NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|636800251|dbj|BAO92273|]
View 

2Fe-2S iron-sulfur cluster binding domain-containing protein (plasmid) [Burkholderia sp. RPE67]

Protein Classification

(2Fe-2S)-binding protein( domain architecture ID 11449880)

(2Fe-2S)-binding protein is the small subunit of a dehydrogenase or oxidoreductase enzyme complex such as carbon monoxide dehydrogenase and isoquinoline 1-oxidoreductase; contains a a 2Fe-2S ferredoxin-type domain which binds 2Fe-2S clusters

Gene Ontology:  GO:0046872|GO:0051536|GO:0051537
PubMed:  11734195
SCOP:  3000113

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 34-181 6.76e-94

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 269.65  E-value: 6.76e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  34 FTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEIEA 113
Cdd:COG2080    4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636800251 114 LHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRA 181
Cdd:COG2080   84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 34-181 6.76e-94

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 269.65  E-value: 6.76e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  34 FTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEIEA 113
Cdd:COG2080    4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636800251 114 LHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRA 181
Cdd:COG2080   84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
 21-179 5.83e-79

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 234.28  E-value: 5.83e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  21 APAPAKTDGANIAFTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGD 100
Cdd:PRK11433  39 SVPAATPAPEISPVTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251 101 TITTIEGIGEIEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDE---------------PIGPSDADVREAMSGNLCR 165
Cdd:PRK11433 119 EITTIEGLGSPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEikdgipshvtvdltaAPELTADEIRERMSGNICR 198

                        170
                 ....*....|....
gi 636800251 166 CGAYQNIVEAIQSV 179
Cdd:PRK11433 199 CGAYSNILEAIEDV 212
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
29-177 6.03e-55

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 171.52  E-value: 6.03e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  29 GANIAFTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGI 108
Cdd:NF041020   6 GEKVKIRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSCTVLAVQADGAEITTIEGL 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251 109 GEIEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQ 177
Cdd:NF041020  86 SKDGKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVK 154
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
 38-185 4.29e-47

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 159.75  E-value: 4.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   38 VNGQSHSLS-LDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHV---------NGRRVNSCLCFAAACDGDTITTIEG 107
Cdd:TIGR02963   5 LNGETVTLSdVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVgelvdggklRYRSVNACIQFLPSLDGKAVVTVED 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251  108 IGEIE-ALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRASKPS 185
Cdd:TIGR02963  85 LRQPDgRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYRPILDAAEAAFDYPCS 163
Fer2_2 pfam01799
[2Fe-2S] binding domain;
104-176 8.72e-37

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 122.15  E-value: 8.72e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636800251  104 TIEGIGEiEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDE-PIGPSDADVREAMSGNLCRCGAYQNIVEAI 176
Cdd:pfam01799   1 TIEGLAE-SGGEPVQQAFAEAGAVQCGYCTPGMIMSAYALLERnPPPPTEAEIREALSGNLCRCTGYRRIVDAV 73
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 35-95 5.09e-08

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 48.16  E-value: 5.09e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251  35 TMTVNGQSHSLSLDPRTTLLDALREHLHltGTKKGCDHGQCGACTVHVN------------------GRRVNSCLCFAA 95
Cdd:cd00207    2 TINVPGSGVEVEVPEGETLLDAAREAGI--DIPYSCRAGACGTCKVEVVegevdqsdpslldeeeaeGGYVLACQTRVT 78
 
Name Accession Description Interval E-value
CutS COG2080
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ...
 34-181 6.76e-94

Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441683 [Multi-domain]  Cd Length: 155  Bit Score: 269.65  E-value: 6.76e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  34 FTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEIEA 113
Cdd:COG2080    4 ITLTVNGKPVEVDVDPDTPLLDVLRDDLGLTGTKFGCGHGQCGACTVLVDGKAVRSCLTLAVQADGKEITTIEGLAEDGE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636800251 114 LHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRA 181
Cdd:COG2080   84 LHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYVRIVRAVKRAAA 151
PRK11433 PRK11433
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
 21-179 5.83e-79

aldehyde oxidoreductase 2Fe-2S subunit; Provisional


Pssm-ID: 236910 [Multi-domain]  Cd Length: 217  Bit Score: 234.28  E-value: 5.83e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  21 APAPAKTDGANIAFTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGD 100
Cdd:PRK11433  39 SVPAATPAPEISPVTLKVNGKTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNGRRLNACLTLAVMHQGA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251 101 TITTIEGIGEIEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDE---------------PIGPSDADVREAMSGNLCR 165
Cdd:PRK11433 119 EITTIEGLGSPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEikdgipshvtvdltaAPELTADEIRERMSGNICR 198

                        170
                 ....*....|....
gi 636800251 166 CGAYQNIVEAIQSV 179
Cdd:PRK11433 199 CGAYSNILEAIEDV 212
glyceraldDH_gamma NF041020
glyceraldehyde dehydrogenase subunit gamma;
29-177 6.03e-55

glyceraldehyde dehydrogenase subunit gamma;


Pssm-ID: 468949 [Multi-domain]  Cd Length: 162  Bit Score: 171.52  E-value: 6.03e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  29 GANIAFTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGI 108
Cdd:NF041020   6 GEKVKIRVKVNGVWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGKSVKSCTVLAVQADGAEITTIEGL 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251 109 GEIEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQ 177
Cdd:NF041020  86 SKDGKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVK 154
XdhA COG4630
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ...
 32-187 8.40e-51

Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];


Pssm-ID: 443668 [Multi-domain]  Cd Length: 476  Bit Score: 169.93  E-value: 8.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  32 IAFTmtVNGQSHSLS-LDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHV----NGRR----VNSCLCFAAACDGDTI 102
Cdd:COG4630    1 IRFL--LNGELVELSdVPPTTTLLDWLREDRGLTGTKEGCAEGDCGACTVVVgeldDGGLryraVNACILFLPQLDGKAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251 103 TTIEGIGEIE-ALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRA 181
Cdd:COG4630   79 VTVEGLAGPDgALHPVQQAMVDHHGSQCGFCTPGFVMSLFALYERGPAPDRADIEDALSGNLCRCTGYRPIIDAARAMAE 158


                 ....*.
gi 636800251 182 SKPSAK 187
Cdd:COG4630  159 APAPDP 164
xanthine_xdhA TIGR02963
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ...
 38-185 4.29e-47

xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 274365 [Multi-domain]  Cd Length: 467  Bit Score: 159.75  E-value: 4.29e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   38 VNGQSHSLS-LDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHV---------NGRRVNSCLCFAAACDGDTITTIEG 107
Cdd:TIGR02963   5 LNGETVTLSdVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVgelvdggklRYRSVNACIQFLPSLDGKAVVTVED 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251  108 IGEIE-ALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVRASKPS 185
Cdd:TIGR02963  85 LRQPDgRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYRPILDAAEAAFDYPCS 163
pucE TIGR03198
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ...
 34-180 1.16e-46

xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.


Pssm-ID: 132242 [Multi-domain]  Cd Length: 151  Bit Score: 150.00  E-value: 1.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   34 FTMTVNGQSHSLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEiEA 113
Cdd:TIGR03198   4 FRFTVNGQAWEVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLIDGKLANACLTMAYQADGHEITTIEGIAE-NE 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636800251  114 LHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQSVR 180
Cdd:TIGR03198  83 LDPCQTAFLEEGGFQCGYCTPGMVVALKALFRETPQPSDEDMEEGLSGNLCRCTGYGGIIRSACRIR 149
Se_dep_XDH TIGR03311
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional ...
 38-177 1.07e-38

selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. [Purines, pyrimidines, nucleosides, and nucleotides, Other]


Pssm-ID: 132354 [Multi-domain]  Cd Length: 848  Bit Score: 140.36  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   38 VNGQSHSLSLDprTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEIEAlHPL 117
Cdd:TIGR03311   5 VNGREVDVNEE--KKLLEFLREDLRLTGVKNGCGEGACGACTVIVNGKAVRACRFTTAKLAGKEITTVEGLTEREK-DVY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  118 QAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQ 177
Cdd:TIGR03311  82 AWAFAKAGAVQCGFCIPGMVISAKALLDKNPNPTEAEIKKALKGNICRCTGYVKIIKAVR 141
PRK09908 PRK09908
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
32-176 5.17e-38

xanthine dehydrogenase iron sulfur-binding subunit XdhC;


Pssm-ID: 182139 [Multi-domain]  Cd Length: 159  Bit Score: 128.11  E-value: 5.17e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  32 IAFTMTVNGQSHSLSLDPRTTLLDALREHlHLTGTKKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGEI 111
Cdd:PRK09908   7 ITIECTINGMPFQLHAAPGTPLSELLREQ-GLLSVKQGCCVGECGACTVLVDGTAIDSCLYLAAWAEGKEIRTLEGEAKG 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636800251 112 EALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGP--SDADVREAMSGNLCRCGAYQNIVEAI 176
Cdd:PRK09908  86 GKLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLAKPREKplTITEIRRGLAGNLCRCTGYQMIVNTV 152
Fer2_2 pfam01799
[2Fe-2S] binding domain;
104-176 8.72e-37

[2Fe-2S] binding domain;


Pssm-ID: 460336 [Multi-domain]  Cd Length: 73  Bit Score: 122.15  E-value: 8.72e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636800251  104 TIEGIGEiEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDE-PIGPSDADVREAMSGNLCRCGAYQNIVEAI 176
Cdd:pfam01799   1 TIEGLAE-SGGEPVQQAFAEAGAVQCGYCTPGMIMSAYALLERnPPPPTEAEIREALSGNLCRCTGYRRIVDAV 73
PLN02906 PLN02906
xanthine dehydrogenase
 52-178 5.28e-35

xanthine dehydrogenase


Pssm-ID: 215491 [Multi-domain]  Cd Length: 1319  Bit Score: 129.82  E-value: 5.28e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   52 TLLDALREhLHLTGTKKGCDHGQCGACTVHV----------NGRRVNSCLCFAAACDGDTITTIEGIGEIE-ALHPLQAA 120
Cdd:PLN02906    3 TLLEYLRD-LGLTGTKLGCGEGGCGACTVMVshydrktgkcVHYAVNACLAPLYSVEGMHVITVEGIGNRRdGLHPVQEA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251  121 FVECDGYQCGYCTAGQLMSAVALL-DEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQS 178
Cdd:PLN02906   82 LASMHGSQCGFCTPGFIMSMYALLrSSKTPPTEEQIEECLAGNLCRCTGYRPILDAFRV 140
mam_aldehyde_ox TIGR02969
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ...
 38-178 4.20e-34

aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.


Pssm-ID: 132014 [Multi-domain]  Cd Length: 1330  Bit Score: 127.43  E-value: 4.20e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251    38 VNGQSH-SLSLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTVHVNGRR----------VNSCLCFAAACDGDTITTIE 106
Cdd:TIGR02969    7 VNGRKVvEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNpstksirhhpVNACLTPICSLYGAAVTTVE 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636800251   107 GIGEIEA-LHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQS 178
Cdd:TIGR02969   87 GIGSTRTrLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKT 159
PLN00192 PLN00192
aldehyde oxidase
 30-178 4.47e-29

aldehyde oxidase


Pssm-ID: 215096 [Multi-domain]  Cd Length: 1344  Bit Score: 112.89  E-value: 4.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   30 ANIAFTMTVNGQSHSL-SLDPRTTLLDALREHLHLTGTKKGCDHGQCGACTV----------HVNGRRVNSCLCFAAACD 98
Cdd:PLN00192    2 SNMSLVFAVNGERFELsSVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVllskydpvldQVEDFTVSSCLTLLCSVN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251   99 GDTITTIEGIGEIE-ALHPLQAAFVECDGYQCGYCTAGQLMSAVALL---------DEPIGPSDADVREA---MSGNLCR 165
Cdd:PLN00192   82 GCSITTSEGLGNSKdGFHPIHKRFAGFHASQCGFCTPGMCISLFSALvnadktdrpEPPSGFSKLTVVEAekaVSGNLCR 161

                         170
                  ....*....|...
gi 636800251  166 CGAYQNIVEAIQS 178
Cdd:PLN00192  162 CTGYRPIVDACKS 174
PRK09800 PRK09800
putative hypoxanthine oxidase; Provisional
 35-187 6.96e-11

putative hypoxanthine oxidase; Provisional


Pssm-ID: 182084 [Multi-domain]  Cd Length: 956  Bit Score: 60.23  E-value: 6.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636800251  35 TMTVNGQSHSLSLDPRttllDALREHLHLTG--TKKGCDHGQ--CGACTVHVNGRRVNSCLCFAAACDGDTITTIEGIGE 110
Cdd:PRK09800   4 HFTLNGAPQELTVNPG----ENVQKLLFNMGmhSVRNSDDGFgfAGSDAIIFNGNIVNASLLIAAQLEKADIRTAESLGK 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251 111 IEALHPLQAAFVECDGYQCGYCTAGQLMSAVALLDEPIGPSDADVREAMSGNLCRCGAYQNIVEAIQ--SVRASKPSAK 187
Cdd:PRK09800  80 WNELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFSRDAGWQQYYQVIElaVARKNNPQAT 158
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 35-95 5.09e-08

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 48.16  E-value: 5.09e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636800251  35 TMTVNGQSHSLSLDPRTTLLDALREHLHltGTKKGCDHGQCGACTVHVN------------------GRRVNSCLCFAA 95
Cdd:cd00207    2 TINVPGSGVEVEVPEGETLLDAAREAGI--DIPYSCRAGACGTCKVEVVegevdqsdpslldeeeaeGGYVLACQTRVT 78
Fer2_3 pfam13085
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 41-103 3.09e-06

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.


Pssm-ID: 432963 [Multi-domain]  Cd Length: 107  Bit Score: 44.15  E-value: 3.09e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636800251   41 QSHSLSLDPRTTLLDALRE-HLHLTGT---KKGCDHGQCGACTVHVNGRRVNSCLCFAAACDGDTIT 103
Cdd:pfam13085  19 QEYEVPYEEGMTVLDALNKiKEEQDPTlafRRSCREGICGSCAMNINGKPRLACKTLIDDLLGQDIT 85
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
37-93 1.34e-05

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 41.74  E-value: 1.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 636800251   37 TVNGQSHSLSL-DPRTTLLDALREHLhlTGTKKGCDHGQCGACTVHVNGRRVNSCLCF 93
Cdd:pfam00111   2 TINGKGVTIEVpDGETTLLDAAEEAG--IDIPYSCRGGGCGTCAVKVLEGEDQSDQSF 57
dhsB TIGR00384
succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase ...
 41-93 2.39e-05

succinate dehydrogenase and fumarate reductase iron-sulfur protein; Succinate dehydrogenase and fumarate reductase are reverse directions of the same enzymatic interconversion, succinate + FAD+ = fumarate + FADH2 (EC 1.3.11.1). In E. coli, the forward and reverse reactions are catalyzed by distinct complexes: fumarate reductase operates under anaerobic conditions and succinate dehydrogenase operates under aerobic conditions. This model also describes a region of the B subunit of a cytosolic archaeal fumarate reductase. [Energy metabolism, Aerobic, Energy metabolism, Anaerobic, Energy metabolism, TCA cycle]


Pssm-ID: 273049 [Multi-domain]  Cd Length: 220  Bit Score: 43.19  E-value: 2.39e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 636800251   41 QSHSLSLDPRTTLLDAL---REHLHLTGT-KKGCDHGQCGACTVHVNGRRVNSCLCF 93
Cdd:TIGR00384  15 QSYEVPADEGMTVLDALnyiKDEQDPSLAfRRSCRNGICGSCAMNVNGKPVLACKTK 71
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 41-85 7.44e-04

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 38.96  E-value: 7.44e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 636800251  41 QSHSLSLDPRTTLLDALRE-HLHLTGT---KKGCDHGQCGACTVHVNGR 85
Cdd:COG0479   21 QTYEVPVSPGMTVLDALDYiKEEQDPTlafRRSCREGICGSCAMVINGR 69
PRK12577 PRK12577
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
41-90 1.66e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 183605 [Multi-domain]  Cd Length: 329  Bit Score: 38.14  E-value: 1.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 636800251  41 QSHSLSLDPRTTLLDAL-REHLHLTGT---KKGCDHGQCGACTVHVNGRRVNSC 90
Cdd:PRK12577  19 QTYTLEVEPGNTILDCLnRIKWEQDGSlafRKNCRNTICGSCAMRINGRSALAC 72
PRK12576 PRK12576
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
41-106 2.91e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 237143 [Multi-domain]  Cd Length: 279  Bit Score: 37.42  E-value: 2.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636800251  41 QSHSLSLDPRTTLLDALR----EHLHLTGTKKGCDHGQCGACTVHVNGRRVNSC--LCFAAACDGDTITTIE 106
Cdd:PRK12576  25 QEYKVKVDRFTQVTEALRrikeEQDPTLSYRASCHMAVCGSCGMKINGEPRLACktLVLDVAKKYNSVITIE 96
Fdx COG0633
Ferredoxin [Energy production and conversion];
37-82 5.60e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 34.44  E-value: 5.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 636800251  37 TVNGQSHSLSLDPRTTLLDALREH-LHLTGtkkGCDHGQCGACTVHV 82
Cdd:COG0633    5 TFIPEGHTVEVPAGESLLEAALRAgIDLPY---SCRSGACGTCHVRV 48
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 35-82 9.67e-03

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 35.99  E-value: 9.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 636800251  35 TMTVNGQSHSLSLDPRTTLLDAL-REHLHLTGtkkGCD-HGQCGACTVHV 82
Cdd:COG2871   36 KITINGDGKEIEVEEGQTLLDALlRQGIFLPS---ACGgGGTCGQCKVKV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH