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Conserved domains on  [gi|6322936|ref|NP_013009|]
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Dad2p [Saccharomyces cerevisiae S288C]

Protein Classification

DASH complex subunit DAD2( domain architecture ID 10554569)

DASH complex subunit DAD2 is a component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DASH_Dad2 pfam08654
DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that ...
 6-129 1.13e-25

DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro.


:

Pssm-ID: 430134  Cd Length: 99  Bit Score: 92.66  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322936      6 EQIAIKRKELQSLQKITSLTDGLKIQLTELNEQIKEMGMNADSVAQLMNNWDSIINNISQASLGLLQYAEGDYEigpwkD 85
Cdd:pfam08654   2 ARIAEKRAELEALKQLRDLSATLANQLEELSEKLSTLADGTEAVASVMANWDSVLRAISMASLKLLQYAENNAA-----D 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6322936     86 SKKKESEQSNEtgleaqendkndedndededlVPLPETMVRIRV 129
Cdd:pfam08654  77 EEEDTSEEEEE---------------------DPLPETLVRIPV 99
 
Name Accession Description Interval E-value
DASH_Dad2 pfam08654
DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that ...
 6-129 1.13e-25

DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro.


Pssm-ID: 430134  Cd Length: 99  Bit Score: 92.66  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322936      6 EQIAIKRKELQSLQKITSLTDGLKIQLTELNEQIKEMGMNADSVAQLMNNWDSIINNISQASLGLLQYAEGDYEigpwkD 85
Cdd:pfam08654   2 ARIAEKRAELEALKQLRDLSATLANQLEELSEKLSTLADGTEAVASVMANWDSVLRAISMASLKLLQYAENNAA-----D 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6322936     86 SKKKESEQSNEtgleaqendkndedndededlVPLPETMVRIRV 129
Cdd:pfam08654  77 EEEDTSEEEEE---------------------DPLPETLVRIPV 99
 
Name Accession Description Interval E-value
DASH_Dad2 pfam08654
DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that ...
 6-129 1.13e-25

DASH complex subunit Dad2; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro.


Pssm-ID: 430134  Cd Length: 99  Bit Score: 92.66  E-value: 1.13e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322936      6 EQIAIKRKELQSLQKITSLTDGLKIQLTELNEQIKEMGMNADSVAQLMNNWDSIINNISQASLGLLQYAEGDYEigpwkD 85
Cdd:pfam08654   2 ARIAEKRAELEALKQLRDLSATLANQLEELSEKLSTLADGTEAVASVMANWDSVLRAISMASLKLLQYAENNAA-----D 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6322936     86 SKKKESEQSNEtgleaqendkndedndededlVPLPETMVRIRV 129
Cdd:pfam08654  77 EEEDTSEEEEE---------------------DPLPETLVRIPV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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