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Conserved domains on  [gi|6322474|ref|NP_012548|]
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Tma22p [Saccharomyces cerevisiae S288C]

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 10795723)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 2-181 1.54e-87

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


:

Pssm-ID: 273472  Cd Length: 173  Bit Score: 254.80  E-value: 1.54e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474      2 LREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTnklaessIGEAREEKLEKDLLKIQK 81
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVT-------IGEAQEEKGEKDLLGIQK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474     82 KQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDE 161
Cdd:TIGR01159  74 AQEAREGGKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDD 153

                         170       180
                  ....*....|....*....|
gi 6322474    162 VETYIHSLLEEKGLKDVKVE 181
Cdd:TIGR01159 154 IEDYIHEKWPEVGDKDIKDL 173
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 2-181 1.54e-87

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 254.80  E-value: 1.54e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474      2 LREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTnklaessIGEAREEKLEKDLLKIQK 81
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVT-------IGEAQEEKGEKDLLGIQK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474     82 KQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDE 161
Cdd:TIGR01159  74 AQEAREGGKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDD 153

                         170       180
                  ....*....|....*....|
gi 6322474    162 VETYIHSLLEEKGLKDVKVE 181
Cdd:TIGR01159 154 IEDYIHEKWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 97-172 1.50e-31

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 109.57  E-value: 1.50e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322474   97 SKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYIHSLLEE 172
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGAEGKDEIVIQGDVTDDIVDLILEKWPE 76
SUI1 pfam01253
Translation initiation factor SUI1;
96-175 2.19e-20

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 80.56  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474     96 SSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNaEKKEEVVIQGDVMDEVETyihsLLEEKGL 175
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKD-GGGEEIQVQGDQRDKVAE----LLTEKGI 75
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
90-174 3.46e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 38.36  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474    90 ELAKKlSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVsknaeKKEEVVIQGDVMDEVEtyihSL 169
Cdd:PRK00939  18 EVAKE-QQRIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVK----EL 87


                 ....*
gi 6322474   170 LEEKG 174
Cdd:PRK00939  88 LIKMG 92
 
Name Accession Description Interval E-value
DRP1 TIGR01159
density-regulated protein DRP1; This protein family shows weak but suggestive similarity to ...
 2-181 1.54e-87

density-regulated protein DRP1; This protein family shows weak but suggestive similarity to translation initiation factor SUI1 and its prokaryotic homologs.


Pssm-ID: 273472  Cd Length: 173  Bit Score: 254.80  E-value: 1.54e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474      2 LREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTnklaessIGEAREEKLEKDLLKIQK 81
Cdd:TIGR01159   1 PLRVLYCGVCSLPPEYCEFSGDLKRCKVWLSENAPDLYAKLYGTDSPTAEAEAVT-------IGEAQEEKGEKDLLGIQK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474     82 KQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDE 161
Cdd:TIGR01159  74 AQEAREGGKKKKKLPQKVTIKREPRTKRKFVTVIKGLETFDIDLKKASKTFAQKFATGCSVSKSVTGKEEIVIQGDVMDD 153

                         170       180
                  ....*....|....*....|
gi 6322474    162 VETYIHSLLEEKGLKDVKVE 181
Cdd:TIGR01159 154 IEDYIHEKWPEVGDKDIKDL 173
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 97-172 1.50e-31

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 109.57  E-value: 1.50e-31
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322474   97 SKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYIHSLLEE 172
Cdd:cd11607   1 SKVTIKRISRNKRKFVTTVTGLETFGIDLKKAAKLFAKKFACGASVTKGAEGKDEIVIQGDVTDDIVDLILEKWPE 76
SUI1 pfam01253
Translation initiation factor SUI1;
96-175 2.19e-20

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 80.56  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474     96 SSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNaEKKEEVVIQGDVMDEVETyihsLLEEKGL 175
Cdd:pfam01253   1 QPKIHIRVEQRGGRKTVTTVSGLEPFGIDLKKLAKELKKKFACGGTVVKD-GGGEEIQVQGDQRDKVAE----LLTEKGI 75
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 98-180 1.00e-11

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 58.34  E-value: 1.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474   98 KVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVS--KNAEKKEEVVIQGDVMDEVetyiHSLLEEKGL 175
Cdd:cd11608   1 PIDITTERRQGNKKVTLISGLESFGIDPEEFAKELQKKCAASTSVSplPGKKKGVEVQVQGNQVKFV----AKLLTEKYG 76


                ....*
gi 6322474  176 KDVKV 180
Cdd:cd11608  77 VPKKY 81
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 98-182 3.79e-07

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 45.88  E-value: 3.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474   98 KVIIKREARTKRKFIVAISGLEVFdIDMKKLAKTFASRFATGCSVSknaEKKEEVVIQGDVMDEVEtyihSLLEEKGLKD 177
Cdd:cd00474   1 KIHIKVEQRSGGKKVTKVEGLPAY-IDLRKLADELKKKLGCGGSVE---GEKMEIEIQGDHTDQII----VALEEKGIDK 72


                ....*
gi 6322474  178 VKVET 182
Cdd:cd00474  73 DWVEL 77
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 97-176 4.46e-06

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 43.29  E-value: 4.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474   97 SKVIIKREARTKRKFIVAISGLEVfDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYihsLLEEKGLK 176
Cdd:cd11566   1 GYIHIRIQQRNGRKTLTTVQGLPE-EFDLKKILKAFKKEFACNGTVVEDPEYGEVIQLQGDQRKNIKEF---LLEEGIAK 76
YciH_like cd11567
Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic ...
 98-180 7.57e-06

Homologs of eIF1/SUI1 including Escherichia coli YciH; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.


Pssm-ID: 211319  Cd Length: 76  Bit Score: 42.47  E-value: 7.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474   98 KVIIKRE-ARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVsknaeKKEEVVIQGDVMDEVETyihsLLEEKGLK 176
Cdd:cd11567   2 KVRVRLEkRGRGGKTVTVIEGLPLSEEDLKELAKELKKKCGCGGTV-----KDGEIELQGDHREKIKE----LLEKKGFK 72


                ....
gi 6322474  177 DVKV 180
Cdd:cd11567  73 VKKI 76
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
90-174 3.46e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 38.36  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322474    90 ELAKKlSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVsknaeKKEEVVIQGDVMDEVEtyihSL 169
Cdd:PRK00939  18 EVAKE-QQRIKIKVDKRRYGKEVTIIEGIDPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVK----EL 87


                 ....*
gi 6322474   170 LEEKG 174
Cdd:PRK00939  88 LIKMG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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