEDDLGLQKQLKWSF--ADYELAVAADRESAIALVRRHEPAVVTLDL-------GLPPDaDGASEGLAALQQILAIAP 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 640544886   87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDsiLLALQVGVSEAVAEQTMEN 142
Cdd:TIGR02915  73 DTKVIVITGNDDRENAVKAIGLGAYDFYQKPIDPD--VLKLIVDRAFHLYTLETEN 126
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-58 8.84e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.40  E-value: 8.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 640544886     8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHL 58
Cdd:smart00448   4 LVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
 
Name Accession Description Interval E-value
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 1-192 1.42e-82

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 242.13  E-value: 1.42e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAP 80
Cdd:COG4567    1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRL-----------GDGSGLDLIEA 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  81 LRQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALqvgvSEAVAEQTMENPAPLSVARLEWEHIQRVL 160
Cdd:COG4567   70 LRERDPDARIVVLTGYASIATAVEAIKLGADDYLAKPADADDLLAAL----ERAEGDAPAPPENPMSLDRLEWEHIQRVL 145

                        170       180       190
                 ....*....|....*....|....*....|..
gi 640544886 161 AEHGGNISATARALNMHRRTLQRKLGKRPVAK 192
Cdd:COG4567  146 AECDGNISATARALGMHRRTLQRKLAKRPPRR 177
ActR_PrrA_rreg NF033791
ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are ...
 8-188 1.00e-55

ActR/PrrA/RegA family redox response regulator transcription factor; ActR, PrrA, and RegA are examples of lineage-specific names given to a response regulator transcription factor that acts as a global regulator and belongs to a sensor-regulator pair that is highly conserved in the alpha-proteobacteria. Examples of this regulator include ActR (acid tolerance regulator) in Sinorhizobium meliloti, stationary phase response regulator SpdR in Caulobacter crescentus,


Pssm-ID: 411371 [Multi-domain]  Cd Length: 173  Bit Score: 173.94  E-value: 1.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAPLRQALPD 87
Cdd:NF033791   5 LIVDDDKPFLQRLARAMEKRGFEVTTAESVAEGLAAAKAAPPAFAVVDLRL-----------GDGNGLDVVEALRERRPD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQtmENPapLSVARLEWEHIQRVLAEHGGNI 167
Cdd:NF033791  74 ARIVVLTGYGNIATAVAAVKLGAVDYLAKPADADDVEAALLARPGEKPEPP--ENP--MSADRVRWEHIQRVYELCDRNV 149

                        170       180
                 ....*....|....*....|.
gi 640544886 168 SATARALNMHRRTLQRKLGKR 188
Cdd:NF033791 150 SETARRLNMHRRTLQRILAKR 170
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 7-127 4.41e-54

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 167.62  E-value: 4.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   7 FLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAPLRQALP 86
Cdd:cd17563    3 LLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRL-----------GGDSGLDLIPPLRALQP 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd17563   72 DARIVVLTGYASIATAVEAIKLGADDYLAKPADADEILAAL 112
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 8-128 1.78e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 95.80  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALPD 87
Cdd:COG2204    6 LVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLR--------MPGM---DGLELLRELRALDPD 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:COG2204   75 LPVILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-117 1.13e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 81.89  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALPD 87
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLM--------MPGM---DGLELLRKLRELPPD 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd00156   70 IPVIVLTAKADEEDAVRALELGADDYLVKP 99
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 8-190 4.23e-19

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 80.77  E-value: 4.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALPD 87
Cdd:COG0745    5 LVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLM--------LPGM---DGLEVCRRLRARPSD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQV-------------GVSEAVAEQTMENPAPLSVARLEWE 154
Cdd:COG0745   74 IPIIMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRAllrrraaevlrvgDLLDLAAREVTRDGEPVELTPKEFR 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 640544886 155 hIQRVLAEHGGNI--------------SATARALNMHRRTLQRKLGKRPV 190
Cdd:COG0745  154 -LLELLMRNPGRVvsreqlleevwgydYGDDRTVDVHISRLRKKLEDDLI 202
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 8-117 1.36e-16

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 71.34  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQI--AHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQAL 85
Cdd:COG4753    3 LIVDDEPLIREGLKRILEWEAGFEVVgeAENGEEALELLEEHKPDLVITDIN--------MP--GMD-GLELLEAIRELD 71

                         90       100       110
                 ....*....|....*....|....*....|..
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:COG4753   72 PDTKIIILSGYSDFEYAQEAIKLGADDYLLKP 103
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 8-128 3.89e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 71.03  E-value: 3.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQ--AL 85
Cdd:COG0784    9 LVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDIN--------MPGM---DGLELLRRIRAlpRL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:COG0784   78 PDIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALR 120
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 8-128 7.83e-16

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 69.83  E-value: 7.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd17550    2 LIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDI--------WLP--DMD-GLELLKEIKEKYPD 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17550   71 LPVIMISGHGTIETAVKATKLGAYDFIEKPLSLDRLLLTIE 111
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 8-128 3.95e-15

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 68.84  E-value: 3.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQI--AHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQAL 85
Cdd:COG4565    7 LIVEDDPMVAELLRRYLERLPGFEVVgvASSGEEALALLAEHRPDLILLDIY--------LPDG---DGLELLRELRARG 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:COG4565   76 PDVDVIVITAARDPETVREALRAGVVDYLIKPFTFERLREALE 118
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 8-117 2.56e-14

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 65.51  E-value: 2.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDV--------MLP--GMD-GFEVCRRLREKGSD 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17574   70 IPIIMLTAKDEEEDKVLGLELGADDYITKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 8-128 2.86e-14

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 65.64  E-value: 2.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886    8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPHggtDSGLHWIAPLRQALPD 87
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDI--------NMPG---MDGLELLKRIRRRDPT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 640544886   88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:pfam00072  71 TPVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
8-156 2.19e-13

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 67.57  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhggTDSGLHWIAPLRQALPD 87
Cdd:PRK11361   8 LIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIR--------MP---EMDGIKALKEMRSHETR 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQvgvsEAVAEQTMENP-----APLSvARLEWEHI 156
Cdd:PRK11361  77 TPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQ----RALQLQSMKKEirhlhQALS-TSWQWGHI 145
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 8-126 3.19e-13

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 64.54  E-value: 3.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQ--AL 85
Cdd:COG3706    5 LVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLE--------MPDM---DGLELCRRLRAdpRT 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANvDSILLA 126
Cdd:COG3706   74 ADIPIIFLTALDDEEDRARALEAGADDYLTKPFD-PEELLA 113
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 9-121 3.71e-13

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 63.06  E-value: 3.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   9 ILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQALPDA 88
Cdd:cd19919    5 IVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIR--------MP--GMD-GLALLAQIKQRHPDL 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 640544886  89 RMLILTGYASIATAVQAVKLGADEYLAKPANVD 121
Cdd:cd19919   74 PVIIMTAHSDLDSAVSAYQGGAFEYLPKPFDID 106
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
12-153 1.69e-12

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 65.05  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  12 DDDVFAQTLARALTRR-GFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkGLmphggtdSGLHWIAPLRQALPdarM 90
Cdd:PRK10365  12 DDDISHCTILQALLRGwGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMD-GI-------ATLKEIKALNPAIP---V 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640544886  91 LILTGYASIATAVQAVKLGADEYLAKPANVDSillaLQVGVSEAVAEQTMENPAPLSVARLEW 153
Cdd:PRK10365  81 LIMTAYSSVETAVEALKTGALDYLIKPLDFDN----LQATLEKALAHTHSIDAETPAVTASQF 139
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 2-142 2.77e-12

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 62.88  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   2 QQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPL 81
Cdd:COG3437    4 GQAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVR--------MPGM---DGFELLRLL 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640544886  82 RQ--ALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQTMEN 142
Cdd:COG3437   73 RAdpSTRDIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDD 135
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 8-117 4.94e-12

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 59.91  E-value: 4.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd17555    4 LVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLR--------MP--EMD-GLEVLKQITKESPD 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17555   73 TPVIVVSGAGVMSDAVEALRLGAWDYLTKP 102
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 8-117 1.31e-11

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 58.22  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd19935    2 LVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDV--------MLP--GLD-GLEVLRRLRAAGKQ 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19935   71 TPVLMLTARDSVEDRVKGLDLGADDYLVKP 100
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 8-117 2.32e-11

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 58.13  E-value: 2.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd17615    3 LVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMD-----------GLEVLRRLRADGPD 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17615   72 VPVLFLTAKDSVEDRIAGLTAGGDDYVTKP 101
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 7-117 2.43e-11

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 57.88  E-value: 2.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   7 FLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmPHGgtdSGLHWIAPLRQALP 86
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGL--------PDG---DGLDLLRRWRRQGQ 69

                         90       100       110
                 ....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17624   70 SLPVLILTARDGVDDRVAGLDAGADDYLVKP 100
PRK10643 PRK10643
two-component system response regulator PmrA;
8-117 4.87e-11

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 59.28  E-value: 4.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:PRK10643   4 LIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDED-----------GLHLLRRWRQKKYT 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:PRK10643  73 LPVLILTARDTLEDRVAGLDVGADDYLVKP 102
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 8-121 6.42e-11

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 57.21  E-value: 6.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphgGTDSgLHWIaplRQALPD 87
Cdd:cd17572    2 LLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMS-------GMEI-LKWI---QERSLP 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVD 121
Cdd:cd17572   71 TSVIVITAHGSVDIAVEAMRLGAYDFLEKPFDAD 104
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 8-128 8.26e-11

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 56.75  E-value: 8.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRrgfAPQI-----AHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLR 82
Cdd:cd17535    2 LIVDDHPLVREGLRRLLES---EPDIevvgeAADGEEALALLRELRPDVVLMDLS--------MP--GMD-GIEALRRLR 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 640544886  83 QALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17535   68 RRYPDLKVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIR 113
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 132-187 1.26e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 59.40  E-value: 1.26e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 640544886 132 SEAVAEQTMENPAPLSVARLEWEHIQRVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:COG3829  389 EAEAASAAEEGSLKEALEEVEKELIEEALEKTGGNKSKAAKALGISRSTLYRKLKK 444
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 9-138 1.64e-10

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 57.42  E-value: 1.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   9 ILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALPDA 88
Cdd:COG4566    4 IVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVR--------MPGM---SGLELQEELAARGSPL 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 640544886  89 RMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQ 138
Cdd:COG4566   73 PVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARR 122
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 8-128 2.76e-10

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 55.42  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHT---GGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQA 84
Cdd:cd17536    2 LIVDDEPLIREGLKKLIDWEELGFEVVGEaenGEEALELIEEHKPDIVITDIR--------MPGM---DGLELIEKIREL 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 640544886  85 LPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17536   71 YPDIKIIILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALE 114
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 8-129 1.10e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 53.76  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMD-----------GLEVLKSLREEGIE 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQV 129
Cdd:cd17625   70 TPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELLARIRA 111
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 8-128 1.64e-09

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 53.18  E-value: 1.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd17569    4 LLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQR--------MP--GMD-GAELLKRVRERYPD 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 640544886  88 ARMLILTGYASIATAVQAVKLGA-DEYLAKPANVDSILLALQ 128
Cdd:cd17569   73 TVRILLTGYADLDAAIEAINEGEiYRFLTKPWDDEELKETIR 114
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 8-119 3.58e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 52.31  E-value: 3.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPHGgtdSGLHWIAPLRQAlPD 87
Cdd:cd17623    2 LLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDV--------MLPKM---NGLDVLKELRKT-SQ 69

                         90       100       110
                 ....*....|....*....|....*....|..
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPAN 119
Cdd:cd17623   70 VPVLMLTARGDDIDRILGLELGADDYLPKPFN 101
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 8-128 4.95e-09

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 51.90  E-value: 4.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd19934    2 LLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMD-----------GLSVLRRWRSEGRA 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd19934   71 TPVLILTARDSWQDKVEGLDAGADDYLTKPFHIEELLARLR 111
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-139 5.45e-09

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 54.46  E-value: 5.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   2 QQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPL 81
Cdd:PRK15115   3 RKPAHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMD-----------GMQLFAEI 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640544886  82 RQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDsillALQVGVSEAVAEQT 139
Cdd:PRK15115  72 QKVQPGMPVIILTAHGSIPDAVAATQQGVFSFLTKPVDRD----ALYKAIDDALEQSA 125
HTH_8 pfam02954
Bacterial regulatory protein, Fis family;
148-187 6.83e-09

Bacterial regulatory protein, Fis family;


Pssm-ID: 427077 [Multi-domain]  Cd Length: 40  Bit Score: 49.70  E-value: 6.83e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 640544886  148 VARLEWEHIQRVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:pfam02954   1 LEEVEKELIEAALERTGGNKSKAARLLGISRRTLYRKLKK 40
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 7-127 1.12e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 50.93  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   7 FLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGL---HWIAPLRQ 83
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQ--------MP--VMD-GLeatRRIRELEG 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 640544886  84 ALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd17546   70 GGRRTPIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 145-187 1.25e-08

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 53.43  E-value: 1.25e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 640544886 145 PLSVARLEWEHIQRVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:COG2204  374 PEALEEVERELIERALEETGGNVSRAAELLGISRRTLYRKLKK 416
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 8-142 1.31e-08

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 53.60  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886    8 LILDDDDVFAQTLARALtrRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkGLMPH-GGTDSGLHWIAPLRQALP 86
Cdd:TIGR02915   2 LIVEDDLGLQKQLKWSF--ADYELAVAADRESAIALVRRHEPAVVTLDL-------GLPPDaDGASEGLAALQQILAIAP 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 640544886   87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDsiLLALQVGVSEAVAEQTMEN 142
Cdd:TIGR02915  73 DTKVIVITGNDDRENAVKAIGLGAYDFYQKPIDPD--VLKLIVDRAFHLYTLETEN 126
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 8-117 3.75e-08

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 49.69  E-value: 3.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPhgGTDsGLHWIAPLRQALPD 87
Cdd:cd17627    2 LVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDV--------MMP--RLD-GLEVCRRLRAAGND 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17627   71 LPILVLTARDSVSDRVAGLDAGADDYLVKP 100
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 7-122 4.66e-08

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 49.18  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   7 FLILDDDDVFAQTLARALTRRGFAP-QIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphGGTDSGLHWIAPLRQA- 84
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVTRiDTASSGEEALRMCENKTYDIVLCDYNL----------GKGKNGQQLLEELRHKk 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 640544886  85 --LPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDS 122
Cdd:cd17589   71 liSPSTVFIMVTGESSRAMVLSALELEPDDYLLKPFTVSE 110
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 8-117 4.86e-08

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 49.04  E-value: 4.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFApqiAHTGGEALALAR---QTRFSYVTVDLhlaasdkgLMPHGgtdSGLHWIAPLRQA 84
Cdd:cd19928    2 LVADDDRAIRTVLTQALGRAGYE---VRTTGNAATLWRwveEGEGDLVITDV--------VMPDE---NGLDLIPRIKKA 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 640544886  85 LPDARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19928   68 RPDLPIIVMSAQNTLMTAVKAAERGAFEYLPKP 100
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 8-128 4.91e-08

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 49.41  E-value: 4.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALArQTRFSYVTV-DLHlaasdkglMPhgGTDsGLHWIAPLRQALP 86
Cdd:cd17549    2 LLVDDDADVREALQQTLELAGFRVRAFADAEEALAAL-SPDFPGVVIsDIR--------MP--GMD-GLELLAQIRELDP 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17549   70 DLPVILITGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVR 111
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
132-187 5.34e-08

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 51.82  E-value: 5.34e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 640544886 132 SEAVAEQTMENPAPLSVARLEWEHIQRVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:COG3284  568 AELAAAAPAAAAPLTSLEEAERDAILRALRACGGNVSAAARALGISRSTLYRKLKR 623
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 8-117 5.54e-08

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 48.70  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQ--AL 85
Cdd:cd17620    2 LVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMD-----------GLEVIRRLREwsAV 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 640544886  86 PdarMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17620   71 P---VIVLSARDEESDKIAALDAGADDYLTKP 99
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 8-127 1.66e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 47.84  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFsyvtvdlHLAASDKGlMPhgGTDsGLHWIAPLRQ--AL 85
Cdd:cd17580    2 LVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRP-------DVILSDIG-MP--GMD-GYELARRLRElpWL 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd17580   71 ANTPAIALTGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 8-124 3.45e-07

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 47.02  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd17616    2 LLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMS-----------GYEVLRTLRLAKVK 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSIL 124
Cdd:cd17616   71 TPILILSGLADIEDKVKGLGFGADDYMTKPFHKDELV 107
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 140-187 3.45e-07

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 49.08  E-value: 3.45e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 640544886 140 MENPAPLSVARLEWEHIQRVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:COG3604  287 LAPGSREALEEVEREHILEALERTGGNIAGAARLLGLTPSTLRSRMKK 334
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-139 3.69e-07

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 48.42  E-value: 3.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPApFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAasdkglmphggtD-SGLHWIA 79
Cdd:PRK11083   1 MQQPT-ILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLP------------DiSGFELCR 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640544886  80 PLRQALPDARMLILTGYASIATAVQAVKLGADEYLAKP-------ANVDSILLALQVGVSEAVAEQT 139
Cdd:PRK11083  68 QLLAFHPALPVIFLTARSDEVDRLVGLEIGADDYVAKPfsprevaARVRTILRRVKKFAAPSPVIRI 134
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 8-141 3.78e-07

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 48.03  E-value: 3.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAP-QIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALP 86
Cdd:COG3707    7 LVVDDEPLRRADLREGLREAGYEVvAEAADGEDAVELVRELKPDLVIVDIDMPDRD-----------GLEAARQISEERP 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 640544886  87 dARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQTME 141
Cdd:COG3707   76 -APVILLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALR 129
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 5-128 4.12e-07

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 46.82  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   5 APFLILDDDDVFAQTLARALTRRGFAPQiAHTGGEA-LALARQTRFSYVTVDLHlaasdkglMPhgGTdSGLHWIAPLRQ 83
Cdd:cd17537    1 ATVYVVDDDEAVRDSLAFLLRSVGLAVK-TFTSASAfLAAAPPDQPGCLVLDVR--------MP--GM-SGLELQDELLA 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 640544886  84 ALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17537   69 RGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIE 113
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
8-188 1.46e-06

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 47.10  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQtrfsyvTVDLHLAASdkgLMPHggtDSGLHWIAPLRQ--AL 85
Cdd:PRK10955   5 LLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDD------SIDLLLLDV---MMPK---KNGIDTLKELRQthQT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  86 PdarMLILTGYASIATAVQAVKLGADEYLAKP-------ANVDSIL-----------------------LALQVGVSEAV 135
Cdd:PRK10955  73 P---VIMLTARGSELDRVLGLELGADDYLPKPfndrelvARIRAILrrshwseqqqnndngsptlevdaLSLNPGRQEAS 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640544886 136 AE-QTME-NPAPLSVARLEWEHIQRVLA-EH------GGNISATARALNMHRRTLQRKLGKR 188
Cdd:PRK10955 150 FDgQTLElTGTEFTLLYLLAQHLGQVVSrEHlsqevlGKRLTPFDRAIDMHISNLRRKLPDR 211
PRK15479 PRK15479
transcriptional regulator TctD;
8-121 2.00e-06

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 46.25  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLR---QA 84
Cdd:PRK15479   4 LLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMD-----------GLEVLQRLRkrgQT 72

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640544886  85 LPdarMLILTGYASIATAVQAVKLGADEYLAKPANVD 121
Cdd:PRK15479  73 LP---VLLLTARSAVADRVKGLNVGADDYLPKPFELE 106
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 8-117 2.73e-06

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 44.07  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALPD 87
Cdd:cd19926    2 LVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMR--------LPDG---SGLELVQHIQQRLPQ 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19926   71 TPVAVITAYGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-117 3.29e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 44.38  E-value: 3.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   5 APFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRqA 84
Cdd:cd17626    1 ARILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGID-----------GIEVCRQIR-A 68

                         90       100       110
                 ....*....|....*....|....*....|...
gi 640544886  85 LPDARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17626   69 ESGVPIVMLTAKSDTVDVVLGLESGADDYVAKP 101
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 8-176 5.76e-06

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 45.30  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:PRK09836   4 LIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVN-----------GWDIVRMLRSANKG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAvaeQTMENPAPLSVARLEWEHIQRVLAEHGGNI 167
Cdd:PRK09836  73 MPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRG---AAVIIESQFQVADLMVDLVSRKVTRSGTRI 149


                 ....*....
gi 640544886 168 SATARALNM 176
Cdd:PRK09836 150 TLTSKEFTL 158
ompR PRK09468
osmolarity response regulator; Provisional
 1-124 7.43e-06

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 44.96  E-value: 7.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGgEAL--ALARQTrFSYVTVDLHLAASDkglmphggtdsGLHWI 78
Cdd:PRK09468   2 MQENYKILVVDDDMRLRALLERYLTEQGFQVRSAANA-EQMdrLLTRES-FHLMVLDLMLPGED-----------GLSIC 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 640544886  79 APLRQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSIL 124
Cdd:PRK09468  69 RRLRSQNNPTPIIMLTAKGEEVDRIVGLEIGADDYLPKPFNPRELL 114
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 8-58 8.84e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.40  E-value: 8.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 640544886     8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHL 58
Cdd:smart00448   4 LVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMM 54
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 8-117 9.51e-06

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 43.03  E-value: 9.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGID-----------GLEVCRILRSDPKT 69

                         90       100       110
                 ....*....|....*....|....*....|..
gi 640544886  88 ARM--LILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19937   70 SSIpiIMLTAKGEEFDKVLGLELGADDYITKP 101
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 3-143 1.58e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 44.48  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   3 QPAPFLILDDDDVFAQTLARALTRRGFAPQIAHTGGEAL-ALARQTRfsyvtvDLHLaaSDKgLMPhgGTDsGLHWIAPL 81
Cdd:PRK10923   2 QRGIVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLeALASKTP------DVLL--SDI-RMP--GMD-GLALLKQI 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640544886  82 RQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQTMENP 143
Cdd:PRK10923  70 KQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPRNI 131
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 8-117 1.68e-05

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 42.23  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTR-RGF-APQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQAL 85
Cdd:cd19925    4 LIVEDDPMVAEIHRAYVEQvPGFtVIGTAGTGEEALKLLKERQPDLILLDIY--------LPDG---NGLDLLRELRAAG 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19925   73 HDVDVIVVTAANDVETVREALRLGVVDYLIKP 104
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 8-128 1.98e-05

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 42.16  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPD 87
Cdd:cd17553    4 LIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMD-----------GIEILKRMKVIDEN 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17553   73 IRVIIMTAYGELDMIQESKELGALTHFAKPFDIDEIRDAVK 113
fixJ PRK09390
response regulator FixJ; Provisional
 9-152 3.66e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 42.68  E-value: 3.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   9 ILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQALPDA 88
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVR--------MP--GID-GIELLRRLKARGSPL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640544886  89 RMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQTMENPAPLSVARLE 152
Cdd:PRK09390  77 PVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSEAVAADIRARIA 140
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 8-117 3.85e-05

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 41.03  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAAsdkglMPhgGTDsglhwIAPLRQALPD 87
Cdd:cd17621    2 LVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPG-----LS--GTE-----VCRQLRARSN 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17621   70 VPVIMVTAKDSEIDKVVGLELGADDYVTKP 99
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-128 4.75e-05

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 42.32  E-value: 4.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   1 MQQPAPFLILDDDDVFAQTLARALtrrGFAPQI-----AHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGL 75
Cdd:PRK10651   3 NQEPATILLIDDHPMLRTGVKQLI---SMAPDItvvgeASNGEQGIELAESLDPDLILLDLN--------MPGM---NGL 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 640544886  76 HWIAPLRQALPDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:PRK10651  69 ETLDKLREKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQ 121
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 8-117 4.76e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 40.89  E-value: 4.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLaasdkglmphgGTDSGLHWIAPLRqALPD 87
Cdd:cd17594    3 LVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRL-----------GQESGLDLLRTIR-ARSD 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATA-VQAVKLGADEYLAKP 117
Cdd:cd17594   71 VPIIIISGDRRDEIDrVVGLELGADDYLAKP 101
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 8-117 4.91e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 40.95  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTR-FSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALP 86
Cdd:cd18160    3 LLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKdIDIVVTDIVMPEMD-----------GIELAREARKIDP 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd18160   72 DVKILFISGGAAAAPELLSDAVGDNATLKKP 102
PRK05022 PRK05022
nitric oxide reductase transcriptional regulator NorR;
154-188 7.12e-05

nitric oxide reductase transcriptional regulator NorR;


Pssm-ID: 235331 [Multi-domain]  Cd Length: 509  Bit Score: 42.47  E-value: 7.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 640544886 154 EHIQRVLAEHGGNISATARALNMHRRTLQRkLGKR 188
Cdd:PRK05022 471 QLIRQALAQHQGNWAAAARALELDRANLHR-LAKR 504
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 8-117 7.46e-05

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 40.05  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLhlaasdkgLMPHGGtdsGLHWIAPLRQ---- 83
Cdd:cd19927    2 LLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDI--------IMPGVD---GYSLLGKLRKnadf 70

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 640544886  84 -ALPdarMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19927   71 dTIP---VIFLTAKGMTSDRIKGYNAGCDGYLSKP 102
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
158-187 9.47e-05

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 41.94  E-value: 9.47e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 640544886 158 RVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:COG3835  244 RAYFENNGNISETAEALFIHRNTLRYRLKK 273
HTH_30 pfam13556
PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the ...
 158-187 1.26e-04

PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.


Pssm-ID: 433305 [Multi-domain]  Cd Length: 56  Bit Score: 38.59  E-value: 1.26e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 640544886  158 RVLAEHGGNISATARALNMHRRTLQRKLGK 187
Cdd:pfam13556   3 RAYLENGGNISATARALHVHRNTLRYRLRR 32
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 8-118 2.54e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 38.89  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALpD 87
Cdd:cd19939    3 LIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMD-----------GLTVCREVREHS-H 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPA 118
Cdd:cd19939   71 VPILMLTARTEEMDRVLGLEMGADDYLCKPF 101
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 8-117 4.10e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 38.65  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALA-LARQTRFSYVTVDLHlaasdkglMPhgGTDsGLHWIAPLRQALP 86
Cdd:cd17544    4 LVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEvLEQHPDIKLVITDYN--------MP--EMD-GFELVREIRKKYS 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 640544886  87 DARMLI--LTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17544   73 RDQLAIigISASGDNALSARFIKAGANDFLTKP 105
PRK10336 PRK10336
two-component system response regulator QseB;
8-117 4.25e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 39.49  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphgGTDSGLHWiaplRQALPD 87
Cdd:PRK10336   4 LLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMD-------GRDILREW----REKGQR 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:PRK10336  73 EPVLILTARDALAERVEGLRLGADDYLCKP 102
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 8-117 4.33e-04

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 38.10  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALA-LARQTRFSYVTVDLhlaasdkgLMPHGGTDSGLhwIAPLRQALP 86
Cdd:cd18161    2 LVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDlLESGPDIDLLVTDV--------IMPGGMNGSQL--AEEARRRRP 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADeYLAKP 117
Cdd:cd18161   72 DLKVLLTSGYAENAIEGGDLAPGVD-VLSKP 101
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 8-124 4.52e-04

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 38.14  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQAlPD 87
Cdd:cd17619    4 LIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKD-----------GLSLTRELREQ-SE 71

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSIL 124
Cdd:cd17619   72 VGIILVTGRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 8-126 7.09e-04

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 37.65  E-value: 7.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQALPd 87
Cdd:cd18159    2 LIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFD-----------GFYWCREIRQISN- 69

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDsILLA 126
Cdd:cd18159   70 VPIIFISSRDDNMDQVMAINMGGDDYITKPFDLD-VLLA 107
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 8-117 7.55e-04

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 37.79  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQAlPD 87
Cdd:cd17614    2 LVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKD-----------GLEVCREVRKT-SN 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17614   70 VPIIMLTAKDSEVDKVLGLELGADDYVTKP 99
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 8-126 1.05e-03

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 37.41  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHT--GGEALALARQtrFSYVTVDLHLaasdkglmPHGgtdSGLHWIAPLRQAL 85
Cdd:cd17573    2 LLIEDDSTLGKEISKGLNEKGYQADVAESlkDGEYYIDIRN--YDLVLVSDKL--------PDG---NGLSIVSRIKEKH 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANVDsILLA 126
Cdd:cd17573   69 PSIVVIVLSDNPKTEQEIEAFKEGADDYIAKPFDFK-VLVA 108
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 8-127 1.45e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 36.87  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQI-AHTGGEALALARQTRFSYVTVDLhlaasdkgLMPHGgtdSGLHWIAPLRQALP 86
Cdd:cd17542    4 LIVDDAAFMRMMLKDILTKAGYEVVGeAANGEEAVEKYKELKPDLVTMDI--------TMPEM---DGIEALKEIKKIDP 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  87 DARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd17542   73 NAKVIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAV 113
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 34-128 2.10e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 36.48  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  34 AHTGGEALALARQTRFSYVTVDLHlaasdkglMPHggtDSGLHWIAPLRQALPDARMLILTGYASIATAVQAVKLGADEY 113
Cdd:cd19930   30 ASNGQEALRLVLKHSPDVAILDIE--------MPG---RTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDGY 98

                         90
                 ....*....|....*
gi 640544886 114 LAKPANVDSILLALQ 128
Cdd:cd19930   99 VLKDRPIEELADAIR 113
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 8-128 2.65e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 36.12  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQaLPD 87
Cdd:cd17562    4 LAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQN--------MPNM---DGIELIKELRK-LPA 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 640544886  88 AR---MLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:cd17562   72 YKftpILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVK 115
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 8-117 3.31e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 35.82  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEAL----ALARQTRFsyVTVDLHLAASDKGlMPhgGTDsGLHWIAPLRQ 83
Cdd:cd19924    2 LVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALnkleNLAKEGND--LSKELDLIITDIE-MP--KMD-GYELTFELRD 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 640544886  84 --ALPDARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19924   76 dpRLANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 8-128 3.44e-03

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 37.10  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRrgfAPQI-----AHTGGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLR 82
Cdd:COG3279    5 LIVDDEPLARERLERLLEK---YPDLevvgeASNGEEALELLEEHKPDLVFLDIQ--------MPGL---DGFELARQLR 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 640544886  83 QALPDARMLILTGYASiaTAVQAVKLGADEYLAKPANVDSILLALQ 128
Cdd:COG3279   71 ELDPPPPIIFTTAYDE--YALEAFEVNAVDYLLKPIDEERLAKALE 114
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
 4-117 3.94e-03

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 36.16  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   4 PAPFLILDDDDVFaQTLARALTRR-GFAPQI--AHTGGEALALARQTRFSYVTVDLHLaaSDKgLMPhggtdsGLHWIAP 80
Cdd:cd17595    1 PIILTVDDDPQVL-RAVARDLRRQyGKDYRVlrADSGAEALDALKELKLRGEAVALFL--VDQ-RMP------EMDGVEF 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640544886  81 LRQAL---PDARMLILTGYASIATAVQAV-KLGADEYLAKP 117
Cdd:cd17595   71 LEKAMelfPEAKRVLLTAYADTDAAIRAInDVQLDYYLLKP 111
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 8-117 5.02e-03

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 35.50  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHT-GGEALALARQTRFSYVTVDLHlaasdkglMPHGgtdSGLHWIAPLRQALP 86
Cdd:cd17551    4 LIVDDNPTNLLLLEALLRSAGYLEVVSFTdPREALAWCRENPPDLILLDYM--------MPGM---DGLEFIRRLRALPG 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 640544886  87 DAR--MLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd17551   73 LEDvpIVMITADTDREVRLRALEAGATDFLTKP 105
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 8-127 5.32e-03

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 35.40  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQI--AHTGGEALALARQTRFSYVTVDLHLaasdKGLmphggtdSGLHWIAPLRQAL 85
Cdd:cd19931    2 LLIDDHPLLRKGIKQLIELDPDFTVVgeASSGEEGIELAERLDPDLILLDLNM----KGM-------SGLDTLKALREEG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 640544886  86 PDARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLAL 127
Cdd:cd19931   71 VSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEAL 112
PRK11517 PRK11517
DNA-binding response regulator HprR;
8-170 5.44e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 36.41  E-value: 5.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQAlPD 87
Cdd:PRK11517   4 LLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMD-----------GWQILQTLRTA-KQ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKPANVDSILLALQVGVSEAVAEQTMenpapLSVARLEWEHIQRVLAEHGGNI 167
Cdd:PRK11517  72 TPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNST-----LEISGLRMDSVSQSVSRDNISI 146


                 ...
gi 640544886 168 SAT 170
Cdd:PRK11517 147 TLT 149
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 8-117 5.83e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 35.05  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640544886   8 LILDDDDVFAQTLARALTRRGFAPQIAHTGGEALALARQTRFSYVTVDLHLAASDkglmphggtdsGLHWIAPLRQAlPD 87
Cdd:cd19938    3 LIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTD-----------GLTLCREIRRF-SD 70

                         90       100       110
                 ....*....|....*....|....*....|
gi 640544886  88 ARMLILTGYASIATAVQAVKLGADEYLAKP 117
Cdd:cd19938   71 VPIIMVTARVEEIDRLLGLELGADDYICKP 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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