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Conserved domains on  [gi|636529684|gb|AHZ97254|]
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early growth response 1, partial [Falcunculus frontatus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12112564)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 7-103 2.31e-15

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 71.02  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636529684    7 GRFSLEPAPNSSNPLWPEPLFSLVSGLVGMANAPPTST*TSSSPSSSSQS----SPLSCSVQASESN*IYSAAPTFPNSS 82
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNSsgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|..
gi 636529684   83 -SDIFPESQ*QSfPNPSGAPIQ 103
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLA 101
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-276 1.37e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 1.37e-07
                          10        20
                  ....*....|....*....|....*.
gi 636529684  251 HLTTHIRTHTGEKPFACDICGRKFAR 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
DUF3432 super family cl25500
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 296-332 3.86e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


The actual alignment was detected with superfamily member pfam11914:

Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 44.71  E-value: 3.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 636529684  296 EKAATVSTASPIPAYSSSVTTSYPSSIATTYPSPVRT 332
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVST 37
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 237-259 1.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|...
gi 636529684  237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 7-103 2.31e-15

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 71.02  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636529684    7 GRFSLEPAPNSSNPLWPEPLFSLVSGLVGMANAPPTST*TSSSPSSSSQS----SPLSCSVQASESN*IYSAAPTFPNSS 82
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNSsgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|..
gi 636529684   83 -SDIFPESQ*QSfPNPSGAPIQ 103
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLA 101
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-276 1.37e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 1.37e-07
                          10        20
                  ....*....|....*....|....*.
gi 636529684  251 HLTTHIRTHTGEKPFACDICGRKFAR 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 296-332 3.86e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 44.71  E-value: 3.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 636529684  296 EKAATVSTASPIPAYSSSVTTSYPSSIATTYPSPVRT 332
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVST 37
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 237-259 1.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|...
gi 636529684  237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-292 4.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636529684 234 Q*PFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 292
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
ZnF_C2H2 smart00355
zinc finger;
237-259 2.89e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.89e-03
                           10        20
                   ....*....|....*....|...
gi 636529684   237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 236-283 6.15e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 6.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 636529684 236 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDICGRKFARSDERKRH 283
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 7-103 2.31e-15

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 71.02  E-value: 2.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636529684    7 GRFSLEPAPNSSNPLWPEPLFSLVSGLVGMANAPPTST*TSSSPSSSSQS----SPLSCSVQASESN*IYSAAPTFPNSS 82
Cdd:pfam11928   1 GKFSIDPQYPGGGSLWPEGLISLVSGLVGMANPPSSSSSSSPSSSSSPNSsgplCTMSCSVQSSEMEHIYSAPPPYPSSG 80

                          90       100
                  ....*....|....*....|..
gi 636529684   83 -SDIFPESQ*QSfPNPSGAPIQ 103
Cdd:pfam11928  81 cGDLYQDPSAFL-STPSGPPLA 101
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-276 1.37e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.98  E-value: 1.37e-07
                          10        20
                  ....*....|....*....|....*.
gi 636529684  251 HLTTHIRTHTGEKPFACDICGRKFAR 276
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 296-332 3.86e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 44.71  E-value: 3.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 636529684  296 EKAATVSTASPIPAYSSSVTTSYPSSIATTYPSPVRT 332
Cdd:pfam11914   1 EKVAPASAVSSISSYSSSVTTSYPSPITTSYPSPVST 37
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 237-259 1.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|...
gi 636529684  237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 237-259 2.60e-04

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.62  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|...
gi 636529684  237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 265-287 2.77e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 2.77e-04
                          10        20
                  ....*....|....*....|...
gi 636529684  265 FACDICGRKFARSDERKRHTKIH 287
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-292 4.22e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636529684 234 Q*PFQCRICMRNFSRSDHLTTHIRTHTGEKPFAC--DICGRKFARSDERKRHTKIHLRQKD 292
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
ZnF_C2H2 smart00355
zinc finger;
237-259 2.89e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.89e-03
                           10        20
                   ....*....|....*....|...
gi 636529684   237 FQCRICMRNFSRSDHLTTHIRTH 259
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 236-283 6.15e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 6.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 636529684 236 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDICGRKFARSDERKRH 283
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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