|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
766-1118 |
0e+00 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 537.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 766 RKLAPIAGVRVSPIALGAGSIGDKWeKYGMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQ 845
Cdd:cd19146 1 RQLSPTAGVRVSPLCLGAMSFGEAW-KSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 846 MVIATKYTTNYKRGDdwqNIKQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKV 925
Cdd:cd19146 80 MVLATKYTTGYRRGG---PIKIKSNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 926 LYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRTDEEEERRRQT 1005
Cdd:cd19146 157 LYLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTEEEFKRRGRS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1006 GEKGeffamlsgavrltvrvgrtivlpdWERTEDEKKMCKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQ 1085
Cdd:cd19146 237 GRKG------------------------GPQTEKERKVSEKLEKVAEEKGT-AITSVALAYVMHKAPYVFPIVGGRKVEH 291
|
330 340 350
....*....|....*....|....*....|...
gi 636624691 1086 LDDNIEALSIALSEEQVKYLESILPFEPGFPHS 1118
Cdd:cd19146 292 LKGNIEALGISLSDEEIQEIEDAYPFDVGFPMN 324
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
768-1106 |
5.86e-148 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 447.73 E-value: 5.86e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 768 LAPIAGVRVSPIALGAGSIGDKWEKYgMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQMV 847
Cdd:cd19147 2 LSKTAGIRVSPLILGAMSIGDAWSGF-MGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRDQIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 848 IATKYTTNYKRGDdwQNIKQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLY 927
Cdd:cd19147 81 IATKFTTDYKAYE--VGKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 928 LGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRTDEEEERRRQTGE 1007
Cdd:cd19147 159 LGVSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKAVEERKKNGE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1008 KgeffamlsgavrltvrvGRTIVLPDwERTEDEKKMCKALEEVAKQVGAKSIQAVAIAYVMQKTPFVFPIIGGRKVEQLD 1087
Cdd:cd19147 239 G-----------------LRSFVGGT-EQTPEEVKISEALEKVAEEHGTESVTAIALAYVRSKAPNVFPLVGGRKIEHLK 300
|
330
....*....|....*....
gi 636624691 1088 DNIEALSIALSEEQVKYLE 1106
Cdd:cd19147 301 DNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
772-1106 |
2.45e-124 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 385.03 E-value: 2.45e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAGSIGDKWekyGMGAmDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARgvRDQMVIATK 851
Cdd:cd19080 6 SGLRVSPLALGTMTFGTEW---GWGA-DREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN--RDRIVLATK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 YTTNYKRGDdwqnikqkTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19080 80 YTMNRRPGD--------PNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGIS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 932 DTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKirtdeeeerrrqtgekgef 1011
Cdd:cd19080 152 DTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGL------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1012 famLSGAVRLTVRVGRTIVLPDW----ERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVEQLD 1087
Cdd:cd19080 213 ---LTGKYQRGEEGRAGEAKGVTvgfgKLTERNWAIVDVVAAVAEELGRSAAQ-VALAWVRQKPGVVIPIIGARTLEQLK 288
|
330
....*....|....*....
gi 636624691 1088 DNIEALSIALSEEQVKYLE 1106
Cdd:cd19080 289 DNLGALDLTLSPEQLARLD 307
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
773-1113 |
2.82e-84 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 277.06 E-value: 2.82e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGDKWekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGvRDQMVIATKY 852
Cdd:COG0667 10 GLKVSRLGLGTMTFGGPW-----GGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRP-RDDVVIATKV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 TtnYKRGDDWqnikqktHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISD 932
Cdd:COG0667 84 G--RRMGPGP-------NGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 933 TPAWIVPKANMYARltGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgeff 1012
Cdd:COG0667 155 YSAEQLRRALAIAE--GLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGG--------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1013 aMLSGAVRLTVRVG----RTIVLPDWERTEDEKKMCKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQLDD 1088
Cdd:COG0667 212 -LLTGKYRRGATFPegdrAATNFVQGYLTERNLALVDALRAIAAEHGV-TPAQLALAWLLAQPGVTSVIPGARSPEQLEE 289
|
330 340
....*....|....*....|....*
gi 636624691 1089 NIEALSIALSEEQVKYLESILPFEP 1113
Cdd:COG0667 290 NLAAADLELSAEDLAALDAALAAVP 314
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
773-1106 |
3.20e-80 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 265.60 E-value: 3.20e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGD-KWEKYgmgAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQMVIATK 851
Cdd:cd19079 9 GLKVSRLCLGCMSFGDpKWRPW---VLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDEVVIATK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 YttnYKRGDDWQNIkqkthyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19079 86 V---YFPMGDGPNG------RGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 932 DTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgef 1011
Cdd:cd19079 157 SMYAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARG-------------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1012 faMLSG-AVRLTVRVGRTIVLPDWER---TEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVEQLD 1087
Cdd:cd19079 217 --RLARpWGDTTERRRSTTDTAKLKYdyfTEADKEIVDRVEEVAKERGVSMAQ-VALAWLLSKPGVTAPIVGATKLEHLE 293
|
330
....*....|....*....
gi 636624691 1088 DNIEALSIALSEEQVKYLE 1106
Cdd:cd19079 294 DAVAALDIKLSEEEIKYLE 312
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
779-1109 |
1.09e-73 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 246.84 E-value: 1.09e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 779 IALGAGSIGDKWekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGV-RDQMVIATKYTTN-- 855
Cdd:pfam00248 1 IGLGTWQLGGGW-----GPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVkRDKVVIATKVPDGdg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 856 -YKRGDDWQNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTP 934
Cdd:pfam00248 76 pWPSGGSKENIRK--------------SLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFD 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 935 AWIVpkanMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgeffaM 1014
Cdd:pfam00248 142 AEQI----EKALTKGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGG----------------------L 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1015 LSGAVRLTVRVGRTIVLPDW-ERTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKVEQLDDNIEAL 1093
Cdd:pfam00248 196 LTGKYTRDPDKGPGERRRLLkKGTPLNLEALEALEEIAKEHG-VSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGAL 274
|
330
....*....|....*.
gi 636624691 1094 SIALSEEQVKYLESIL 1109
Cdd:pfam00248 275 EFPLSDEEVARIDELL 290
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
773-1105 |
2.52e-73 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 246.36 E-value: 2.52e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGdkWEkygmgaMDKTSSFKLLDAYYDKGGNFIDTANGYQDE-------SSEEFIGEWMEARGVRDQ 845
Cdd:cd19081 6 GLSVSPLCLGTMVFG--WT------ADEETSFALLDAFVDAGGNFIDTADVYSAWvpgnaggESETIIGRWLKSRGKRDR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 846 MVIATKYttnykRGDDWQNIKqkthymGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKV 925
Cdd:cd19081 78 VVIATKV-----GFPMGPNGP------GLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 926 LYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLA----SGKIRTDeeee 1000
Cdd:cd19081 147 RYIGASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAggflTGKYRSE---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1001 rrrqtgekgeffAMLSGAVRltvrvgrtiVLPDWERTEDEK--KMCKALEEVAKQVGAKSIQaVAIAYVMQKtPFVF-PI 1077
Cdd:cd19081 223 ------------ADLPGSTR---------RGEAAKRYLNERglRILDALDEVAAEHGATPAQ-VALAWLLAR-PGVTaPI 279
|
330 340
....*....|....*....|....*...
gi 636624691 1078 IGGRKVEQLDDNIEALSIALSEEQVKYL 1105
Cdd:cd19081 280 AGARTVEQLEDLLAAAGLRLTDEEVARL 307
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
764-1108 |
1.13e-65 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 225.18 E-value: 1.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAGSIGDKWEKYGM-GAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaRGV 842
Cdd:cd19091 2 EYRTLGR-SGLKVSELALGTMTFGGGGGFFGAwGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKAL--KGR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 RDQMVIATKYTtnYKRGDDWQNIKQKTHYMGNnmkalhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19091 79 RDDVLIATKVR--GRMGEGPNDVGLSRHHIIR-------AVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLA----SGKIRTDEE 998
Cdd:cd19091 150 GKVRYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAggllSGKYRRGQP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 999 EERRRQTGEKGEFFamlsgavrltvrvgrtiVLPDWERTEDekkMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPII 1078
Cdd:cd19091 230 APEGSRLRRTGFDF-----------------PPVDRERGYD---VVDALREIAKETG-ATPAQVALAWLLSRPTVSSVII 288
|
330 340 350
....*....|....*....|....*....|
gi 636624691 1079 GGRKVEQLDDNIEALSIALSEEQVKYLESI 1108
Cdd:cd19091 289 GARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
777-1091 |
1.64e-65 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 221.24 E-value: 1.64e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGdkwekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQMVIATK-YTTN 855
Cdd:cd06660 1 SRLGLGTMTFG--------GDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKgGHPP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 856 YKRGDDWqnikqkthymGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPA 935
Cdd:cd06660 73 GGDPSRS----------RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 936 WIVPKANMYARLTGKTPFVIYQGLWNILQRDF-ERDIIPMAREEGLALALWSVLASGKIrtdeeeerrrqtgekgeffam 1014
Cdd:cd06660 143 ERLAEALAYAKAHGLPGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARGPA--------------------- 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636624691 1015 lsgavrltvrvgrtivlpdwertedekkmckaleevakqvgaksiqAVAIAYVMQKTPFVFPIIGGRKVEQLDDNIE 1091
Cdd:cd06660 202 ----------------------------------------------QLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
760-1110 |
3.63e-64 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 220.52 E-value: 3.63e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 760 TPLGRhrklapiAGVRVSPIALGAGSIGdkwekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEA 839
Cdd:cd19087 4 RTLGR-------TGLKVSRLCLGTMNFG--------GRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 840 RgvRDQMVIATKYttnYKRGDDWQNIKqkthymGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNL 919
Cdd:cd19087 69 R--RDDIVLATKV---FGPMGDDPNDR------GLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 920 IVSGKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeee 999
Cdd:cd19087 138 VRQGKIRYIGVSNFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGG-------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1000 errrqtgekgeffaMLSGAVRLT--VRVGRTIVLPDWERTEDEKKMCKALEE---VAKQVGaKSIQAVAIAYVMQKTPFV 1074
Cdd:cd19087 210 --------------LLTGKYGKGkrPESGRLVERARYQARYGLEEYRDIAERfeaLAAEAG-LTPASLALAWVLSHPAVT 274
|
330 340 350
....*....|....*....|....*....|....*.
gi 636624691 1075 FPIIGGRKVEQLDDNIEALSIALSEEQVKYLESILP 1110
Cdd:cd19087 275 SPIIGPRTLEQLEDSLAALEITLTPELLAEIDELFP 310
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
773-1106 |
4.17e-56 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 196.98 E-value: 4.17e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGDKWekygMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEarGVRDQMVIATKY 852
Cdd:cd19084 1 DLKVSRIGLGTWAIGGTW----WGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALK--GRRDDVVIATKC 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 ttnykrGDDWQNIKQKTHymgnNMKALHL--SVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGI 930
Cdd:cd19084 75 ------GLRWDGGKGVTK----DLSPESIrkEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 931 SDTPawivpkANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekge 1010
Cdd:cd19084 145 SNFS------VEQLEEARKYGPIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQG------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 ffaMLSGAVRLTVRVGRTivlpDW---------ERTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGR 1081
Cdd:cd19084 200 ---LLTGKYKKEPTFPPD----DRrsrfpffrgENFEKNLEIVDKLKEIAEKYG-KSLAQLAIAWTLAQPGVTSAIVGAK 271
|
330 340
....*....|....*....|....*
gi 636624691 1082 KVEQLDDNIEALSIALSEEQVKYLE 1106
Cdd:cd19084 272 NPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
794-1094 |
2.12e-54 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 191.78 E-value: 2.12e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 794 GMGAM------DKTSSFKLLDAYYDKGGNFIDTAN-------GYQDESSEEFIGEWMEARGVRDQMVIATKYTTNYKRGD 860
Cdd:cd19752 4 CLGTMyfgtrtDEETSFAILDRYVAAGGNFLDTANnyafwteGGVGGESERLIGRWLKDRGNRDDVVIATKVGAGPRDPD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 861 DWQNIkqkthYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPAWIVPK 940
Cdd:cd19752 84 GGPES-----PEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLER 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 941 ANMYARLTGKTPFVIYQGLWNILQRDFERD----------IIPMAREEGlALALWSvlasgkirtdeeeerrrqtgekge 1010
Cdd:cd19752 159 ARQIARQQGWAEFSAIQQRHSYLRPRPGADfgvqrivtdeLLDYASSRP-DLTLLA------------------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 FFAMLSGAVrltVRVGRtiVLPDWERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVEQLDDNI 1090
Cdd:cd19752 214 YSPLLSGAY---TRPDR--PLPEQYDGPDSDARLAVLEEVAGELGATPNQ-VVLAWLLHRTPAIIPLLGASTVEQLEENL 287
|
....
gi 636624691 1091 EALS 1094
Cdd:cd19752 288 AALD 291
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
777-1094 |
1.92e-47 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 171.58 E-value: 1.92e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKWekygmgamDKTSSFKLLDAYYDKGGNFIDTANGYQDES----SEEFIGEWMEARGVRDQMVIATKy 852
Cdd:cd19082 1 SRIVLGTADFGTRI--------DEEEAFALLDAFVELGGNFIDTARVYGDWVergaSERVIGEWLKSRGNRDKVVIATK- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 ttnykrGddwqnikqkTHYMGNNM-------KALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKV 925
Cdd:cd19082 72 ------G---------GHPDLEDMsrsrlspEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 926 LYLGISDtpaWIVPK---ANMYARLTGKTPFVIYQGLWNI--LQRDFERD--IIPM-------AREEGLALALWSVLASG 991
Cdd:cd19082 137 RAFGASN---WSTERiaeANAYAKAHGLPGFAASSPQWSLarPNEPPWPGptLVAMdeemrawHEENQLPVFAYSSQARG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 992 kirtdeeeerrrqtgekgeFFAML--SGAVRLTVRVGRTIVLPDWERTEdekkmckALEEVAKQVGAkSIQAVAIAYVMQ 1069
Cdd:cd19082 214 -------------------FFSKRaaGGAEDDSELRRVYYSEENFERLE-------RAKELAEEKGV-SPTQIALAYVLN 266
|
330 340
....*....|....*....|....*
gi 636624691 1070 KTPFVFPIIGGRKVEQLDDNIEALS 1094
Cdd:cd19082 267 QPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
773-1100 |
2.45e-45 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 165.84 E-value: 2.45e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeARGVRDQMVIATKY 852
Cdd:cd19074 1 GLKVSELSLGT------WLTFGGQVDDEDAK-ACVRKAYDLGINFFDTADVYAAGQAEEVLGKAL-KGWPRESYVISTKV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 ttnYKRGDDWQNIKqkthymGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISD 932
Cdd:cd19074 73 ---FWPTGPGPNDR------GLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 933 TPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIrtdeeeerrrqTG--EKGE 1010
Cdd:cd19074 144 WSAEQIAEAHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLL-----------TGkyRDGI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 FFAmlSGAvRLTVRVGRTIVLPDweRTEDEKKMCKALEEVAKQVGAKSIQAvAIAYVMQKTPFVFPIIGGRKVEQLDDNI 1090
Cdd:cd19074 213 PPP--SRS-RATDEDNRDKKRRL--LTDENLEKVKKLKPIADELGLTLAQL-ALAWCLRNPAVSSAIIGASRPEQLEENV 286
|
330
....*....|
gi 636624691 1091 EALSIALSEE 1100
Cdd:cd19074 287 KASGVKLSPE 296
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
776-1100 |
1.23e-43 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 161.96 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 776 VSPIALGAGSIGdkwekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGY----QDE---SSEEFIGEWMEARGVRDQMVI 848
Cdd:cd19094 1 VSEICLGTMTWG--------EQNTEAEAHEQLDYAFDEGVNFIDTAEMYpvppSPEtqgRTEEIIGSWLKKKGNRDKVVL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 849 ATKYTTnykRGDDWQNIKQKTHYMgnNMKALHLSVAASLKKLRTDYIDILYVHWWDFDT------------------TME 910
Cdd:cd19094 73 ATKVAG---PGEGITWPRGGGTRL--DRENIREAVEGSLKRLGTDYIDLYQLHWPDRYTplfgggyytepseeedsvSFE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 911 EVMNGLHNLIVSGKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLA- 989
Cdd:cd19094 148 EQLEALGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAg 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 990 ---SGKiRTDEEEERrrqtgEKGEFFAMLSGAVRLtvrvgrtivlpdweRTEDEKKMCKALEEVAKQVGAKSIQAvAIAY 1066
Cdd:cd19094 228 gvlTGK-YLDGAARP-----EGGRLNLFPGYMARY--------------RSPQALEAVAEYVKLARKHGLSPAQL-ALAW 286
|
330 340 350
....*....|....*....|....*....|....*
gi 636624691 1067 VMQKtPFVFP-IIGGRKVEQLDDNIEALSIALSEE 1100
Cdd:cd19094 287 VRSR-PFVTStIIGATTLEQLKENIDAFDVPLSDE 320
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
776-1108 |
7.10e-43 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 158.52 E-value: 7.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 776 VSPIALGAGSIGDKwekYGMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEarGVRDQMVIATKYTTN 855
Cdd:cd19085 1 VSRLGLGCWQFGGG---YWWGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALK--GRRDDVVIATKVSPD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 856 YKRGDDwqnIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTpa 935
Cdd:cd19085 76 NLTPED---VRK--------------SCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNF-- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 936 wivPKANMyARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgeffaML 1015
Cdd:cd19085 137 ---GPAQL-EEALDAGRIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQG----------------------LL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1016 SGAVRLTVRVGrtivlPDWERT--------EDEKKMCKA---LEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKVE 1084
Cdd:cd19085 191 TGKFSSAEDFP-----PGDARTrlfrhfepGAEEETFEAlekLKEIADELG-VTMAQLALAWVLQQPGVTSVIVGARNPE 264
|
330 340
....*....|....*....|....
gi 636624691 1085 QLDDNIEALSIALSEEQVKYLESI 1108
Cdd:cd19085 265 QLEENAAAVDLELSPSVLERLDEI 288
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
766-1107 |
9.58e-41 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 153.20 E-value: 9.58e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 766 RKLAPiAGVRVSPIALGAGSIG-DKWEkygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaRGVRD 844
Cdd:cd19149 2 RKLGK-SGIEASVIGLGTWAIGgGPWW----GGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAI--KGRRD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 845 QMVIATKYTTNYKRGDDWQNIKQKTHYMGNNM--KALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19149 75 KVVLATKCGLRWDREGGSFFFVRDGVTVYKNLspESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTgktpfvIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerr 1002
Cdd:cd19149 155 GKIRAIGASNVSVEQIKEYVKAGQLD------IIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQG----------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1003 rqtgekgeffaMLSGavrlTVRVGRTIVLPDWERT------EDEKKMCKALEE---VAKQVGAkSIQAVAIAYVMQKTPF 1073
Cdd:cd19149 218 -----------LLTG----KITPDREFDAGDARSGipwfspENREKVLALLEKwkpLCEKYGC-TLAQLVIAWTLAQPGI 281
|
330 340 350
....*....|....*....|....*....|....
gi 636624691 1074 VFPIIGGRKVEQLDDNIEALSIALSEEQVKYLES 1107
Cdd:cd19149 282 TSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
764-1105 |
4.10e-40 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 150.83 E-value: 4.10e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAgsigdkwekYGM----GAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMea 839
Cdd:cd19076 1 PTRKLGT-QGLEVSALGLGC---------MGMsafyGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKAL-- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 840 RGVRDQMVIATKytTNYKRGDDwqnikqkTHYMGNNMKALHL--SVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLH 917
Cdd:cd19076 69 KDRRDEVVIATK--FGIVRDPG-------SGFRGVDGRPEYVraACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 918 NLIVSGKVLYLGISDTPAWIVPKANMYARLTgktpFViyQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtde 997
Cdd:cd19076 140 ELVEEGKVRYIGLSEASADTIRRAHAVHPIT----AV--QSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRG------ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 998 eeerrrqtgekgeffaMLSGAVRLTVRVGRTivlpDWERT---------EDEKKMCKALEEVAKQVGAKSIQaVAIAYVM 1068
Cdd:cd19076 208 ----------------FLTGAIKSPEDLPED----DFRRNnprfqgenfDKNLKLVEKLEAIAAEKGCTPAQ-LALAWVL 266
|
330 340 350
....*....|....*....|....*....|....*..
gi 636624691 1069 QKTPFVFPIIGGRKVEQLDDNIEALSIALSEEQVKYL 1105
Cdd:cd19076 267 AQGDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
773-1109 |
5.24e-38 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 144.68 E-value: 5.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIgdkweKYGMG-AMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEarGVRDQMVIATK 851
Cdd:cd19078 1 GLEVSAIGLGCMGM-----SHGYGpPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALK--PFRDQVVIATK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 YttnykrGDDWQNIKQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19078 74 F------GFKIDGGKPGPLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 932 DTPAWIVPKANmyarltGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgef 1011
Cdd:cd19078 148 EAGVETIRRAH------AVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKG-------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1012 faMLSGAVRLTVRVGRT---IVLPDW--ERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVEQL 1086
Cdd:cd19078 202 --FLTGKIDENTKFDEGddrASLPRFtpEALEANQALVDLLKEFAEEKGATPAQ-IALAWLLAKKPWIVPIPGTTKLSRL 278
|
330 340
....*....|....*....|...
gi 636624691 1087 DDNIEALSIALSEEQVKYLESIL 1109
Cdd:cd19078 279 EENIGAADIELTPEELREIEDAL 301
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
776-1109 |
2.41e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 142.81 E-value: 2.41e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 776 VSPIALGAGSIGDKWEKYGMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaRGVRDQMVIATKYttn 855
Cdd:cd19102 1 LTTIGLGTWAIGGGGWGGGWGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRAL--KGLRDRPIVATKC--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 856 ykrGDDWQNIKQ-KTHYMGNNMKAlhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTP 934
Cdd:cd19102 76 ---GLLWDEEGRiRRSLKPASIRA---ECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 935 awivpkANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgeffaM 1014
Cdd:cd19102 150 ------VDQMKRCQAIHPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSG----------------------L 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1015 LSGAvrltvrVGRTIVLPDWER---------TEDEKKMCKALEEVAKQVGAK---SIQAVAIAYVMQKTPFVFPIIGGRK 1082
Cdd:cd19102 202 LTGK------MTPERVASLPADdwrrrspffQEPNLARNLALVDALRPIAERhgrTVAQLAIAWVLRRPEVTSAIVGARR 275
|
330 340
....*....|....*....|....*..
gi 636624691 1083 VEQLDDNIEALSIALSEEQVKYLESIL 1109
Cdd:cd19102 276 PDQIDETVGAADLRLTPEELAEIEALL 302
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
775-1106 |
1.93e-36 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 140.06 E-value: 1.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 775 RVSPIALGAGSIGDKWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQMVIATKYTt 854
Cdd:cd19093 1 EVSPLGLGTWQWGDRLWWGYGEYGDEDLQ-AAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATKFA- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 855 nykrGDDWqnikqkTHYMGNNMKALHlsvaASLKKLRTDYIDILYVHW-WDFDTTMEEVMNGLHNLIVSGKVLYLGISDT 933
Cdd:cd19093 79 ----PLPW------RLTRRSVVKALK----ASLERLGLDSIDLYQLHWpGPWYSQIEALMDGLADAVEEGLVRAVGVSNY 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 934 PAWIVPKAnmYARLTGKT-PFVIYQGLWNILQRDFERD-IIPMAREEGLALALWSVLA----SGKIRTDeeeerRRQTGE 1007
Cdd:cd19093 145 SADQLRRA--HKALKERGvPLASNQVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAqgllTGKYSPE-----NPPPGG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1008 KGEFFamlsgavrltvrvGRTIVLPDWErtedekkMCKALEEVAKQVGaKSIQAVAIAYVMQKTpfVFPIIGGRKVEQLD 1087
Cdd:cd19093 218 RRRLF-------------GRKNLEKVQP-------LLDALEEIAEKYG-KTPAQVALNWLIAKG--VVPIPGAKNAEQAE 274
|
330
....*....|....*....
gi 636624691 1088 DNIEALSIALSEEQVKYLE 1106
Cdd:cd19093 275 ENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
775-1092 |
1.12e-34 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 132.99 E-value: 1.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 775 RVSPIALGAGSIGDKWEkygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARgvRDQMVIATK--- 851
Cdd:cd19086 2 EVSEIGFGTWGLGGDWW----GDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGR--RDKVVIATKfgn 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 -YTTNYKRGDDW--QNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVH-WWDFDTTMEEVMNGLHNLIVSGKVLY 927
Cdd:cd19086 76 rFDGGPERPQDFspEYIRE--------------AVEASLKRLGTDYIDLYQLHnPPDEVLDNDELFEALEKLKQEGKIRA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 928 LGISdtpawIVPKANMYARLTGKTPFVIyQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtge 1007
Cdd:cd19086 142 YGVS-----VGDPEEALAALRRGGIDVV-QVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASG---------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1008 kgeffaMLSGavrltvrvgrtivlpdwertedekKMckaleevakqvgaksIQAvAIAYVMQKtPFVF-PIIGGRKVEQL 1086
Cdd:cd19086 200 ------LLTG------------------------KL---------------AQA-ALRFILSH-PAVStVIPGARSPEQV 232
|
....*.
gi 636624691 1087 DDNIEA 1092
Cdd:cd19086 233 EENAAA 238
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
762-1108 |
6.45e-34 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 133.49 E-value: 6.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 762 LGRhrklapiAGVRVSPIALGAgsigdkWEKYGmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG 841
Cdd:cd19143 6 LGR-------SGLKVSALSFGS------WVTFG-NQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 842 V-RDQMVIATKYTTNYKRGDDWQNikqkthymGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLI 920
Cdd:cd19143 72 WpRSDYVVSTKIFWGGGGPPPNDR--------GLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 921 VSGKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLASGkirtdeee 999
Cdd:cd19143 144 DQGKAFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLASG-------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1000 errrqtgekgeffaMLSGAVRLTVRVGRTIVLPDWER------TEDEKKMCKA--LEEVAKQVGAkSIQAVAIAYVMqKT 1071
Cdd:cd19143 216 --------------LLTGKYNNGIPEGSRLALPGYEWlkdrkeELGQEKIEKVrkLKPIAEELGC-SLAQLAIAWCL-KN 279
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 636624691 1072 PFVFPII-GGRKVEQLDDNIEALSIA--LSEEQVKYLESI 1108
Cdd:cd19143 280 PNVSTVItGATKVEQLEENLKALEVLpkLTPEVMEKIEAI 319
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
773-1109 |
3.33e-33 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 130.89 E-value: 3.33e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSI-GDKWekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGVRDQMVIATK 851
Cdd:cd19148 1 DLPVSRIALGTWAIgGWMW-----GGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 YttnykrGDDWQNIKQKTHymgNNMKA-LHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGI 930
Cdd:cd19148 76 V------GLEWDEGGEVVR---NSSPArIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 931 SDtpaWIVPKANMYARltgKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekge 1010
Cdd:cd19148 147 SN---FSPEQMETFRK---VAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRG------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 ffaMLSGAVRLTVRVGrtivlPDWERTEDEK----------KMCKALEEVAKQVGAKSIQAVAIAYVMQKTPFVFPIIGG 1080
Cdd:cd19148 202 ---LLSGKMTKDTKFE-----GDDLRRTDPKfqeprfsqylAAVEELDKLAQERYGKSVIHLAVRWLLDQPGVSIALWGA 273
|
330 340
....*....|....*....|....*....
gi 636624691 1081 RKVEQLDDNIEALSIALSEEQVKYLESIL 1109
Cdd:cd19148 274 RKPEQLDAVDEVFGWSLNDEDMKEIDAIL 302
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
773-1108 |
6.13e-33 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 130.23 E-value: 6.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGdkwekygmG-----AMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARgVRDQMV 847
Cdd:cd19083 8 DIDVNPIGLGTNAVG--------GhnlypNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEY-NRNEVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 848 IATKyTTNYKRGDDWQnikqkthyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLY 927
Cdd:cd19083 79 IATK-GAHKFGGDGSV--------LNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 928 LGISDTPAWIVPKANMYARLTgktpfvIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIrtdeeeerrrqTGE 1007
Cdd:cd19083 150 IGVSNFSLEQLKEANKDGYVD------VLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLL-----------AGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1008 KGEFFAMLSGAVRltvrvgRTIVLPDWERTEDEKKMCKALEEVAKQVGAkSIQAVAIAYVMQKtPFVFPII-GGRKVEQL 1086
Cdd:cd19083 213 YTKDTKFPDNDLR------NDKPLFKGERFSENLDKVDKLKSIADEKGV-TVAHLALAWYLTR-PAIDVVIpGAKRAEQV 284
|
330 340
....*....|....*....|..
gi 636624691 1087 DDNIEALSIALSEEQVKYLESI 1108
Cdd:cd19083 285 IDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
773-1106 |
9.49e-33 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 128.12 E-value: 9.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGDKWEKygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGvRDQMVIATKY 852
Cdd:cd19072 1 GEEVPVLGLGTWGIGGGMSK---DYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFD-REDLFITTKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 TTNYKRGDDwqnikqkthymgnnmkaLHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISD 932
Cdd:cd19072 77 SPDHLKYDD-----------------VIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 933 tpawiVPKANM--YARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekge 1010
Cdd:cd19072 140 -----FSLEELeeAQSYLKKGPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKG------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 ffaMLSGAVRLTVrvgrtivlpdwertedekkmckaLEEVAKQVGaKSIQAVAIAYVMQKtPFVFPIIGGRKVEQLDDNI 1090
Cdd:cd19072 196 ---KLSNAKGSPL-----------------------LDEIAKKYG-KTPAQIALNWLISK-PNVIAIPKASNIEHLEENA 247
|
330
....*....|....*.
gi 636624691 1091 EALSIALSEEQVKYLE 1106
Cdd:cd19072 248 GALGWELSEEDLQRLD 263
|
|
| Ribosomal_S30 |
pfam04758 |
Ribosomal protein S30; |
1147-1203 |
5.80e-32 |
|
Ribosomal protein S30;
Pssm-ID: 398432 Cd Length: 58 Bit Score: 118.52 E-value: 5.80e-32
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 636624691 1147 HGSLARAGKVKSQTPKVEKQEKKKTPKGRAKKRILYNRRFVNVTllPNGKRKMNANP 1203
Cdd:pfam04758 3 HGSLARAGKVRNQTPKVEKQEKKKKPTGRAKKRLQYNRRFVNVV--PGGGRKKGPNS 57
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
773-1103 |
4.73e-31 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 124.68 E-value: 4.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAgsigdkWEKYGmGAMDKTSSFKLLDAYYDKGGNFIDTANGY--QDESSEEFIGEWME--ARGVRDQMVI 848
Cdd:cd19089 8 GLHLPAISLGL------WHNFG-DYTSPEEARELLRTAFDLGITHFDLANNYgpPPGSAEENFGRILKrdLRPYRDELVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 849 ATK--YTTnykrgddWQNIkqkthyMGN--NMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGK 924
Cdd:cd19089 81 STKagYGM-------WPGP------YGDggSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 925 VLYLGISDTPAwiVPKANMYARLTG-KTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRTDEeeerrr 1003
Cdd:cd19089 148 ALYVGISNYPG--AKARRAIALLRElGVPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKY------ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1004 qtgekgeffamLSGAVRLTVRVGRTIVLPDWERTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKV 1083
Cdd:cd19089 220 -----------LNGIPPDSRRAAESKFLTEEALTPEKLEQLRKLNKIAAKRG-QSLAQLALSWVLRDPRVTSVLIGASSP 287
|
330 340
....*....|....*....|.
gi 636624691 1084 EQLDDNIEAL-SIALSEEQVK 1103
Cdd:cd19089 288 SQLEDNVAALkNLDFSEEELA 308
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
757-1108 |
2.22e-28 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 117.16 E-value: 2.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 757 LPATPLGRHRKLAPiagvrvspiALGAGSIGDKwEKYGmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEW 836
Cdd:cd19144 1 IPTRTLGRNGPSVP---------ALGFGAMGLS-AFYG-PPKPDEERFAVLDAAFELGCTFWDTADIYGD--SEELIGRW 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 837 M-EARGVRDQMVIATK--YTTNYKRGDDWQNikqkthymgNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVM 913
Cdd:cd19144 68 FkQNPGKREKIFLATKfgIEKNVETGEYSVD---------GSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 914 NGLHNLIVSGKVLYLGISDtpawivPKANMYARLTGKTPFVIYQGLWNILQRDFER---DIIPMAREEGLALALWSVLAS 990
Cdd:cd19144 139 AAMAELVQEGKIKHIGLSE------CSAETLRRAHAVHPIAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 991 GkirtdeeeerrrqtgekgeffaMLSGAVRLTVRVGRTivlpDWERT------EDEKK---MCKALEEVAKQVGAKSIQA 1061
Cdd:cd19144 213 G----------------------FLTGAIRSPDDFEEG----DFRRMaprfqaENFPKnleLVDKIKAIAKKKNVTAGQL 266
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 636624691 1062 vAIAYVMQKTPFVFPIIGGRKVEQLDDNIEALSIALSEEQVKYLESI 1108
Cdd:cd19144 267 -TLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIREI 312
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
765-1108 |
2.62e-27 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 114.57 E-value: 2.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 765 HRklAPIAGVRVSPIALGAGSIGDKwekygmgaMDKTSSFKLLDAYYDKGGNFIDTANGY----QDES---SEEFIGEWM 837
Cdd:PRK10625 4 HR--IPHSSLEVSTLGLGTMTFGEQ--------NSEADAHAQLDYAVAQGINLIDVAEMYpvppRPETqglTETYIGNWL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 838 EARGVRDQMVIATKyTTNYKRGDDwQNIKQKTHYMGNNMK-ALHlsvaASLKKLRTDYIDILYVHW-------------- 902
Cdd:PRK10625 74 AKRGSREKLIIASK-VSGPSRNND-KGIRPNQALDRKNIReALH----DSLKRLQTDYLDLYQVHWpqrptncfgklgys 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 903 WDFDT---TMEEVMNGLHNLIVSGKVLYLGISDTPAWIVPKanmYARLTGKTPF---VIYQGLWNILQRDFERDIIPMAR 976
Cdd:PRK10625 148 WTDSApavSLLETLDALAEQQRAGKIRYIGVSNETAFGVMR---YLHLAEKHDLpriVTIQNPYSLLNRSFEVGLAEVSQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 977 EEGLALALWSVLASGKIrTDEEEERRRQTGEKGEFFAmlsgavRLTVRVGrtivlpdwertEDEKKMCKALEEVAKQVGA 1056
Cdd:PRK10625 225 YEGVELLAYSCLAFGTL-TGKYLNGAKPAGARNTLFS------RFTRYSG-----------EQTQKAVAAYVDIAKRHGL 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 636624691 1057 KSIQaVAIAYVMQKtPFVFP-IIGGRKVEQLDDNIEALSIALSEEQVKYLESI 1108
Cdd:PRK10625 287 DPAQ-MALAFVRRQ-PFVAStLLGATTMEQLKTNIESLHLTLSEEVLAEIEAV 337
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
779-1108 |
4.82e-27 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 112.65 E-value: 4.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 779 IALGAGSIGdkwekYGMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEwmeARGVRDQMVIATKYTTNYKR 858
Cdd:cd19075 3 IILGTMTFG-----SQGRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGE---LGLGERGFKIDTKANPGVGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 859 GDDWQNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPAWIV 938
Cdd:cd19075 75 GLSPENVRK--------------QLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 939 PKANMYARLTG-KTPFViYQGLWNILQRDFERDIIPMAREEGLALALWSVLA----SGKIRTDEEEerrrqtGEKGEFFA 1013
Cdd:cd19075 141 AEIVEICKENGwVLPTV-YQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAggflTGKYKYSEDK------AGGGRFDP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1014 MLSGAVRLTVRVGRtivlpdwertedeKKMCKALEEVAKQVGAKSIQAVAIAY--VMQKTPFVFP-----IIGGRKVEQL 1086
Cdd:cd19075 214 NNALGKLYRDRYWK-------------PSYFEALEKVEEAAEKEGISLAEAALrwLYHHSALDGEkgdgvILGASSLEQL 280
|
330 340
....*....|....*....|...
gi 636624691 1087 DDNIEALSI-ALSEEQVKYLESI 1108
Cdd:cd19075 281 EENLAALEKgPLPEEVVKAIDEA 303
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
773-1101 |
5.97e-27 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 112.26 E-value: 5.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGDKWekygmgaMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWM-EARGVRDQMVIATK 851
Cdd:cd19092 3 GLEVSRLVLGCMRLADWG-------ESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALaLNPGLREKIEIQTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 ytTNYKRGDDWQNIKQKtHYmgnNMKALHL--SVAASLKKLRTDYIDILYVHwwDFDTTM--EEVMNGLHNLIVSGKVLY 927
Cdd:cd19092 76 --CGIRLGDDPRPGRIK-HY---DTSKEHIlaSVEGSLKRLGTDYLDLLLLH--RPDPLMdpEEVAEAFDELVKSGKVRY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 928 LGISD-TPAWIvpkANMYARLtgKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLAsgkirtdeeeerrrqt 1005
Cdd:cd19092 148 FGVSNfTPSQI---ELLQSYL--DQPLVTNQIELSLLHTEaIDDGTLDYCQLLDITPMAWSPLG---------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1006 geKGEFFamlSGAVRLTVRVGrtivlpdwertedekkmcKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQ 1085
Cdd:cd19092 207 --GGRLF---GGFDERFQRLR------------------AALEELAEEYGV-TIEAIALAWLLRHPARIQPILGTTNPER 262
|
330
....*....|....*.
gi 636624691 1086 LDDNIEALSIALSEEQ 1101
Cdd:cd19092 263 IRSAVKALDIELTREE 278
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
784-1105 |
8.33e-27 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 112.14 E-value: 8.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 784 GSIGDKWEKYGMGAMDKTSSF----------KLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEArGVRDQMVIATKYT 853
Cdd:cd19145 6 GSQGLEVSAQGLGCMGLSGDYgapkpeeegiALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKD-GPREKVQLATKFG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 854 TNYKRGDDWQnIKQKTHYMgnnmKAlhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDT 933
Cdd:cd19145 85 IHEIGGSGVE-VRGDPAYV----RA---ACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 934 PAWIVPKANMYARLTGktpfviYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgeFFA 1013
Cdd:cd19145 157 SADTIRRAHAVHPITA------VQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRG-------------------FFA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1014 mlSGAVRLTVRVGRTIV--LPDW--ERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVEQLDDN 1089
Cdd:cd19145 212 --GKAKLEELLENSDVRksHPRFqgENLEKNKVLYERVEALAKKKGCTPAQ-LALAWVLHQGEDVVPIPGTTKIKNLNQN 288
|
330
....*....|....*.
gi 636624691 1090 IEALSIALSEEQVKYL 1105
Cdd:cd19145 289 IGALSVKLTKEDLKEI 304
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
772-1103 |
3.38e-26 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 110.57 E-value: 3.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAgsigdkWEKYGmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDE--SSEEFIGEWMEA--RGVRDQMV 847
Cdd:cd19151 8 SGLKLPAISLGL------WHNFG-DVDRYENSRAMLRRAFDLGITHFDLANNYGPPpgSAEENFGRILKEdlKPYRDELI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 848 IATK--YTTNYKRGDDWqnikqkthymgNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKV 925
Cdd:cd19151 81 ISTKagYTMWPGPYGDW-----------GSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 926 LYLGISDTPAWIVPKANMYARLTGkTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIrTDEeeerrrqt 1005
Cdd:cd19151 150 LYVGISNYPPEEAREAAAILKDLG-TPCLIHQPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLL-TDR-------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1006 gekgeffaMLSGaVRLTVRVGR-TIVLPDWERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGRKVE 1084
Cdd:cd19151 220 --------YLNG-IPEDSRAAKgSSFLKPEQITEEKLAKVRRLNEIAQARGQKLAQ-MALAWVLRNKRVTSVLIGASKPS 289
|
330 340
....*....|....*....|
gi 636624691 1085 QLDDNIEALS-IALSEEQVK 1103
Cdd:cd19151 290 QIEDAVGALDnREFSEEELA 309
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
777-1020 |
5.28e-25 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 105.39 E-value: 5.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKWekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMEARgVRDQMVIATKYTTNY 856
Cdd:cd19095 1 SVLGLGTSGIGRVW-----GVPSEAEAARLLNTALDLGINLIDTAPAYGR--SEERLGRALAGL-RRDDLFIATKVGTHG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 857 KRGDDWQNIKQKthymgnnmkALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGIS-DTPA 935
Cdd:cd19095 73 EGGRDRKDFSPA---------AIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSgDGEE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 936 wivpkanmYARLTGKTPFVIYQGLWNILQRDfERDIIPMAREEGLALALWSVLASGKIRTDEEEERRRQTGEKGEFFAML 1015
Cdd:cd19095 144 --------LEAAIASGVFDVVQLPYNVLDRE-EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARRPEFAAE 214
|
....*
gi 636624691 1016 SGAVR 1020
Cdd:cd19095 215 IGGAT 219
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
777-1100 |
7.11e-25 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 105.71 E-value: 7.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKWEKygmgaMDKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMeARGVRDQMVIATKYTTNY 856
Cdd:cd19090 1 SALGLGTAGLGGVFGG-----VDDDEAVATIRAALDLGINYIDTAPAYGD--SEERLGLAL-AELPREPLVLSTKVGRLP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 857 KRGDDWqnikqkthymgnNMKALHLSVAASLKKLRTDYIDILYVH---W--WDFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19090 73 EDTADY------------SADRVRRSVEESLERLGRDRIDLLMIHdpeRvpWVDILAPGGALEALLELKEEGLIKHIGLG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 932 DTPawivPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGkirtdeeeerrrqtgekgef 1011
Cdd:cd19090 141 GGP----PDLLRRAIETGDFDVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMG-------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1012 faMLSGavrltVRVGRTIVLPDWeRTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKtPFVFPII-GGRKVEQLDDNI 1090
Cdd:cd19090 197 --LLAG-----RPPERVRYTYRW-LSPELLDRAKRLYELCDEHG-VPLPALALRFLLRD-PRISTVLvGASSPEELEQNV 266
|
330
....*....|
gi 636624691 1091 EALSIALSEE 1100
Cdd:cd19090 267 AAAEGPLPEE 276
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
776-1098 |
1.60e-24 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 104.22 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 776 VSPIALGAG--SIGDKWEkygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGvrDQMVIATKyT 853
Cdd:cd19088 1 VSRLGYGAMrlTGPGIWG----PPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYP--DDVVIATK-G 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 854 TNYKRGDDWQNIKQKTHYmgnnmkaLHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDT 933
Cdd:cd19088 74 GLVRTGPGWWGPDGSPEY-------LRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 934 PAWIVPKANMYARLtgktpfVIYQGLWNILQRDFErDIIPMAREEGLALALWSVLASGKIRTDEEeerrrqtgekgeffa 1013
Cdd:cd19088 147 TVAQIEEARAIVRI------VSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDLAQPGG--------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1014 mlsgavrltvrvgrtivlpdwertedekkmckALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQLDDNIEAL 1093
Cdd:cd19088 205 --------------------------------LLAEVAARLGA-TPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAA 251
|
....*
gi 636624691 1094 SIALS 1098
Cdd:cd19088 252 GLRLS 256
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
761-993 |
1.04e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 101.40 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 761 PLGRhrklapiAGVRVSPIALGAGSIGDKWEKYGmgamdktssFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMeaR 840
Cdd:cd19100 3 RLGR-------TGLKVSRLGFGGGPLGRLSQEEA---------AAIIRRALDLGINYFDTAPSYGD--SEEKIGKAL--K 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 841 GVRDQMVIATKyTTNYKRGDDWQNIKQkthymgnnmkalhlsvaaSLKKLRTDYIDILYVH------WWDFDTTMEEVMN 914
Cdd:cd19100 63 GRRDKVFLATK-TGARDYEGAKRDLER------------------SLKRLGTDYIDLYQLHavdteeDLDQVFGPGGALE 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 915 GLHNLIVSGKVLYLGISD-TPAwivpkanMYARLTGKTPFVIYQGLWNILQR---DFERDIIPMAREEGLALALWSVLAS 990
Cdd:cd19100 124 ALLEAKEEGKIRFIGISGhSPE-------VLLRALETGEFDVVLFPINPAGDhidSFREELLPLAREKGVGVIAMKVLAG 196
|
...
gi 636624691 991 GKI 993
Cdd:cd19100 197 GRL 199
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
772-1093 |
1.26e-22 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 99.84 E-value: 1.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAgsigdkWEKYGmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDE--SSEEFIGEWMEA--RGVRDQMV 847
Cdd:cd19150 8 SGLKLPALSLGL------WHNFG-DDTPLETQRAILRTAFDLGITHFDLANNYGPPpgSAEENFGRILREdfAGYRDELI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 848 IATKytTNYkrgDDWQNikqkTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLY 927
Cdd:cd19150 81 ISTK--AGY---DMWPG----PYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 928 LGISDTPAwiVPKANMYARLTG-KTPFVIYQGLWNILQRDFERD-IIPMAREEGLALALWSVLASGkIRTDEEEerrrqt 1005
Cdd:cd19150 152 VGISSYSP--ERTREAAAILRElGTPLLIHQPSYNMLNRWVEESgLLDTLQELGVGCIAFTPLAQG-LLTDKYL------ 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1006 gekgeffamlsGAVRLTVRVGRTIVLPDWERTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKVEQ 1085
Cdd:cd19150 223 -----------NGIPEGSRASKERSLSPKMLTEANLNSIRALNEIAQKRG-QSLAQMALAWVLRDGRVTSALIGASRPEQ 290
|
....*...
gi 636624691 1086 LDDNIEAL 1093
Cdd:cd19150 291 LEENVGAL 298
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
772-1106 |
1.48e-22 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 100.83 E-value: 1.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAgsigdkWEKYG-MGAMDktSSFKLLDAYYDKGGNFIDTANGYQDE--SSEEFIGEWMEA--RGVRDQM 846
Cdd:PRK09912 21 SGLRLPALSLGL------WHNFGhVNALE--SQRAILRKAFDLGITHFDLANNYGPPpgSAEENFGRLLREdfAAYRDEL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 847 VIATKytTNYkrgDDWQNikqkTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVL 926
Cdd:PRK09912 93 IISTK--AGY---DMWPG----PYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 927 YLGISD-TPAWIVPKANMYARLtgKTPFVIYQGLWNILQRDFERD-IIPMAREEGLALALWSVLASGKIrtdeeeerrrq 1004
Cdd:PRK09912 164 YVGISSySPERTQKMVELLREW--KIPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLL----------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1005 tgeKGEFFAMLSGAVRLTVRVGRTIVLPDWERTEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKVE 1084
Cdd:PRK09912 231 ---TGKYLNGIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRG-QSMAQMALSWLLKDERVTSVLIGASRAE 306
|
330 340
....*....|....*....|...
gi 636624691 1085 QLDDNIEALS-IALSEEQVKYLE 1106
Cdd:PRK09912 307 QLEENVQALNnLTFSTEELAQID 329
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
773-1103 |
3.82e-22 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 98.01 E-value: 3.82e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGdkwekyGM-GAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaRGV-RDQMVIAT 850
Cdd:cd19163 10 GLKVSKLGFGASPLG------GVfGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKAL--KGIpRDSYYLAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 851 K---YTTNYKRGDDW--QNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMN----GLHNLIV 921
Cdd:cd19163 82 KvgrYGLDPDKMFDFsaERITK--------------SVEESLKRLGLDYIDIIQVHDIEFAPSLDQILNetlpALQKLKE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 922 SGKVLYLGISDTP----AWIVPKANM-------YARLTgktpfviyqglwniLQRDFERDIIPMAREEGLALALWSVLAS 990
Cdd:cd19163 148 EGKVRFIGITGYPldvlKEVLERSPVkidtvlsYCHYT--------------LNDTSLLELLPFFKEKGVGVINASPLSM 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 991 GkirtdeeeerrrqtgekgeffaMLSGAvrltvrvGrtivLPDWER-TEDEKKMCKALEEVAKQVGaKSIQAVAIAYVMQ 1069
Cdd:cd19163 214 G----------------------LLTER-------G----PPDWHPaSPEIKEACAKAAAYCKSRG-VDISKLALQFALS 259
|
330 340 350
....*....|....*....|....*....|....
gi 636624691 1070 KTPFVFPIIGGRKVEQLDDNIEALSIALSEEQVK 1103
Cdd:cd19163 260 NPDIATTLVGTASPENLRKNLEAAEEPLDAHLLA 293
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
757-931 |
6.41e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 96.50 E-value: 6.41e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 757 LPATPLGRhrklapiAGVRVSPIALGagsigdkwekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEW 836
Cdd:cd19105 1 MPYRTLGK-------TGLKVSRLGFG-------------GGGLPRESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEA 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 837 MeARGVRDQMVIATKYTTNYKRGDdwqnikqKTHYMGnnmkalhlSVAASLKKLRTDYIDILYVH---WWDFDTTMEEVM 913
Cdd:cd19105 61 L-KGLRRDKVFLATKASPRLDKKD-------KAELLK--------SVEESLKRLQTDYIDIYQLHgvdTPEERLLNEELL 124
|
170
....*....|....*...
gi 636624691 914 NGLHNLIVSGKVLYLGIS 931
Cdd:cd19105 125 EALEKLKKEGKVRFIGFS 142
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
794-1108 |
3.37e-21 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 96.81 E-value: 3.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 794 GMGAM-----DKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMeaRGVRDQMVIATKYTTNYKRGDDWQnikqk 868
Cdd:COG1453 17 GFGGMrlprkDEEEAEALIRRAIDNGINYIDTARGYGD--SEEFLGKAL--KGPRDKVILATKLPPWVRDPEDMR----- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 869 thymgnnmKALHlsvaASLKKLRTDYIDILYVH----WWDFDTTMEE--VMNGLHNLIVSGKVLYLGIS--DTPAWIVPK 940
Cdd:COG1453 88 --------KDLE----ESLKRLQTDYIDLYLIHglntEEDLEKVLKPggALEALEKAKAEGKIRHIGFSthGSLEVIKEA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 941 ANmyarlTGKTPFVIYQglWNILQRDF--ERDIIPMAREEGLALALWSVLASGKIrtdeeeerrrqtgekgeffAMLSGA 1018
Cdd:COG1453 156 ID-----TGDFDFVQLQ--YNYLDQDNqaGEEALEAAAEKGIGVIIMKPLKGGRL-------------------ANPPEK 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1019 VRLTVRVGRTIVlpDWertedekkmckaleevakqvgaksiqavAIAYVMQKTPFVFPIIGGRKVEQLDDNIEALS--IA 1096
Cdd:COG1453 210 LVELLCPPLSPA--EW----------------------------ALRFLLSHPEVTTVLSGMSTPEQLDENLKTADnlEP 259
|
330
....*....|..
gi 636624691 1097 LSEEQVKYLESI 1108
Cdd:COG1453 260 LTEEELAILERL 271
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
773-1106 |
8.89e-20 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 90.32 E-value: 8.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGdkwekyGMGAMDKT---SSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGvRDQMVIA 849
Cdd:cd19137 1 GEKIPALGLGTWGIG------GFLTPDYSrdeEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFP-REDLFIV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 850 TK-YTTNYKRGDdwqnikqkthymgnnmkaLHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYL 928
Cdd:cd19137 74 TKvWPTNLRYDD------------------LLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 929 GISDTPAWIVPKANMYARltgkTPFVIYQGLWNILQRDFERD-IIPMAREEGLALALWSVLAsgkirtdeeeerrrqtge 1007
Cdd:cd19137 136 GVSNFNRRLLEEAISKSQ----TPIVCNQVKYNLEDRDPERDgLLEYCQKNGITVVAYSPLR------------------ 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1008 kgeffamlsgavrltvrvgRTIVLpdwerTEDEkkmckaLEEVAKQVGaKSIQAVAIAYVMQKtPFVFPIIGGRKVEQLD 1087
Cdd:cd19137 194 -------------------RGLEK-----TNRT------LEEIAKNYG-KTIAQIALAWLIQK-PNVVAIPKAGRVEHLK 241
|
330
....*....|....*....
gi 636624691 1088 DNIEALSIALSEEQVKYLE 1106
Cdd:cd19137 242 ENLKATEIKLSEEEMKLLD 260
|
|
| PTZ00467 |
PTZ00467 |
40S ribosomal protein S30; Provisional |
1146-1203 |
2.22e-19 |
|
40S ribosomal protein S30; Provisional
Pssm-ID: 185646 Cd Length: 66 Bit Score: 83.28 E-value: 2.22e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 636624691 1146 LHGSLARAGKVKSQTPKVEKQEKKKTPKGRAKKRILYNRRFVNVTLLPNGKRKMNANP 1203
Cdd:PTZ00467 4 IHGSLARAGKVKNQTPKVAKQEKPKQPRGRALKRLKYTRRFLAKTVKPGEKVHMNKQP 61
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
780-1106 |
4.23e-19 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 88.46 E-value: 4.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 780 ALGAGSigdkWekyGMG--AMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaRGVRDQMVIATK-YTTNY 856
Cdd:cd19138 13 ALGQGT----W---YMGedPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAI--RGRRDKVFLVSKvLPSNA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 857 KRgddwqnikqkthymgnnmKALHLSVAASLKKLRTDYIDiLYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGIS--DTp 934
Cdd:cd19138 84 SR------------------QGTVRACERSLRRLGTDYLD-LYLLHWRGGVPLAETVAAMEELKKEGKIRAWGVSnfDT- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 935 awivpkANMYA--RLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRtdeeeerrrqtgekgeff 1012
Cdd:cd19138 144 ------DDMEElwAVPGGGNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLL------------------ 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1013 amlsgavrltvrvgRTIVLPDwertedekkmcKALEEVAKQVGAkSIQAVAIAYVMqKTPFVFPIIGGRKVEQLDDNIEA 1092
Cdd:cd19138 200 --------------RRGLLEN-----------PTLKEIAARHGA-TPAQVALAWVL-RDGNVIAIPKSGSPEHARENAAA 252
|
330
....*....|....
gi 636624691 1093 LSIALSEEQVKYLE 1106
Cdd:cd19138 253 ADLELTEEDLAELD 266
|
|
| Pkinase_fungal |
pfam17667 |
Fungal protein kinase; This domain appears to be a variant of the protein kinase domain that ... |
132-431 |
6.40e-19 |
|
Fungal protein kinase; This domain appears to be a variant of the protein kinase domain that is found in a variety of fungal species.
Pssm-ID: 435959 Cd Length: 387 Bit Score: 90.51 E-value: 6.40e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 132 RALRRYARSFLSNNPDRTgiYCLDLVVDG--FQVYYADFMEFACTEPMAWDDDGLKVLMSYV-YSLYDPPARHYtrDPTM 208
Cdd:pfam17667 44 LQLARYAREVFAAQPTRR--FVHGFTLCGslMRLWVFDRSGAISSESFDIHDDPEKFIRVVLgFLFMNDDELGF--DPTI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 209 V--WREGHKRSTMSIVSNGEVFPDVRCIFAQPP-GGKGTQVFIAgRRPTRQA--IIKECYRgppfpyQTERPAEGfmevE 283
Cdd:pfam17667 120 TlrPDGGRSIEIASENGNGEKLELEEPIFRQHAiVGRGTTCWRA-RRLDSEWgyVIKDSWQ------DISRRPEA----D 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 284 ILTKIHQHGfVPGVVRLAHHELVPLGG---------------------PGQVEITTVHNSP----------------RVK 326
Cdd:pfam17667 189 LLKLATERG-VEGVARLVHHETVQVDGkdddilanirrgldftkahsfRRTRKSISLSSARkktsslppskrsrlenRVH 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 327 HRMVLADVGESLLQAKSVNDLLKAVYDALEVHRTLANRARVLHRDMSINNILMYprcaqatnaqvleglppfiddvldEP 406
Cdd:pfam17667 268 RRLVVSPFGKPIYEFSSPLELLEALRDAIKAHRSLYEKAGILHRDISINNIMIT------------------------EP 323
|
330 340
....*....|....*....|....*
gi 636624691 407 DRVPGervPRCLLIDFDLAMTLDDP 431
Cdd:pfam17667 324 EQEGG---RRGFLIDLDLAKELSRS 345
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
777-1107 |
2.54e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 83.92 E-value: 2.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKWEKYGM---GAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeARGVRDQMVIATKYT 853
Cdd:cd19103 5 PKIALGTWSWGSGGAGGDQvfgNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFL-KRYPREDYIISTKFT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 854 tnykrgddwqniKQKTHYMGNNMKAlhlSVAASLKKLRTDYIDILYVHwwdFDTTMEEVMNGLHNLIVSGKVLYLGISDT 933
Cdd:cd19103 84 ------------PQIAGQSADPVAD---MLEGSLARLGTDYIDIYWIH---NPADVERWTPELIPLLKSGKVKHVGVSNH 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 934 PAWIVPKANmyaRLTGKTPFVIY--QGLWNILQRDFERD-IIPMAREEGLALALWSVLASGKIrtdeeeerrrqTGEKGE 1010
Cdd:cd19103 146 NLAEIKRAN---EILAKAGVSLSavQNHYSLLYRSSEEAgILDYCKENGITFFAYMVLEQGAL-----------SGKYDT 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1011 FFAMLSGAVRLTVRVGrtiVLPDWERTEDekkmckALEEVAKQVGAkSIQAVAIAYVMQKTpfVFPIIGGRKVEQLDDNI 1090
Cdd:cd19103 212 KHPLPEGSGRAETYNP---LLPQLEELTA------VMAEIGAKHGA-SIAQVAIAWAIAKG--TTPIIGVTKPHHVEDAA 279
|
330
....*....|....*..
gi 636624691 1091 EALSIALSEEQVKYLES 1107
Cdd:cd19103 280 RAASITLTDDEIKELEQ 296
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
772-1113 |
2.85e-17 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 84.37 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG-VRDQMVIAT 850
Cdd:cd19158 9 SGLRVSCLGLGT------WVTFGGQITDEMAE-HLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGwRRSSLVITT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 851 KYTtnykrgddWQNiKQKTHyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGI 930
Cdd:cd19158 82 KIF--------WGG-KAETE-RGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 931 SDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLASGKIrtdeeeerrrqtgeKG 1009
Cdd:cd19158 152 SRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREkVEVQLPELFHKIGVGAMTWSPLACGIV--------------SG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1010 EFFAMLSGAVRLTVRVGRTI---VLPDWERTEDEKkmCKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQL 1086
Cdd:cd19158 218 KYDSGIPPYSRASLKGYQWLkdkILSEEGRRQQAK--LKELQAIAERLGC-TLPQLAIAWCLRNEGVSSVLLGASNAEQL 294
|
330 340
....*....|....*....|....*....
gi 636624691 1087 DDNIEALSI--ALSEEQVKYLESILPFEP 1113
Cdd:cd19158 295 MENIGAIQVlpKLSSSIVHEIDSILGNKP 323
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
764-1113 |
6.86e-17 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 83.50 E-value: 6.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG-V 842
Cdd:cd19160 4 KYRNLGK-SGLRVSCLGLGT------WVTFGSQISDETAE-DLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGwR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 RDQMVIATKYttnYKRGddwqnikQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19160 76 RSSYVVTTKI---YWGG-------QAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLASGKIrtdeeeer 1001
Cdd:cd19160 146 GMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREkVEMQLPELYHKIGVGSVTWSPLACGLI-------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1002 rrqtgeKGEFFAMLSGAVRLTVRVGRTivLPDWERTEDEKKM---CKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPII 1078
Cdd:cd19160 218 ------TGKYDGRVPDTCRAAVKGYQW--LKEKVQSEEGKKQqakVKELHPIADRLGC-TVAQLAIAWCLRSEGVSSVLL 288
|
330 340 350
....*....|....*....|....*....|....*..
gi 636624691 1079 GGRKVEQLDDNIEALSI--ALSEEQVKYLESILPFEP 1113
Cdd:cd19160 289 GVSSAEQLIENLGSIQVlsQLTPQTVMEIDALLGNKP 325
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
764-1113 |
7.31e-17 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 83.17 E-value: 7.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG-V 842
Cdd:cd19159 2 KYRNLGK-SGLRVSCLGLGT------WVTFGGQISDEVAE-RLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGwR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 RDQMVIATKYttnYKRGddwqniKQKTHyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19159 74 RSSLVITTKL---YWGG------KAETE-RGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQ 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLASGKIrtdeeeer 1001
Cdd:cd19159 144 GMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREkVEVQLPELYHKIGVGAMTWSPLACGII-------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1002 rrqtgeKGEFFAMLSGAVRLTVRVGRTivLPDWERTEDEKKMCKALEE---VAKQVGAkSIQAVAIAYVMQKTPFVFPII 1078
Cdd:cd19159 216 ------SGKYGNGVPESSRASLKCYQW--LKERIVSEEGRKQQNKLKDlspIAERLGC-TLPQLAVAWCLRNEGVSSVLL 286
|
330 340 350
....*....|....*....|....*....|....*..
gi 636624691 1079 GGRKVEQLDDNIEALSI--ALSEEQVKYLESILPFEP 1113
Cdd:cd19159 287 GSSTPEQLIENLGAIQVlpKMTSHVVNEIDNILRNKP 323
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
818-1117 |
9.67e-17 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 81.64 E-value: 9.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQdesSEEFIGEWMEARGV-RDQMVIATK-YTTNYKRGDdwqnikqkthymgnnmkALHlSVAASLKKLRTDYI 895
Cdd:COG0656 35 IDTAAMYG---NEEGVGEAIAASGVpREELFVTTKvWNDNHGYDD-----------------TLA-AFEESLERLGLDYL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 896 DILYVHwWDFDTTMEEVMNGLHNLIVSGKVLYLGISdtpawivpkaNMYA-------RLTGKTPFVIyQGLWNILQRdfE 968
Cdd:COG0656 94 DLYLIH-WPGPGPYVETWRALEELYEEGLIRAIGVS----------NFDPehleellAETGVKPAVN-QVELHPYLQ--Q 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 969 RDIIPMAREEGLALALWSVLASGKIRTDeeeerrrqtgekgeffamlsgavrltvrvgrtivlpdwertedekkmcKALE 1048
Cdd:COG0656 160 RELLAFCREHGIVVEAYSPLGRGKLLDD------------------------------------------------PVLA 191
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636624691 1049 EVAKQVGaKSIQAVAIAYVMQKTpfVFPIIGGRKVEQLDDNIEALSIALSEEQVKYLESILPFEPGFPH 1117
Cdd:COG0656 192 EIAEKHG-KTPAQVVLRWHLQRG--VVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGPD 257
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
777-1096 |
1.39e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 81.03 E-value: 1.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKwekYGM----GAMDKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMEARgvrDQMVIATKy 852
Cdd:cd19097 1 SKLALGTAQFGLD---YGIanksGKPSEKEAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRL---DKFKIITK- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 853 ttnykrgddwqnIKQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWW-DFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19097 72 ------------LPPLKEDKKEDEAAIEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVS 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 932 dtpawivpkanMYA-----RLTGKTPFVIYQGLWNIL-QRDFERDIIPMAREEGLALALWSVLasgkirtdeeeerrrqt 1005
Cdd:cd19097 140 -----------VYSpeeleKALESFKIDIIQLPFNILdQRFLKSGLLAKLKKKGIEIHARSVF----------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1006 gekgeffamLSGAVrLTVRVGRTIVLPDWertedeKKMCKALEEVAKQVGAKSIQAvAIAYVMQKtPFVFPI-IGGRKVE 1084
Cdd:cd19097 192 ---------LQGLL-LMEPDKLPAKFAPA------KPLLKKLHELAKKLGLSPLEL-ALGFVLSL-PEIDKIvVGVDSLE 253
|
330
....*....|..
gi 636624691 1085 QLDDNIEALSIA 1096
Cdd:cd19097 254 QLKEIIAAFKKP 265
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
764-1108 |
1.61e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 81.93 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAGSIGdkwekygmGAMDKTS---SFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeaR 840
Cdd:cd19104 1 KYRRFGR-TGLKVSELTFGGGGIG--------GLMGRTTreeQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRAL--K 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 841 GVRDQMVIATKYTTnykRGDDWQNIKQKthymgnnmkaLHLSVAASLKKLRTDYIDILYVH------------------W 902
Cdd:cd19104 70 GLPAGPYITTKVRL---DPDDLGDIGGQ----------IERSVEKSLKRLKRDSVDLLQLHnrigderdkpvggtlsttD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 903 WDFDttmEEVMNGLHNLIVSGKVLYLGISdtpAWIVPKAnmYARLTGKTPFVIYQGLWNIL-----------QRDFE-RD 970
Cdd:cd19104 137 VLGL---GGVADAFERLRSEGKIRFIGIT---GLGNPPA--IRELLDSGKFDAVQVYYNLLnpsaaearprgWSAQDyGG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 971 IIPMAREEGLALALWSVLASGKIRTdeeeerrrqtgekgeffamlsgavrlTVRVGRTIVLPDWERTEDEKKMCKALEEV 1050
Cdd:cd19104 209 IIDAAAEHGVGVMGIRVLAAGALTT--------------------------SLDRGREAPPTSDSDVAIDFRRAAAFRAL 262
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1051 AKQVGAkSIQAVAIAYVMqKTPFVFPIIGGRK-VEQLDDNIEALSIA-LSEEQVKYLESI 1108
Cdd:cd19104 263 AREWGE-TLAQLAHRFAL-SNPGVSTVLVGVKnREELEEAVAAEAAGpLPAENLARLEAL 320
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
764-1113 |
1.36e-15 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 79.43 E-value: 1.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG-V 842
Cdd:cd19142 2 KYRNLGK-SGLRVSNVGLGT------WSTFSTAISEEQAE-EIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGwK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 RDQMVIATKYTTNYKRGDdwqnikqkthyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19142 74 RSSYIVSTKIYWSYGSEE-----------RGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDN 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRD-FERDIIPMAREEGLALALWSVLASGkirTDEEEER 1001
Cdd:cd19142 143 GLIMYWGTSRWSPVEIMEAFSIARQFNCPTPICEQSEYHMFCREkMELYMPELYNKVGVGLITWSPLSLG---LDPGISE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1002 RRQTGEKGEFFAmlsGAVRLTVRVGRTIVlpdwERTEDEKKMCKALEEVAKQVGAKSIQaVAIAYVMQKTPFVFPIIGGR 1081
Cdd:cd19142 220 ETRRLVTKLSFK---SSKYKVGSDGNGIH----EETRRASHKLRELSLIAERLGCDLTQ-LLIAWSLKNENVQCVLIGAS 291
|
330 340 350
....*....|....*....|....*....|....
gi 636624691 1082 KVEQLDDNIEALSI--ALSEEQVKYLESILPFEP 1113
Cdd:cd19142 292 SLEQLYSQLNSLQLlpKLNSAVMEELERILDNKP 325
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
793-1107 |
2.01e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 78.93 E-value: 2.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 793 YGMGAMdKTSSFKLLDAYYDKGGNFIDTANGYQdeSSEEFIGEWMEARGV-RDQMVIATK----YTTNYKRGDDWQNIKQ 867
Cdd:cd19098 28 RSVEAM-RAHTHAVLDAAWAAGVRYFDAARSYG--RAEEFLGSWLRSRNIaPDAVFVGSKwgytYTADWQVDAAVHEVKD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 868 KTHymgNNMKALHLSVAASLKklrtDYIDILYVHWWDFDTTM---EEVMNGLHNLIVSGKVLYLGISDTPAWIVPKANMY 944
Cdd:cd19098 105 HSL---ARLLKQWEETRSLLG----KHLDLYQIHSATLESGVledADVLAALAELKAEGVKIGLSLSGPQQAETLRRALE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 945 ARLTGKTPFVIYQGLWNIlqrdFERDIIP---MAREEGLALALWSVLASGkirtdeeeerrrqtgekgeffamlsgavRL 1021
Cdd:cd19098 178 IEIDGARLFDSVQATWNL----LEQSAGEaleEAHEAGMGVIVKEALANG----------------------------RL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1022 TVRVGRTIVLPDWErtedekkmckALEEVAKQVGAkSIQAVAIAYVMQKtPFVfPII--GGRKVEQLDDNIEALSIALSE 1099
Cdd:cd19098 226 TDRNPSPELAPLMA----------VLKAVADRLGV-TPDALALAAVLAQ-PFV-DVVlsGAATPEQLRSNLRALDVSLDL 292
|
....*...
gi 636624691 1100 EQVKYLES 1107
Cdd:cd19098 293 ELLAALAD 300
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
764-1095 |
7.17e-15 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 77.10 E-value: 7.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPiAGVRVSPIALGAgsigdkWEKYGMGAMDKTSSfKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARG-V 842
Cdd:cd19141 1 PYRNLGK-SGLRVSCLGLGT------WVTFGSQISDEVAE-ELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGwR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 RDQMVIATKYTtnykrgddWQNiKQKTHyMGNNMKALHLSVAASLKKLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVS 922
Cdd:cd19141 73 RSSYVITTKIF--------WGG-KAETE-RGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 923 GKVLYLGISDTPAWIVPKANMYARLTGKTPFVIYQGLWNILQRDFERDIIP-MAREEGLALALWSVLASGKIrtdeeeer 1001
Cdd:cd19141 143 GMAMYWGTSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPeLFHKIGVGAMTWSPLACGIL-------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1002 rrqTGEKGEFF-----AMLSGAVRLTVRVgrtivlpdweRTEDEKKMCKALEEV---AKQVGAKSIQaVAIAYVMQKTPF 1073
Cdd:cd19141 215 ---SGKYDDGVpeysrASLKGYQWLKEKI----------LSEEGRRQQAKLKELqiiADRLGCTLPQ-LAIAWCLKNEGV 280
|
330 340
....*....|....*....|..
gi 636624691 1074 VFPIIGGRKVEQLDDNIEALSI 1095
Cdd:cd19141 281 SSVLLGASSTEQLYENLQAIQV 302
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
818-1103 |
8.51e-15 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 75.76 E-value: 8.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQdesSEEFIGEWMEARGV-RDQMVIATK-YTTNYKRGDdwqnikqkthymgnnmkaLHLSVAASLKKLRTDYI 895
Cdd:cd19140 38 IDTAQMYG---NEAQVGEAIAASGVpRDELFLTTKvWPDNYSPDD------------------FLASVEESLRKLRTDYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 896 DILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPAWIVPKanmyARLTGKTPFVIYQGLWNILQRdfERDIIPMA 975
Cdd:cd19140 97 DLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLRE----AVELSEAPLFTNQVEYHPYLD--QRKLLDAA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 976 REEGLALALWSVLASGKIRTDEeeerrrqtgekgeffamlsgavrltvrvgrtivlpdwertedekkmckALEEVAKQVG 1055
Cdd:cd19140 171 REHGIALTAYSPLARGEVLKDP------------------------------------------------VLQEIGRKHG 202
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 636624691 1056 AKSIQaVAIAYVMQKTPfVFPIIGGRKVEQLDDNIEALSIALSEEQVK 1103
Cdd:cd19140 203 KTPAQ-VALRWLLQQEG-VAAIPKATNPERLEENLDIFDFTLSDEEMA 248
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
811-1103 |
8.83e-14 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 72.30 E-value: 8.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 811 YDKGGNFIDTANGYQDEsseEFIGEWMEARGV-RDQMVIATK-YTTNYKRGDdwqnIKQkthymgnnmkalhlSVAASLK 888
Cdd:cd19073 24 LELGYRHIDTAEIYNNE---AEVGEAIAESGVpREDLFITTKvWRDHLRPED----LKK--------------SVDRSLE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 889 KLRTDYIDILYVHWWDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPAWIVPKAnmyARLTGKTPFViyqglwniLQRDF- 967
Cdd:cd19073 83 KLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEA---LDISPLPIAV--------NQVEFh 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 968 ----ERDIIPMAREEGLALALWSVLASGKIRTDeeeerrrqtgekgeffamlsgavrltvrvgrtivlpdwertedekkm 1043
Cdd:cd19073 152 pflyQAELLEYCRENDIVITAYSPLARGEVLRD----------------------------------------------- 184
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1044 cKALEEVAKQVGAKSIQaVAIAYVMQKTpfVFPIIGGRKVEQLDDNIEALSIALSEEQVK 1103
Cdd:cd19073 185 -PVIQEIAEKYDKTPAQ-VALRWLVQKG--IVVIPKASSEDHLKENLAIFDWELTSEDVA 240
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
774-931 |
2.57e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 72.35 E-value: 2.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 774 VRVSPIALGAgsigdkwekYGMGAMDKTSS--FKLLDAYYDKGGNFIDTANGYQDESSEEFIG----EWMEARGV-RDQM 846
Cdd:cd19099 1 LTLSSLGLGT---------YRGDSDDETDEeyREALKAALDSGINVIDTAINYRGGRSERLIGkalrELIEKGGIkRDEV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 847 VIATK---YTTNYKRGDDWQNIKQK--------THYMGNNMKALH-----LSVAASLKKLRTDYIDILYVH--------- 901
Cdd:cd19099 72 VIVTKagyIPGDGDEPLRPLKYLEEklgrglidVADSAGLRHCISpayleDQIERSLKRLGLDTIDLYLLHnpeeqllel 151
|
170 180 190
....*....|....*....|....*....|.
gi 636624691 902 -WWDFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19099 152 gEEEFYDRLEEAFEALEEAVAEGKIRYYGIS 182
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
773-1109 |
2.72e-13 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 72.12 E-value: 2.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 773 GVRVSPIALGAGSIGDKWekygmGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGV-RDQMVIATK 851
Cdd:PLN02587 8 GLKVSSVGFGASPLGSVF-----GPVSEEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGIpREKYVVSTK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 852 yTTNYKRGDDWqnikqkthymgnNMKALHLSVAASLKKLRTDYIDILYVHWWDF---DTTMEEVMNGLHNLIVSGKVLYL 928
Cdd:PLN02587 83 -CGRYGEGFDF------------SAERVTKSVDESLARLQLDYVDILHCHDIEFgslDQIVNETIPALQKLKESGKVRFI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 929 GISDTPAWIVPKanMYARLTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRtdeeeerrrqtgEK 1008
Cdd:PLN02587 150 GITGLPLAIFTY--VLDRVPPGTVDVILSYCHYSLNDSSLEDLLPYLKSKGVGVISASPLAMGLLT------------EN 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1009 GEffamlsgavrltvrvgrtivlPDWERTEDE-KKMCKALEEVAKQVGaKSIQAVAIAYVMQKTPFVFPIIGGRKVEQLD 1087
Cdd:PLN02587 216 GP---------------------PEWHPAPPElKSACAAAATHCKEKG-KNISKLALQYSLSNKDISTTLVGMNSVQQVE 273
|
330 340
....*....|....*....|....*.
gi 636624691 1088 DN----IEALSIALSEEQVKYLESIL 1109
Cdd:PLN02587 274 ENvaaaTELETSGIDEELLSEVEAIL 299
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
779-1100 |
3.11e-13 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 71.62 E-value: 3.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 779 IALGAGSIGDkwekygMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeARGVRDQMVIATKYTTNYKR 858
Cdd:cd19162 3 LGLGAASLGN------LARAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAAL-ARHPRAEYVVSTKVGRLLEP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 859 GDDWQNiKQKTHYMGNNMKALHLSVAASLKKLRTDYIDILYVHWWD--FDTTMEEVMNGLHNLIVSGKVLYLGISDTPaw 936
Cdd:cd19162 76 GAAGRP-AGADRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVGVTD-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 937 iVPKANMYARlTGKTPFVIYQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIRTDEEeerrrqtgeKGEFFAMls 1016
Cdd:cd19162 153 -WAALLRAAR-RADVDVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDP---------AGDRYDY-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1017 GAVrltvrvgrtivlpdwerTEDEKKMCKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQLDDNIEALSIA 1096
Cdd:cd19162 220 RPA-----------------TPEVLARARRLAAVCRRYGV-PLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTP 281
|
....
gi 636624691 1097 LSEE 1100
Cdd:cd19162 282 IPAE 285
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
807-1109 |
4.11e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 71.47 E-value: 4.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 807 LDAYYDKGGNFIDTANGYQdeSSEEFIGE----WMEARGVRDQMVIATKYTTNYKRGD-DWQNIKQkthymgnnmkalhl 881
Cdd:cd19101 29 MAAYVDAGLTTFDCADIYG--PAEELIGEfrkrLRRERDAADDVQIHTKWVPDPGELTmTRAYVEA-------------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 882 SVAASLKKLRTDYIDILYVHWWDF-DTTMEEVMNGLHNLIVSGKVLYLGIS--DTPawivpkaNMYARLTGKTPFVIYQG 958
Cdd:cd19101 93 AIDRSLKRLGVDRLDLVQFHWWDYsDPGYLDAAKHLAELQEEGKIRHLGLTnfDTE-------RLREILDAGVPIVSNQV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 959 LWNILQRDFERDIIPMAREEGLALALWSVLASGKIrTDEEEERRRQTGEKGEFFAMLSGavRLTVRVGrtivlPDWERTE 1038
Cdd:cd19101 166 QYSLLDRRPENGMAALCEDHGIKLLAYGTLAGGLL-SEKYLGVPEPTGPALETRSLQKY--KLMIDEW-----GGWDLFQ 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636624691 1039 DekkMCKALEEVAKQVGAkSIQAVAIAYVMQKTPFVFPIIGGRKVEQLDDNIEALSIALSEEQVKYLESIL 1109
Cdd:cd19101 238 E---LLRTLKAIADKHGV-SIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDAVL 304
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
771-938 |
1.10e-12 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 70.26 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 771 IAGVRVSPIALGAGSIGdkwEKYGMGaMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGV-RDQMVIA 849
Cdd:cd19153 7 IALGNVSPVGLGTAALG---GVYGDG-LEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVpRSSYTVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 850 TKYTtnykrgddwqNIKQKTH-YMGNNMKAlhlSVAASLKKLRTDYIDILYVH---WWDFDTTMEEVMNGLHNLIVSGKV 925
Cdd:cd19153 83 TKVG----------RYRDSEFdYSAERVRA---SVATSLERLHTTYLDVVYLHdieFVDYDTLVDEALPALRTLKDEGVI 149
|
170
....*....|....*..
gi 636624691 926 LYLGIS----DTPAWIV 938
Cdd:cd19153 150 KRIGIAgyplDTLTRAT 166
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
792-902 |
5.71e-12 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 67.20 E-value: 5.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 792 KYGMGAM----------DKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMeARGVRDQMVIATKYTTN-YKRGD 860
Cdd:cd19096 2 VLGFGTMrlpesdddsiDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEAL-KEGPREKFYLATKLPPWsVKSAE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 636624691 861 DWQNIkqkthymgnnmkalhlsVAASLKKLRTDYIDILYVHW 902
Cdd:cd19096 81 DFRRI-----------------LEESLKRLGVDYIDFYLLHG 105
|
|
| RPS30 |
COG4919 |
Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 ... |
1147-1187 |
2.42e-11 |
|
Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 is part of the Pathway/BioSystem: Archaeal ribosomal proteins
Pssm-ID: 443947 Cd Length: 52 Bit Score: 59.64 E-value: 2.42e-11
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 636624691 1147 HGSLARAGKVKSQTPKVEKQEKKKTPKgRAKKRILYNRRFV 1187
Cdd:COG4919 4 HGSLTKAGKVRSQTPKIPAKPRKNPPP-RVRNRREYRKRFV 43
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
772-1106 |
2.64e-11 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 66.11 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 772 AGVRVSPIALGAgsigdkwekygMG---AMDKTS---SFKLLDAYYDKGGNFIDTANGY---QDESSEEFIGEWMEARG- 841
Cdd:cd19077 1 NGKLVGPIGLGL-----------MGltwRPNPTPdeeAFETMKAALDAGSNLWNGGEFYgppDPHANLKLLARFFRKYPe 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 842 VRDQMVIATKYTTNYKrgddwqnikqkTHYMGNNMKALHLSVAASLKKLR-TDYIDILYVHWWDFDTTMEEVMNGLHNLI 920
Cdd:cd19077 70 YADKVVLSVKGGLDPD-----------TLRPDGSPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 921 VSGKVLYLGISDtpawivPKANMYARLTGKTPFVIYQ---GLWNilqRD-FERDIIPMAREEGLALALWSVLASGkirtd 996
Cdd:cd19077 139 KEGKIRGIGLSE------VSAETIRRAHAVHPIAAVEveySLFS---REiEENGVLETCAELGIPIIAYSPLGRG----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 997 eeeerrrqtgekgeffaMLSGAV--RLTVRVGRTIVLPDweRTEDE-----KKMCKALEEVAKQVGAkSIQAVAIAYVM- 1068
Cdd:cd19077 205 -----------------LLTGRIksLADIPEGDFRRHLD--RFNGEnfeknLKLVDALQELAEKKGC-TPAQLALAWILa 264
|
330 340 350
....*....|....*....|....*....|....*...
gi 636624691 1069 QKTPFVFPIIGGRKVEQLDDNIEALSIALSEEQVKYLE 1106
Cdd:cd19077 265 QSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
793-1106 |
6.35e-11 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 64.04 E-value: 6.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 793 YGMGAMDKTSSFKLLDAYYDKGGNFIDTANGYQDEsseEFIGEWMEARGV-RDQMVIATKYTTNYKRGDdwqNIKQkthy 871
Cdd:cd19071 6 LGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNE---AEVGEAIRESGVpREELFITTKLWPTDHGYE---RVRE---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 872 mgnnmkalhlSVAASLKKLRTDYIDILYVHW------WDFDTTMEEVMNGLHNLIVSGKVLYLGISdtpawivpkaNMYA 945
Cdd:cd19071 76 ----------ALEESLKDLGLDYLDLYLIHWpvpgkeGGSKEARLETWRALEELVDEGLVRSIGVS----------NFNV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 946 RL-------TGKTPFV----IYQGLWNILQRDF--ERDIIPMAreeglalalWSVLASGKIRtdeeeerrrqtgekgeff 1012
Cdd:cd19071 136 EHleellaaARIKPAVnqieLHPYLQQKELVEFckEHGIVVQA---------YSPLGRGRRP------------------ 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 1013 amlsgavrltvrvgrtiVLPDwertedekkmcKALEEVAKQVGaKSIQAVAIAYVMQKTpfVFPIIGGRKVEQLDDNIEA 1092
Cdd:cd19071 189 -----------------LLDD-----------PVLKEIAKKYG-KTPAQVLLRWALQRG--VVVIPKSSNPERIKENLDV 237
|
330
....*....|....
gi 636624691 1093 LSIALSEEQVKYLE 1106
Cdd:cd19071 238 FDFELSEEDMAAID 251
|
|
| PRK09336 |
PRK09336 |
30S ribosomal protein S30e; Provisional |
1147-1190 |
1.74e-09 |
|
30S ribosomal protein S30e; Provisional
Pssm-ID: 181786 Cd Length: 50 Bit Score: 54.41 E-value: 1.74e-09
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 636624691 1147 HGSLARAGKVKSQTPKVEKQEKKKTPKgRAKKRILYNRRFVNVT 1190
Cdd:PRK09336 4 HGSLTKAGKVRSQTPKIPPKPKKNEVP-RVRNRREYERRVLKAR 46
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
777-1100 |
6.50e-09 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 58.88 E-value: 6.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 777 SPIALGAGSIGDKWEkygmgAMDKTSSFKLLDAYYDKGGNFIDTANGYQDESSEEFIGEWMEARGvRDQMVIATKYTTNY 856
Cdd:cd19161 1 SELGLGTAGLGNLYT-----AVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKP-RDEFVLSTKVGRLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 857 KRGDDWQNIKQKTHYMGNNMKALH--------LSVAASLKKLRTDYIDILYVHWWD------------FDTTMEEVMNGL 916
Cdd:cd19161 75 KPAREGSVPDPNGFVDPLPFEIVYdysydgimRSFEDSLQRLGLNRIDILYVHDIGvythgdrkerhhFAQLMSGGFKAL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 917 HNLIVSG--KVLYLGISDTPawIVPKANMYARLTGktpFVIyQGLWNILQRDFERDIIPMAREEGLALALWSVLASGKIR 994
Cdd:cd19161 155 EELKKAGviKAFGLGVNEVQ--ICLEALDEADLDC---FLL-AGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 995 TDEEEERRRQTGEkgeffamlsgavrltvrVGRTIVlpdwERTEDEKKMCKALeEVAkqvgaksIQAVAIAYVMQKTPFV 1074
Cdd:cd19161 229 TGTKSGAKFNYGD-----------------APAEII----SRVMEIEKICDAY-NVP-------LAAAALQFPLRHPAVA 279
|
330 340
....*....|....*....|....*.
gi 636624691 1075 FPIIGGRKVEQLDDNIEALSIALSEE 1100
Cdd:cd19161 280 SVLTGARNPAQLRQNVEAFQTDIPEE 305
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
818-1100 |
2.96e-08 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 56.21 E-value: 2.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDESSeefIGEWMEARGV-RDQMVIATK-YTTNYKRGddwqnikqkthymgnnmkALHLSVAASLKKLRTDYI 895
Cdd:cd19139 31 IDTAQIYDNEAA---VGQAIAESGVpRDELFITTKiWIDNLSKD------------------KLLPSLEESLEKLRTDYV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 896 DILYVHW--WDFDTTMEEVMNGLHNLIVSGKVLYLGISDTPAWIVPKANmyaRLTGKTPFVIYQ-GLWNILQrdfERDII 972
Cdd:cd19139 90 DLTLIHWpsPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAI---AVVGAGAIATNQiELSPYLQ---NRKLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 973 PMAREEGLALALWSVLASGKIRTDeeeerrrqtgekgeffamlsgavrltvrvgrtivlpdwertedekkmcKALEEVAK 1052
Cdd:cd19139 164 AHCKQHGIHVTSYMTLAYGKVLDD------------------------------------------------PVLAAIAE 195
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 636624691 1053 QVGAKSIQaVAIAYVMQKTPFVFPiiGGRKVEQLDDNIEALSIALSEE 1100
Cdd:cd19139 196 RHGATPAQ-IALAWAMARGYAVIP--SSTKREHLRSNLLALDLTLDAD 240
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
818-1100 |
5.54e-08 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 55.42 E-value: 5.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDESSeefIGEWMEARGV-RDQMVIATK-YTTNYKRGddwqnikqkthymgnnmkALHLSVAASLKKLRTDYI 895
Cdd:PRK11172 33 IDTAQIYDNEAA---VGQAIAESGVpRDELFITTKiWIDNLAKD------------------KLIPSLKESLQKLRTDYV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 896 DILYVHW--WDFDTTMEEVMNGLHNLIVSGKVLYLGISdtpawivpkaNMYARLTGKTPFVIYQGlwNILQRDFE----- 968
Cdd:PRK11172 92 DLTLIHWpsPNDEVSVEEFMQALLEAKKQGLTREIGIS----------NFTIALMKQAIAAVGAE--NIATNQIElspyl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 969 --RDIIPMAREEGLALALWSVLASGKirtdeeeerrrqtgekgeffamlsgavrltvrvgrtiVLPDwertedekkmcKA 1046
Cdd:PRK11172 160 qnRKVVAFAKEHGIHVTSYMTLAYGK-------------------------------------VLKD-----------PV 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 636624691 1047 LEEVAKQVGAKSIQaVAIAYVMQKTPFVFPiiGGRKVEQLDDNIEALSIALSEE 1100
Cdd:PRK11172 192 IARIAAKHNATPAQ-VILAWAMQLGYSVIP--SSTKRENLASNLLAQDLQLDAE 242
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
814-932 |
5.05e-06 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 49.71 E-value: 5.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 814 GGNFIDTANGYQDESSeefIGEWMEARGV-RDQMVIATK-YTTNYkrGDDwqnikqkthymgnnmKALHlSVAASLKKLR 891
Cdd:cd19127 35 GYRLIDTAAAYGNERE---VGEGIRRSGVdRSDIFVTTKlWISDY--GYD---------------KALR-GFDASLRRLG 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 636624691 892 TDYIDILYVHW---WDFDTTMeEVMNGLHNLIVSGKVLYLGISD 932
Cdd:cd19127 94 LDYVDLYLLHWpvpNDFDRTI-QAYKALEKLLAEGRVRAIGVSN 136
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
779-931 |
1.40e-05 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 48.00 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 779 IALGAGSigdKWEKYGMGAMDKTSSFKLLDAYyDKGGNFIDTANGYqdeSSEEFIGEWMEARGV-RDQMVIATKYTTNYK 857
Cdd:cd19120 7 IAFGTGT---AWYKSGDDDIQRDLVDSVKLAL-KAGFRHIDTAEMY---GNEKEVGEALKESGVpREDLFITTKVSPGIK 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636624691 858 rgddwqNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVH--WW--DFDTTMEEVMNGLHNLIVSGKVLYLGIS 931
Cdd:cd19120 80 ------DPRE--------------ALRKSLAKLGVDYVDLYLIHspFFakEGGPTLAEAWAELEALKDAGLVRSIGVS 137
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
764-934 |
2.58e-05 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 47.66 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 764 RHRKLAPIAGVrvSPIALGAGSIGDKWEKygmgAMDKTSSFKLLDAYYDKGGNFIDTANGYQDesSEEFIGEWMEARGV- 842
Cdd:cd19164 3 PKPVALSLAGL--PPLIFGAATFSYQYTT----DPESIPPVDIVRRALELGIRAFDTSPYYGP--SEIILGRALKALRDe 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 843 --RDQMVIATK------YTTNYKRgddwQNIKQkthymgnnmkalhlSVAASLKKLRTDYIDILYVHWWDFdTTMEEVMN 914
Cdd:cd19164 75 fpRDTYFIITKvgrygpDDFDYSP----EWIRA--------------SVERSLRRLHTDYLDLVYLHDVEF-VADEEVLE 135
|
170 180
....*....|....*....|...
gi 636624691 915 G---LHNLIVSGKVLYLGISDTP 934
Cdd:cd19164 136 AlkeLFKLKDEGKIRNVGISGYP 158
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
818-992 |
9.07e-05 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 45.64 E-value: 9.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDEsseEFIGEWMEARGV-RDQMVIATKYttnykrgddWqniKQKTHYmGNNMKALHlsvaASLKKLRTDYID 896
Cdd:cd19133 40 IDTAAAYGNE---EAVGRAIKKSGIpREELFITTKL---------W---IQDAGY-EKAKKAFE----RSLKRLGLDYLD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 897 ILYVHW--------WDfdtTMEEvmnglhnLIVSGKVLYLGISdtpawivpkaNMYA-RLTG------KTPFVIYQGLWN 961
Cdd:cd19133 100 LYLIHQpfgdvygaWR---AMEE-------LYKEGKIRAIGVS----------NFYPdRLVDlilhneVKPAVNQIETHP 159
|
170 180 190
....*....|....*....|....*....|.
gi 636624691 962 ILQRDFERDIIpmaREEGLALALWSVLASGK 992
Cdd:cd19133 160 FNQQIEAVEFL---KKYGVQIEAWGPFAEGR 187
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
812-996 |
1.54e-04 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 44.90 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 812 DKGGNFIDTANGYqdeSSEEFIGEWMEARGV-RDQMVIATKYTTNYKRGDDwqnikqkthymgnnmkaLHLSVAASLKKL 890
Cdd:cd19130 34 EVGYRHIDTAAIY---GNEEGVGAAIAASGIpRDELFVTTKLWNDRHDGDE-----------------PAAAFAESLAKL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 891 RTDYIDILYVHW-----WDFDTTMEEvmngLHNLIVSGKVLYLGISDtpaWIVPKANMYARLTGKTPFVIYQGLWNILQr 965
Cdd:cd19130 94 GLDQVDLYLVHWptpaaGNYVHTWEA----MIELRAAGRTRSIGVSN---FLPPHLERIVAATGVVPAVNQIELHPAYQ- 165
|
170 180 190
....*....|....*....|....*....|.
gi 636624691 966 dfERDIIPMAREEGLALALWSVLASGKIRTD 996
Cdd:cd19130 166 --QRTIRDWAQAHDVKIEAWSPLGQGKLLGD 194
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
818-996 |
1.76e-04 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 44.62 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYqdeSSEEFIGEWMEARGV-RDQMVIATKYttnykrgddWqnikqKTHYMGNNMKAlhlSVAASLKKLRTDYID 896
Cdd:cd19135 43 IDTAKRY---GCEELLGKAIKESGVpREDLFLTTKL---------W-----PSDYGYESTKQ---AFEASLKRLGVDYLD 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 897 ILYVHWWD-------FDTTMEEVMNGLHNLIVSGKVLYLGISD----------TPAWIVPKANmyarltgktpfviyQGL 959
Cdd:cd19135 103 LYLLHWPDcpssgknVKETRAETWRALEELYDEGLCRAIGVSNfliehleqllEDCSVVPHVN--------------QVE 168
|
170 180 190
....*....|....*....|....*....|....*..
gi 636624691 960 WNILQRDfeRDIIPMAREEGLALALWSVLASGKIRTD 996
Cdd:cd19135 169 FHPFQNP--VELIEYCRDNNIVFEGYCPLAKGKALEE 203
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
818-942 |
2.37e-04 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 44.41 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDEsseEFIGEWMEARGV-RDQMVIATKYTTNYKRgddwqnikqkthymgnnmkalHLSVA--ASLKKLRTDY 894
Cdd:cd19117 44 IDTAAIYGNE---EEVGQGIKDSGVpREEIFITTKLWCTWHR---------------------RVEEAldQSLKKLGLDY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 895 IDILYVHW-------------------------WDFDTTMEEvmngLHNLIVSGKVLYLGIS------------DTPAWI 937
Cdd:cd19117 100 VDLYLMHWpvpldpdgndflfkkddgtkdhepdWDFIKTWEL----MQKLPATGKVKAIGVSnfsiknlekllaSPSAKI 175
|
....*
gi 636624691 938 VPKAN 942
Cdd:cd19117 176 VPAVN 180
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
818-902 |
7.03e-04 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 43.14 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDEsseEFIGEWMEARGV-RDQMVIATKYTTnykrgDDWQNIKQkthymgnnmkALHlsvaASLKKLRTDYID 896
Cdd:PRK11565 45 IDTAAIYKNE---EGVGKALKEASVaREELFITTKLWN-----DDHKRPRE----------ALE----ESLKKLQLDYVD 102
|
....*.
gi 636624691 897 ILYVHW 902
Cdd:PRK11565 103 LYLMHW 108
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
818-902 |
1.69e-03 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 41.59 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 818 IDTANGYQDEsseEFIGEWMEARGV-RDQMVIATKYTTNYKRGDDwqnikqkthymgnNMKALHlsvaASLKKLRTDYID 896
Cdd:cd19131 40 IDTAAIYGNE---EGVGKAIRASGVpREELFITTKLWNSDQGYDS-------------TLRAFD----ESLRKLGLDYVD 99
|
....*.
gi 636624691 897 ILYVHW 902
Cdd:cd19131 100 LYLIHW 105
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
812-996 |
1.89e-03 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 41.65 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 812 DKGGNFIDTANGYQDESSeefIGEWMEARGV-RDQMVIATKYTTNYKRGDDWQNIKQKthymgnnmkalhlsvaaSLKKL 890
Cdd:cd19126 34 ENGYRSIDTAAIYKNEEG---VGEAIRESGVpREELFVTTKLWNDDQRARRTEDAFQE-----------------SLDRL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 891 RTDYIDILYVHWWDFDtTMEEVMNGLHNLIVSGKVLYLGISD----------TPAWIVPKAN---MYARLTgktpfviyq 957
Cdd:cd19126 94 GLDYVDLYLIHWPGKD-KFIDTWKALEKLYASGKVKAIGVSNfqehhleellAHADVVPAVNqveFHPYLT--------- 163
|
170 180 190
....*....|....*....|....*....|....*....
gi 636624691 958 glwnilqrdfERDIIPMAREEGLALALWSVLASGKIRTD 996
Cdd:cd19126 164 ----------QKELRGYCKSKGIVVEAWSPLGQGGLLSN 192
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
817-902 |
3.62e-03 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 40.69 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636624691 817 FIDTANGYQDEsseEFIGEWMEARGVrdqmviatKYttNYKRGDDWQNIKQKTHYMGNN--MKAlhlsVAASLKKLRTDY 894
Cdd:cd19136 31 LIDTASVYRNE---ADIGKALRDLLP--------KY--GLSREDIFITSKLAPKDQGYEkaRAA----CLGSLERLGTDY 93
|
....*...
gi 636624691 895 IDILYVHW 902
Cdd:cd19136 94 LDLYLIHW 101
|
|
| |
