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Conserved domains on  [gi|639228792|ref|WP_024564378|]
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trehalase family glycosidase [Elizabethkingia anophelis]

Protein Classification

trehalase domain-containing protein( domain architecture ID 108014)

trehalase domain-containing protein may catalyze the hydrolysis of alpha,alpha-trehalose to form alpha- and beta-D-glucose

CAZY:  GH37
EC:  3.2.1.28
Gene Ontology:  GO:0004555|GO:0005991

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Trehalase super family cl17346
Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a ...
45-645 7.57e-157

Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi.


The actual alignment was detected with superfamily member PRK10137:

Pssm-ID: 418443  Cd Length: 786  Bit Score: 470.79  E-value: 7.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  45 NLFSDMGAWHAYALPQNKEDYGSFIGPVIMDLD-GQWLANTISKIRIKENGIAIDLQKSKVVQhyyPGLLKQIFTVDGLD 123
Cdd:PRK10137  57 NPFFDLGAWHGHLLPDGPNTMGGFPGVALLTEEyINFMASNFDRLTVWQDGKKVDFTLEAYSI---PGALVQKLTADDVQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 124 IEQQLIFVSGREARIKISIYNRSkaqkDLTVSFDGKFLPDVVLDKGN----------------------NEITVK----- 176
Cdd:PRK10137 134 VEMTLRFATPRTSLLETKITSNK----PLDLVWDGELLEKLEAKEGKplsdktiageypdyqrkisatrDGLKVTfgkvr 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 177 -----LKDKENTFRLVFDQPVNLELNTDSYTALAgniKIpaGGKTDFTQSQYYFLQSKED-----KIKKPISDFSAQLKL 246
Cdd:PRK10137 210 atwdlLTSGESEYQVHKSLPVQTEINGNRFTSKA---HI--NGSTTLYTTYSHLLTAQEVskeqmQIRDILARPAFYLTA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 247 NEKRWNNYLQQYFSHTSRLDEKkQRLAVKAIVTLMTNWRTAAKDLLHDGVFPSVSYQGFYG--FWSWDSWKQAVGLSYFN 324
Cdd:PRK10137 285 SQQRWEEYLKKGLTNPDATPEQ-TRVAVKAMETLNGNWRSPAGAVKFNTVTPSVTARWFSGnqTWPWDTWKQAYAMAHFN 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 325 TSLAKDNIRSMFDYM---------DDYGMVADCV-YTDKKE-----NNW--RDTKPPLAAWAVWKVYEQTKDAAFVKEMY 387
Cdd:PRK10137 364 PDVAKENIRAVFSWQiqpddsvrpQDVGFVPDLIaYNLSPErggdgGNWneRNTKPSLAAWSVMEVYNVTQDKAWLAEMY 443
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 388 PKLVKYHQWWYENRDHDKNRLCEYGSTD--------------------------------------------GTRIAAAW 423
Cdd:PRK10137 444 PKLVAYHDWWLRNRDHNGNGVPEYGATRdkahntesgemlftvkkgdkeetqsglnnyarvvekgqydsleiPAQVAASW 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 424 ESGMDNAVRF--------DEAVLMKNNDKAW-----------------SLNQESVDLNAYLYAEKKYLSQLASVIGNKKE 478
Cdd:PRK10137 524 ESGRDDAAVFgfidkeqlDKYVANGGKRSDWtvkfaenrsqdgtllgySLLQESVDQASYMYSDNHYLAEMATILGKPEE 603
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 479 AQDWNNSVIGLADKINQRFYDDTKGYYYDKLLGKQ--------EPIaVE---GPEGWIPLWAGIATKEQAGTVTKVMMNV 547
Cdd:PRK10137 604 AKRYRQLAQQLADYINTCMFDETTGFYYDVRIEDKplangcagKPI-VErgkGPEGWSPLFNGAATQANADAVVKVMLDP 682
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 548 HKFNTKVPLPTLTADHPKFDPlKGYWRGPVWIDQFYFGVTGLKKYGYQQEADELINKFMNNAEGLLEDKPIHETYHPVTG 627
Cdd:PRK10137 683 KEFNTFVPLGTAALTNPAFGA-DIYWRGRVWVDQFYFGLKGMERYGYRDDALKLADTFFRHAKGLTADGPIQENYNPLTG 761
                        730
                 ....*....|....*...
gi 639228792 628 KGLNAINFSWSSAHILML 645
Cdd:PRK10137 762 AQQGAPNFSWSAAHLYML 779
 
Name Accession Description Interval E-value
PRK10137 PRK10137
alpha-glucosidase; Provisional
45-645 7.57e-157

alpha-glucosidase; Provisional


Pssm-ID: 236653  Cd Length: 786  Bit Score: 470.79  E-value: 7.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  45 NLFSDMGAWHAYALPQNKEDYGSFIGPVIMDLD-GQWLANTISKIRIKENGIAIDLQKSKVVQhyyPGLLKQIFTVDGLD 123
Cdd:PRK10137  57 NPFFDLGAWHGHLLPDGPNTMGGFPGVALLTEEyINFMASNFDRLTVWQDGKKVDFTLEAYSI---PGALVQKLTADDVQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 124 IEQQLIFVSGREARIKISIYNRSkaqkDLTVSFDGKFLPDVVLDKGN----------------------NEITVK----- 176
Cdd:PRK10137 134 VEMTLRFATPRTSLLETKITSNK----PLDLVWDGELLEKLEAKEGKplsdktiageypdyqrkisatrDGLKVTfgkvr 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 177 -----LKDKENTFRLVFDQPVNLELNTDSYTALAgniKIpaGGKTDFTQSQYYFLQSKED-----KIKKPISDFSAQLKL 246
Cdd:PRK10137 210 atwdlLTSGESEYQVHKSLPVQTEINGNRFTSKA---HI--NGSTTLYTTYSHLLTAQEVskeqmQIRDILARPAFYLTA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 247 NEKRWNNYLQQYFSHTSRLDEKkQRLAVKAIVTLMTNWRTAAKDLLHDGVFPSVSYQGFYG--FWSWDSWKQAVGLSYFN 324
Cdd:PRK10137 285 SQQRWEEYLKKGLTNPDATPEQ-TRVAVKAMETLNGNWRSPAGAVKFNTVTPSVTARWFSGnqTWPWDTWKQAYAMAHFN 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 325 TSLAKDNIRSMFDYM---------DDYGMVADCV-YTDKKE-----NNW--RDTKPPLAAWAVWKVYEQTKDAAFVKEMY 387
Cdd:PRK10137 364 PDVAKENIRAVFSWQiqpddsvrpQDVGFVPDLIaYNLSPErggdgGNWneRNTKPSLAAWSVMEVYNVTQDKAWLAEMY 443
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 388 PKLVKYHQWWYENRDHDKNRLCEYGSTD--------------------------------------------GTRIAAAW 423
Cdd:PRK10137 444 PKLVAYHDWWLRNRDHNGNGVPEYGATRdkahntesgemlftvkkgdkeetqsglnnyarvvekgqydsleiPAQVAASW 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 424 ESGMDNAVRF--------DEAVLMKNNDKAW-----------------SLNQESVDLNAYLYAEKKYLSQLASVIGNKKE 478
Cdd:PRK10137 524 ESGRDDAAVFgfidkeqlDKYVANGGKRSDWtvkfaenrsqdgtllgySLLQESVDQASYMYSDNHYLAEMATILGKPEE 603
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 479 AQDWNNSVIGLADKINQRFYDDTKGYYYDKLLGKQ--------EPIaVE---GPEGWIPLWAGIATKEQAGTVTKVMMNV 547
Cdd:PRK10137 604 AKRYRQLAQQLADYINTCMFDETTGFYYDVRIEDKplangcagKPI-VErgkGPEGWSPLFNGAATQANADAVVKVMLDP 682
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 548 HKFNTKVPLPTLTADHPKFDPlKGYWRGPVWIDQFYFGVTGLKKYGYQQEADELINKFMNNAEGLLEDKPIHETYHPVTG 627
Cdd:PRK10137 683 KEFNTFVPLGTAALTNPAFGA-DIYWRGRVWVDQFYFGLKGMERYGYRDDALKLADTFFRHAKGLTADGPIQENYNPLTG 761
                        730
                 ....*....|....*...
gi 639228792 628 KGLNAINFSWSSAHILML 645
Cdd:PRK10137 762 AQQGAPNFSWSAAHLYML 779
GDB1 COG3408
Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism];
271-646 1.20e-75

Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism];


Pssm-ID: 442634 [Multi-domain]  Cd Length: 353  Bit Score: 245.94  E-value: 1.20e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 271 RLAVKAIVTLMTNWRtaakdllHDGVFPSVSYQGFYGFWSWDSWKQAVGLSYFNTSLAKDNIRSMFDYMDDYGMVADCVY 350
Cdd:COG3408    2 RALRRAADQLRTNTP-------GDGPTVIAGYPWFSTDWGRDTLIALPGLLLLDPELARGILRTLARYQEEPGKIPHEVR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 351 TDkkENNWRDT--KPPLAAWAVWKVYEQTKDAAFVKEMYPKLVKYHQWWyENRDHDKNRLCEYGstdgtriaaawESGMD 428
Cdd:COG3408   75 DG--EEPYYGTvdATPWFIIALGEYYRWTGDLAFLRELLPALEAALDWI-LRGDRDGDGLLEYG-----------RSGLD 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 429 NaVRFDEAVLmknnDKAWSLNQESVDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDDTKGYYYDK 508
Cdd:COG3408  141 N-QTWMDSKV----DSVTPRSGALVEVQALWYNALRALAELARALGDPELAARWRELAERLKESFNERFWNEELGYLADA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 509 LLGKQEPIAVEGPEGWI--PLWAGIATKEQAGTVTKVMMNVHkFNTKVPLPTLTADHPKFDPLkGYWRGPVWIDQFYFGV 586
Cdd:COG3408  216 LDGDGRPDDSIRPNQLFahALPTGILDPERARAVLRRLVSPE-LLTPWGLRTLSPGDPAYNPM-AYHNGSVWPWLNGLYA 293
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639228792 587 TGLKKYGYQQEADELINKFmnnaEGLLEDKPIH---ETYHPVTGKGLNAINFSWSSAHILMLL 646
Cdd:COG3408  294 EGLLRYGFREEARRLLEGL----LDALEEFGLGrlpELFDGFDGYPRGCIPQAWSAAEVLRLL 352
Trehalase pfam01204
Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a ...
305-646 2.37e-26

Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi.


Pssm-ID: 395961 [Multi-domain]  Cd Length: 509  Bit Score: 113.19  E-value: 2.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  305 FYGfwsWDSWKQAVGLSYFN-TSLAKDNIRSMFDYMDDYGMV---ADCVYTDKkennwrdTKPPLAAWAVWKVYEQTKDA 380
Cdd:pfam01204 128 LYY---WDSYFTILGLLESGmHDLAKGMVENFIYLIETYGHIpngNRSYYLNR-------SQPPFLTDMVLLVYEKTEDD 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  381 AFVKEMYPKLVKYHQWWYEN-------RDHDKNRLCEYGSTDGT---------------------------RIAAAWESG 426
Cdd:pfam01204 198 ALLRRYLAALKKEYAFWMANprldpvtGLSDGYLLNRYGVPPETprpesyledveyaeklpkerpkaynyrDLKAGAESG 277
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  427 MDNAVRFdeavlMKNNDKAWSLNQES------VDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDD 500
Cdd:pfam01204 278 WDFSSRW-----VREGHDTGYLAEIRttslvpVDLNALLYKYEKDIAFFCDVLGDSETSAIWEERAEQRRLAIDKYLWNE 352
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  501 TKGYYYDKLLGKQEPIAVEGPEGWIPLWAGIATKEQAGTVTKVMMNVHKFNTKVP---LPTLTADHPKfdplkgYWRGP- 576
Cdd:pfam01204 353 EAGVWFDYDLKKRKQTNYFSATNFWPLWAGLASPDQAKMVAKVLPKLEESGLLVFpggRPTSLLDSGQ------QWDYPn 426
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639228792  577 VWIDQFYFGVTGLKKYGYQQEADELINKFM-NNAEGLLEDKPIHETYHPVT--------GKGLNAINFSWSSAHILMLL 646
Cdd:pfam01204 427 GWAPLQWLAVEGLQRYGYDELAERLAYRWLfTNTKAFVDEGKMVEKYDVTRggeyggggGEYVPQEGFGWTNGVYLYFL 505
 
Name Accession Description Interval E-value
PRK10137 PRK10137
alpha-glucosidase; Provisional
45-645 7.57e-157

alpha-glucosidase; Provisional


Pssm-ID: 236653  Cd Length: 786  Bit Score: 470.79  E-value: 7.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  45 NLFSDMGAWHAYALPQNKEDYGSFIGPVIMDLD-GQWLANTISKIRIKENGIAIDLQKSKVVQhyyPGLLKQIFTVDGLD 123
Cdd:PRK10137  57 NPFFDLGAWHGHLLPDGPNTMGGFPGVALLTEEyINFMASNFDRLTVWQDGKKVDFTLEAYSI---PGALVQKLTADDVQ 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 124 IEQQLIFVSGREARIKISIYNRSkaqkDLTVSFDGKFLPDVVLDKGN----------------------NEITVK----- 176
Cdd:PRK10137 134 VEMTLRFATPRTSLLETKITSNK----PLDLVWDGELLEKLEAKEGKplsdktiageypdyqrkisatrDGLKVTfgkvr 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 177 -----LKDKENTFRLVFDQPVNLELNTDSYTALAgniKIpaGGKTDFTQSQYYFLQSKED-----KIKKPISDFSAQLKL 246
Cdd:PRK10137 210 atwdlLTSGESEYQVHKSLPVQTEINGNRFTSKA---HI--NGSTTLYTTYSHLLTAQEVskeqmQIRDILARPAFYLTA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 247 NEKRWNNYLQQYFSHTSRLDEKkQRLAVKAIVTLMTNWRTAAKDLLHDGVFPSVSYQGFYG--FWSWDSWKQAVGLSYFN 324
Cdd:PRK10137 285 SQQRWEEYLKKGLTNPDATPEQ-TRVAVKAMETLNGNWRSPAGAVKFNTVTPSVTARWFSGnqTWPWDTWKQAYAMAHFN 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 325 TSLAKDNIRSMFDYM---------DDYGMVADCV-YTDKKE-----NNW--RDTKPPLAAWAVWKVYEQTKDAAFVKEMY 387
Cdd:PRK10137 364 PDVAKENIRAVFSWQiqpddsvrpQDVGFVPDLIaYNLSPErggdgGNWneRNTKPSLAAWSVMEVYNVTQDKAWLAEMY 443
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 388 PKLVKYHQWWYENRDHDKNRLCEYGSTD--------------------------------------------GTRIAAAW 423
Cdd:PRK10137 444 PKLVAYHDWWLRNRDHNGNGVPEYGATRdkahntesgemlftvkkgdkeetqsglnnyarvvekgqydsleiPAQVAASW 523
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 424 ESGMDNAVRF--------DEAVLMKNNDKAW-----------------SLNQESVDLNAYLYAEKKYLSQLASVIGNKKE 478
Cdd:PRK10137 524 ESGRDDAAVFgfidkeqlDKYVANGGKRSDWtvkfaenrsqdgtllgySLLQESVDQASYMYSDNHYLAEMATILGKPEE 603
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 479 AQDWNNSVIGLADKINQRFYDDTKGYYYDKLLGKQ--------EPIaVE---GPEGWIPLWAGIATKEQAGTVTKVMMNV 547
Cdd:PRK10137 604 AKRYRQLAQQLADYINTCMFDETTGFYYDVRIEDKplangcagKPI-VErgkGPEGWSPLFNGAATQANADAVVKVMLDP 682
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 548 HKFNTKVPLPTLTADHPKFDPlKGYWRGPVWIDQFYFGVTGLKKYGYQQEADELINKFMNNAEGLLEDKPIHETYHPVTG 627
Cdd:PRK10137 683 KEFNTFVPLGTAALTNPAFGA-DIYWRGRVWVDQFYFGLKGMERYGYRDDALKLADTFFRHAKGLTADGPIQENYNPLTG 761
                        730
                 ....*....|....*...
gi 639228792 628 KGLNAINFSWSSAHILML 645
Cdd:PRK10137 762 AQQGAPNFSWSAAHLYML 779
GDB1 COG3408
Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism];
271-646 1.20e-75

Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism];


Pssm-ID: 442634 [Multi-domain]  Cd Length: 353  Bit Score: 245.94  E-value: 1.20e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 271 RLAVKAIVTLMTNWRtaakdllHDGVFPSVSYQGFYGFWSWDSWKQAVGLSYFNTSLAKDNIRSMFDYMDDYGMVADCVY 350
Cdd:COG3408    2 RALRRAADQLRTNTP-------GDGPTVIAGYPWFSTDWGRDTLIALPGLLLLDPELARGILRTLARYQEEPGKIPHEVR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 351 TDkkENNWRDT--KPPLAAWAVWKVYEQTKDAAFVKEMYPKLVKYHQWWyENRDHDKNRLCEYGstdgtriaaawESGMD 428
Cdd:COG3408   75 DG--EEPYYGTvdATPWFIIALGEYYRWTGDLAFLRELLPALEAALDWI-LRGDRDGDGLLEYG-----------RSGLD 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 429 NaVRFDEAVLmknnDKAWSLNQESVDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDDTKGYYYDK 508
Cdd:COG3408  141 N-QTWMDSKV----DSVTPRSGALVEVQALWYNALRALAELARALGDPELAARWRELAERLKESFNERFWNEELGYLADA 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 509 LLGKQEPIAVEGPEGWI--PLWAGIATKEQAGTVTKVMMNVHkFNTKVPLPTLTADHPKFDPLkGYWRGPVWIDQFYFGV 586
Cdd:COG3408  216 LDGDGRPDDSIRPNQLFahALPTGILDPERARAVLRRLVSPE-LLTPWGLRTLSPGDPAYNPM-AYHNGSVWPWLNGLYA 293
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639228792 587 TGLKKYGYQQEADELINKFmnnaEGLLEDKPIH---ETYHPVTGKGLNAINFSWSSAHILMLL 646
Cdd:COG3408  294 EGLLRYGFREEARRLLEGL----LDALEEFGLGrlpELFDGFDGYPRGCIPQAWSAAEVLRLL 352
Trehalase pfam01204
Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a ...
305-646 2.37e-26

Trehalase; Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi.


Pssm-ID: 395961 [Multi-domain]  Cd Length: 509  Bit Score: 113.19  E-value: 2.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  305 FYGfwsWDSWKQAVGLSYFN-TSLAKDNIRSMFDYMDDYGMV---ADCVYTDKkennwrdTKPPLAAWAVWKVYEQTKDA 380
Cdd:pfam01204 128 LYY---WDSYFTILGLLESGmHDLAKGMVENFIYLIETYGHIpngNRSYYLNR-------SQPPFLTDMVLLVYEKTEDD 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  381 AFVKEMYPKLVKYHQWWYEN-------RDHDKNRLCEYGSTDGT---------------------------RIAAAWESG 426
Cdd:pfam01204 198 ALLRRYLAALKKEYAFWMANprldpvtGLSDGYLLNRYGVPPETprpesyledveyaeklpkerpkaynyrDLKAGAESG 277
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  427 MDNAVRFdeavlMKNNDKAWSLNQES------VDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDD 500
Cdd:pfam01204 278 WDFSSRW-----VREGHDTGYLAEIRttslvpVDLNALLYKYEKDIAFFCDVLGDSETSAIWEERAEQRRLAIDKYLWNE 352
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  501 TKGYYYDKLLGKQEPIAVEGPEGWIPLWAGIATKEQAGTVTKVMMNVHKFNTKVP---LPTLTADHPKfdplkgYWRGP- 576
Cdd:pfam01204 353 EAGVWFDYDLKKRKQTNYFSATNFWPLWAGLASPDQAKMVAKVLPKLEESGLLVFpggRPTSLLDSGQ------QWDYPn 426
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639228792  577 VWIDQFYFGVTGLKKYGYQQEADELINKFM-NNAEGLLEDKPIHETYHPVT--------GKGLNAINFSWSSAHILMLL 646
Cdd:pfam01204 427 GWAPLQWLAVEGLQRYGYDELAERLAYRWLfTNTKAFVDEGKMVEKYDVTRggeyggggGEYVPQEGFGWTNGVYLYFL 505
TreA COG1626
Neutral trehalase [Carbohydrate transport and metabolism];
311-610 4.18e-15

Neutral trehalase [Carbohydrate transport and metabolism];


Pssm-ID: 441233  Cd Length: 438  Bit Score: 77.97  E-value: 4.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 311 WDSWKQAVGLsyfntslAKDN----IRSM---FDYM-DDYGMVAdcvytdkkeNNWRD-----TKPPLAAWAVWKVYEQT 377
Cdd:COG1626   62 WDSYFTMLGL-------AESGrwdlARDMvdnFAYLiDRYGHIP---------NGNRTyylsrSQPPFFALMVELLAEHT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 378 KDAAfVKEMYPKLVKYHQWWYENRDHDK-----------------NRLceYGSTDGTR---------------------- 418
Cdd:COG1626  126 GDEW-LRRYLPQLEKEYAFWMDGADSLApgqayrrvvrlpdgtvlNRY--WDDRDTPRpesyredvetakqsperpaeev 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 419 ---IAAAWESGMDNAVRFdeavlMKNNDKAWSLNQES---VDLNAYLYAEKKYLSQLASVIGNKKEAQDWNnsviGLADK 492
Cdd:COG1626  203 yrdLRAGAESGWDFSSRW-----LADGKDLATIRTTDivpVDLNALLYHLETTLAKAYALAGDPAKAAEYR----ARAER 273
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 493 ----INQRFYDDTKGYYYDKLLGKQEPIAVEGPEGWIPLWAGIATKEQAGTVTKVMMnvHKFntKVP---LPTLTADHPK 565
Cdd:COG1626  274 rkeaINRYLWDEERGFYFDYDFVTGKQTAVLSAAAFYPLFAGIATPEQAARVAETLE--PQL--LKPgglVTTLVNSGQQ 349
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 639228792 566 FD------PLKgywrgpvWIdqfyfGVTGLKKYGYQQEADELINKFMNNAE 610
Cdd:COG1626  350 WDapngwaPLQ-------WM-----AVKGLRNYGYDDLAREIARRWLALVE 388
PLN02567 PLN02567
alpha,alpha-trehalase
311-544 2.28e-11

alpha,alpha-trehalase


Pssm-ID: 215307  Cd Length: 554  Bit Score: 66.60  E-value: 2.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 311 WDSWKQAVGL---SYFNTslAKDNIRSMFDYMDDYGMV---ADCVYTDKkennwrdTKPPLAAWAVWKVYEQTKDAAFVK 384
Cdd:PLN02567 156 WDSYWVIRGLlasKMYET--AKGVVENLLYLVDTYGFVpngARAYYTNR-------SQPPLLSAMVLAVYAATKDVELVR 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 385 EMYPKLVKYHQWW-----------YENRDH-------------------DKNRLCEYGSTDGTR-----IAAAWESGMDN 429
Cdd:PLN02567 227 RALPALLKEHAFWtsgrhtvtirdANGVVHvlsryyamwdkprpessriDKEVASKFSSSSEKQqlyrdIASAAESGWDF 306
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 430 AVRFdeavlMKNNDKAWSLNQES---VDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDDTKGYYY 506
Cdd:PLN02567 307 SSRW-----MRDGSNLTTLRTTSilpVDLNAFLLKMELDIAFFAKLLGDKATAERFLKAAKARKRAINAVLWNEEMGQWL 381
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 639228792 507 DKLLGKQEPIAVEG-------------PEGWIPLWAGIATKEQAgTVTKVM 544
Cdd:PLN02567 382 DYWLPPNGATCQESytwdaenqntnvyASNFVPLWCGVVPPGDA-KVEKVV 431
Glyco_hydro_63 pfam03200
Glycosyl hydrolase family 63 C-terminal domain; This is a family of eukaryotic enzymes ...
298-645 3.40e-06

Glycosyl hydrolase family 63 C-terminal domain; This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain.


Pssm-ID: 397353  Cd Length: 494  Bit Score: 50.04  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  298 PSVSY--QGFYgfwsWDSWKQAVGLSYFNTSLAKDNIRSMFDYMDDYG--------------MVADCVYTDKKENnwrdT 361
Cdd:pfam03200  84 PSRPFfpRGFL----WDEGFHQLLISRWDSDLTLEILGHWLDLINDDGwipreqilgaearsKVPEEFQVQSPEN----A 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  362 KPP---------LAAWAVWKVYEQTKD--AAFVKEMYPKLVKYHQW-----------WYENRDHDKNRLCEYGSTDGTri 419
Cdd:pfam03200 156 NPPtlflalkklLESIRLESVSEKNPEliLEFLKRAYPRLKTWFEWfrttqsglieeTYRWRGRDLTTTRELNPKTLA-- 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  420 aaaweSGMDNAVRFDEAvlmknndkawSLNQESVDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLAD--KINQRF 497
Cdd:pfam03200 234 -----SGLDDYPRASHP----------SVAERHVDLRCWMALAARSMASIAEFLGEDDDAEKYAKTENLLSDndLLDKLH 298
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  498 YDDTKGYYYDKLLGKQEPIAVEGP-EGWIPLWAGIATKEQAGTVTKV----MMNVHKFNTKVplptLTADHPKF------ 566
Cdd:pfam03200 299 WSEEEGAYCDFGNHTEAVRLKWVEvRAGPPQPELIRVTRDDPELQLVchkgYVSLFPFLLKL----LPPDSPKLeklldl 374
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792  567 -------------------DPLKG---------YWRGPVWIDQFYFGVTGLKKYG-----YQQEA----DELINKFMNN- 608
Cdd:pfam03200 375 irdpeelwsdyglrslsksSPLYGkrntehdepYWRGPIWININYLILSALHHYYdvdgpYRDKAkeiyKELRTNLVNNi 454
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 639228792  609 AEGLLEDKPIHETYHPVTGKGLNAINFS-WSSAHILML 645
Cdd:pfam03200 455 YRQYKETGFVWEQYDDITGRGKGARPFTgWTSLVVLIM 492
treF PRK13270
alpha,alpha-trehalase TreF;
453-629 2.03e-03

alpha,alpha-trehalase TreF;


Pssm-ID: 183934  Cd Length: 549  Bit Score: 41.33  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 453 VDLNAYLYAEKKYLSQLASVIGNKKEAQDWNNSVIGLADKINQRFYDDTKGYY--YDkllGKQEPIAVEGPEGWIPLWAG 530
Cdd:PRK13270 349 IDLNAFLYKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYrdYD---WRREQLALFSAAAIVPLYVG 425
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639228792 531 IATKEQAGTVTKVMMNvHKFNTKVPLPTLTADHPKFDPLKGywrgpvWIDQFYFGVTGLKKYGYQQEADEL-------IN 603
Cdd:PRK13270 426 MANHEQADRLANAVRS-RLLTPGGILASEYETGEQWDKPNG------WAPLQWMAIQGFKMYGDDLLGDEIarswlktVN 498
                        170       180
                 ....*....|....*....|....*.
gi 639228792 604 KFMNNAEGLLEDKPIhETYHPVTGKG 629
Cdd:PRK13270 499 QFYQEHHKLIEKYHI-AGGVPREGGG 523
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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