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Conserved domains on  [gi|6323237|ref|NP_013309|]
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GTPase-activating protein SEC13 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-281 4.16e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.16e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   21 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 100
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  101 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 180
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  181 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 260
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
gi 6323237  261 SWSLSGNVLALSGGDNKVTLW 281
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-281 4.16e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.16e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   21 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 100
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  101 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 180
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  181 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 260
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
gi 6323237  261 SWSLSGNVLALSGGDNKVTLW 281
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-282 1.80e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 1.80e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEthKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENG 87
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   88 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKengTTSPI-IIDAHAIGVNSASWAPatieedgehng 166
Cdd:cd00200 126 K--CLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLR---TGKCVaTLTGHTGEVNSVAFSP----------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  167 tkESRKFVTGGADNLVKIWKYNSDAQTYvlesTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQGpwKKT 246
Cdd:cd00200 188 --DGEKLLSSSSDGTIKLWDLSTGKCLG----TLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVWDLRTGEC--VQT 256

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6323237  247 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLWK 282
Cdd:cd00200 257 LSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-83 1.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.23e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6323237      42 THKLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWK 83
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
196-234 2.72e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6323237    196 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 234
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-185 4.01e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    19 YYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDW--AHPkfgTILASCSYDGKVLIWKEENGrwsqIAVHA 96
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLWSINQG----VSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    97 VHS-ASVNSVQWaPHEYGPLLLVASSDGKVSVVEFKeNGTTSPIIIDAHAIGVNSASWApatieedgehngtkESRKFVT 175
Cdd:PLN00181 614 IKTkANICCVQF-PSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHSKTVSYVRFV--------------DSSTLVS 677

                        170
                 ....*....|
gi 6323237   176 GGADNLVKIW 185
Cdd:PLN00181 678 SSTDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
21-281 4.16e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 4.16e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   21 GKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 100
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGK--LLRTLTGHSG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  101 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 180
Cdd:COG2319 248 SVRSVAFSPD--GRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSP-----DG--------KLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  181 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 260
Cdd:COG2319 311 TVRLW----DLATGKLLRTLTGHTGAVRSVAFSPD---GKTLASGSDDGTVRLW--DLATGELLRTL---TGHTGAVTSV 378

                       250       260
                ....*....|....*....|.
gi 6323237  261 SWSLSGNVLALSGGDNKVTLW 281
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
21-292 4.08e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.08e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   21 GKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSA 100
Cdd:COG2319 132 GKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  101 SVNSVQWAPHeyGPLLLVASSDGKVSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADN 180
Cdd:COG2319 206 AVRSVAFSPD--GKLLASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSP-----DG--------RLLASGSADG 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  181 LVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRA 260
Cdd:COG2319 269 TVRLW----DLATGELLRTLTGHSGGVNSVAFSPD---GKLLASGSDDGTVRLW--DLATGKLLRTL---TGHTGAVRSV 336

                       250       260       270
                ....*....|....*....|....*....|..
gi 6323237  261 SWSLSGNVLALSGGDNKVTLWkeNLEGKWEPA 292
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLW--DLATGELLR 366
WD40 COG2319
WD40 repeat [General function prediction only];
8-281 2.82e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENG 87
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   88 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKENGTTSpiIIDAHAIGVNSASWAPatieeDGehngt 167
Cdd:COG2319 153 K--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGAVRSVAFSP-----DG----- 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  168 kesRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTL 247
Cdd:COG2319 217 ---KLLASGSADGTVRLW----DLATGKLLRTLTGHSGSVRSVAFSPD---GRLLASGSADGTVRLW--DLATGELLRTL 284

                       250       260       270
                ....*....|....*....|....*....|....
gi 6323237  248 lkeEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281
Cdd:COG2319 285 ---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-282 1.80e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 1.80e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEthKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENG 87
Cdd:cd00200  50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--ECVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   88 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKengTTSPI-IIDAHAIGVNSASWAPatieedgehng 166
Cdd:cd00200 126 K--CLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLR---TGKCVaTLTGHTGEVNSVAFSP----------- 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  167 tkESRKFVTGGADNLVKIWKYNSDAQTYvlesTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQGpwKKT 246
Cdd:cd00200 188 --DGEKLLSSSSDGTIKLWDLSTGKCLG----TLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVWDLRTGEC--VQT 256

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6323237  247 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLWK 282
Cdd:cd00200 257 LSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-281 2.41e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 2.41e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGEThkLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWKEENG 87
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   88 RwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGKVSVVEFKENGTTspIIIDAHAIGVNSASWAPatieedgehngt 167
Cdd:cd00200  84 E--CVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSP------------ 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  168 keSRKFVTGG-ADNLVKIWkynsDAQTYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKT 246
Cdd:cd00200 146 --DGTFVASSsQDGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSPD---GEKLLSSSSDGTIKLW--DLSTGKCLGT 214

                       250       260       270
                ....*....|....*....|....*....|....*
gi 6323237  247 LLKEEKFpdvLWRASWSLSGNVLALSGGDNKVTLW 281
Cdd:cd00200 215 LRGHENG---VNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-281 2.75e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.75e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   45 LIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGK 124
Cdd:cd00200   1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASAD--GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  125 VSVveFKENGTTSPIIIDAHAIGVNSASWAPatieedgehngtkESRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHS 204
Cdd:cd00200  75 IRL--WDLETGECVRTLTGHTSYVSSVAFSP-------------DGRILSSSSRDKTIKVW----DVETGKCLTTLRGHT 135

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323237  205 DWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLLKEEkfpDVLWRASWSLSGNVLALSGGDNKVTLW 281
Cdd:cd00200 136 DWVNSVAFSPD---GTFVASSSQDGTIKLW--DLRTGKCVATLTGHT---GEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
45-281 1.10e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 1.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   45 LIDTLTGHEGPVWRVDWAHPkfGTILASCSYDGKVLIWKEENGRwsQIAVHAVHSASVNSVQWAPHeyGPLLLVASSDGK 124
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPD--GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGT 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  125 VSVVEFkeNGTTSPIIIDAHAIGVNSASWAPatieeDGehngtkesRKFVTGGADNLVKIWkynsDAQTYVLESTLEGHS 204
Cdd:COG2319 102 VRLWDL--ATGLLLRTLTGHTGAVRSVAFSP-----DG--------KTLASGSADGTVRLW----DLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323237  205 DWVRDVAWSPTvllRSYLASVSQDRTCIIWtqDNEQGPWKKTLlkeEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281
Cdd:COG2319 163 GAVTSVAFSPD---GKLLASGSDDGTVRLW--DLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-186 2.74e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 2.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVegETHKLIDTLTGHEGPVWRVDWaHPKfGTILASCSYDGKVLIWKEE 85
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWDLS 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237   86 NGRWsqIAVHAVHSASVNSVQWAPHEYgpLLLVASSDGKV---SVVEFKENGTtspiiIDAHAIGVNSASWAPatieedg 162
Cdd:cd00200 208 TGKC--LGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIrvwDLRTGECVQT-----LSGHTNSVTSLAWSP------- 271

                       170       180
                ....*....|....*....|....
gi 6323237  163 ehngtkESRKFVTGGADNLVKIWK 186
Cdd:cd00200 272 ------DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 196-282 5.34e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237  196 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIWTQDNEQgpwKKTLLKEEKFPdvLWRASWSLSGNVLALSGGD 275
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD---GKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGP--VRDVAASADGTYLASGSSD 72


                ....*..
gi 6323237  276 NKVTLWK 282
Cdd:cd00200  73 KTIRLWD 79
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-83 1.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.23e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6323237      42 THKLIDTLTGHEGPVWRVDWAHpkFGTILASCSYDGKVLIWK 83
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-234 2.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.68e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6323237     193 TYVLESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 234
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
196-234 2.72e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6323237    196 LESTLEGHSDWVRDVAWSPTvllRSYLASVSQDRTCIIW 234
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
44-82 2.80e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6323237     44 KLIDTLTGHEGPVWRVDWahPKFGTILASCSYDGKVLIW 82
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-185 4.01e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    19 YYGKRLATCSSDKTIKIFEVEgeTHKLIDTLTGHEGPVWRVDW--AHPkfgTILASCSYDGKVLIWKEENGrwsqIAVHA 96
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYssADP---TLLASGSDDGSVKLWSINQG----VSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    97 VHS-ASVNSVQWaPHEYGPLLLVASSDGKVSVVEFKeNGTTSPIIIDAHAIGVNSASWApatieedgehngtkESRKFVT 175
Cdd:PLN00181 614 IKTkANICCVQF-PSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHSKTVSYVRFV--------------DSSTLVS 677

                        170
                 ....*....|
gi 6323237   176 GGADNLVKIW 185
Cdd:PLN00181 678 SSTDNTLKLW 687
PTZ00420 PTZ00420
coronin; Provisional
 20-107 4.89e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323237    20 YGKRLATCSSDKTIKIFEV--EGETHKLID----TLTGHEGPVWRVDWaHPKFGTILASCSYDGKVLIWKEENgrwSQIA 93
Cdd:PTZ00420  86 FSEILASGSEDLTIRVWEIphNDESVKEIKdpqcILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVNIWDIEN---EKRA 161

                         90
                 ....*....|....
gi 6323237    94 VHAVHSASVNSVQW 107
Cdd:PTZ00420 162 FQINMPKKLSSLKW 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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