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Conserved domains on  [gi|63996099|gb|AAY41050|]
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unknown, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB super family cl34209
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 27-44 6.95e-05

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


The actual alignment was detected with superfamily member COG1250:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 37.01  E-value: 6.95e-05
                        10
                ....*....|....*...
gi 63996099  27 VKHVTVIGGGLMGAGIAQ 44
Cdd:COG1250   2 IKKVAVIGAGTMGAGIAA 19
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 27-44 6.95e-05

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 37.01  E-value: 6.95e-05
                        10
                ....*....|....*...
gi 63996099  27 VKHVTVIGGGLMGAGIAQ 44
Cdd:COG1250   2 IKKVAVIGAGTMGAGIAA 19
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
27-43 6.12e-04

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 34.49  E-value: 6.12e-04
                         10
                 ....*....|....*..
gi 63996099   27 VKHVTVIGGGLMGAGIA 43
Cdd:PRK11154 309 VNKVGVLGGGLMGGGIA 325
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 27-44 6.57e-04

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 34.43  E-value: 6.57e-04
                          10
                  ....*....|....*...
gi 63996099    27 VKHVTVIGGGLMGAGIAQ 44
Cdd:TIGR02441 335 VKTLAVLGAGLMGAGIAQ 352
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 29-44 6.58e-04

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 34.44  E-value: 6.58e-04
                          10
                  ....*....|....*.
gi 63996099    29 HVTVIGGGLMGAGIAQ 44
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQ 16
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 27-44 6.95e-05

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 37.01  E-value: 6.95e-05
                        10
                ....*....|....*...
gi 63996099  27 VKHVTVIGGGLMGAGIAQ 44
Cdd:COG1250   2 IKKVAVIGAGTMGAGIAA 19
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
27-43 6.12e-04

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 34.49  E-value: 6.12e-04
                         10
                 ....*....|....*..
gi 63996099   27 VKHVTVIGGGLMGAGIA 43
Cdd:PRK11154 309 VNKVGVLGGGLMGGGIA 325
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 27-44 6.57e-04

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 34.43  E-value: 6.57e-04
                          10
                  ....*....|....*...
gi 63996099    27 VKHVTVIGGGLMGAGIAQ 44
Cdd:TIGR02441 335 VKTLAVLGAGLMGAGIAQ 352
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 29-44 6.58e-04

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 34.44  E-value: 6.58e-04
                          10
                  ....*....|....*.
gi 63996099    29 HVTVIGGGLMGAGIAQ 44
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQ 16
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 27-44 5.61e-03

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 31.74  E-value: 5.61e-03
                         10
                 ....*....|....*...
gi 63996099   27 VKHVTVIGGGLMGAGIAQ 44
Cdd:PRK08268   7 IATVAVIGAGAMGAGIAQ 24
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 30-44 8.79e-03

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 31.11  E-value: 8.79e-03
                         10
                 ....*....|....*
gi 63996099   30 VTVIGGGLMGAGIAQ 44
Cdd:PRK07819   8 VGVVGAGQMGAGIAE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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