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Conserved domains on  [gi|635376878|gb|AHZ89070|]
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RadA, partial [Halorubrum sp. C191]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
radA super family cl35256
DNA repair and recombination protein RadA; Validated
 1-161 1.53e-79

DNA repair and recombination protein RadA; Validated


The actual alignment was detected with superfamily member PRK04301:

Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 238.24  E-value: 1.53e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDDEIlaDEmerreiegtpsdeealeelveaFLDQI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEALGLDP--DE----------------------VLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEheetEWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 635376878 161 V 161
Cdd:PRK04301 248 V 248
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 1-161 1.53e-79

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 238.24  E-value: 1.53e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDDEIlaDEmerreiegtpsdeealeelveaFLDQI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEALGLDP--DE----------------------VLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEheetEWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 635376878 161 V 161
Cdd:PRK04301 248 V 248
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 1-161 6.45e-69

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 210.76  E-value: 6.45e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGldDEILADEmerreiegtpsdeealeelveaFLDQI 80
Cdd:TIGR02236 109 TQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEA--RGLDPDE----------------------VLKNI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   81 HVAKAFNSNHQILLAEKAKELAGEHEEtewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:TIGR02236 165 YVARAYNSNHQMLLVEKAEDLIKELNN---PVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVV 241


                  .
gi 635376878  161 V 161
Cdd:TIGR02236 242 V 242
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 1-161 8.08e-69

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 207.99  E-value: 8.08e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDdeILADEmerreiegtpsdeealeelveaFLDQI 80
Cdd:cd19515   33 TQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKALG--LDPDE----------------------VLDNI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEHeeteWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:cd19515   89 YVARAYNSNHQMLLVEKAEDLIKEG----NNIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLYNIAVL 164


                 .
gi 635376878 161 V 161
Cdd:cd19515  165 V 165
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 1-161 1.63e-36

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 126.26  E-value: 1.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDDEilademerreiegtpsdeealeelveAFLD 78
Cdd:pfam08423  51 TQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAEryGLDPE--------------------------DVLD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   79 QIHVAKAFNSNHQI-LLAEKAKELAGEheetewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNT 157
Cdd:pfam08423 105 NVAYARAYNSEHQMqLLQQAAAMMSES------RFALLIVDSATALYRTDFSGRGELAERQQHLAKFLRTLQRLADEFGV 178


                  ....
gi 635376878  158 AILV 161
Cdd:pfam08423 179 AVVI 182
 
Name Accession Description Interval E-value
radA PRK04301
DNA repair and recombination protein RadA; Validated
 1-161 1.53e-79

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 238.24  E-value: 1.53e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDDEIlaDEmerreiegtpsdeealeelveaFLDQI 80
Cdd:PRK04301 116 TQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEALGLDP--DE----------------------VLDNI 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEheetEWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:PRK04301 172 HVARAYNSDHQMLLAEKAEELIKE----GENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHDLLRLADLYNAAVV 247


                 .
gi 635376878 161 V 161
Cdd:PRK04301 248 V 248
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 1-161 6.45e-69

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 210.76  E-value: 6.45e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGldDEILADEmerreiegtpsdeealeelveaFLDQI 80
Cdd:TIGR02236 109 TQICHQLAVNVQLPEEKGGLGGKAVYIDTENTFRPERIMQMAEA--RGLDPDE----------------------VLKNI 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   81 HVAKAFNSNHQILLAEKAKELAGEHEEtewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:TIGR02236 165 YVARAYNSNHQMLLVEKAEDLIKELNN---PVKLLIVDSLTSHFRAEYVGRGALAERQQKLNKHLHDLLRLADLYNAAVV 241


                  .
gi 635376878  161 V 161
Cdd:TIGR02236 242 V 242
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 1-161 8.08e-69

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 207.99  E-value: 8.08e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDdeILADEmerreiegtpsdeealeelveaFLDQI 80
Cdd:cd19515   33 TQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKALG--LDPDE----------------------VLDNI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEHeeteWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:cd19515   89 YVARAYNSNHQMLLVEKAEDLIKEG----NNIKLLIVDSLTSHFRAEYVGRGTLAERQQKLNKHLHDLHRLADLYNIAVL 164


                 .
gi 635376878 161 V 161
Cdd:cd19515  165 V 165
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 1-161 3.73e-41

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 137.66  E-value: 3.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMV--RGLDdeilademerreiegtPSDEealeelveafLD 78
Cdd:cd01123   33 TQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIAqrFGLD----------------PDDV----------LD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQILLAEKAKELAgeHEEtewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTA 158
Cdd:cd01123   87 NVAYARAFNSDHQTQLLDQAAAMM--VES---RFKLLIVDSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEFGVA 161


                 ...
gi 635376878 159 ILV 161
Cdd:cd01123  162 VVV 164
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 1-161 1.63e-36

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 126.26  E-value: 1.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDDEilademerreiegtpsdeealeelveAFLD 78
Cdd:pfam08423  51 TQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAEryGLDPE--------------------------DVLD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   79 QIHVAKAFNSNHQI-LLAEKAKELAGEheetewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNT 157
Cdd:pfam08423 105 NVAYARAYNSEHQMqLLQQAAAMMSES------RFALLIVDSATALYRTDFSGRGELAERQQHLAKFLRTLQRLADEFGV 178


                  ....
gi 635376878  158 AILV 161
Cdd:pfam08423 179 AVVI 182
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 1-161 8.04e-35

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 121.31  E-value: 8.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDdeilADEMerreiegtpsdeealeelveafLD 78
Cdd:cd19514   33 TQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRPIAErfGVD----HDAV----------------------LD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQI-LLAEKAKELageHEETewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNT 157
Cdd:cd19514   87 NILYARAYTSEHQMeLLDYVAAKF---HEEA--VFRLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNV 161


                 ....
gi 635376878 158 AILV 161
Cdd:cd19514  162 AVFI 165
PTZ00035 PTZ00035
Rad51 protein; Provisional
 1-161 9.84e-34

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 120.87  E-value: 9.84e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDDEILademerreiegtpsdeealeelveafLD 78
Cdd:PTZ00035 132 TQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQIAErfGLDPEDV--------------------------LD 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQI-LLAEKAKELAgeheetEWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNT 157
Cdd:PTZ00035 186 NIAYARAYNHEHQMqLLSQAAAKMA------EERFALLIVDSATALFRVDYSGRGELAERQQHLGKFLRALQKLADEFNV 259


                 ....
gi 635376878 158 AILV 161
Cdd:PTZ00035 260 AVVI 263
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 1-161 1.15e-32

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 117.57  E-value: 1.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVrglddeilademERREIEGTPSdeealeelveafLDQI 80
Cdd:TIGR02238 110 TQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRAIA------------ERFGVDPDAV------------LDNI 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   81 HVAKAFNSNHQI-LLAEKAKELAGEheetewPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAI 159
Cdd:TIGR02238 166 LYARAYTSEHQMeLLDYLAAKFSEE------PFRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSRLNKISEEFNVAV 239


                  ..
gi 635376878  160 LV 161
Cdd:TIGR02238 240 FV 241
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
 1-161 1.69e-32

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 115.49  E-value: 1.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDdeilademerreiegtPSDEealeelveafLD 78
Cdd:cd19513   33 TQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAEryGLN----------------GEDV----------LD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQILLAEKAkelAGEHEETEWPIRIVcvDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTA 158
Cdd:cd19513   87 NVAYARAYNTDHQMQLLIQA---SAMMAESRYALLIV--DSATALYRTDYSGRGELSARQMHLAKFLRMLQRLADEFGVA 161


                 ...
gi 635376878 159 ILV 161
Cdd:cd19513  162 VVI 164
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 1-161 6.72e-27

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 103.32  E-value: 6.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDDEILademerreiegtpsdeealeelveafLD 78
Cdd:PLN03187 140 TQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPDRIVPIAErfGMDADAV--------------------------LD 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQ--ILLAEKAKElageheeTEWPIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFN 156
Cdd:PLN03187 194 NIIYARAYTYEHQynLLLGLAAKM-------AEEPFRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSRLTKIAEEFN 266


                 ....*
gi 635376878 157 TAILV 161
Cdd:PLN03187 267 VAVYM 271
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 1-161 8.99e-27

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 102.50  E-value: 8.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878    1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVR--GLDdeilademerreiegtPSDEealeelveafLD 78
Cdd:TIGR02239 110 TQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAEryGLN----------------PEDV----------LD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   79 QIHVAKAFNSNHQILLAEKAKELAGEHEetewpIRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTA 158
Cdd:TIGR02239 164 NVAYARAYNTDHQLQLLQQAAAMMSESR-----FALLIVDSATALYRTDFSGRGELSARQMHLARFLRSLQRLADEFGVA 238


                  ...
gi 635376878  159 ILV 161
Cdd:TIGR02239 239 VVI 241
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 1-161 3.82e-26

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 100.96  E-value: 3.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVrglddeilademERREIEGTpsdeealeelveAFLDQI 80
Cdd:PLN03186 137 TQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQIA------------ERFGLNGA------------DVLENV 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQillAEKAKELAGEHEETEWPIRIVcvDSLTAHFRAEYVGRGELADRQQKLNKHLHDLMRIGDLFNTAIL 160
Cdd:PLN03186 193 AYARAYNTDHQ---SELLLEAASMMAETRFALMIV--DSATALYRTEFSGRGELSARQMHLGKFLRSLQRLADEFGVAVV 267


                 .
gi 635376878 161 V 161
Cdd:PLN03186 268 I 268
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 1-161 3.76e-17

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 75.41  E-value: 3.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMvrglddeilADEMERREIEGTPSDeealeelveaFLDQI 80
Cdd:cd19491   26 TQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQL---------ASSLPKRYHLEKAKN----------FLDNI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQI-LLAEKAKELAGEHeetewPIRIVCVDSLTAHFRAEYV-GRGELADRQQKLNKHLHDLMRIGDLFNTA 158
Cdd:cd19491   87 FVEHVADLETLEhCLNYQLPALLERG-----PIRLVVIDSIAALFRSEFDtSRSDLVERAKYLRRLADHLKRLADKYNLA 161


                 ...
gi 635376878 159 ILV 161
Cdd:cd19491  162 VVV 164
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-161 1.38e-14

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 67.38  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLepenggLDGGCIFVDSEDTFRPERIDDMvrglddeilADEMERREIEGtpsdeealeelvEAFLDQI 80
Cdd:cd01393   15 TQLALQLAANALL------LGGGVVWIDTEGAFPPSRLVQI---------LEASPSSELEL------------AEALSRL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAFNSNHQILLAEKAKELAGEHEETewpiRIVCVDSLTAHFRAEYVGRGELADRQQKLNKHLHDLM----RIGDLFN 156
Cdd:cd01393   68 LYFRPPDTLAHLLALDSLPESLFPPPNT----SLVVVDSVSALFRKAFPRGGDGDSSSSLRARLLSQLAralqKLAAQFN 143


                 ....*
gi 635376878 157 TAILV 161
Cdd:cd01393  144 LAVVV 148
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 1-161 2.59e-12

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 61.95  E-value: 2.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPERIDDMVRGLDDEILADEMERREIEGTpsdeealeelveaFLDQI 80
Cdd:cd19493   25 TQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIAEARFPEAFSGFMEENERAEE-------------MLKRV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  81 HVAKAfNSNHQILlaEKAKELagEHEETEWPIRIVCVDSLTAHFRAEYVG-RGELADRQQKLNKHLHDLMRIGDLFNTAI 159
Cdd:cd19493   92 AVVRV-TTLAQLL--ERLPNL--EEHILSSGVRLVVIDSIAALVRREFGGsDGEVTERHNALAREASSLKRLAEEFRIAV 166


                 ..
gi 635376878 160 LV 161
Cdd:cd19493  167 LV 168
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 1-161 6.88e-09

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 51.84  E-value: 6.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878   1 SQVTHQMAVNVQLEPENGGLDGGCIFVDSEDTFRPE--RIDDMVrglddEILAdemerreiegtpsdeealeelveafld 78
Cdd:cd19492   15 TQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSFNIHyfRVHDYV-----ELLA--------------------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635376878  79 QIHVAKAFNSNHQillaekakelageheetewPIRIVCVDSLTAHFRAEYvgrGELADRQQKLNKHLHDLMRIGDLFNTA 158
Cdd:cd19492   63 LINSLPKFLEDHP-------------------KVKLIVVDSIAFPFRHDF---DDLAQRTRLLNGLAQLLHSLARQHNLA 120


                 ...
gi 635376878 159 ILV 161
Cdd:cd19492  121 VVL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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