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Conserved domains on  [gi|6324697|ref|NP_014766|]
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Leo1p [Saccharomyces cerevisiae S288C]

Protein Classification

RNA polymerase-associated LEO1 family protein( domain architecture ID 10512693)

RNA polymerase-associated LEO1 family protein similar to Saccharomyces cerevisiae protein LEO1, a component of the multifunctional PAF1 complex that is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection.

Gene Ontology:  GO:0006368|GO:0016593|GO:0016593

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Leo1 pfam04004
Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The ...
 169-335 1.50e-63

Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors.


:

Pssm-ID: 461126  Cd Length: 163  Bit Score: 202.80  E-value: 1.50e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    169 FYARIPNFLTIDPIPFDPPSFEAKVNERASNsASREDQLDDRLIDENTVRWRYSRDKdqhVFKESNTQIVQWSDGTYSLK 248
Cdd:pfam04004   1 YLLKVPNFLSIEPKPFDPETFEPEVDEESEV-LDEEGRFSIKLTVENTIRWRYSPDT---GIKESNARIVRWSDGSLSLQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    249 VGEECTDILVNDT--SNTFLTVSHDQQELIQCYegGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMD 326
Cdd:pfam04004  77 LGDEHFDIQSKPLqdDHTYLAARHESSELLQTQ--GHITEQLTFRPTSTQSDTHRRLTAALAARHKKTGAKIMLIITTED 154


                  ....*....
gi 6324697    327 PEVEKKELE 335
Cdd:pfam04004 155 PELEKKEAE 163
 
Name Accession Description Interval E-value
Leo1 pfam04004
Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The ...
 169-335 1.50e-63

Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors.


Pssm-ID: 461126  Cd Length: 163  Bit Score: 202.80  E-value: 1.50e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    169 FYARIPNFLTIDPIPFDPPSFEAKVNERASNsASREDQLDDRLIDENTVRWRYSRDKdqhVFKESNTQIVQWSDGTYSLK 248
Cdd:pfam04004   1 YLLKVPNFLSIEPKPFDPETFEPEVDEESEV-LDEEGRFSIKLTVENTIRWRYSPDT---GIKESNARIVRWSDGSLSLQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    249 VGEECTDILVNDT--SNTFLTVSHDQQELIQCYegGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMD 326
Cdd:pfam04004  77 LGDEHFDIQSKPLqdDHTYLAARHESSELLQTQ--GHITEQLTFRPTSTQSDTHRRLTAALAARHKKTGAKIMLIITTED 154


                  ....*....
gi 6324697    327 PEVEKKELE 335
Cdd:pfam04004 155 PELEKKEAE 163
 
Name Accession Description Interval E-value
Leo1 pfam04004
Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The ...
 169-335 1.50e-63

Leo1-like protein; Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors.


Pssm-ID: 461126  Cd Length: 163  Bit Score: 202.80  E-value: 1.50e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    169 FYARIPNFLTIDPIPFDPPSFEAKVNERASNsASREDQLDDRLIDENTVRWRYSRDKdqhVFKESNTQIVQWSDGTYSLK 248
Cdd:pfam04004   1 YLLKVPNFLSIEPKPFDPETFEPEVDEESEV-LDEEGRFSIKLTVENTIRWRYSPDT---GIKESNARIVRWSDGSLSLQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324697    249 VGEECTDILVNDT--SNTFLTVSHDQQELIQCYegGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMD 326
Cdd:pfam04004  77 LGDEHFDIQSKPLqdDHTYLAARHESSELLQTQ--GHITEQLTFRPTSTQSDTHRRLTAALAARHKKTGAKIMLIITTED 154


                  ....*....
gi 6324697    327 PEVEKKELE 335
Cdd:pfam04004 155 PELEKKEAE 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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