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Conserved domains on  [gi|6323135|ref|NP_013207|]
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AAA family ATPase midasin [Saccharomyces cerevisiae S288C]

Protein Classification

YSIRK_signal and PspC_subgroup_1 domain-containing protein( domain architecture ID 11474476)

YSIRK_signal and PspC_subgroup_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
vWA_midasin cd01460
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are ...
 4643-4910 5.12e-139

VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The AAA domains in midasin is followed by a D/E rich domain that is following by a VWA domain. The members of this subgroup have a conserved MIDAS motif. The function of this domain is not exactly known although it has been speculated to play a crucial role in midasin function.


:

Pssm-ID: 238737  Cd Length: 266  Bit Score: 435.63  E-value: 5.12e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4643 LVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIASQFRKDKIWLRRTKPSKRQYQIMIALDDSKSMSESKCVK 4722
Cdd:cd01460    1 LSSELCEQLRLILEPTLATKLKGDYRTGKRLNMKKIIPYIASQFRKDKIWLRRTKPAKRDYQILIAIDDSKSMSENNSKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4723 LAFDSLCLVSKTLTQLEAGGLSIVKFGENIKEVHSFDQQFSNESGARAFQWFGFQETKTDVKKLVAESTKIFERARAMVH 4802
Cdd:cd01460   81 LALESLCLVSKALTLLEVGQLGVCSFGEDVQILHPFDEQFSSQSGPRILNQFTFQQDKTDIANLLKFTAQIFEDARTQSS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4803 NDQ-WQLEIVISDGICEDHETIQKL-VRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQYGnpqlKITKYLDTFPF 4880
Cdd:cd01460  161 SGSlWQLLLIISDGRGEFSEGAQKVrLREAREQNVFVVFIIIDNPDNKQSILDIKVVSFKNDKSG----VITPYLDEFPF 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 6323135  4881 EFYVVVHDISELPEMLSLILRQYFTDLASS 4910
Cdd:cd01460  237 PYYVIVRDLNQLPSVLSDALRQWFELVNSS 266
AAA_lid_5 pfam17865
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 910-1015 4.87e-32

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


:

Pssm-ID: 407722  Cd Length: 104  Bit Score: 122.31  E-value: 4.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     910 DLLSIIDKYIGKYSVSDEWVgNDIAELYLEAKKLSdNNTIVDGSNQKPHFSIRTLTRTLLYVTDIIHIYGLRRSLYDGFC 989
Cdd:pfam17865    1 DLELLVKAYLKGVSSDDDLV-RDIVKFYLEAKKLA-EKSLVDGAGQRPHYSLRTLCRALSYARAIAPRYGLRRALYEGFC 78

                           90       100
                   ....*....|....*....|....*.
gi 6323135     990 MSFLTLLDQKSEAILKPVIEKFTLGR 1015
Cdd:pfam17865   79 MSFLTQLDAESRKIVEKLIRKHLLKG 104
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4046-4671 7.81e-24

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 111.65  E-value: 7.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4046 PQPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNG 4125
Cdd:COG5271  335 DEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTD 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4126 EENDDEDTDSEEEELDEEiddlNEDDPNAIDDKMWDDKASD--NSKEKDTDQNLDGKNQEEDVQAAENDEQ---QRDNKE 4200
Cdd:COG5271  415 EEEEEADEDASAGETEDE----STDVTSAEDDIATDEEADSlaDEEEEAEAELDTEEDTESAEEDADGDEAtdeDDASDD 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4201 GGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDlpEDMNLDSEHEESDEDVDMSDGMPD 4280
Cdd:COG5271  491 GDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSDEDALEDETEGEE--NAPGSDQDADETDEPEATAEEDEP 568

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4281 DLNKEEVGNEDEEVkqesgiESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQ 4360
Cdd:COG5271  569 DEAEAETEDATENA------DADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPET 642

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4361 DAAMEENKEKGGEQNTEG-----LDGVEEKADTEDIDQEAAvqQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEE---D 4432
Cdd:COG5271  643 DASEAADEDADAETEAEAsadesEEEAEDESETSSEDAEED--ADAAAAEASDDEEETEEADEDAETASEEADAEEadtE 720

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4433 QEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQ- 4511
Cdd:COG5271  721 ADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVa 800

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4512 DQLQTIDEDMAIDDDREEQEVD-QKELVEDADDEKMDIDEE--EMLSDIDAHDANNDVDSKKSGFIGKRK----SEEDFE 4584
Cdd:COG5271  801 DEDQDTDEDALLDEAEADEEEDlDGEDEETADEALEDIEAGiaEDDEEDDDAAAAKDVDADLDLDADLAAdeheAEEAQE 880

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4585 NELSNEHFSADQEDDSEIQSLiENIEDNPPDASASLTPERSLEESRELWHKSEISTADLVSRLGEQLRLILEPTLATKLK 4664
Cdd:COG5271  881 AETDADADADAGEADSSGESS-AAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEE 959


                 ....*..
gi 6323135  4665 GDYKTGK 4671
Cdd:COG5271  960 SDDAAAD 966
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1078-1214 9.33e-24

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 99.67  E-value: 9.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1078 PVLIQGPTSSGKTSMIKYLAD-ITGHKFVRINNHEHTDLQEYLGTYVTDDTGKlSFKEGVLVEALRKGYWIVLDELNLAP 1156
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGA-SWVDGPLVRAAREGEIAVLDEINRAN 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    1157 TDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPgiYGGRKILSRAFRNRF 1214
Cdd:pfam07728   80 PDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPL--DRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1891-1990 2.57e-22

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


:

Pssm-ID: 465540  Cd Length: 106  Bit Score: 94.68  E-value: 2.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1891 DLLLIAKHLYPsIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLN---QYSICEDV--DVFDFVD 1965
Cdd:pfam17867    1 DLEQILSHRFP-LLASLAEKLIEVYSRLQELVSSSRSFGSSGSPREFNLRDLLRWCRRLSsllPTLLSPTVreEIFLEAV 79

                           90       100
                   ....*....|....*....|....*
gi 6323135    1966 IIVKQRFRTISDKNKAQLLIEDIFG 1990
Cdd:pfam17867   80 DVFAGRFRTPEDREAVAELIAEVLG 104
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1363-1558 7.68e-22

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 94.28  E-value: 7.68e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1363 PVLLVGETGCGKTTICQLLAQ-FMGRELITLNAHQNTETGDILGAqrpvrnrseiqyklikslktalniandqdvdlkel 1441
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGR----------------------------------- 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1442 lqlysksdnkniaedvqleiqklRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEpERSLLLAEQG 1521
Cdd:pfam07728   46 -----------------------RNIDPGGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLLPDGG 101

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 6323135    1522 SSDSLvtASENFQFFATMNPgGDYGKKELSPALRNRF 1558
Cdd:pfam07728  102 ELVKA--APDGFRLIATMNP-LDRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 465-579 6.54e-21

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


:

Pssm-ID: 465540  Cd Length: 106  Bit Score: 90.44  E-value: 6.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     465 DLTHILAQKFPILTNLIPKLIDSYKNVKSIYMNTKFISLnkGAHTRVVSVRDLIKLCERLDILFKNnginkpdqLIQSSV 544
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGS--SGSPREFNLRDLLRWCRRLSSLLPT--------LLSPTV 70

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 6323135     545 YDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDI 579
Cdd:pfam17867   71 REEIFLEAVDVFAGRFRTPEDREAVAELIAEVLGI 105
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 310-427 1.17e-18

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 85.42  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     310 PIMLIGKAGSGKTFLINELSKYMgCHDSIVKIHLGEQTDAKLLIGTYTSgdKPGTFEWRAGVLATAVKEGRWVLIEDIDK 389
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAAL-SNRPVFYVQLTRDTTEEDLFGRRNI--DPGGASWVDGPLVRAAREGEIAVLDEINR 77

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 6323135     390 APTDVLSILLSLLEKRELTIPSRGETVKAAN-GFQLIST 427
Cdd:pfam07728   78 ANPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIAT 116
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 1742-1879 1.29e-16

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 79.26  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1742 PILLEGSPGVGKTSLITALAN-ITGNKLTRINLSEQTDLVDLFGADAPGERSGEflWHDAPFLRAMKKGEWVLLDEMNLA 1820
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGAS--WVDGPLVRAAREGEIAVLDEINRA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135    1821 SQSVLEGLNACLDHRgeaYIPELDISFSCH---PNFLVFAAQNPQYQGGgrKGLPKSFVNRF 1879
Cdd:pfam07728   79 NPDVLNSLLSLLDER---RLLLPDGGELVKaapDGFRLIATMNPLDRGL--NELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1226-1320 4.82e-16

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


:

Pssm-ID: 465540  Cd Length: 106  Bit Score: 76.57  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1226 ELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNS--FATLRDLFRWALR---------DAVGYEQLAASGYM 1294
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGSSGSprEFNLRDLLRWCRRlssllptllSPTVREEIFLEAVD 80

                           90       100
                   ....*....|....*....|....*.
gi 6323135    1295 LLAERCRTPQEKVTVKKTLEKVMKVK 1320
Cdd:pfam17867   81 VFAGRFRTPEDREAVAELIAEVLGIS 106
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 2190-2276 1.12e-08

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 56.53  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    2190 VKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEiDGSLLInecsqEDGQPRVLKPHPNFRLFLTMDPKYG-- 2267
Cdd:pfam07728   51 GGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLL-----PDGGELVKAAPDGFRLIATMNPLDRgl 124

                           90
                   ....*....|
gi 6323135    2268 -ELSRAMRNR 2276
Cdd:pfam07728  125 nELSPALRSR 134
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 648-703 2.15e-06

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 49.98  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135     648 PVLLVGETGTGKTTVVQQLAKMLA-KKLTVINVSQQTETGDLLGGYKPVNSKTVAVP 703
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSnRPVFYVQLTRDTTEEDLFGRRNIDPGGASWVD 57
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 811-896 1.07e-05

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam07728:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 135  Bit Score: 48.06  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     811 FVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLtepDSRSILLSEKGdaEPIKAHPD-FRIFACMNPAtDVGKRDLP 889
Cdd:pfam07728   55 WVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLL---DERRLLLPDGG--ELVKAAPDgFRLIATMNPL-DRGLNELS 128


                   ....*..
gi 6323135     890 MGIRSRF 896
Cdd:pfam07728  129 PALRSRF 135
 
Name Accession Description Interval E-value
vWA_midasin cd01460
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are ...
 4643-4910 5.12e-139

VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The AAA domains in midasin is followed by a D/E rich domain that is following by a VWA domain. The members of this subgroup have a conserved MIDAS motif. The function of this domain is not exactly known although it has been speculated to play a crucial role in midasin function.


Pssm-ID: 238737  Cd Length: 266  Bit Score: 435.63  E-value: 5.12e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4643 LVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIASQFRKDKIWLRRTKPSKRQYQIMIALDDSKSMSESKCVK 4722
Cdd:cd01460    1 LSSELCEQLRLILEPTLATKLKGDYRTGKRLNMKKIIPYIASQFRKDKIWLRRTKPAKRDYQILIAIDDSKSMSENNSKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4723 LAFDSLCLVSKTLTQLEAGGLSIVKFGENIKEVHSFDQQFSNESGARAFQWFGFQETKTDVKKLVAESTKIFERARAMVH 4802
Cdd:cd01460   81 LALESLCLVSKALTLLEVGQLGVCSFGEDVQILHPFDEQFSSQSGPRILNQFTFQQDKTDIANLLKFTAQIFEDARTQSS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4803 NDQ-WQLEIVISDGICEDHETIQKL-VRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQYGnpqlKITKYLDTFPF 4880
Cdd:cd01460  161 SGSlWQLLLIISDGRGEFSEGAQKVrLREAREQNVFVVFIIIDNPDNKQSILDIKVVSFKNDKSG----VITPYLDEFPF 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 6323135  4881 EFYVVVHDISELPEMLSLILRQYFTDLASS 4910
Cdd:cd01460  237 PYYVIVRDLNQLPSVLSDALRQWFELVNSS 266
AAA_lid_5 pfam17865
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 910-1015 4.87e-32

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 407722  Cd Length: 104  Bit Score: 122.31  E-value: 4.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     910 DLLSIIDKYIGKYSVSDEWVgNDIAELYLEAKKLSdNNTIVDGSNQKPHFSIRTLTRTLLYVTDIIHIYGLRRSLYDGFC 989
Cdd:pfam17865    1 DLELLVKAYLKGVSSDDDLV-RDIVKFYLEAKKLA-EKSLVDGAGQRPHYSLRTLCRALSYARAIAPRYGLRRALYEGFC 78

                           90       100
                   ....*....|....*....|....*.
gi 6323135     990 MSFLTLLDQKSEAILKPVIEKFTLGR 1015
Cdd:pfam17865   79 MSFLTQLDAESRKIVEKLIRKHLLKG 104
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4046-4671 7.81e-24

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 111.65  E-value: 7.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4046 PQPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNG 4125
Cdd:COG5271  335 DEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTD 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4126 EENDDEDTDSEEEELDEEiddlNEDDPNAIDDKMWDDKASD--NSKEKDTDQNLDGKNQEEDVQAAENDEQ---QRDNKE 4200
Cdd:COG5271  415 EEEEEADEDASAGETEDE----STDVTSAEDDIATDEEADSlaDEEEEAEAELDTEEDTESAEEDADGDEAtdeDDASDD 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4201 GGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDlpEDMNLDSEHEESDEDVDMSDGMPD 4280
Cdd:COG5271  491 GDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSDEDALEDETEGEE--NAPGSDQDADETDEPEATAEEDEP 568

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4281 DLNKEEVGNEDEEVkqesgiESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQ 4360
Cdd:COG5271  569 DEAEAETEDATENA------DADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPET 642

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4361 DAAMEENKEKGGEQNTEG-----LDGVEEKADTEDIDQEAAvqQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEE---D 4432
Cdd:COG5271  643 DASEAADEDADAETEAEAsadesEEEAEDESETSSEDAEED--ADAAAAEASDDEEETEEADEDAETASEEADAEEadtE 720

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4433 QEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQ- 4511
Cdd:COG5271  721 ADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVa 800

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4512 DQLQTIDEDMAIDDDREEQEVD-QKELVEDADDEKMDIDEE--EMLSDIDAHDANNDVDSKKSGFIGKRK----SEEDFE 4584
Cdd:COG5271  801 DEDQDTDEDALLDEAEADEEEDlDGEDEETADEALEDIEAGiaEDDEEDDDAAAAKDVDADLDLDADLAAdeheAEEAQE 880

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4585 NELSNEHFSADQEDDSEIQSLiENIEDNPPDASASLTPERSLEESRELWHKSEISTADLVSRLGEQLRLILEPTLATKLK 4664
Cdd:COG5271  881 AETDADADADAGEADSSGESS-AAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEE 959


                 ....*..
gi 6323135  4665 GDYKTGK 4671
Cdd:COG5271  960 SDDAAAD 966
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1078-1214 9.33e-24

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 99.67  E-value: 9.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1078 PVLIQGPTSSGKTSMIKYLAD-ITGHKFVRINNHEHTDLQEYLGTYVTDDTGKlSFKEGVLVEALRKGYWIVLDELNLAP 1156
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGA-SWVDGPLVRAAREGEIAVLDEINRAN 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    1157 TDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPgiYGGRKILSRAFRNRF 1214
Cdd:pfam07728   80 PDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPL--DRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1891-1990 2.57e-22

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 94.68  E-value: 2.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1891 DLLLIAKHLYPsIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLN---QYSICEDV--DVFDFVD 1965
Cdd:pfam17867    1 DLEQILSHRFP-LLASLAEKLIEVYSRLQELVSSSRSFGSSGSPREFNLRDLLRWCRRLSsllPTLLSPTVreEIFLEAV 79

                           90       100
                   ....*....|....*....|....*
gi 6323135    1966 IIVKQRFRTISDKNKAQLLIEDIFG 1990
Cdd:pfam17867   80 DVFAGRFRTPEDREAVAELIAEVLG 104
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1363-1558 7.68e-22

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 94.28  E-value: 7.68e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1363 PVLLVGETGCGKTTICQLLAQ-FMGRELITLNAHQNTETGDILGAqrpvrnrseiqyklikslktalniandqdvdlkel 1441
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGR----------------------------------- 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1442 lqlysksdnkniaedvqleiqklRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEpERSLLLAEQG 1521
Cdd:pfam07728   46 -----------------------RNIDPGGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLLPDGG 101

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 6323135    1522 SSDSLvtASENFQFFATMNPgGDYGKKELSPALRNRF 1558
Cdd:pfam07728  102 ELVKA--APDGFRLIATMNP-LDRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 465-579 6.54e-21

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 90.44  E-value: 6.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     465 DLTHILAQKFPILTNLIPKLIDSYKNVKSIYMNTKFISLnkGAHTRVVSVRDLIKLCERLDILFKNnginkpdqLIQSSV 544
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGS--SGSPREFNLRDLLRWCRRLSSLLPT--------LLSPTV 70

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 6323135     545 YDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDI 579
Cdd:pfam17867   71 REEIFLEAVDVFAGRFRTPEDREAVAELIAEVLGI 105
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 310-427 1.17e-18

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 85.42  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     310 PIMLIGKAGSGKTFLINELSKYMgCHDSIVKIHLGEQTDAKLLIGTYTSgdKPGTFEWRAGVLATAVKEGRWVLIEDIDK 389
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAAL-SNRPVFYVQLTRDTTEEDLFGRRNI--DPGGASWVDGPLVRAAREGEIAVLDEINR 77

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 6323135     390 APTDVLSILLSLLEKRELTIPSRGETVKAAN-GFQLIST 427
Cdd:pfam07728   78 ANPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIAT 116
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1742-1879 1.29e-16

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 79.26  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1742 PILLEGSPGVGKTSLITALAN-ITGNKLTRINLSEQTDLVDLFGADAPGERSGEflWHDAPFLRAMKKGEWVLLDEMNLA 1820
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGAS--WVDGPLVRAAREGEIAVLDEINRA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135    1821 SQSVLEGLNACLDHRgeaYIPELDISFSCH---PNFLVFAAQNPQYQGGgrKGLPKSFVNRF 1879
Cdd:pfam07728   79 NPDVLNSLLSLLDER---RLLLPDGGELVKaapDGFRLIATMNPLDRGL--NELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1226-1320 4.82e-16

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 76.57  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1226 ELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNS--FATLRDLFRWALR---------DAVGYEQLAASGYM 1294
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGSSGSprEFNLRDLLRWCRRlssllptllSPTVREEIFLEAVD 80

                           90       100
                   ....*....|....*....|....*.
gi 6323135    1295 LLAERCRTPQEKVTVKKTLEKVMKVK 1320
Cdd:pfam17867   81 VFAGRFRTPEDREAVAELIAEVLGIS 106
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1078-1281 1.09e-14

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 77.90  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1078 PVLIQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTD-DTGKLSFKEGVLVEAlrkgywIVL-DELNLA 1155
Cdd:COG0714   33 HLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDqQTGEFEFRPGPLFAN------VLLaDEINRA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1156 PTDV----LEALnrlldDNRELFIPEtQEVVHPHPdFLLFATQNPPGIYGGRKiLSRAFRNRFL-ELHFdDIPQDELEI- 1229
Cdd:COG0714  107 PPKTqsalLEAM-----EERQVTIPG-GTYKLPEP-FLVIATQNPIEQEGTYP-LPEAQLDRFLlKLYI-GYPDAEEERe 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6323135  1230 ILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNSFATLRDLFRwALRD 1281
Cdd:COG0714  178 ILRRHTGRHLAEVEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVR-ATRE 228
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1732-1922 1.26e-14

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 77.90  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1732 RVVRAMQV----HKPILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAPGERSGEFLWHDAPFLRAMk 1807
Cdd:COG0714   19 ELIELVLIallaGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGEFEFRPGPLFANV- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1808 kgewVLLDEMNLAS---QSVLegLNAcLDHRgEAYIPELDISFScHPnFLVFAAQNPQYQGGGRKgLPKSFVNRFSV-VF 1883
Cdd:COG0714   98 ----LLADEINRAPpktQSAL--LEA-MEER-QVTIPGGTYKLP-EP-FLVIATQNPIEQEGTYP-LPEAQLDRFLLkLY 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 6323135  1884 IDMLTSDDLLLI----AKHLYPSIEPDIIAKMIKLMSTLEDQV 1922
Cdd:COG0714  167 IGYPDAEEEREIlrrhTGRHLAEVEPVLSPEELLALQELVRQV 209
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4183-4451 1.56e-12

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 74.65  E-value: 1.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4183 EEDVQAAENDEQQRDNkEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEvKDEEGEDLEANVPEIETLDLPEDMNLD 4262
Cdd:TIGR00927  632 KGDVAEAEHTGERTGE-EGERPTEAEGENGEESGGEAEQEGETETKGENESE-GEIPAERKGEQEGEGEIEAKEADHKGE 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4263 SEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQE------SGIESDNENDEPGPEEDAG-ETETALDEEEG---AEEDV 4332
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEgegeaeGKHEVETEGDRKETEHEGEtEAEGKEDEDEGeiqAGEDG 789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4333 DMTNDEGkedeengpEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKG-AGADAT 4411
Cdd:TIGR00927  790 EMKGDEG--------AEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGgGGSDGG 861

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 6323135    4412 DTQEQDDvggsgttQNTYEEDQEDVTKNNEESREEATAAL 4451
Cdd:TIGR00927  862 DSEEEEE-------EEEEEEEEEEEEEEEEEEEEENEEPL 894
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4148-4457 1.28e-11

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 71.48  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4148 NEDDPNAidDKMWDDKASDNSKEKDTDQNLD-GKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEEN 4226
Cdd:NF033609  561 SDSDPGS--DSGSDSSNSDSGSDSGSDSTSDsGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4227 DVGEQEDEvkdeegeDLEANVPEIETLDLPEDMNLDSEHE-ESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNE 4305
Cdd:NF033609  639 DSDSDSDS-------DSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4306 NDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEK 4385
Cdd:NF033609  712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323135   4386 ADTE-DIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDS 4457
Cdd:NF033609  792 SDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDS 864
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4162-4460 2.76e-11

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 70.32  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4162 DKASDNSKEKDTDQNLDGKNQEEDVQAAENDEqqrdnkeggDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGE 4241
Cdd:NF033609  605 DSASDSDSASDSDSASDSDSASDSDSASDSDS---------ASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4242 -DLEANVPEIETLDLPEDMNLDSEHE-ESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETE 4319
Cdd:NF033609  676 sDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4320 TALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTE-DIDQEAAVQ 4398
Cdd:NF033609  756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSD 835

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135   4399 QDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKN------NEESREEATAALKQLGDSMKE 4460
Cdd:NF033609  836 SDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNspkngtNASNKNEAKDSKEPLPDTGSE 903
PHA03169 PHA03169
hypothetical protein; Provisional
 4178-4376 3.32e-11

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 68.84  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4178 DGKNQEEDVQAAENDEQQR-DNKEGGDEDPNAPEDgdeeiendENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLP 4256
Cdd:PHA03169   50 APTTSGPQVRAVAEQGHRQtESDTETAEESRHGEK--------EERGQGGPSGSGSESVGSPTPSPSGSAEELASGLSPE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4257 EDMNLDSEHEESDEDV--DMSDGMPDDLNKEEVGNEDEEVKQESGIESDNEN-DEPG------PEEDA---GETETALDE 4324
Cdd:PHA03169  122 NTSGSSPESPASHSPPpsPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDsPEEPepptsePEPDSpgpPQSETPTSS 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323135   4325 EEGAEEdvdmtNDEGKEDEENGPEEQAMSDE-EELKQDAAMEENKEKGGEQNT 4376
Cdd:PHA03169  202 PPPQSP-----PDEPGEPQSPTPQQAPSPNTqQAVEHEDEPTEPEREGPPFPG 249
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4255-4631 1.98e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 67.63  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4255 LPEDMNLDSEHEESDEDVDM---SDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEED 4331
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSdpgSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSD 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4332 VDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGlDGVEEKADTEDIDQEAAVQQDSGSKGAGADAT 4411
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4412 DTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSmkeyhrrrqdikEAQTNGEEDENLEKNNErpdef 4491
Cdd:NF033609  703 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS------------DSDSDSDSDSDSDSDSD----- 765

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4492 ehvegANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDAD-DEKMDIDeeemlSDIDAhDANNDVDSKK 4570
Cdd:NF033609  766 -----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSD-----SDSDS-DSDSDSDSDS 834

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323135   4571 SGFIGKRKSEEDFENELSNEHFSADQEDDSEIQSLIENIEDNPPDASASLTPERSLEESRE 4631
Cdd:NF033609  835 DSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKE 895
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4046-4393 3.57e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 66.86  E-value: 3.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4046 PQPPSEEVDDKNLQEGT----GLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELED 4121
Cdd:NF033609  545 PEQPDEPGEIEPIPEDSdsdpGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDS 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4122 LSNGEENDDEDTDSEEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEqqrDNKEG 4201
Cdd:NF033609  625 ASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS---DSDSD 701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4202 GDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGE-DLEANVPEIETLDLPEDMNLDSEhEESDEDVDMSDGMPD 4280
Cdd:NF033609  702 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDS 780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4281 DLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKE---------DEENGPEEQA 4351
Cdd:NF033609  781 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsdsdsdsDSDSDSESDS 860

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 6323135   4352 MSDEEELKQDAAMEENKEKGG---EQNTEGLDGVEEKADTEDIDQ 4393
Cdd:NF033609  861 NSDSESGSNNNVVPPNSPKNGtnaSNKNEAKDSKEPLPDTGSEDE 905
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 2190-2276 1.12e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.53  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    2190 VKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEiDGSLLInecsqEDGQPRVLKPHPNFRLFLTMDPKYG-- 2267
Cdd:pfam07728   51 GGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLL-----PDGGELVKAAPDGFRLIATMNPLDRgl 124

                           90
                   ....*....|
gi 6323135    2268 -ELSRAMRNR 2276
Cdd:pfam07728  125 nELSPALRSR 134
Granin pfam01271
Granin (chromogranin or secretogranin);
4162-4562 2.20e-08

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 60.43  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4162 DKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQqrdnkeggdEDPNAPEDGDeeiendenaeeenDVGEQEDEVKDEEGE 4241
Cdd:pfam01271  184 DTPSKQKREKSDEREKSSQESGEDTYRQENIPQ---------EDQVGPEDQE-------------PSEEGEEDATQEEVK 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4242 DLEANVPEIETLdlPEDMNLDSEHEESDEDVDMSDG---MPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGEt 4318
Cdd:pfam01271  242 RSRPRTHHGRSL--PDESSRGGQLGLEEEASEEEEEygeESRGLSAVQTYLLRLVNARGRGRSEKRAERERSEESEEEE- 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4319 etalDEEEGAEEDVDMTNDEgkedeeNGPEeqamSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDidQEAAVQ 4398
Cdd:pfam01271  319 ----LKRASPYEELEITANL------QIPP----SEEERMLKKAGRSPRGRVDEAGALEALEALEEKRKLDL--DHSRVF 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4399 QDSGSKGAGADATDTQEQD----DVGGSGTTQNTyeeDQEDVTKNNEESREEATAALKQ-LGDSMKEYHRRRQ---DIKE 4470
Cdd:pfam01271  383 ESSEDGAPRAPQGAWVEALrnylSYGEEGMEGKW---NQQGPYFPNEENREEARFRLPQyLGELSNPWEDPKQwkpSDFE 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4471 AQTN-------GEEDENL---------EKNNERPdEFEhVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVdQ 4534
Cdd:pfam01271  460 RKELtadkfleGEEENEYtlsmknsfpEYNYDGY-EKR-VPSPGLDLKRQYDPVAREDQLLHYRKKSSEFPDFYDSEE-K 536

                          410       420       430
                   ....*....|....*....|....*....|...
gi 6323135    4535 KELVEDADDEK-----MDIDEEEMLSDIDAHDA 4562
Cdd:pfam01271  537 KEPPVGAEKEEdsanrQTRDEDKELENLAAMDL 569
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 310-427 2.60e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 58.64  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   310 PIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHlgEQTDAKLLIGTYTSGDKPGTFEWRAGVLATAVkegrwVLIEDIDK 389
Cdd:COG0714   33 HLLLEGVPGVGKTTLAKALARALGLPFIRIQFT--PDLLPSDILGTYIYDQQTGEFEFRPGPLFANV-----LLADEINR 105

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 6323135   390 APTDVLSILLSLLEKRELTIPsrGETVKAANGFQLIST 427
Cdd:COG0714  106 APPKTQSALLEAMEERQVTIP--GGTYKLPEPFLVIAT 141
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 648-703 2.15e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 49.98  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135     648 PVLLVGETGTGKTTVVQQLAKMLA-KKLTVINVSQQTETGDLLGGYKPVNSKTVAVP 703
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSnRPVFYVQLTRDTTEEDLFGRRNIDPGGASWVD 57
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1729-1881 4.05e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.84  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1729 NLVRVVRAMQVHKPILLEGSPGVGKTSLITALANITGNKLTRINlseQTDLVDLFGADAPGERSGEFLWHDAPFLRAMKK 1808
Cdd:cd00009    8 EALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFL---YLNASDLLEGLVVAELFGHFLVRLLFELAEKAK 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323135  1809 GEWVLLDEMNLASQSVLEGLNACLDhrgeayipELDISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSV 1881
Cdd:cd00009   85 PGVLFIDEIDSLSRGAQNALLRVLE--------TLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVI 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1361-1558 4.42e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 4.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1361 KEPVLLVGETGCGKTTICQLLAQFMGRE---LITLNAhQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVD 1437
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDG-EDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1438 LkellqlysksdnkniaedvqleiqklrdslnvlfewsdgpliqamrtgnfFLLDEISLADDSVLERLNSVLEPERSLLL 1517
Cdd:smart00382   81 V--------------------------------------------------LILDEITSLLDAEQEALLLLLEELRLLLL 110

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 6323135     1518 AEQgssdslvtaSENFQFFATMNPGGDYGKKELSPALRNRF 1558
Cdd:smart00382  111 LKS---------EKNLTVILTTNDEKDLGPALLRRRFDRRI 142
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4329-4618 6.67e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.60  E-value: 6.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4329 EEDVDMTNDEGKEDEENGPEEQAMSDE----EELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSK 4404
Cdd:NF033609  524 DNEVAFNNGSGSGDGIDKPVVPEQPDEpgeiEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASD 603

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4405 GAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKN 4484
Cdd:NF033609  604 SDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4485 NERPDEFEHVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDA-HDAN 4563
Cdd:NF033609  684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSD 763

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6323135   4564 NDVDS-KKSGFIGKRKSEEDFENElSNEHFSADQEDDSEIQSLIENIEDNPPDASA 4618
Cdd:NF033609  764 SDSDSdSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 818
PHA02244 PHA02244
ATPase-like protein
 1078-1229 1.03e-05

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 51.27  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1078 PVLIQGPTSSGKTSMIKYLADITGHKFVRINnhehTDLQEYLGTYVTDDTGKlsFKEGVLVEALRKGYWIVLDELNLAPT 1157
Cdd:PHA02244  121 PVFLKGGAGSGKNHIAEQIAEALDLDFYFMN----AIMDEFELKGFIDANGK--FHETPFYEAFKKGGLFFIDEIDASIP 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135   1158 DVLEALNRLLDDNRELFIPETqevVHPHPDFLLFATQNPPG-----IYGGRKILSRAFRNRFLELHFDDIPQDELEI 1229
Cdd:PHA02244  195 EALIIINSAIANKFFDFADER---VTAHEDFRVISAGNTLGkgadhIYVARNKIDGATLDRFAPIEFDYDEKIEHLI 268
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 811-896 1.07e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 48.06  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     811 FVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLtepDSRSILLSEKGdaEPIKAHPD-FRIFACMNPAtDVGKRDLP 889
Cdd:pfam07728   55 WVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLL---DERRLLLPDGG--ELVKAAPDgFRLIATMNPL-DRGLNELS 128


                   ....*..
gi 6323135     890 MGIRSRF 896
Cdd:pfam07728  129 PALRSRF 135
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 4705-4879 1.29e-05

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 48.99  E-value: 1.29e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     4705 IMIALDDSKSMSESK--CVKLAfdslclVSKTLTQLEAGG----LSIVKFGENIKEVHSFDQQFSNE---SGARAFQWFG 4775
Cdd:smart00327    2 VVFLLDGSGSMGGNRfeLAKEF------VLKLVEQLDIGPdgdrVGLVTFSDDARVLFPLNDSRSKDallEALASLSYKL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     4776 FQETKTD--VKKLVAESTKIFERARAMVHndqwQLEIVISDGICEDHET-IQKLVRRARENKIMLVFViidGITSNESIL 4852
Cdd:smart00327   76 GGGTNLGaaLQYALENLFSKSAGSRRGAP----KVVILITDGESNDGPKdLLKAAKELKRSGVKVFVV---GVGNDVDEE 148

                           170       180
                    ....*....|....*....|....*..
gi 6323135     4853 DMSQVNYIPDQYGNPQLKITKYLDTFP 4879
Cdd:smart00327  149 ELKKLASAPGGVYVFLPELLDLLIDLL 175
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1075-1214 1.80e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 47.75  E-value: 1.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1075 KRFPVLIQGPTSSGKTSMIKYLA---DITGHKFVRIN--NHEHTDLQEYLGTYVTDDTGKLSFKEGV--LVEALRKGYW- 1146
Cdd:smart00382    1 PGEVILIVGPPGSGKTTLARALArelGPPGGGVIYIDgeDILEEVLDQLLLIIVGGKKASGSGELRLrlALALARKLKPd 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135     1147 -IVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHphpdfLLFATQNPPGIygGRKILSRAFRNRF 1214
Cdd:smart00382   81 vLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT-----VILTTNDEKDL--GPALLRRRFDRRI 142
PHA02244 PHA02244
ATPase-like protein
 1724-1894 2.42e-05

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 50.12  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1724 PTTASNLVRVVRAMQVHKPILLEGSPGVGKTSLITALAnitgnKLTRINLSEQTDLVDLFGADAPGERSGEFlwHDAPFL 1803
Cdd:PHA02244  103 PTFHYETADIAKIVNANIPVFLKGGAGSGKNHIAEQIA-----EALDLDFYFMNAIMDEFELKGFIDANGKF--HETPFY 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1804 RAMKKGEWVLLDEMNLASQSVLEGLNACLDHRgeaYIPELDISFSCHPNFLVFAAQNPQYQGG-----GRKGLPKSFVNR 1878
Cdd:PHA02244  176 EAFKKGGLFFIDEIDASIPEALIIINSAIANK---FFDFADERVTAHEDFRVISAGNTLGKGAdhiyvARNKIDGATLDR 252

                         170
                  ....*....|....*.
gi 6323135   1879 FSVVFIDMLTSDDLLL 1894
Cdd:PHA02244  253 FAPIEFDYDEKIEHLI 268
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1352-1426 5.19e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 46.37  E-value: 5.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135  1352 VLVSSCLKNKEPVLLVGETGCGKTTICQLLAQ---FMGRELITLNAHQNTETGDILGAQRPVRNRSEIQYKLIKSLKT 1426
Cdd:cd00009   10 LREALELPPPKNLLLYGPPGTGKTTLARAIANelfRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGV 87
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4045-4376 1.36e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.37  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4045 SPQPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSN 4124
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4125 GEENDDEdtdseeeeldeeiddlnedDPNAIDDKmwdDKASDNSKEKDTDQNLDgKNQEEDVQAAENDEQQRDNKEGGDE 4204
Cdd:NF033609  704 SDSDSDS-------------------DSDSDSDS---DSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDS 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4205 DPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGedleanvpeietlDLPEDMNLDSeheESDEDVDMSDGMPDDLNK 4284
Cdd:NF033609  761 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-------------DSDSDSDSDS---DSDSDSDSDSDSDSDSDS 824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4285 EEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDegKEDEENGPEEQAMSDEEELKQDAAM 4364
Cdd:NF033609  825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNS--PKNGTNASNKNEAKDSKEPLPDTGS 902

                         330
                  ....*....|..
gi 6323135   4365 EenkekgGEQNT 4376
Cdd:NF033609  903 E------DEANT 908
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1068-1214 2.34e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 44.83  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1068 LVRATSGKRFPVLIQGPTSSGKTSMIKYLADIT---GHKFVRINNHEhtdlqEYLGTYVTDDTGKLSFKEGVLVEALRKG 1144
Cdd:cd00009   11 REALELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASD-----LLEGLVVAELFGHFLVRLLFELAEKAKP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1145 YWIVLDELNLAPTDVLEALNRLLDDnrelfipETQEVVHPHPDFLLFATQNPPGIyggrkILSRAFRNRF 1214
Cdd:cd00009   86 GVLFIDEIDSLSRGAQNALLRVLET-------LNDLRIDRENVRVIGATNRPLLG-----DLDRALYDRL 143
PRK04195 PRK04195
replication factor C large subunit; Provisional
 1342-1394 1.46e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 44.91  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323135   1342 TWTKGmrrlsvlvssclKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNA 1394
Cdd:PRK04195   32 SWLKG------------KPKKALLLYGPPGVGKTSLAHALANDYGWEVIELNA 72
clpC CHL00095
Clp protease ATP binding subunit
 310-420 3.11e-03

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 43.89  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    310 PI---MLIGKAGSGKTFLINELSKYM-GCHDSIVKIHLGE----QTDAKLLigtytsGDKPGTFEW-RAGVLATAVKEGR 380
Cdd:CHL00095  538 PIasfLFSGPTGVGKTELTKALASYFfGSEDAMIRLDMSEymekHTVSKLI------GSPPGYVGYnEGGQLTEAVRKKP 611

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6323135    381 W--VLIEDIDKAPTDVLSILLSLLEKRELTiPSRGETVKAAN 420
Cdd:CHL00095  612 YtvVLFDEIEKAHPDIFNLLLQILDDGRLT-DSKGRTIDFKN 652
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 312-416 6.54e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 41.01  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   312 MLIGKAGSGKTFLINELSKYM-GCHDSIVKIHLGEQT---DAKLLIGT------YTSGdkpgtfewraGVLATAVKEGRW 381
Cdd:cd19499   45 LFLGPTGVGKTELAKALAELLfGDEDNLIRIDMSEYMekhSVSRLIGAppgyvgYTEG----------GQLTEAVRRKPY 114

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 6323135   382 --VLIEDIDKAPTDVLSILLSLLEKRELTiPSRGETV 416
Cdd:cd19499  115 svVLLDEIEKAHPDVQNLLLQVLDDGRLT-DSHGRTV 150
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 310-415 6.97e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135      310 PIMLIGKAGSGKTFLINELSKYMGCHDSIVKI----HLGEQTDAKLLIGTYTSGDKPGTFEWRAGVLATAVKEGRW--VL 383
Cdd:smart00382    4 VILIVGPPGSGKTTLARALARELGPPGGGVIYidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPdvLI 83

                            90       100       110
                    ....*....|....*....|....*....|..
gi 6323135      384 IEDIDKAPTDVLSILLSLLEKRELTIPSRGET 415
Cdd:smart00382   84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEK 115
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 630-686 7.48e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 41.43  E-value: 7.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323135   630 NHSLRLMEQISVCIQMTE----PVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETG 686
Cdd:cd19497   30 NHYKRIRNNLKQKDDDVEleksNILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAG 90
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 647-712 8.12e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 8.12e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135      647 EPVLLVGETGTGKTTVVQQLAKMLAKKLT---VINVSQQTETGDLLGGYKPVNSKTVAVPIQENFETLF 712
Cdd:smart00382    3 EVILIVGPPGSGKTTLARALARELGPPGGgviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71
 
Name Accession Description Interval E-value
vWA_midasin cd01460
VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are ...
 4643-4910 5.12e-139

VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The AAA domains in midasin is followed by a D/E rich domain that is following by a VWA domain. The members of this subgroup have a conserved MIDAS motif. The function of this domain is not exactly known although it has been speculated to play a crucial role in midasin function.


Pssm-ID: 238737  Cd Length: 266  Bit Score: 435.63  E-value: 5.12e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4643 LVSRLGEQLRLILEPTLATKLKGDYKTGKRLNMKRIIPYIASQFRKDKIWLRRTKPSKRQYQIMIALDDSKSMSESKCVK 4722
Cdd:cd01460    1 LSSELCEQLRLILEPTLATKLKGDYRTGKRLNMKKIIPYIASQFRKDKIWLRRTKPAKRDYQILIAIDDSKSMSENNSKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4723 LAFDSLCLVSKTLTQLEAGGLSIVKFGENIKEVHSFDQQFSNESGARAFQWFGFQETKTDVKKLVAESTKIFERARAMVH 4802
Cdd:cd01460   81 LALESLCLVSKALTLLEVGQLGVCSFGEDVQILHPFDEQFSSQSGPRILNQFTFQQDKTDIANLLKFTAQIFEDARTQSS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4803 NDQ-WQLEIVISDGICEDHETIQKL-VRRARENKIMLVFVIIDGITSNESILDMSQVNYIPDQYGnpqlKITKYLDTFPF 4880
Cdd:cd01460  161 SGSlWQLLLIISDGRGEFSEGAQKVrLREAREQNVFVVFIIIDNPDNKQSILDIKVVSFKNDKSG----VITPYLDEFPF 236

                        250       260       270
                 ....*....|....*....|....*....|
gi 6323135  4881 EFYVVVHDISELPEMLSLILRQYFTDLASS 4910
Cdd:cd01460  237 PYYVIVRDLNQLPSVLSDALRQWFELVNSS 266
AAA_lid_5 pfam17865
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 910-1015 4.87e-32

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 407722  Cd Length: 104  Bit Score: 122.31  E-value: 4.87e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     910 DLLSIIDKYIGKYSVSDEWVgNDIAELYLEAKKLSdNNTIVDGSNQKPHFSIRTLTRTLLYVTDIIHIYGLRRSLYDGFC 989
Cdd:pfam17865    1 DLELLVKAYLKGVSSDDDLV-RDIVKFYLEAKKLA-EKSLVDGAGQRPHYSLRTLCRALSYARAIAPRYGLRRALYEGFC 78

                           90       100
                   ....*....|....*....|....*.
gi 6323135     990 MSFLTLLDQKSEAILKPVIEKFTLGR 1015
Cdd:pfam17865   79 MSFLTQLDAESRKIVEKLIRKHLLKG 104
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4046-4671 7.81e-24

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 111.65  E-value: 7.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4046 PQPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNG 4125
Cdd:COG5271  335 DEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEASADGGTSPTSDTD 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4126 EENDDEDTDSEEEELDEEiddlNEDDPNAIDDKMWDDKASD--NSKEKDTDQNLDGKNQEEDVQAAENDEQ---QRDNKE 4200
Cdd:COG5271  415 EEEEEADEDASAGETEDE----STDVTSAEDDIATDEEADSlaDEEEEAEAELDTEEDTESAEEDADGDEAtdeDDASDD 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4201 GGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDlpEDMNLDSEHEESDEDVDMSDGMPD 4280
Cdd:COG5271  491 GDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSDEDALEDETEGEE--NAPGSDQDADETDEPEATAEEDEP 568

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4281 DLNKEEVGNEDEEVkqesgiESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQ 4360
Cdd:COG5271  569 DEAEAETEDATENA------DADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPET 642

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4361 DAAMEENKEKGGEQNTEG-----LDGVEEKADTEDIDQEAAvqQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEE---D 4432
Cdd:COG5271  643 DASEAADEDADAETEAEAsadesEEEAEDESETSSEDAEED--ADAAAAEASDDEEETEEADEDAETASEEADAEEadtE 720

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4433 QEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQ- 4511
Cdd:COG5271  721 ADGTAEEAEEAAEEAESADEEAASLPDEADAEEEAEEAEEAEEDDADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVa 800

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4512 DQLQTIDEDMAIDDDREEQEVD-QKELVEDADDEKMDIDEE--EMLSDIDAHDANNDVDSKKSGFIGKRK----SEEDFE 4584
Cdd:COG5271  801 DEDQDTDEDALLDEAEADEEEDlDGEDEETADEALEDIEAGiaEDDEEDDDAAAAKDVDADLDLDADLAAdeheAEEAQE 880

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4585 NELSNEHFSADQEDDSEIQSLiENIEDNPPDASASLTPERSLEESRELWHKSEISTADLVSRLGEQLRLILEPTLATKLK 4664
Cdd:COG5271  881 AETDADADADAGEADSSGESS-AAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEE 959


                 ....*..
gi 6323135  4665 GDYKTGK 4671
Cdd:COG5271  960 SDDAAAD 966
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1078-1214 9.33e-24

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 99.67  E-value: 9.33e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1078 PVLIQGPTSSGKTSMIKYLAD-ITGHKFVRINNHEHTDLQEYLGTYVTDDTGKlSFKEGVLVEALRKGYWIVLDELNLAP 1156
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGA-SWVDGPLVRAAREGEIAVLDEINRAN 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    1157 TDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPgiYGGRKILSRAFRNRF 1214
Cdd:pfam07728   80 PDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPL--DRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1891-1990 2.57e-22

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 94.68  E-value: 2.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1891 DLLLIAKHLYPsIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLN---QYSICEDV--DVFDFVD 1965
Cdd:pfam17867    1 DLEQILSHRFP-LLASLAEKLIEVYSRLQELVSSSRSFGSSGSPREFNLRDLLRWCRRLSsllPTLLSPTVreEIFLEAV 79

                           90       100
                   ....*....|....*....|....*
gi 6323135    1966 IIVKQRFRTISDKNKAQLLIEDIFG 1990
Cdd:pfam17867   80 DVFAGRFRTPEDREAVAELIAEVLG 104
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1363-1558 7.68e-22

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 94.28  E-value: 7.68e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1363 PVLLVGETGCGKTTICQLLAQ-FMGRELITLNAHQNTETGDILGAqrpvrnrseiqyklikslktalniandqdvdlkel 1441
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGR----------------------------------- 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1442 lqlysksdnkniaedvqleiqklRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEpERSLLLAEQG 1521
Cdd:pfam07728   46 -----------------------RNIDPGGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLLPDGG 101

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 6323135    1522 SSDSLvtASENFQFFATMNPgGDYGKKELSPALRNRF 1558
Cdd:pfam07728  102 ELVKA--APDGFRLIATMNP-LDRGLNELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 465-579 6.54e-21

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 90.44  E-value: 6.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     465 DLTHILAQKFPILTNLIPKLIDSYKNVKSIYMNTKFISLnkGAHTRVVSVRDLIKLCERLDILFKNnginkpdqLIQSSV 544
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGS--SGSPREFNLRDLLRWCRRLSSLLPT--------LLSPTV 70

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 6323135     545 YDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDI 579
Cdd:pfam17867   71 REEIFLEAVDVFAGRFRTPEDREAVAELIAEVLGI 105
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4049-4637 2.04e-19

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 97.01  E-value: 2.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4049 PSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQqdKDERDDENEDDAVEMEGDMAGELEDLSNGEEN 4128
Cdd:COG5271  187 IEATPGGTDAVELTATLGATVTTDPGDSVAADDDLAAEEGASAVVE--EEDASEDAVAAADETLLADDDDTESAGATAEV 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4129 DDEDTDSEEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNA 4208
Cdd:COG5271  265 GGTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAE 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4209 PEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSEH-------EESDEDVDMSDGMPDD 4281
Cdd:COG5271  345 DAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAsadggtsPTSDTDEEEEEADEDA 424

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4282 LNKEEVGNEDEEVKQESGIESDNE-------------NDEPGPEEDAGETETALDE---EEGAEEDVDMTNDEGKEDEEN 4345
Cdd:COG5271  425 SAGETEDESTDVTSAEDDIATDEEadsladeeeeaeaELDTEEDTESAEEDADGDEatdEDDASDDGDEEEAEEDAEAEA 504

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4346 GPEEqamSDEEELKQDAAMEENKEKGGEQNTEG--LDGVEEKADTEDIDQEAAVQQDsgskgagADATDTQEQDDVGGSG 4423
Cdd:COG5271  505 DSDE---LTAEETSADDGADTDAAADPEDSDEDalEDETEGEENAPGSDQDADETDE-------PEATAEEDEPDEAEAE 574

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4424 TTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDT 4503
Cdd:COG5271  575 TEDATENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADEDADA 654

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4504 QALGSATQD-QLQTIDEDMAIDDDREEQEVDQKELVEDADDEKM---DIDEEEMLSDIDAHDANNDVDSKKSGFIGKRKS 4579
Cdd:COG5271  655 ETEAEASADeSEEEAEDESETSSEDAEEDADAAAAEASDDEEETeeaDEDAETASEEADAEEADTEADGTAEEAEEAAEE 734

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135  4580 EEDFENELSNEHFSADQEDD---------SEIQSLIENIEDNPPDASASLTPERSLEESRELWHKSE 4637
Cdd:COG5271  735 AESADEEAASLPDEADAEEEaeeaeeaeeDDADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVAD 801
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4051-4619 2.96e-19

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 96.62  E-value: 2.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4051 EEVDDKNLQEGTGLGDGEGAQNNNKDvEQDEDLTEDAQNENKEQQDKDeRDDENEDDAVEMEGDMAGELEDLSNGEENDD 4130
Cdd:COG5271  418 EEADEDASAGETEDESTDVTSAEDDI-ATDEEADSLADEEEEAEAELD-TEEDTESAEEDADGDEATDEDDASDDGDEEE 495

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4131 EDTDS-------EEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGD 4203
Cdd:COG5271  496 AEEDAeaeadsdELTAEETSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAET 575

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4204 EDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEA---NVPEIETLDLPEDMNLDSEHE-----ESDEDVDMS 4275
Cdd:COG5271  576 EDATENADADETEESADESEEAEASEDEAAEEEEADDDEADAdadGAADEEETEEEAAEDEAAEPEtdaseAADEDADAE 655

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4276 DGMPDDLNKEEVGNEDEEVKQESGIESDNE---------NDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKE----- 4341
Cdd:COG5271  656 TEAEASADESEEEAEDESETSSEDAEEDADaaaaeasddEEETEEADEDAETASEEADAEEADTEADGTAEEAEEaaeea 735

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4342 ---DEENGPEEQAmSDEEELKQDAAMEENKEkgGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGA--------GADA 4410
Cdd:COG5271  736 esaDEEAASLPDE-ADAEEEAEEAEEAEEDD--ADGLEEALEEEKADAEEAATDEEAEAAAEEKEKVAdedqdtdeDALL 812

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4411 TDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQT--NGEEDENLEKNNERP 4488
Cdd:COG5271  813 DEAEADEEEDLDGEDEETADEALEDIEAGIAEDDEEDDDAAAAKDVDADLDLDADLAADEHEAeeAQEAETDADADADAG 892

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4489 DEFEHVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDAHDANNDVDS 4568
Cdd:COG5271  893 EADSSGESSAAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAEDDLDALALDEAGDEESDDAAADDAGDDS 972

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6323135  4569 KKSGF-IGKRKSEEDFENELSNEHFSADQEDDSEIQSLIENIEDNPPDASAS 4619
Cdd:COG5271  973 LADDDeALADAADDAEADDSELDASESTGEAEGDEDDDELEDGEAAAGEATA 1024
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 310-427 1.17e-18

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 85.42  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     310 PIMLIGKAGSGKTFLINELSKYMgCHDSIVKIHLGEQTDAKLLIGTYTSgdKPGTFEWRAGVLATAVKEGRWVLIEDIDK 389
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAAL-SNRPVFYVQLTRDTTEEDLFGRRNI--DPGGASWVDGPLVRAAREGEIAVLDEINR 77

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 6323135     390 APTDVLSILLSLLEKRELTIPSRGETVKAAN-GFQLIST 427
Cdd:pfam07728   78 ANPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIAT 116
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4069-4631 3.97e-18

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 93.16  E-value: 3.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4069 GAQNNNKDVEQDEDLTEDAQN-ENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNGEENDDEDTDSEEEELDEEIDDL 4147
Cdd:COG5271  142 GGDLDLATKDGDELLPSLADNdEAAADEGDELAADGDDTLAVADAIEATPGGTDAVELTATLGATVTTDPGDSVAADDDL 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4148 NEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEEND 4227
Cdd:COG5271  222 AAEEGASAVVEEEDASEDAVAAADETLLADDDDTESAGATAEVGGTPDTDDEATDDADGLEAAEDDALDAELTAAQAADP 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4228 VGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSEHEESDEDVDMSDGMPDDLNKEE-VGNEDEEVKQESGIESDNEN 4306
Cdd:COG5271  302 ESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDtQDAEDEAAGEAADESEGADT 381

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4307 DEPGPEEDAGETETALDEE-------------EGAEEDVDMTNDEGKEDEENG----PEEQAMSDEEElkQDAAMEENKE 4369
Cdd:COG5271  382 DAAADEADAAADDSADDEEasadggtsptsdtDEEEEEADEDASAGETEDESTdvtsAEDDIATDEEA--DSLADEEEEA 459

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4370 KGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNtyEEDQEDVTKNNEESREEATA 4449
Cdd:COG5271  460 EAELDTEEDTESAEEDADGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAEETSAD--DGADTDAAADPEDSDEDALE 537

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4450 ALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREE 4529
Cdd:COG5271  538 DETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEADA 617

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4530 QEVDQKELVEDADDEKMDIDEEEMLSDIDAHDANNDVDSKKSGFIGKRKSEEDFENELSNEhfSADQEDDSEIQS-LIEN 4608
Cdd:COG5271  618 DADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAEASADESEEEAEDESETSSE--DAEEDADAAAAEaSDDE 695

                        570       580
                 ....*....|....*....|...
gi 6323135  4609 IEDNPPDASASLTPERSLEESRE 4631
Cdd:COG5271  696 EETEEADEDAETASEEADAEEAD 718
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4047-4590 6.26e-18

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 92.39  E-value: 6.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4047 QPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVE---QDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLS 4123
Cdd:COG5271  481 ATDEDDASDDGDEEEAEEDAEAEADSDELTAEetsADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADETDEPE 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4124 NGEENDDEDTDSEEEELDEEIDDLNED----DPNAIDDKMWDDKASDNSKEKDTDQNlDGKNQEEDVQAAENDEQQRDNK 4199
Cdd:COG5271  561 ATAEEDEPDEAEAETEDATENADADETeesaDESEEAEASEDEAAEEEEADDDEADA-DADGAADEEETEEEAAEDEAAE 639

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4200 EGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSEHEESDEDVDMSDgmp 4279
Cdd:COG5271  640 PETDASEAADEDADAETEAEASADESEEEAEDESETSSEDAEEDADAAAAEASDDEEETEEADEDAETASEEADAEE--- 716

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4280 DDLNKEEVGNEDEEVKQESGiESDNENDEPGPEEDAGETEtaLDEEEGAEEDVDmTNDEGKEDEENGPEEQAmSDEEELK 4359
Cdd:COG5271  717 ADTEADGTAEEAEEAAEEAE-SADEEAASLPDEADAEEEA--EEAEEAEEDDAD-GLEEALEEEKADAEEAA-TDEEAEA 791

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4360 QDAAMEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKN 4439
Cdd:COG5271  792 AAEEKEKVADEDQDTDEDALLDEAEADEEEDLDGEDEETADEALEDIEAGIAEDDEEDDDAAAAKDVDADLDLDADLAAD 871

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4440 NEESREEATAALKQLGD----SMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQAlGSATQDQLQ 4515
Cdd:COG5271  872 EHEAEEAQEAETDADADadagEADSSGESSAAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELG-AAEDDLDAL 950

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6323135  4516 TIDEDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDAHDANNDVDSKKSGFIGKRKSEEDFENELSNE 4590
Cdd:COG5271  951 ALDEAGDEESDDAAADDAGDDSLADDDEALADAADDAEADDSELDASESTGEAEGDEDDDELEDGEAAAGEATAD 1025
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4050-4633 7.71e-17

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 88.92  E-value: 7.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4050 SEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSNGEEND 4129
Cdd:COG5271   79 SAESDAGASLITAANLEEGDIAGNAADDSADEESDANAKEDATDDADSSGDAQGDPLATDTLGGGDLDLATKDGDELLPS 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4130 DEDTDSEEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNaP 4209
Cdd:COG5271  159 LADNDEAAADEGDELAADGDDTLAVADAIEATPGGTDAVELTATLGATVTTDPGDSVAADDDLAAEEGASAVVEEEDA-S 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4210 EDGDEEIENDENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSE-HEESDEDVDMSDGMPDDLNKEEVG 4288
Cdd:COG5271  238 EDAVAAADETLLADDDDTESAGATAEVGGTPDTDDEATDDADGLEAAEDDALDAElTAAQAADPESDDDADDSTLAALEG 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4289 NEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDmTNDEGKEDEENGPEEQAMSDEEELK-QDAAMEEN 4367
Cdd:COG5271  318 AAEDTEIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQ-DAEDEAAGEAADESEGADTDAAADEaDAAADDSA 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4368 KEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQD--------SGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTK- 4438
Cdd:COG5271  397 DDEEASADGGTSPTSDTDEEEEEADEDASAGETedestdvtSAEDDIATDEEADSLADEEEEAEAELDTEEDTESAEEDa 476

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4439 NNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQTID 4518
Cdd:COG5271  477 DGDEATDEDDASDDGDEEEAEEDAEAEADSDELTAEETSADDGADTDAAADPEDSDEDALEDETEGEENAPGSDQDADET 556

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4519 EDmaIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDAhDANNDVDSKKSGFI-GKRKSEEDFENELSNEHFSADQE 4597
Cdd:COG5271  557 DE--PEATAEEDEPDEAEAETEDATENADADETEESADESE-EAEASEDEAAEEEEaDDDEADADADGAADEEETEEEAA 633

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 6323135  4598 DDSEIQSLIENIEDNPPDASASLTPERSLEESRELW 4633
Cdd:COG5271  634 EDEAAEPETDASEAADEDADAETEAEASADESEEEA 669
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 1742-1879 1.29e-16

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 79.26  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1742 PILLEGSPGVGKTSLITALAN-ITGNKLTRINLSEQTDLVDLFGADAPGERSGEflWHDAPFLRAMKKGEWVLLDEMNLA 1820
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTRDTTEEDLFGRRNIDPGGAS--WVDGPLVRAAREGEIAVLDEINRA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135    1821 SQSVLEGLNACLDHRgeaYIPELDISFSCH---PNFLVFAAQNPQYQGGgrKGLPKSFVNRF 1879
Cdd:pfam07728   79 NPDVLNSLLSLLDER---RLLLPDGGELVKaapDGFRLIATMNPLDRGL--NELSPALRSRF 135
AAA_lid_7 pfam17867
Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found ...
 1226-1320 4.82e-16

Midasin AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. This lid domain is found in midasin proteins.


Pssm-ID: 465540  Cd Length: 106  Bit Score: 76.57  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1226 ELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNS--FATLRDLFRWALR---------DAVGYEQLAASGYM 1294
Cdd:pfam17867    1 DLEQILSHRFPLLASLAEKLIEVYSRLQELVSSSRSFGSSGSprEFNLRDLLRWCRRlssllptllSPTVREEIFLEAVD 80

                           90       100
                   ....*....|....*....|....*.
gi 6323135    1295 LLAERCRTPQEKVTVKKTLEKVMKVK 1320
Cdd:pfam17867   81 VFAGRFRTPEDREAVAELIAEVLGIS 106
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1078-1281 1.09e-14

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 77.90  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1078 PVLIQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTD-DTGKLSFKEGVLVEAlrkgywIVL-DELNLA 1155
Cdd:COG0714   33 HLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDqQTGEFEFRPGPLFAN------VLLaDEINRA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1156 PTDV----LEALnrlldDNRELFIPEtQEVVHPHPdFLLFATQNPPGIYGGRKiLSRAFRNRFL-ELHFdDIPQDELEI- 1229
Cdd:COG0714  107 PPKTqsalLEAM-----EERQVTIPG-GTYKLPEP-FLVIATQNPIEQEGTYP-LPEAQLDRFLlKLYI-GYPDAEEERe 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6323135  1230 ILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNSFATLRDLFRwALRD 1281
Cdd:COG0714  178 ILRRHTGRHLAEVEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVR-ATRE 228
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1732-1922 1.26e-14

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 77.90  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1732 RVVRAMQV----HKPILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAPGERSGEFLWHDAPFLRAMk 1807
Cdd:COG0714   19 ELIELVLIallaGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGEFEFRPGPLFANV- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1808 kgewVLLDEMNLAS---QSVLegLNAcLDHRgEAYIPELDISFScHPnFLVFAAQNPQYQGGGRKgLPKSFVNRFSV-VF 1883
Cdd:COG0714   98 ----LLADEINRAPpktQSAL--LEA-MEER-QVTIPGGTYKLP-EP-FLVIATQNPIEQEGTYP-LPEAQLDRFLLkLY 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 6323135  1884 IDMLTSDDLLLI----AKHLYPSIEPDIIAKMIKLMSTLEDQV 1922
Cdd:COG0714  167 IGYPDAEEEREIlrrhTGRHLAEVEPVLSPEELLALQELVRQV 209
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4183-4451 1.56e-12

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 74.65  E-value: 1.56e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4183 EEDVQAAENDEQQRDNkEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEvKDEEGEDLEANVPEIETLDLPEDMNLD 4262
Cdd:TIGR00927  632 KGDVAEAEHTGERTGE-EGERPTEAEGENGEESGGEAEQEGETETKGENESE-GEIPAERKGEQEGEGEIEAKEADHKGE 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4263 SEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQE------SGIESDNENDEPGPEEDAG-ETETALDEEEG---AEEDV 4332
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEgegeaeGKHEVETEGDRKETEHEGEtEAEGKEDEDEGeiqAGEDG 789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4333 DMTNDEGkedeengpEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKG-AGADAT 4411
Cdd:TIGR00927  790 EMKGDEG--------AEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGgGGSDGG 861

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 6323135    4412 DTQEQDDvggsgttQNTYEEDQEDVTKNNEESREEATAAL 4451
Cdd:TIGR00927  862 DSEEEEE-------EEEEEEEEEEEEEEEEEEEEENEEPL 894
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4147-4631 1.16e-11

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 71.58  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4147 LNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEEN 4226
Cdd:COG5271   66 KLLDLKSADGAALSAESDAGASLITAANLEEGDIAGNAADDSADEESDANAKEDATDDADSSGDAQGDPLATDTLGGGDL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4227 DVGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSEHEESDEDvdmsdgmPDDLNKEEVGNEDEEVKQESGIESDNEN 4306
Cdd:COG5271  146 DLATKDGDELLPSLADNDEAAADEGDELAADGDDTLAVADAIEAT-------PGGTDAVELTATLGATVTTDPGDSVAAD 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4307 DEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEqamsDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKA 4386
Cdd:COG5271  219 DDLAAEEGASAVVEEEDASEDAVAAADETLLADDDDTESAGAT----AEVGGTPDTDDEATDDADGLEAAEDDALDAELT 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4387 DTEDIDQEAAVQQDSGSKGAGADATDTQEqddvggsGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQ 4466
Cdd:COG5271  295 AAQAADPESDDDADDSTLAALEGAAEDTE-------IATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDE 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4467 DIKEAQTNGE--EDENLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQTIDED---MAIDDDREEQEVDQKELVEDA 4541
Cdd:COG5271  368 AAGEAADESEgaDTDAAADEADAAADDSADDEEASADGGTSPTSDTDEEEEEADEDasaGETEDESTDVTSAEDDIATDE 447

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4542 DDEKMDIDEEEMLSDIDAHDANNDVDSKKSGfiGKRKSEEDFENELSNEHFSADQEDDSEIQSLIENI--EDNPPDASAS 4619
Cdd:COG5271  448 EADSLADEEEEAEAELDTEEDTESAEEDADG--DEATDEDDASDDGDEEEAEEDAEAEADSDELTAEEtsADDGADTDAA 525

                        490
                 ....*....|..
gi 6323135  4620 LTPERSLEESRE 4631
Cdd:COG5271  526 ADPEDSDEDALE 537
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4148-4457 1.28e-11

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 71.48  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4148 NEDDPNAidDKMWDDKASDNSKEKDTDQNLD-GKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEEN 4226
Cdd:NF033609  561 SDSDPGS--DSGSDSSNSDSGSDSGSDSTSDsGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSAS 638

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4227 DVGEQEDEvkdeegeDLEANVPEIETLDLPEDMNLDSEHE-ESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNE 4305
Cdd:NF033609  639 DSDSDSDS-------DSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4306 NDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEK 4385
Cdd:NF033609  712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323135   4386 ADTE-DIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDS 4457
Cdd:NF033609  792 SDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDS 864
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 4045-4447 1.64e-11

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 71.20  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4045 SPQPPSEEVDDKNLQEGTglGDGEgaqnnNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSN 4124
Cdd:COG5271  644 ASEAADEDADAETEAEAS--ADES-----EEEAEDESETSSEDAEEDADAAAAEASDDEEETEEADEDAETASEEADAEE 716

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4125 GEENDDEDTDSEEEELDEEiddlNEDDPNAIDDKMWDDKASDNSKEKDtdqnldgKNQEEDVQAAENDEQQRDNKEGGDE 4204
Cdd:COG5271  717 ADTEADGTAEEAEEAAEEA----ESADEEAASLPDEADAEEEAEEAEE-------AEEDDADGLEEALEEEKADAEEAAT 785

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4205 DPNAPEDGDEEIEND-ENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLPEDMNlDSEHEESDEDVDMSDGMPDDLN 4283
Cdd:COG5271  786 DEEAEAAAEEKEKVAdEDQDTDEDALLDEAEADEEEDLDGEDEETADEALEDIEAGI-AEDDEEDDDAAAAKDVDADLDL 864

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4284 KEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAA 4363
Cdd:COG5271  865 DADLAADEHEAEEAQEAETDADADADAGEADSSGESSAAAEDDDAAEDADSDDGANDEDDDDDAEEERKDAEEDELGAAE 944

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4364 MEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEES 4443
Cdd:COG5271  945 DDLDALALDEAGDEESDDAAADDAGDDSLADDDEALADAADDAEADDSELDASESTGEAEGDEDDDELEDGEAAAGEATA 1024


                 ....
gi 6323135  4444 REEA 4447
Cdd:COG5271 1025 DLAA 1028
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4162-4460 2.76e-11

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 70.32  E-value: 2.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4162 DKASDNSKEKDTDQNLDGKNQEEDVQAAENDEqqrdnkeggDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGE 4241
Cdd:NF033609  605 DSASDSDSASDSDSASDSDSASDSDSASDSDS---------ASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4242 -DLEANVPEIETLDLPEDMNLDSEHE-ESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETE 4319
Cdd:NF033609  676 sDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4320 TALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTE-DIDQEAAVQ 4398
Cdd:NF033609  756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSD 835

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135   4399 QDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKN------NEESREEATAALKQLGDSMKE 4460
Cdd:NF033609  836 SDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNspkngtNASNKNEAKDSKEPLPDTGSE 903
PHA03169 PHA03169
hypothetical protein; Provisional
 4178-4376 3.32e-11

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 68.84  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4178 DGKNQEEDVQAAENDEQQR-DNKEGGDEDPNAPEDgdeeiendENAEEENDVGEQEDEVKDEEGEDLEANVPEIETLDLP 4256
Cdd:PHA03169   50 APTTSGPQVRAVAEQGHRQtESDTETAEESRHGEK--------EERGQGGPSGSGSESVGSPTPSPSGSAEELASGLSPE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4257 EDMNLDSEHEESDEDV--DMSDGMPDDLNKEEVGNEDEEVKQESGIESDNEN-DEPG------PEEDA---GETETALDE 4324
Cdd:PHA03169  122 NTSGSSPESPASHSPPpsPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDsPEEPepptsePEPDSpgpPQSETPTSS 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323135   4325 EEGAEEdvdmtNDEGKEDEENGPEEQAMSDE-EELKQDAAMEENKEKGGEQNT 4376
Cdd:PHA03169  202 PPPQSP-----PDEPGEPQSPTPQQAPSPNTqQAVEHEDEPTEPEREGPPFPG 249
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 1743-1879 5.25e-11

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 63.35  E-value: 5.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    1743 ILLEGSPGVGKTSLITALANITGNKLTRINLSeqTDLV--DLFGADAPGERSGEFLWHDAPFLramkkGEWVLLDEMNLA 1820
Cdd:pfam07726    2 VLLEGVPGLAKTLLVRTLARSLGLDFRRIQFT--PDLLpsDITGTEVFDQKTREFEFRPGPVF-----ANVLLADEINRA 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135    1821 S---QSVLegLNACLDHR----GEAY-IPELdisfschpnFLVFAAQNPQYQGGGRKgLPKSFVNRF 1879
Cdd:pfam07726   75 PpktQSAL--LEAMQERQvtidGETHpLPEP---------FFVLATQNPIEQEGTYP-LPEAQLDRF 129
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4247-4555 5.53e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 69.64  E-value: 5.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4247 VPEIETL-DLPEDMNLDSEH--EESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETald 4323
Cdd:TIGR00927  621 VAKVMALgDLSKGDVAEAEHtgERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEG--- 697

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4324 EEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEEnKEKGGEQNTEGLDGVEEKADTEDIDQEAavqQDSGS 4403
Cdd:TIGR00927  698 EIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEE-VEDEGEGEAEGKHEVETEGDRKETEHEG---ETEAE 773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4404 KGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEyhrrrqdikeaqTNGEEDENLEK 4483
Cdd:TIGR00927  774 GKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKD------------ETGEQELNAEN 841

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135    4484 NNERPDEFEHVEGANtetdtqalGSATQDQlqtidedmaiDDDREEQEVDQKELVEDADDEKMDIDEEEMLS 4555
Cdd:TIGR00927  842 QGEAKQDEKGVDGGG--------GSDGGDS----------EEEEEEEEEEEEEEEEEEEEEEEEEENEEPLS 895
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4198-4495 1.32e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 68.48  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4198 NKEGGDEDPNAPEDGDEEIENDEnaeeendVGEQEdevKDEEGEDleanvpeietldlpedmnlDSEHEESDEDVDMSDG 4277
Cdd:TIGR00927  631 SKGDVAEAEHTGERTGEEGERPT-------EAEGE---NGEESGG-------------------EAEQEGETETKGENES 681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4278 MPDDLNKEEVGNEDE-EVKQESGIESDNENDEPGPEEDAGETETALDEEEG-AEEDVDMTNDEGKEDEENGPEEQAMSDE 4355
Cdd:TIGR00927  682 EGEIPAERKGEQEGEgEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIeTGEEGEEVEDEGEGEAEGKHEVETEGDR 761

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4356 EELKQDAAME-ENKEKGGEQNTEGLDGVEEKADTEDIDQ-EAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQ 4433
Cdd:TIGR00927  762 KETEHEGETEaEGKEDEDEGEIQAGEDGEMKGDEGAEGKvEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEN 841

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135    4434 EDVTKNNEESREEATAAlkQLGDSMKEYHRRRQDIKEAQTNGEEDENlEKNNERPDEFEHVE 4495
Cdd:TIGR00927  842 QGEAKQDEKGVDGGGGS--DGGDSEEEEEEEEEEEEEEEEEEEEEEE-EEENEEPLSLEWPE 900
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4255-4631 1.98e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 67.63  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4255 LPEDMNLDSEHEESDEDVDM---SDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEED 4331
Cdd:NF033609  544 VPEQPDEPGEIEPIPEDSDSdpgSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSD 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4332 VDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGlDGVEEKADTEDIDQEAAVQQDSGSKGAGADAT 4411
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4412 DTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSmkeyhrrrqdikEAQTNGEEDENLEKNNErpdef 4491
Cdd:NF033609  703 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS------------DSDSDSDSDSDSDSDSD----- 765

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4492 ehvegANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDAD-DEKMDIDeeemlSDIDAhDANNDVDSKK 4570
Cdd:NF033609  766 -----SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSD-----SDSDS-DSDSDSDSDS 834

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323135   4571 SGFIGKRKSEEDFENELSNEHFSADQEDDSEIQSLIENIEDNPPDASASLTPERSLEESRE 4631
Cdd:NF033609  835 DSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNSPKNGTNASNKNEAKDSKE 895
PHA03169 PHA03169
hypothetical protein; Provisional
 4229-4450 3.14e-10

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 65.76  E-value: 3.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4229 GEQEDEVKDEEGEDLEANvpeietldlpEDMNLDSEHEESDEDvdmSDGMPDDLNKEEVGNEDeevkqesgiesdnende 4308
Cdd:PHA03169   55 GPQVRAVAEQGHRQTESD----------TETAEESRHGEKEER---GQGGPSGSGSESVGSPT----------------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4309 PGPEEDAGETETALDEEEGAEEdvdmtNDEGKEDEENGPEEQAmsdEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADT 4388
Cdd:PHA03169  105 PSPSGSAEELASGLSPENTSGS-----SPESPASHSPPPSPPS---HPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPE 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323135   4389 EDIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAA 4450
Cdd:PHA03169  177 EPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPT 238
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4046-4393 3.57e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 66.86  E-value: 3.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4046 PQPPSEEVDDKNLQEGT----GLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELED 4121
Cdd:NF033609  545 PEQPDEPGEIEPIPEDSdsdpGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDS 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4122 LSNGEENDDEDTDSEEEELDEEIDDLNEDDPNAIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEqqrDNKEG 4201
Cdd:NF033609  625 ASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS---DSDSD 701

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4202 GDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGE-DLEANVPEIETLDLPEDMNLDSEhEESDEDVDMSDGMPD 4280
Cdd:NF033609  702 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDS 780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4281 DLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKE---------DEENGPEEQA 4351
Cdd:NF033609  781 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsdsdsdsdsDSDSDSESDS 860

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 6323135   4352 MSDEEELKQDAAMEENKEKGG---EQNTEGLDGVEEKADTEDIDQ 4393
Cdd:NF033609  861 NSDSESGSNNNVVPPNSPKNGtnaSNKNEAKDSKEPLPDTGSEDE 905
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 4153-4393 4.63e-10

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 66.35  E-value: 4.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4153 NAIDDKMWDDKASDNSKEKDTdQNLDGK--------NQEEDVQAAENDEQQRDNKEGgdedpNAPEDGDEEIENDENAEE 4224
Cdd:PTZ00341  890 NAIEKYAGGGKKDKKAKKKDA-KDLSGNiaheinliNKELKNQNENVPEHLKEHAEA-----NIEEDAEENVEEDAEENV 963

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4225 ENDVGEQ-EDEVKDEEGEDLEANVPEIETLDLPEDM--NLDSEHEES-DEDVDMSDGMPDDLNKEEVGNEDEEVKQESgI 4300
Cdd:PTZ00341  964 EENVEENvEENVEENVEENVEENVEENVEENVEENVeeNIEENVEENvEENIEENVEEYDEENVEEVEENVEEYDEEN-V 1042

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4301 ESDNENDEPGPEEDAGETETALDEE--EGAEEDVDMTNDEGKED--EENgPEEQAMSDEEELKQDAamEENKEKGGEQNT 4376
Cdd:PTZ00341 1043 EEIEENAEENVEENIEENIEEYDEEnvEEIEENIEENIEENVEEnvEEN-VEEIEENVEENVEENA--EENAEENAEENA 1119

                         250
                  ....*....|....*..
gi 6323135   4377 EGLDGVEEKADTEDIDQ 4393
Cdd:PTZ00341 1120 EEYDDENPEEHNEEYDE 1136
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 4282-4490 1.01e-09

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 65.58  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4282 LNKE---EVGNEDEEVKQ--ESGIESD-NENDEPGPEEDAGET-ETALDE--EEGAEEDVDMTNDEGKED--EENGPEEQ 4350
Cdd:PTZ00341  924 INKElknQNENVPEHLKEhaEANIEEDaEENVEEDAEENVEENvEENVEEnvEENVEENVEENVEENVEEnvEENVEENI 1003

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4351 AMSDEEELKQDaaMEENKEKGGEQNTEGLDGVEEKADTEDIDQ-EAAVQQDSgskgagadATDTQEQDDVGGSGTTQNTY 4429
Cdd:PTZ00341 1004 EENVEENVEEN--IEENVEEYDEENVEEVEENVEEYDEENVEEiEENAEENV--------EENIEENIEEYDEENVEEIE 1073

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323135   4430 EEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEE--DENLEKNNERPDE 4490
Cdd:PTZ00341 1074 ENIEENIEENVEENVEENVEEIEENVEENVEENAEENAEENAEENAEEydDENPEEHNEEYDE 1136
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4270-4552 1.68e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 64.63  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4270 EDVDMSDGMPDDLNKEEVGNEDE-------EVKQESGIESDN--ENDEPGPEEDAGETETAL-----DEEEGAEEDVDMT 4335
Cdd:TIGR00927  628 GDLSKGDVAEAEHTGERTGEEGErpteaegENGEESGGEAEQegETETKGENESEGEIPAERkgeqeGEGEIEAKEADHK 707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4336 NDEGKEDEENGPEEQAMSDEEElKQDAAMEENKEKGGEQNTE--GLDGVEEKADTEDIDQEAavqQDSGSKGAGADATDT 4413
Cdd:TIGR00927  708 GETEAEEVEHEGETEAEGTEDE-GEIETGEEGEEVEDEGEGEaeGKHEVETEGDRKETEHEG---ETEAEGKEDEDEGEI 783

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4414 QEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEyhrrrqdikeaqTNGEEDENLEKNNERPDEFEH 4493
Cdd:TIGR00927  784 QAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKD------------ETGEQELNAENQGEAKQDEKG 851

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135    4494 VEGANtetdtqalGSATQDQLQTIDEDMAIDDDREEQEVDQKElvEDADDEKMDIDEEE 4552
Cdd:TIGR00927  852 VDGGG--------GSDGGDSEEEEEEEEEEEEEEEEEEEEEEE--EEENEEPLSLEWPE 900
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 4703-4855 2.50e-09

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 59.50  E-value: 2.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4703 YQIMIALDDSKSMSESKcVKLAFDSLCLVSKTLTQLEAGG-LSIVKFGENIKEVHSFDQQFSNESGARAFQWFGFQ-ETK 4780
Cdd:cd00198    1 ADIVFLLDVSGSMGGEK-LDKAKEALKALVSSLSASPPGDrVGLVTFGSNARVVLPLTTDTDKADLLEAIDALKKGlGGG 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323135  4781 TDVKKLVAESTKIFERARamvHNDQWQLEIVISDGICEDH-ETIQKLVRRARENKIMLVFVIIDGITSNESILDMS 4855
Cdd:cd00198   80 TNIGAALRLALELLKSAK---RPNARRVIILLTDGEPNDGpELLAEAARELRKLGITVYTIGIGDDANEDELKEIA 152
PTZ00121 PTZ00121
MAEBL; Provisional
 4163-4569 2.65e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.39  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4163 KASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGED 4242
Cdd:PTZ00121 1535 KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK 1614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4243 LEANVPEIETLDLPEDMNLDSEHEESDEDVDMSDGmpDDLNKEEVGN----------EDEEVKQESGIESDNENDEPGPE 4312
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKA--EELKKAEEENkikaaeeakkAEEDKKKAEEAKKAEEDEKKAAE 1692

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4313 EDAGETETALDEEE---GAEEDVDMTNDEGKEDEENGPE-EQAMSDEEELKQDAamEENKEKGGEQN-TEGLDGVEEKAD 4387
Cdd:PTZ00121 1693 ALKKEAEEAKKAEElkkKEAEEKKKAEELKKAEEENKIKaEEAKKEAEEDKKKA--EEAKKDEEEKKkIAHLKKEEEKKA 1770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4388 TEDIDQEAAVQQDsgskgaGADATDTQEQDDVGGS-GTTQNTYEEDQEDVTKNN---EESREEATAALKQLGDSmKEYHR 4463
Cdd:PTZ00121 1771 EEIRKEKEAVIEE------ELDEEDEKRRMEVDKKiKDIFDNFANIIEGGKEGNlviNDSKEMEDSAIKEVADS-KNMQL 1843

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4464 RRQDIKEAQTNGEEDENLEKNNERPDefehvegANTETDtqaLGSATQDQLQTIDEDMAIDDDREEQEVDQKELV---ED 4540
Cdd:PTZ00121 1844 EEADAFEKHKFNKNNENGEDGNKEAD-------FNKEKD---LKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAgknND 1913

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 6323135   4541 ADDEKMDIDE----------EEMLSDIDAHDANNDVDSK 4569
Cdd:PTZ00121 1914 IIDDKLDKDEyikrdaeetrEEIIKISKKDMCINDFSSK 1952
PHA03169 PHA03169
hypothetical protein; Provisional
 4161-4347 4.26e-09

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 62.30  E-value: 4.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4161 DDKASDNSKEKDTDQNLDGKNQEEDvQAAENDEQQRDNKEGGDEDPNAPEDgdeeiendenaeEENDVGEQEDEVKDEEG 4240
Cdd:PHA03169   84 KEERGQGGPSGSGSESVGSPTPSPS-GSAEELASGLSPENTSGSSPESPAS------------HSPPPSPPSHPGPHEPA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4241 EDLEANVPEIETldlpEDMNLDSEHEESDEDVDMSDGMPDDlnkEEVGNEDEEVKQESGIESDnENDEPGPE-EDAGETE 4319
Cdd:PHA03169  151 PPESHNPSPNQQ----PSSFLQPSHEDSPEEPEPPTSEPEP---DSPGPPQSETPTSSPPPQS-PPDEPGEPqSPTPQQA 222

                         170       180
                  ....*....|....*....|....*...
gi 6323135   4320 TALDEEEGAEEDVDMTNDEGKEDEENGP 4347
Cdd:PHA03169  223 PSPNTQQAVEHEDEPTEPEREGPPFPGH 250
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4328-4601 4.39e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 63.48  E-value: 4.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4328 AEEDVDMTNDEGKEdeengPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDidqEAAVQQDSGSKGAG 4407
Cdd:TIGR00927  638 AEHTGERTGEEGER-----PTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEG---EGEIEAKEADHKGE 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4408 ADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAalkqlgdsmKEYHRRRQDIKEAQTNGEEdENLEKNNER 4487
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEG---------KHEVETEGDRKETEHEGET-EAEGKEDED 779

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4488 PDEFEHVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDAddekmdidEEEMLSDI--DAHDANND 4565
Cdd:TIGR00927  780 EGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETG--------EQELNAENqgEAKQDEKG 851

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 6323135    4566 VDSKKSGFIGKRKSEEDFENELSNEHFSADQEDDSE 4601
Cdd:TIGR00927  852 VDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEE 887
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4065-4364 4.86e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 63.09  E-value: 4.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4065 GDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVE--MEGDMAGELEDlsngeenddedtdseeeelde 4142
Cdd:TIGR00927  633 GDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGEneSEGEIPAERKG--------------------- 691

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4143 eiddlNEDDPNAIDDKMWDDKASDNSKEKDTDQNL--DGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENDE 4220
Cdd:TIGR00927  692 -----EQEGEGEIEAKEADHKGETEAEEVEHEGETeaEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEH 766

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4221 NAEEENDVGEQEDEVKDEEGEDLEANVPEIEtldlpEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGI 4300
Cdd:TIGR00927  767 EGETEAEGKEDEDEGEIQAGEDGEMKGDEGA-----EGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAEN 841

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135    4301 ESDNENDEPGPEE----DAGETEtalDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDE-EELKQDAAM 4364
Cdd:TIGR00927  842 QGEAKQDEKGVDGgggsDGGDSE---EEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLEwPETRQKQAI 907
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 2190-2276 1.12e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.53  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    2190 VKFEWFDGMLVKAVEKGHWLILDNANLCSPSVLDRLNSLLEiDGSLLInecsqEDGQPRVLKPHPNFRLFLTMDPKYG-- 2267
Cdd:pfam07728   51 GGASWVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLLD-ERRLLL-----PDGGELVKAAPDGFRLIATMNPLDRgl 124

                           90
                   ....*....|
gi 6323135    2268 -ELSRAMRNR 2276
Cdd:pfam07728  125 nELSPALRSR 134
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4156-4369 1.53e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 61.55  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4156 DDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIENdeNAEEENDVGEQEDEV 4235
Cdd:TIGR00927  674 ETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGE--EGEEVEDEGEGEAEG 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4236 KDEEGEDLEANVPEIETLDLPEDMNLDSEHE-ESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEED 4314
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323135    4315 AGETETALDEEEGAEEDVDMTNDEG------KEDEENGPEEQAMSDEEELKQDAAMEENKE 4369
Cdd:TIGR00927  832 TGEQELNAENQGEAKQDEKGVDGGGgsdggdSEEEEEEEEEEEEEEEEEEEEEEEEEENEE 892
Granin pfam01271
Granin (chromogranin or secretogranin);
4162-4562 2.20e-08

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 60.43  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4162 DKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQqrdnkeggdEDPNAPEDGDeeiendenaeeenDVGEQEDEVKDEEGE 4241
Cdd:pfam01271  184 DTPSKQKREKSDEREKSSQESGEDTYRQENIPQ---------EDQVGPEDQE-------------PSEEGEEDATQEEVK 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4242 DLEANVPEIETLdlPEDMNLDSEHEESDEDVDMSDG---MPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGEt 4318
Cdd:pfam01271  242 RSRPRTHHGRSL--PDESSRGGQLGLEEEASEEEEEygeESRGLSAVQTYLLRLVNARGRGRSEKRAERERSEESEEEE- 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4319 etalDEEEGAEEDVDMTNDEgkedeeNGPEeqamSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDidQEAAVQ 4398
Cdd:pfam01271  319 ----LKRASPYEELEITANL------QIPP----SEEERMLKKAGRSPRGRVDEAGALEALEALEEKRKLDL--DHSRVF 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4399 QDSGSKGAGADATDTQEQD----DVGGSGTTQNTyeeDQEDVTKNNEESREEATAALKQ-LGDSMKEYHRRRQ---DIKE 4470
Cdd:pfam01271  383 ESSEDGAPRAPQGAWVEALrnylSYGEEGMEGKW---NQQGPYFPNEENREEARFRLPQyLGELSNPWEDPKQwkpSDFE 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4471 AQTN-------GEEDENL---------EKNNERPdEFEhVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVdQ 4534
Cdd:pfam01271  460 RKELtadkfleGEEENEYtlsmknsfpEYNYDGY-EKR-VPSPGLDLKRQYDPVAREDQLLHYRKKSSEFPDFYDSEE-K 536

                          410       420       430
                   ....*....|....*....|....*....|...
gi 6323135    4535 KELVEDADDEK-----MDIDEEEMLSDIDAHDA 4562
Cdd:pfam01271  537 KEPPVGAEKEEdsanrQTRDEDKELENLAAMDL 569
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 310-427 2.60e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 58.64  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   310 PIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHlgEQTDAKLLIGTYTSGDKPGTFEWRAGVLATAVkegrwVLIEDIDK 389
Cdd:COG0714   33 HLLLEGVPGVGKTTLAKALARALGLPFIRIQFT--PDLLPSDILGTYIYDQQTGEFEFRPGPLFANV-----LLADEINR 105

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 6323135   390 APTDVLSILLSLLEKRELTIPsrGETVKAANGFQLIST 427
Cdd:COG0714  106 APPKTQSALLEAMEERQVTIP--GGTYKLPEPFLVIAT 141
DMP1 pfam07263
Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix ...
 4285-4630 5.15e-08

Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.


Pssm-ID: 462128 [Multi-domain]  Cd Length: 519  Bit Score: 59.17  E-value: 5.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4285 EEVGNED--EEVKQESGIESDNENDEPGPeeDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPeeqamsdeeelkqda 4362
Cdd:pfam07263   58 EEQANEDpsDSTESEEDLGSDDGQYVYRP--AGGLSRSGGKEGDDKDDDEDDSGDDTFGDEDNGP--------------- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4363 ameenkekGGEQNTEGldGVEEKADTEDidqeaavqqdsgskgaGADATDTQEQDDVGGSGTTQNTYEEDQEdvtKNNEE 4442
Cdd:pfam07263  121 --------GPEERQEG--GNSRLGSDED----------------SADTTQSREDSASQGEDSAQDTTSESRD---LDNED 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4443 SREEATAALKQLGDSMKEYHRR--RQDIKEAQTNGEEDENLEKNNERPDEFEHvEGANTETDTQALGSatqDQLQTIDED 4520
Cdd:pfam07263  172 EVSSRPESGDSTQDSESEEHWVggGSEGDSSHGDGSEFDDEGMQSDDPDSIRS-ERGNSRMSSASVKS---KESKGDSEQ 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4521 MAIDDDREEQEVDQKelvEDADDEKMDIDEEEMLSDIDAHDANNDVDS-----KKSGFIGKRKSEEDFENElSNE--HFS 4593
Cdd:pfam07263  248 ASTQDSGDSQSVEYP---SRKFFRKSRISEEDDRGELDDSNTMEEVKSdstesTSSKEAGLSQSREDSKSE-SQEdsEES 323

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 6323135    4594 ADQEDDSEIQSLIENI---EDNPPDASASLTPERSLEESR 4630
Cdd:pfam07263  324 QSQEDSQNSQDPSSESsqeADLPSQESSSESQEEVVSESR 363
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 4323-4590 7.03e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 59.24  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4323 DEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGlDGVEEKADTEDIDQEAavqqdsg 4402
Cdd:TIGR00927  646 GEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEA-KEADHKGETEAEEVEH------- 717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4403 SKGAGADATDTQEQDDVGGSGTtqntyEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLE 4482
Cdd:TIGR00927  718 EGETEAEGTEDEGEIETGEEGE-----EVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMK 792

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4483 KNNERPDEFEHveGANTETDTQALGsatQDQLQTIDEDMAIDDDREEQEVDQKELVEDADDEKmDIDEEEMLSDIDAHDA 4562
Cdd:TIGR00927  793 GDEGAEGKVEH--EGETEAGEKDEH---EGQSETQADDTEVKDETGEQELNAENQGEAKQDEK-GVDGGGGSDGGDSEEE 866

                          250       260
                   ....*....|....*....|....*...
gi 6323135    4563 NNDVDSKKSgfigkrKSEEDFENELSNE 4590
Cdd:TIGR00927  867 EEEEEEEEE------EEEEEEEEEEEEE 888
PTZ00121 PTZ00121
MAEBL; Provisional
 4158-4631 9.44e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 9.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4158 KMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDeeiendenaeeendvgEQEDEVKD 4237
Cdd:PTZ00121 1349 KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDK----------------KKADELKK 1412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4238 EEGEDLEANVPEIETLDLPEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPE--EDA 4315
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEakKKA 1492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4316 GETETALDEEEGAEEDvDMTNDEGKEDEENGPEEQAMSDEEELKQDAAME-ENKEKGGE-QNTEGLDGVEEKADTEDIDQ 4393
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEA-KKKADEAKKAEEAKKADEAKKAEEAKKADEAKKaEEKKKADElKKAEELKKAEEKKKAEEAKK 1571

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4394 EAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQNTYEEDQ----EDVTKNNEESR--EEATAALKQLGDSMKEYHRRRQD 4467
Cdd:PTZ00121 1572 AEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEakkaEEAKIKAEELKkaEEEKKKVEQLKKKEAEEKKKAEE 1651

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4468 IKEAqtngEEDENLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQTIDEDMaidddREEQEVDQKELVEDADDEKMD 4547
Cdd:PTZ00121 1652 LKKA----EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA-----KKAEELKKKEAEEKKKAEELK 1722

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4548 IDEEEMLSDIDAHDANNDVDSKKSGFIGKRKSEEDFENELSNEHFSADQEDDSEIQSLIENiEDNPPDASASLTPERSLE 4627
Cdd:PTZ00121 1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE-ELDEEDEKRRMEVDKKIK 1801


                  ....
gi 6323135   4628 ESRE 4631
Cdd:PTZ00121 1802 DIFD 1805
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 4331-4552 1.38e-07

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 58.26  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4331 DVDMTNDEGKEDEENGPEEQAMSDEEELKQDAamEENKEKGGEQNTEglDGVEEKADtEDIDQ--EAAVQQDSgskgaga 4408
Cdd:PTZ00341  920 EINLINKELKNQNENVPEHLKEHAEANIEEDA--EENVEEDAEENVE--ENVEENVE-ENVEEnvEENVEENV------- 987

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4409 datdtqeQDDVggsgtTQNTYEEDQEDVTKNNEESREE---------ATAALKQLGDSMKEYHrrRQDIKEAQTNGEE-- 4477
Cdd:PTZ00341  988 -------EENV-----EENVEENVEENIEENVEENVEEnieenveeyDEENVEEVEENVEEYD--EENVEEIEENAEEnv 1053

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4478 DENLEKNNERPDE--FEHVEGANTETDTQALGSATQDQLQTIDEDMA--IDDDREEQ-EVDQKELVEDADDEKMDIDEEE 4552
Cdd:PTZ00341 1054 EENIEENIEEYDEenVEEIEENIEENIEENVEENVEENVEEIEENVEenVEENAEENaEENAEENAEEYDDENPEEHNEE 1133
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
 2198-2264 4.82e-07

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 51.29  E-value: 4.82e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135    2198 MLVKAVEKGHWLILDNANLcSPSVLDRLNSLLEIDGSLlinecsqedgqprvlKPHPNFRLFLTMDP 2264
Cdd:pfam03028   49 LIEEAAKEGGWVLLQNCHL-ALSWMPELEKILEELPEE---------------TLHPDFRLWLTSEP 99
Caldesmon pfam02029
Caldesmon;
4230-4553 1.21e-06

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 54.87  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4230 EQEDEVKDEEGEDLEANVPEIETldlPEDMNLDSEHEES--------DEDVDMSD-----------GMPDDLNKEEvgNE 4290
Cdd:pfam02029   15 AREERRRQKEEEEPSGQVTESVE---PNEHNSYEEDSELkpsgqgglDEEEAFLDrtakreerrqkRLQEALERQK--EF 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4291 DEEVKQES-GIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDegKEDEENGPEEQAMSDEEELKQDAAMEENKE 4369
Cdd:pfam02029   90 DPTIADEKeSVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIRE--KEYQENKWSTEVRQAEEEGEEEEDKSEEAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4370 KGGEQNTEGLDGVEEKADTED---IDQEAAVQQDSG-SKGAGADATDTqeqddvggsgTTQNTYEEDQEDVTKNNEESRE 4445
Cdd:pfam02029  168 EVPTENFAKEEVKDEKIKKEKkvkYESKVFLDQKRGhPEVKSQNGEEE----------VTKLKVTTKRRQGGLSQSQERE 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4446 EATAALKQLGDSMKEYHRRRQDIKEaqtngEEDENL-EKNNERPDEFEHvegantetdtqaLGSATQDQLQTIDEdmaiD 4524
Cdd:pfam02029  238 EEAEVFLEAEQKLEELRRRRQEKES-----EEFEKLrQKQQEAELELEE------------LKKKREERRKLLEE----E 296

                          330       340
                   ....*....|....*....|....*....
gi 6323135    4525 DDREEQEVDQKELVEDADDEKMdidEEEM 4553
Cdd:pfam02029  297 EQRRKQEEAERKLREEEEKRRM---KEEI 322
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 648-703 2.15e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 49.98  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135     648 PVLLVGETGTGKTTVVQQLAKMLA-KKLTVINVSQQTETGDLLGGYKPVNSKTVAVP 703
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSnRPVFYVQLTRDTTEEDLFGRRNIDPGGASWVD 57
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 4280-4396 3.47e-06

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 53.26  E-value: 3.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4280 DDLNKEEVGNEDEEVKQEsgiESDNENDEPGPEEDAGETETALDEEEGAEEDvdmtNDEGKEDEENGPEEQAMSDEEELK 4359
Cdd:COG4547  203 RDLDLAEELGEDEDEEDE---DDEDDSGEQEEDEEDGEDEDEESDEGAEAED----AEASGDDAEEGESEAAEAESDEMA 275

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 6323135  4360 QDAAMEENKEKGG--EQNTEGLDGVEE---KADTEDIDQEAA 4396
Cdd:COG4547  276 EEAEGEDSEEPGEpwRPNAPPPDDPADpdyKVFTTAFDEVVA 317
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1729-1881 4.05e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.84  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1729 NLVRVVRAMQVHKPILLEGSPGVGKTSLITALANITGNKLTRINlseQTDLVDLFGADAPGERSGEFLWHDAPFLRAMKK 1808
Cdd:cd00009    8 EALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFL---YLNASDLLEGLVVAELFGHFLVRLLFELAEKAK 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323135  1809 GEWVLLDEMNLASQSVLEGLNACLDhrgeayipELDISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSV 1881
Cdd:cd00009   85 PGVLFIDEIDSLSRGAQNALLRVLE--------TLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVI 149
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 629-683 4.39e-06

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 50.08  E-value: 4.39e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135     629 TNHSLRLMEQISVCIQMTEPVLLVGETGTGKTTVVQQLAKMLAKK---LTVINVSQQT 683
Cdd:pfam12775   14 TVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEkylPLFINFSAQT 71
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1361-1558 4.42e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 49.68  E-value: 4.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1361 KEPVLLVGETGCGKTTICQLLAQFMGRE---LITLNAhQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVD 1437
Cdd:smart00382    2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDG-EDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1438 LkellqlysksdnkniaedvqleiqklrdslnvlfewsdgpliqamrtgnfFLLDEISLADDSVLERLNSVLEPERSLLL 1517
Cdd:smart00382   81 V--------------------------------------------------LILDEITSLLDAEQEALLLLLEELRLLLL 110

                           170       180       190       200
                    ....*....|....*....|....*....|....*....|.
gi 6323135     1518 AEQgssdslvtaSENFQFFATMNPGGDYGKKELSPALRNRF 1558
Cdd:smart00382  111 LKS---------EKNLTVILTTNDEKDLGPALLRRRFDRRI 142
TFIIF_alpha pfam05793
Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation ...
 4161-4397 5.26e-06

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.


Pssm-ID: 310411 [Multi-domain]  Cd Length: 528  Bit Score: 52.64  E-value: 5.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4161 DDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQqrdnkEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEG 4240
Cdd:pfam05793  189 PAAFGEHDEETEGEKGGGGRGKDLKIKDLEGDDE-----DDGDESDKGGEDGDEEKKKKKKKKLAKNKKKLDDDKKKKRG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4241 EDLEANVPEIEtldlpedmnlDSEHEESDEDVdMSDGmpddlnkEEVGNEDEEvkqesgiesdnENDEPgpeedagetet 4320
Cdd:pfam05793  264 GDDDAFEYDSD----------DGDDEGREEDY-ISDS-------SASGNDPEE-----------REDKL----------- 303

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    4321 alDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEE-ELKQDaameeNKEKGGEQNTEGLDGveEKADTEDIDQEAAV 4397
Cdd:pfam05793  304 --SPEEPAKGEIEQSDDSEESEEEKNEEEGKLSKKGkKAKKL-----KGKKNGKDKSESSDG--DDSDDSDIDDEDSV 372
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 4263-4447 5.78e-06

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 51.54  E-value: 5.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4263 SEHEESDEDVDMSDgmpddlNKEEVGNEDEEVKQESGIE-SDNENDEPGPE-EDAGETETALDEEEGAEEDvdmtndegK 4340
Cdd:COG5137  126 SDVEEPSEKVDEED------VEREILAEKPRVTRFNIVWdNDEDNDEAPPAqPDVDNEEEERLEESDGREE--------E 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4341 EDEENGPEEQAMSDEEELKQdaamEENKEKGGEQNTEGLDGVEEKADTEDIDQEaavqqdsgskgagadatdtQEQDDVG 4420
Cdd:COG5137  192 EDEEVGSDSYGEGNRELNEE----EEEEAEGSDDGEDVVDYEGERIDKKQGEEE-------------------EMEEEVI 248

                        170       180
                 ....*....|....*....|....*..
gi 6323135  4421 GSGTTQNTYEEDQEDVTKNNEESREEA 4447
Cdd:COG5137  249 NLFEIEWEEESPSEEVPRNNEESPAKK 275
TFIIF_alpha pfam05793
Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation ...
 4155-4413 6.40e-06

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II.


Pssm-ID: 310411 [Multi-domain]  Cd Length: 528  Bit Score: 52.64  E-value: 6.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4155 IDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKE---GGDEDPNAPE--DGDeeiendenaeeenDVG 4229
Cdd:pfam05793  214 IKDLEGDDEDDGDESDKGGEDGDEEKKKKKKKKLAKNKKKLDDDKKkkrGGDDDAFEYDsdDGD-------------DEG 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4230 EQEDEVKDEEGEdleanvpeietldlpedmnlDSEHEEsdedvdmsdgmpddlnKEEVGNEDEEVKQESGI-ESDNENDE 4308
Cdd:pfam05793  281 REEDYISDSSAS--------------------GNDPEE----------------REDKLSPEEPAKGEIEQsDDSEESEE 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4309 PGPEEDAGETEtaldEEEGAEEDVDMTNDEGKEDEENGpEEQAMSDEEELKQDAAMEENKEKggeqntegldgveEKADT 4388
Cdd:pfam05793  325 EKNEEEGKLSK----KGKKAKKLKGKKNGKDKSESSDG-DDSDDSDIDDEDSVPLFTAKKKK-------------EPKKE 386

                          250       260
                   ....*....|....*....|....*
gi 6323135    4389 EDIDQEAAVQQDSGSKGAGADATDT 4413
Cdd:pfam05793  387 EPVDSGPSSPGNSGPARPSPESGST 411
DMP1 pfam07263
Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix ...
 4169-4545 6.43e-06

Dentin matrix protein 1 (DMP1); This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.


Pssm-ID: 462128 [Multi-domain]  Cd Length: 519  Bit Score: 52.62  E-value: 6.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4169 KEKDTDQNLDGKNQEEDvqaaeNDEQQRDNKEGGDEDPNAPEDGDEEIENDENAEEENDVGEQ--EDEVKDEEGEDLEAN 4246
Cdd:pfam07263  101 KDDDEDDSGDDTFGDED-----NGPGPEERQEGGNSRLGSDEDSADTTQSREDSASQGEDSAQdtTSESRDLDNEDEVSS 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4247 VPEietldlPEDMNLDSEHEE------SDEDVDMSDGMPDDlnKEEVGNED-EEVKQESG---IESD-------NENDEP 4309
Cdd:pfam07263  176 RPE------SGDSTQDSESEEhwvgggSEGDSSHGDGSEFD--DEGMQSDDpDSIRSERGnsrMSSAsvkskesKGDSEQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4310 GPEEDAGETETA------------LDEEEG--------AEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKE 4369
Cdd:pfam07263  248 ASTQDSGDSQSVeypsrkffrksrISEEDDrgelddsnTMEEVKSDSTESTSSKEAGLSQSREDSKSESQEDSEESQSQE 327

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4370 KG-GEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSKGAGADAT----------DTQEQDDVGGSGTTQNTYEEDQEDVTK 4438
Cdd:pfam07263  328 DSqNSQDPSSESSQEADLPSQESSSESQEEVVSESRGDNPDNTssseedqedsDSSEEDSLSTFSSSESESREEQADSES 407

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4439 N-----NEESREeataalkqlgdSMKEYHRRRQDIKEAQTNGEEDENLEKNNERPDEFEHvegaNTETDTQALGSATQDQ 4513
Cdd:pfam07263  408 NeslrsSEESPE-----------SSEDENSSSQEGLQSHSASTESQSEESQSEQDSQSEE----DDESDSQDSSRSKEDS 472

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 6323135    4514 LQTidEDMA-IDDDREEQ--EVDQKELVEDADDEK 4545
Cdd:pfam07263  473 NST--ESTSsSEEDGQSKnmEIESRKLTVDAYHNK 505
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4329-4618 6.67e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.60  E-value: 6.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4329 EEDVDMTNDEGKEDEENGPEEQAMSDE----EELKQDAAMEENKEKGGEQNTEGLDGVEEKADTEDIDQEAAVQQDSGSK 4404
Cdd:NF033609  524 DNEVAFNNGSGSGDGIDKPVVPEQPDEpgeiEPIPEDSDSDPGSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASD 603

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4405 GAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDENLEKN 4484
Cdd:NF033609  604 SDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4485 NERPDEFEHVEGANTETDTQALGSATQDQLQTIDEDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDA-HDAN 4563
Cdd:NF033609  684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSD 763

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6323135   4564 NDVDS-KKSGFIGKRKSEEDFENElSNEHFSADQEDDSEIQSLIENIEDNPPDASA 4618
Cdd:NF033609  764 SDSDSdSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 818
COG5644 COG5644
U3 small nucleolar RNA-associated protein 14 [Function unknown];
4162-4553 6.75e-06

U3 small nucleolar RNA-associated protein 14 [Function unknown];


Pssm-ID: 227931 [Multi-domain]  Cd Length: 869  Bit Score: 52.78  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4162 DKASDNSKEKDTDQNldGKNQEEDVQAAEN-DEQQRDNKEGGDEDPNAPEDGdeeiendenaeeendvgeqedevKDEEG 4240
Cdd:COG5644   32 DSEELEDNDEQGYSF--GVNSEDDEEIDSDeAFDEEDEKRFADWSFNASKSG-----------------------KSNKD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4241 EDLEANVPEIETLDLPEDMNLDSEHEE-SDEDVDMSDGMPDDlnkeEVGNEDEEVKQESGIESDNENDEPGPEEDAGETE 4319
Cdd:COG5644   87 HKNLNNTKEISLNDSDDSVNSDKLENEgSVSSIDENELVDLD----TLLDNDQPEKNESGNNDHATDKENLLESDASSSN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4320 TALDEEEGAEEDVDmtndegkeDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDgveekadteDIDQEAAVQQ 4399
Cdd:COG5644  163 DSESEESDSESEIE--------SSDSDHDDENSDSKLDNLRNYIVSLKKDEADAESVLSSD---------DNDSIEEIKY 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4400 DSGSKGAGADATDTQEQDDVGGSgttqntyeEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKEAQTNGEEDE 4479
Cdd:COG5644  226 DPHETNKESGSSETIDITDLLDS--------IPMEQLKVSLKPLVSESSKLDAPLAKSIQDRLERQAAYEQTKNDLEKWK 297

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6323135  4480 NLEKNNERPDEFEHVEGANTETDTQALGSATQDQLQTidedmaidddREEQEVDQKELVEDADDEKMDIDEEEM 4553
Cdd:COG5644  298 PIVADNRKSDQLIFPMNETARPVPSNNGLASSFEPRT----------ESERKMHQALLDAGLENESALKKQEEL 361
Mpp10 COG5384
U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and ...
 4232-4564 1.00e-05

U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227674 [Multi-domain]  Cd Length: 569  Bit Score: 52.00  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4232 EDEVKDEEGEDLEANVPEIETLDlPEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNED----EEVKQESGIES----- 4302
Cdd:COG5384   89 SSSGEESELEEAESVFKEKQMLS-ADVSEIEEQSNDSLSENDEEPSMDDEKTSAEAAREEfaeeKRIPDPYGINDkffdl 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4303 DNENDEPGPEEDAGETETAlDEEEGAEEDVDMtnDEGKEDEEN-------GPEEQAmsDEEELKQDAAMEENKEKGGEQN 4375
Cdd:COG5384  168 EKFNRDTLAAEDSNEASEG-SEDEDIDYFQDM--PSDDEEEEAiyyedffDKPTKE--PVKKHSDVKDPKEDEELDEEEH 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4376 TEGLDGVEEKADTEDIDQEAAvqqdsgskgagadatdtQEQDDVggSGTTQNTYEEDQEDVTKNNEESREEATAAlkqlg 4455
Cdd:COG5384  243 DSAMDKVKLDLFADEEDEPNA-----------------EGVGEA--SDKNLSSFEKQQIEMDEQIEELEKELVAP----- 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4456 dsmKEYHRRRQ-DIKEAQTNGEEDENLE-KNNERPDEFEHVEGANTETDT--QALGSATQDQLQ-TIDEDMAIDDDREEQ 4530
Cdd:COG5384  299 ---KEWKYAGEvSAKKRPKNSLLAEELEfKQGAKPVPVSTKEDTESLEDIilQRIREGTFDDHAyRIREEVTIADEIPEF 375

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 6323135  4531 EV----DQKELVEDADDEKMDIDEEEMLSDIDAHDANN 4564
Cdd:COG5384  376 ELleskSILSLAEEYEGDLMQIVDESALSEELDKGHNE 413
PHA02244 PHA02244
ATPase-like protein
 1078-1229 1.03e-05

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 51.27  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1078 PVLIQGPTSSGKTSMIKYLADITGHKFVRINnhehTDLQEYLGTYVTDDTGKlsFKEGVLVEALRKGYWIVLDELNLAPT 1157
Cdd:PHA02244  121 PVFLKGGAGSGKNHIAEQIAEALDLDFYFMN----AIMDEFELKGFIDANGK--FHETPFYEAFKKGGLFFIDEIDASIP 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323135   1158 DVLEALNRLLDDNRELFIPETqevVHPHPDFLLFATQNPPG-----IYGGRKILSRAFRNRFLELHFDDIPQDELEI 1229
Cdd:PHA02244  195 EALIIINSAIANKFFDFADER---VTAHEDFRVISAGNTLGkgadhIYVARNKIDGATLDRFAPIEFDYDEKIEHLI 268
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 811-896 1.07e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 48.06  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     811 FVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLtepDSRSILLSEKGdaEPIKAHPD-FRIFACMNPAtDVGKRDLP 889
Cdd:pfam07728   55 WVDGPLVRAAREGEIAVLDEINRANPDVLNSLLSLL---DERRLLLPDGG--ELVKAAPDgFRLIATMNPL-DRGLNELS 128


                   ....*..
gi 6323135     890 MGIRSRF 896
Cdd:pfam07728  129 PALRSRF 135
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 4705-4879 1.29e-05

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 48.99  E-value: 1.29e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     4705 IMIALDDSKSMSESK--CVKLAfdslclVSKTLTQLEAGG----LSIVKFGENIKEVHSFDQQFSNE---SGARAFQWFG 4775
Cdd:smart00327    2 VVFLLDGSGSMGGNRfeLAKEF------VLKLVEQLDIGPdgdrVGLVTFSDDARVLFPLNDSRSKDallEALASLSYKL 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     4776 FQETKTD--VKKLVAESTKIFERARAMVHndqwQLEIVISDGICEDHET-IQKLVRRARENKIMLVFViidGITSNESIL 4852
Cdd:smart00327   76 GGGTNLGaaLQYALENLFSKSAGSRRGAP----KVVILITDGESNDGPKdLLKAAKELKRSGVKVFVV---GVGNDVDEE 148

                           170       180
                    ....*....|....*....|....*..
gi 6323135     4853 DMSQVNYIPDQYGNPQLKITKYLDTFP 4879
Cdd:smart00327  149 ELKKLASAPGGVYVFLPELLDLLIDLL 175
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 4227-4367 1.61e-05

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 49.99  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4227 DVGEQEDEVKDEEGEDLEANV----PEIETLDLPEDMNLDSEHEESDEDvdmSDGMPDDlnkeevgnEDEEVKQESGIES 4302
Cdd:COG5137  136 DEEDVEREILAEKPRVTRFNIvwdnDEDNDEAPPAQPDVDNEEEERLEE---SDGREEE--------EDEEVGSDSYGEG 204

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6323135  4303 DNENDEPGPEEDAGeTETALDEEEGAEEDVdmtnDEGKEDEENGPEEQAMSDEEELKQDAAMEEN 4367
Cdd:COG5137  205 NRELNEEEEEEAEG-SDDGEDVVDYEGERI----DKKQGEEEEMEEEVINLFEIEWEEESPSEEV 264
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 1075-1214 1.80e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 47.75  E-value: 1.80e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     1075 KRFPVLIQGPTSSGKTSMIKYLA---DITGHKFVRIN--NHEHTDLQEYLGTYVTDDTGKLSFKEGV--LVEALRKGYW- 1146
Cdd:smart00382    1 PGEVILIVGPPGSGKTTLARALArelGPPGGGVIYIDgeDILEEVLDQLLLIIVGGKKASGSGELRLrlALALARKLKPd 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135     1147 -IVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHphpdfLLFATQNPPGIygGRKILSRAFRNRF 1214
Cdd:smart00382   81 vLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT-----VILTTNDEKDL--GPALLRRRFDRRI 142
Mpp10 pfam04006
Mpp10 protein; This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The ...
 4162-4370 1.83e-05

Mpp10 protein; This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites.


Pssm-ID: 461128 [Multi-domain]  Cd Length: 506  Bit Score: 51.12  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4162 DKASDNSKEKDtDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIEndenaeeenDVGEQEDEV--KDEE 4239
Cdd:pfam04006   70 KKIGSLLKDEK-ELRLLLDSEQDDEEDEDEEEDEEDEEDEEEDEDEEEEEEEEEED---------DEDEDSDDEglEEED 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4240 GEDLEANVPEIETLDLP----------EDMN--LDSE---------HEESDEDVDMSDGMPDDLNKEEVGNE-------- 4290
Cdd:pfam04006  140 VKELEQKTKKDAKKGRKsvvddkffklDEMEkfLEDEekkeerkdkGKEDEDDIDYFEDDDSEDDEDDGARNlkyedffd 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4291 --DEEVKQESGIESDNENDEPGPEEDAGEtetalDEEEGAEEDVDMTNDEGKEDEENGPEEqaMSDEEELKQDAAMEENK 4368
Cdd:pfam04006  220 ppEEEDEKETKKKKDKKKEEDEKDDEEEE-----DEEDDAMEEEKEDEFAEDEDEEEDDDE--DSDDEEEEASPEELSSF 292


                   ..
gi 6323135    4369 EK 4370
Cdd:pfam04006  293 EK 294
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 1711-1846 1.93e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 50.92  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1711 FPDAQSSSFNLTAPTTASNLVRVVRAMQVHKPILLEGSPGVGKTSLITALAN-ITGNKLTRINL----SEQTDLVDLFGA 1785
Cdd:COG1401  192 LESEDDYLKDLLREKFEETLEAFLAALKTKKNVILAGPPGTGKTYLARRLAEaLGGEDNGRIEFvqfhPSWSYEDFLLGY 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323135  1786 dAPGERSGEFLWHDAPFLRAMKKGE-------WVLLDEMNLA--SQ------SVLEglnacLDHRGEAYIPELDIS 1846
Cdd:COG1401  272 -RPSLDEGKYEPTPGIFLRFCLKAEknpdkpyVLIIDEINRAnvEKyfgellSLLE-----SDKRGEELSIELPYS 341
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
4348-4652 1.95e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4348 EEQAMSDEeeLKQDAAMEENKEKGGEQNTegldGVEekaDTEDIDQEAAVQQDSgsKGAGADATDTQEqddvggsgtTQN 4427
Cdd:PRK02224  150 DRQDMIDD--LLQLGKLEEYRERASDARL----GVE---RVLSDQRGSLDQLKA--QIEEKEEKDLHE---------RLN 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4428 TYEEDQEDVT---KNNEESREEATAALKQLGDSMKEYHRRRQDIKE------------AQTNGEEDENLEKNNERPDEFE 4492
Cdd:PRK02224  210 GLESELAELDeeiERYEEQREQARETRDEADEVLEEHEERREELETleaeiedlretiAETEREREELAEEVRDLRERLE 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4493 HVEGANTET-DTQALGSATQ----DQLQTID-EDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDiDAHDANNDV 4566
Cdd:PRK02224  290 ELEEERDDLlAEAGLDDADAeaveARREELEdRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAE-ELREEAAEL 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4567 DSKksgfIGKRKSE-EDFENELSnehfsadqEDDSEIQSLIENIEDNP------PDASASLTPERSLEESRELWHKSEIS 4639
Cdd:PRK02224  369 ESE----LEEAREAvEDRREEIE--------ELEEEIEELRERFGDAPvdlgnaEDFLEELREERDELREREAELEATLR 436

                         330
                  ....*....|...
gi 6323135   4640 TADLVSRLGEQLR 4652
Cdd:PRK02224  437 TARERVEEAEALL 449
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 4250-4352 1.98e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 50.95  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4250 IETLDLPEDmnLDSEHEESDEDVDmsdgmpddlnkeevgnEDEEVKQESGIESDNENDEPGPEEDAGETETALDE-EEGA 4328
Cdd:COG4547  202 LRDLDLAEE--LGEDEDEEDEDDE----------------DDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDaEEGE 263

                         90       100
                 ....*....|....*....|....
gi 6323135  4329 EEDVDMTNDEGKEDEENGPEEQAM 4352
Cdd:COG4547  264 SEAAEAESDEMAEEAEGEDSEEPG 287
PHA03169 PHA03169
hypothetical protein; Provisional
 4338-4552 2.37e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 50.35  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4338 EGKEDEENGPEEQAMSDEEELKQDAAMEEN-KEKGGEQNTEGlDGVEEKADTEDIDQEAAvqQDSGSKGAGADATDTQEQ 4416
Cdd:PHA03169   47 APPAPTTSGPQVRAVAEQGHRQTESDTETAeESRHGEKEERG-QGGPSGSGSESVGSPTP--SPSGSAEELASGLSPENT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4417 DDVGGSGTTQNT-YEEDQEDVTKNNEESREEATAALKQLGDSmkeyhrrrqdikEAQTNGEE--DENLEKNNERPDEFEH 4493
Cdd:PHA03169  124 SGSSPESPASHSpPPSPPSHPGPHEPAPPESHNPSPNQQPSS------------FLQPSHEDspEEPEPPTSEPEPDSPG 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135   4494 VEGANTETDTQALGSATqdqlqtiDEDmAIDDDREEQEVDQKELVEDADDEKMDIDEEE 4552
Cdd:PHA03169  192 PPQSETPTSSPPPQSPP-------DEP-GEPQSPTPQQAPSPNTQQAVEHEDEPTEPER 242
PHA02244 PHA02244
ATPase-like protein
 1724-1894 2.42e-05

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 50.12  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1724 PTTASNLVRVVRAMQVHKPILLEGSPGVGKTSLITALAnitgnKLTRINLSEQTDLVDLFGADAPGERSGEFlwHDAPFL 1803
Cdd:PHA02244  103 PTFHYETADIAKIVNANIPVFLKGGAGSGKNHIAEQIA-----EALDLDFYFMNAIMDEFELKGFIDANGKF--HETPFY 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1804 RAMKKGEWVLLDEMNLASQSVLEGLNACLDHRgeaYIPELDISFSCHPNFLVFAAQNPQYQGG-----GRKGLPKSFVNR 1878
Cdd:PHA02244  176 EAFKKGGLFFIDEIDASIPEALIIINSAIANK---FFDFADERVTAHEDFRVISAGNTLGKGAdhiyvARNKIDGATLDR 252

                         170
                  ....*....|....*.
gi 6323135   1879 FSVVFIDMLTSDDLLL 1894
Cdd:PHA02244  253 FAPIEFDYDEKIEHLI 268
PLN03021 PLN03021
Low-temperature-induced protein; Provisional
 4184-4483 2.64e-05

Low-temperature-induced protein; Provisional


Pssm-ID: 178593 [Multi-domain]  Cd Length: 619  Bit Score: 50.74  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4184 EDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIEndenaeeenDVGEQEDEVKDEEGEDLEANVPEIEtldlpedmnlds 4263
Cdd:PLN03021  211 EDDYLGGQRKVNVETPKRLEEDPAAPGGGSDYLS---------GVSNYQSKVTDPTHKGGEAGVPEIA------------ 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4264 eheESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDEGKE-- 4341
Cdd:PLN03021  270 ---ESLGRMKVTDESPDQKSRQGREEDFPTRSHEFDLKKESDINKNSPARFGGESKAGMEEDFPTRGDVKVESGLGRDlp 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4342 --------DEENGPEEQamSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKAdtedIDQEAAVQQDSGSKG-AGADATD 4412
Cdd:PLN03021  347 tgthdqfsPELSRPKER--DDSEETKDESTHETKPSTYTEQLASATSAITNKA----IAAKNVVASKLGYTGeNGGGQSE 420

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4413 TQEQDDVGGSGTT--QNTYEEDQEDVTKNNEESREEATAALKQL-----GDSMKEYHR-------RRQDIKEAQTNGEED 4478
Cdd:PLN03021  421 SPVKDETPRSVTAygQKVAGTVAEKLTPVYEKVKETGSTVMTKLplsggGSGVKETQQgeekgvtAKNYISEKLKPGEED 500


                  ....*
gi 6323135   4479 ENLEK 4483
Cdd:PLN03021  501 KALSE 505
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 1740-1775 4.74e-05

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 46.89  E-value: 4.74e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 6323135  1740 HKPILLEGSPGVGKTSLITALANITGNKLTRINLSE 1775
Cdd:cd19481   26 PKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSS 61
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 4236-4363 5.16e-05

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 48.45  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4236 KDEEGEDLEANVPEIETldlpEDMNLDSEHEESDEDVDMSDGMPDDLNKEEVGNEDEEVKQESgiESDNENDEPGPEEDA 4315
Cdd:COG5137  160 NDEDNDEAPPAQPDVDN----EEEERLEESDGREEEEDEEVGSDSYGEGNRELNEEEEEEAEG--SDDGEDVVDYEGERI 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 6323135  4316 GETEtaLDEEEGaEEDVDmtNDEGKEDEENGPEEQAMSDEEELKQDAA 4363
Cdd:COG5137  234 DKKQ--GEEEEM-EEEVI--NLFEIEWEEESPSEEVPRNNEESPAKKQ 276
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1352-1426 5.19e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 46.37  E-value: 5.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135  1352 VLVSSCLKNKEPVLLVGETGCGKTTICQLLAQ---FMGRELITLNAHQNTETGDILGAQRPVRNRSEIQYKLIKSLKT 1426
Cdd:cd00009   10 LREALELPPPKNLLLYGPPGTGKTTLARAIANelfRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPGV 87
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
 4229-4376 5.26e-05

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 461196  Cd Length: 835  Bit Score: 49.93  E-value: 5.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4229 GEQEDEVKDEEGEDleanvPEIETLDLPEDMNLDseHEESDEDVDMSDGMPDDLNKEEVGNEDEEvkqESGIESDNENDE 4308
Cdd:pfam04147  280 GEEDEEEEDGKKKK-----KHKSADDLDDDFVVD--DDDDDEEFGLGKGIKERPTATELGDEDED---DFIIDDDLVESE 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    4309 PGPEEDAGETetalDEEEGAEEDVDMTNDEGKEDEENGPEEQaMSDEEELKQDAAMEENKEKGGEQNT 4376
Cdd:pfam04147  350 SDLELDEEEE----DEEEEDDEDEDEEEEEDDDDLSDLESEE-DEEDDEFEEEKKKKKKKDEEGAKEE 412
Mpp10 pfam04006
Mpp10 protein; This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The ...
 4329-4573 5.55e-05

Mpp10 protein; This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites.


Pssm-ID: 461128 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 5.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4329 EEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADtEDIDQEAAvQQDSGSKGAGA 4408
Cdd:pfam04006   79 EKELRLLLDSEQDDEEDEDEEEDEEDEEDEEEDEDEEEEEEEEEEDDEDEDSDDEGLEE-EDVKELEQ-KTKKDAKKGRK 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4409 DATDTQ--EQDDVggsgttqNTYEEDQEDvtknNEESREEATAalkqlGDSMKEYHrrrQDIkeaqtNGEEDENLEKNNE 4486
Cdd:pfam04006  157 SVVDDKffKLDEM-------EKFLEDEEK----KEERKDKGKE-----DEDDIDYF---EDD-----DSEDDEDDGARNL 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4487 RPDEFEHVEGANTETDTQALGSATQDQLQTIDEDmaiDDDREEQEVDQKELVEDADDekmdIDEEEMLSDIDAHDANNDV 4566
Cdd:pfam04006  213 KYEDFFDPPEEEDEKETKKKKDKKKEEDEKDDEE---EEDEEDDAMEEEKEDEFAED----EDEEEDDDEDSDDEEEEAS 285


                   ....*..
gi 6323135    4567 DSKKSGF 4573
Cdd:pfam04006  286 PEELSSF 292
COG5137 COG5137
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ...
 4167-4315 6.11e-05

Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];


Pssm-ID: 227466 [Multi-domain]  Cd Length: 279  Bit Score: 48.45  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4167 NSKEKDTDQNLDGKNQEEDVQAAENDEQQR--------DNKEGGDEDPNAPEDGDEEIENDENAEEENDVGEQEDEVKDE 4238
Cdd:COG5137  121 TKLEKSDVEEPSEKVDEEDVEREILAEKPRvtrfnivwDNDEDNDEAPPAQPDVDNEEEERLEESDGREEEEDEEVGSDS 200

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135  4239 EGE-DLEANVPEIETLDLPEDMNLDSEHEEsdEDVDMSDGmPDDLNKEEVGNEDE-EVKQESGIESDNENDEPGPEEDA 4315
Cdd:COG5137  201 YGEgNRELNEEEEEEAEGSDDGEDVVDYEG--ERIDKKQG-EEEEMEEEVINLFEiEWEEESPSEEVPRNNEESPAKKQ 276
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 311-417 6.18e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 46.80  E-value: 6.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135     311 IMLIGKAGSGKTFLINELSKYM-GCHDSIVKIHLGEQTDAKL---LIGTytsgdKPG--TFEwRAGVLATAVKEGRW--V 382
Cdd:pfam07724    6 FLFLGPTGVGKTELAKALAELLfGDERALIRIDMSEYMEEHSvsrLIGA-----PPGyvGYE-EGGQLTEAVRRKPYsiV 79

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 6323135     383 LIEDIDKAPTDVLSILLSLLEKRELTiPSRGETVK 417
Cdd:pfam07724   80 LIDEIEKAHPGVQNDLLQILEGGTLT-DKQGRTVD 113
BMS1 COG5192
GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and ...
 4231-4553 7.32e-05

GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227519 [Multi-domain]  Cd Length: 1077  Bit Score: 49.35  E-value: 7.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4231 QEDEVKDEEGEDLEANVPEIETLDlPEDMNLDSEHEES----------DEDVDMsDGMPDDLNKEEVGNEDEEVKQESGI 4300
Cdd:COG5192  373 EQDPGVDGVGLQLFSNSDAIDTVD-RESSEIDNVGRKTrrqptgkaiaEETSRE-DELSFDDSDVSTSDENEDVDFTGKK 450

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4301 ESDNENDEPGPEEDAGETETALDEEEGaeedvdmtndegkedeengpeeqAMSDEEELKQDAAMEENKEKGGEqntegld 4380
Cdd:COG5192  451 GAINNEDESDNEEVAFDSDSQFDESEG-----------------------NLRWKEGLASKLAYSQSGKRGRN------- 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4381 gVEEKADTEDIDQEAAVQQDSGSKGAGADATDTQEQDDVGGSGTTQntyeEDQEDVTKNNEESREEATAALKQLGDSMKE 4460
Cdd:COG5192  501 -IQKIFYDESLSPEECIEEYKGESAKSSESDLVVQDEPEDFFDVSK----VANESISSNHEKLMESEFEELKKKWSSLAQ 575

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4461 YHRRRQD--IKEAQTNGEE-DENLEKNNERPDEFEHVEGANTETDTQalGSATQDQLQTIDEDMAIDDDREEQEVDQK-- 4535
Cdd:COG5192  576 LKSRFQKdaTLDSIEGEEElIQDDEKGNFEDLEDEENSSDNEMEESR--GSSVTAENEESADEVDYETEREENARKKEel 653

                        330       340
                 ....*....|....*....|..
gi 6323135  4536 ----ELVEDADDEKMDIDEEEM 4553
Cdd:COG5192  654 rgnfELEERGDPEKKDVDWYTE 675
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 4320-4426 1.33e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 48.25  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4320 TALD--EEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENkEKGGEQNTEGLDGVEEKADTEDIDQEAAv 4397
Cdd:COG4547  203 RDLDlaEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDA-EASGDDAEEGESEAAEAESDEMAEEAEG- 280

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6323135  4398 qqDSGSKGAGADATDTQEQDDVGGSG----TTQ 4426
Cdd:COG4547  281 --EDSEEPGEPWRPNAPPPDDPADPDykvfTTA 311
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 4045-4376 1.36e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 48.37  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4045 SPQPPSEEVDDKNLQEGTGLGDGEGAQNNNKDVEQDEDLTEDAQNENKEQQDKDERDDENEDDAVEMEGDMAGELEDLSN 4124
Cdd:NF033609  624 SASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4125 GEENDDEdtdseeeeldeeiddlnedDPNAIDDKmwdDKASDNSKEKDTDQNLDgKNQEEDVQAAENDEQQRDNKEGGDE 4204
Cdd:NF033609  704 SDSDSDS-------------------DSDSDSDS---DSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDS 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4205 DPNAPEDGDEEIENDENAEEENDVGEQEDEVKDEEGedleanvpeietlDLPEDMNLDSeheESDEDVDMSDGMPDDLNK 4284
Cdd:NF033609  761 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-------------DSDSDSDSDS---DSDSDSDSDSDSDSDSDS 824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4285 EEVGNEDEEVKQESGIESDNENDEPGPEEDAGETETALDEEEGAEEDVDMTNDegKEDEENGPEEQAMSDEEELKQDAAM 4364
Cdd:NF033609  825 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVPPNS--PKNGTNASNKNEAKDSKEPLPDTGS 902

                         330
                  ....*....|..
gi 6323135   4365 EenkekgGEQNT 4376
Cdd:NF033609  903 E------DEANT 908
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 1743-1778 1.40e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.89  E-value: 1.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 6323135    1743 ILLEGSPGVGKTSLITALANITGNKLTRINLSEQTD 1778
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVS 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 4238-4542 2.03e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 47.65  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4238 EEGEDLeanvPEIETLDLPEDMnldseheesdedvdmsDGMPDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEEDAGE 4317
Cdd:PTZ00441  278 EEEECP----VEPEPLPVPAPV----------------PPTPEDDNPRPTDDEFAVPNFNEGLDVPDNPQDPVPPPNEGK 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4318 TETALdeeegaEEDVDMTNDEGKEDEENG---PEEQAMSDEEELKQDAAMEENKEK-GGEQNTEGLDGVEEKADTEDIDQ 4393
Cdd:PTZ00441  338 DGNPN------EENLFPPGDDEVPDESNVppnPPNVPGGSNSEFSSDVENPPNPPNpDIPEQEPNIPEDSNKEVPEDVPM 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4394 EAAVQQDsgskgagaDATDTQEQDDVGGSGTTQNTY------EEDQED----VTKNNEESREEATAALKQLGDSMKEYHR 4463
Cdd:PTZ00441  412 EPEDDRD--------NNFNEPKKPENKGDGQNEPVIpkpldnERDQSNknkqVNPGNRHNSEDRYTRPHGRNNENRNYNN 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4464 RRQDIKEAQTNGEEDENLEKNNERPDEFEHVEG-----------ANTETDTQALGSAT--QDQLQTIDEDMAiDDDREEQ 4530
Cdd:PTZ00441  484 KNSDIPKHPERSEHEQPEDKKKKSSNNGYKIAGgviaglalvgcVGFAYNFVVPGGAAgmAGEPAPFDEAMA-EDEKDLD 562

                         330
                  ....*....|..
gi 6323135   4531 EVDQKELVEDAD 4542
Cdd:PTZ00441  563 EADQFKLPEDND 574
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 1068-1214 2.34e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 44.83  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1068 LVRATSGKRFPVLIQGPTSSGKTSMIKYLADIT---GHKFVRINNHEhtdlqEYLGTYVTDDTGKLSFKEGVLVEALRKG 1144
Cdd:cd00009   11 REALELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASD-----LLEGLVVAELFGHFLVRLLFELAEKAKP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1145 YWIVLDELNLAPTDVLEALNRLLDDnrelfipETQEVVHPHPDFLLFATQNPPGIyggrkILSRAFRNRF 1214
Cdd:cd00009   86 GVLFIDEIDSLSRGAQNALLRVLET-------LNDLRIDRENVRVIGATNRPLLG-----DLDRALYDRL 143
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
 1349-1393 2.99e-04

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 44.69  E-value: 2.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 6323135    1349 RLSVLVSSCLKNKEPVLLVGETGCGKTTICQ-LLAQFMGRELITLN 1393
Cdd:pfam12775   19 RYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQnLLRKLDKEKYLPLF 64
PHA02664 PHA02664
hypothetical protein; Provisional
 4306-4456 5.63e-04

hypothetical protein; Provisional


Pssm-ID: 177447  Cd Length: 534  Bit Score: 46.15  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4306 NDEPGPEEDAGE--TETALDEEEGAEEDVDMTNDEGKE-DEENG-PEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDG 4381
Cdd:PHA02664  399 NGARGSPMAAPEegRAAAAAAAANAPADQDVEAEAHDEfDQDPGaPAHADRADSDEDDMDEQESGDERADGEDDSDSSYS 478

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6323135   4382 VEEKADTEDidqeaavqQDSGSKGAGaDATDTQEQDDVGGSGttQNTYEEDqedvtknnEESREEATAALKQLGD 4456
Cdd:PHA02664  479 YSTTSSEDE--------SDSADDSWG-DESDSGIEHDDGGVG--QAIEEEE--------EEERAVLGAVAEMLGD 534
PTZ00121 PTZ00121
MAEBL; Provisional
 4141-4599 6.20e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4141 DEEIDDLNEDDPNAIDDKMWDDKA-----SDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDG--- 4212
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAeearkADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAkkk 1330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4213 -DEEIENDENAEEENDVGEQEDEVKDEEGEDLEANvPEIETLDLPEDMNLDSEHEESDEDVDMSdgmpDDLNK--EEVGN 4289
Cdd:PTZ00121 1331 aDAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEK-AEAAEKKKEEAKKKADAAKKKAEEKKKA----DEAKKkaEEDKK 1405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4290 EDEEVKQESGIESDNENDEPGPEE---------DAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQ 4360
Cdd:PTZ00121 1406 KADELKKAAAAKKKADEAKKKAEEkkkadeakkKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKA 1485

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4361 DAA---MEENKEKGGE--------QNTEGLDGVEEKADTEDIDQ-EAAVQQDSGSKgagadATDTQEQDDVGGSGTTQNT 4428
Cdd:PTZ00121 1486 DEAkkkAEEAKKKADEakkaaeakKKADEAKKAEEAKKADEAKKaEEAKKADEAKK-----AEEKKKADELKKAEELKKA 1560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4429 YEEDQEDVTKNNEESR-------EEATAALKQLGDSMKEYHRRRQDIKEAQTNGEED-----ENLEKNNERPDEFEHVEG 4496
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKnmalrkaEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEakikaEELKKAEEEKKKVEQLKK 1640

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   4497 ANTETDTQAlgsatqDQLQTIDEDMAIDDDRE-EQEVDQKELVEDADDEKMDIDEEEMLSDIDAHDANNDVDSKKSGFIG 4575
Cdd:PTZ00121 1641 KEAEEKKKA------EELKKAEEENKIKAAEEaKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE 1714

                         490       500
                  ....*....|....*....|....*...
gi 6323135   4576 KRKSEE----DFENELSNEHFSADQEDD 4599
Cdd:PTZ00121 1715 KKKAEElkkaEEENKIKAEEAKKEAEED 1742
PRK10787 PRK10787
DNA-binding ATP-dependent protease La; Provisional
 1735-1910 6.66e-04

DNA-binding ATP-dependent protease La; Provisional


Pssm-ID: 182730 [Multi-domain]  Cd Length: 784  Bit Score: 46.09  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1735 RAMQVHKPIL-LEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAP--GERSGEFLWHDApflRAMKKGEW 1811
Cdd:PRK10787  343 RVNKIKGPILcLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTyiGSMPGKLIQKMA---KVGVKNPL 419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   1812 VLLDEMNLASQsvleglnaclDHRG-------EAYIPELDISFSCH--------PNFLVFAAQNPQyqgggrkGLPKSFV 1876
Cdd:PRK10787  420 FLLDEIDKMSS----------DMRGdpasallEVLDPEQNVAFSDHylevdydlSDVMFVATSNSM-------NIPAPLL 482

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 6323135   1877 NRFSVVFIDMLTSDDLLLIAK-HLYP-SIEPDIIAK 1910
Cdd:PRK10787  483 DRMEVIRLSGYTEDEKLNIAKrHLLPkQIERNALKK 518
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
 4323-4602 1.17e-03

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 461196  Cd Length: 835  Bit Score: 45.31  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4323 DEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAA--MEE------------NKEKggeqntegldgvEEKAD- 4387
Cdd:pfam04147  125 DDDDSEEEEDGQLDLKRVRRAHFGGGEDDEEEEPERKKSKKevMEEviaksklhkyerQKAK------------EEDEEl 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4388 TEDIDQE-AAVQQD-SGSKGAGADATDTQEqddvggsgTTQNTYEEDQE-----------------DVTKNNEESREEAT 4448
Cdd:pfam04147  193 REELDKElKDLRSLlSGSKRPKPEQAKKPE--------EKPDRKKPDDDydklvrelafdkrakpsDRTKTEEELAEEEK 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4449 AALKQLgdsmkEyhRRRQdikeAQTNGEEDENLEKNNERP---------DEFEHVEGANTETDTQALGSATQDQ----LQ 4515
Cdd:pfam04147  265 ERLEKL-----E--EERL----RRMRGEEDEEEEDGKKKKkhksaddldDDFVVDDDDDDEEFGLGKGIKERPTatelGD 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    4516 TIDEDMAIDDDREEQEVDQKELVEDADDEKMDIDEEEMLSDIDAHDANNDVDSKKSgfigkrkSEEDFENELSNEHFSAD 4595
Cdd:pfam04147  334 EDEDDFIIDDDLVESESDLELDEEEEDEEEEDDEDEDEEEEEDDDDLSDLESEEDE-------EDDEFEEEKKKKKKKDE 406


                   ....*..
gi 6323135    4596 QEDDSEI 4602
Cdd:pfam04147  407 EGAKEEL 413
PRK04195 PRK04195
replication factor C large subunit; Provisional
 1342-1394 1.46e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 44.91  E-value: 1.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323135   1342 TWTKGmrrlsvlvssclKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNA 1394
Cdd:PRK04195   32 SWLKG------------KPKKALLLYGPPGVGKTSLAHALANDYGWEVIELNA 72
PRK04195 PRK04195
replication factor C large subunit; Provisional
 1740-1762 1.68e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 44.53  E-value: 1.68e-03
                          10        20
                  ....*....|....*....|...
gi 6323135   1740 HKPILLEGSPGVGKTSLITALAN 1762
Cdd:PRK04195   39 KKALLLYGPPGVGKTSLAHALAN 61
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 1083-1171 1.94e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 42.55  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  1083 GPTSSGKTSMIKYLADI---TGHKFVRIN------NHEHTDLQEYLGTYVTDDTGklsfkeGVLVEAL-RKGYWIVL-DE 1151
Cdd:cd19499   48 GPTGVGKTELAKALAELlfgDEDNLIRIDmseymeKHSVSRLIGAPPGYVGYTEG------GQLTEAVrRKPYSVVLlDE 121

                         90       100
                 ....*....|....*....|
gi 6323135  1152 LNLAPTDVLEALNRLLDDNR 1171
Cdd:cd19499  122 IEKAHPDVQNLLLQVLDDGR 141
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
4154-4556 2.32e-03

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 44.22  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4154 AIDDKMWDDKASDNSKEKDTDQNLDGKNQEEDVQAAENDEQQRDNKEGGDEDPNAPEDGDEEIendenaeeendVGEQED 4233
Cdd:COG5281   47 AAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAAALAEDAAAAAAAAEAALAALAAAALAL-----------AAAALA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4234 EVKDEEGEDLEANVPEIETLDLPEDMNLDSEHEESDEDvdmsdgmpDDLNKEEVGNEDEEVKQESGIESDNENDEPGPEE 4313
Cdd:COG5281  116 EAALAAAAAAAAAAAAAAAAAAAAAAAAAEAAKAAAAA--------AAAAALAAAAAAAAAAAAAAAAAAALAAASAAAA 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4314 DAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKG---GEQNTEGLDGVEEKADTED 4390
Cdd:COG5281  188 AAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAAASAAAQalaALAAAAAAAALALAAAAEL 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4391 IDQEAAVQQdsgSKGAGADATDTQEQDDVGGSGTTQNTYEEDQEDVTKNNEESREEATAALKQLGDSMKEYHRRRQDIKE 4470
Cdd:COG5281  268 ALTAQAEAA---AAAAAAAAAAAQAAEAAAAAAEAQALAAAAAAAAAQLAAAAAAAAQALRAAAQALAALAQRALAAAAL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4471 AQTNGEEDENLEKnnerpdefehvEGANTETDTQALGSATQDQLQtidEDMAIDDDREEQEVDQKELVEDADDEKMDIDE 4550
Cdd:COG5281  345 AAAAQEAALAAAA-----------AALQAALEAAAAAAAAELAAA---GDWAAGAKAALAEYADSATNVAAQVAQAATSA 410


                 ....*.
gi 6323135  4551 EEMLSD 4556
Cdd:COG5281  411 FSGLTD 416
COG5593 COG5593
Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal ...
 4229-4370 2.43e-03

Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227880 [Multi-domain]  Cd Length: 821  Bit Score: 44.26  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4229 GEQEDEVKDEEGEDLEANVPEI--ETLDLPEDMNLDSEHEESD-EDVDMSDGMPDDLNKEEvGNEDEEVKQESGIESDNE 4305
Cdd:COG5593  669 GKGKKSNKASFDSDDEMDENEIwsALVKSRPDVEDDSDDSELDfAEDDFSDSTSDDEPKLD-AIDDEDAKSEGSQESDQE 747

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6323135  4306 ndepgpeEDAGETETALDEEEgaeEDVDMTNDEGKEDEENGPEEQamsdEEELKQDAAMEENKEK 4370
Cdd:COG5593  748 -------EGLDEIFYSFDGEQ---DNSDSFAESSEEDESSEEEKE----EEENKEVSAKRAKKKQ 798
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 4197-4330 3.09e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 44.01  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135  4197 DNKEGGDEDPNAPEDGDeeiendenaeeendvgEQEDEVKDEEGEDLEANVPEIETLDLPEDMNLDSEHEEsDEDVDMSD 4276
Cdd:COG4547  206 DLAEELGEDEDEEDEDD----------------EDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAE-EGESEAAE 268

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135  4277 GMPDDLNKEEVGNEDEEVKQESgiesdnENDEPGPEEDAGET----ETALDEEEGAEE 4330
Cdd:COG4547  269 AESDEMAEEAEGEDSEEPGEPW------RPNAPPPDDPADPDykvfTTAFDEVVAAED 320
clpC CHL00095
Clp protease ATP binding subunit
 310-420 3.11e-03

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 43.89  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135    310 PI---MLIGKAGSGKTFLINELSKYM-GCHDSIVKIHLGE----QTDAKLLigtytsGDKPGTFEW-RAGVLATAVKEGR 380
Cdd:CHL00095  538 PIasfLFSGPTGVGKTELTKALASYFfGSEDAMIRLDMSEymekHTVSKLI------GSPPGYVGYnEGGQLTEAVRKKP 611

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6323135    381 W--VLIEDIDKAPTDVLSILLSLLEKRELTiPSRGETVKAAN 420
Cdd:CHL00095  612 YtvVLFDEIEKAHPDIFNLLLQILDDGRLT-DSKGRTIDFKN 652
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 1364-1408 3.66e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 40.65  E-value: 3.66e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 6323135    1364 VLLVGETGCGKTTICQLLAQFMGRELITLNAHQNTETGDILGAQR 1408
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKR 45
Merozoite_SPAM pfam07133
Merozoite surface protein (SPAM); This family consists of several Plasmodium falciparum SPAM ...
 4312-4389 3.94e-03

Merozoite surface protein (SPAM); This family consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-repeat domain. Heptad repeats in which the a and d position contain hydrophobic residues generate amphipathic alpha-helices which give rise to helical bundles or coiled-coil structures in proteins. SPAM is an example of a P. falciparum antigen in which a repetitive sequence has features characteriztic of a well-defined structural element.


Pssm-ID: 429310 [Multi-domain]  Cd Length: 176  Bit Score: 41.50  E-value: 3.94e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323135    4312 EEDAGETETALDEEEGAEEDVDMTNDEGKEDEENGPEEQAMSDEEELKQDAAMEENKEKGGEQNTEGLDGVEEKADTE 4389
Cdd:pfam07133   34 EDIAKENEDVEDEKEDEEEETEDEETEEKNEEETEEETEDEEDEEEVEEEEEKEENEDKKKELEEEQINKNTDTSDLE 111
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 312-416 6.54e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 41.01  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135   312 MLIGKAGSGKTFLINELSKYM-GCHDSIVKIHLGEQT---DAKLLIGT------YTSGdkpgtfewraGVLATAVKEGRW 381
Cdd:cd19499   45 LFLGPTGVGKTELAKALAELLfGDEDNLIRIDMSEYMekhSVSRLIGAppgyvgYTEG----------GQLTEAVRRKPY 114

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 6323135   382 --VLIEDIDKAPTDVLSILLSLLEKRELTiPSRGETV 416
Cdd:cd19499  115 svVLLDEIEKAHPDVQNLLLQVLDDGRLT-DSHGRTV 150
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 310-415 6.97e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323135      310 PIMLIGKAGSGKTFLINELSKYMGCHDSIVKI----HLGEQTDAKLLIGTYTSGDKPGTFEWRAGVLATAVKEGRW--VL 383
Cdd:smart00382    4 VILIVGPPGSGKTTLARALARELGPPGGGVIYidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPdvLI 83

                            90       100       110
                    ....*....|....*....|....*....|..
gi 6323135      384 IEDIDKAPTDVLSILLSLLEKRELTIPSRGET 415
Cdd:smart00382   84 LDEITSLLDAEQEALLLLLEELRLLLLLKSEK 115
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 630-686 7.48e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 41.43  E-value: 7.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323135   630 NHSLRLMEQISVCIQMTE----PVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETG 686
Cdd:cd19497   30 NHYKRIRNNLKQKDDDVEleksNILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAG 90
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 647-712 8.12e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 8.12e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323135      647 EPVLLVGETGTGKTTVVQQLAKMLAKKLT---VINVSQQTETGDLLGGYKPVNSKTVAVPIQENFETLF 712
Cdd:smart00382    3 EVILIVGPPGSGKTTLARALARELGPPGGgviYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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