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Conserved domains on  [gi|6321879|ref|NP_011955|]
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Rtc3p [Saccharomyces cerevisiae S288C]

Protein Classification

SBDS family protein( domain architecture ID 10471837)

SBDS (Shwachman-Bodian-Diamond syndrome) family protein similar to Saccharomyces cerevisiae restriction of telomere capping protein 3 that may play a role in RNA metabolism, rRNA-processing, and in a process influencing telomere capping

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SBDS pfam01172
Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ...
 6-95 4.37e-14

Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterized by bone marrow failure and leukemia predisposition. Members of this family play a role in RNA metabolism. In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.


:

Pssm-ID: 460097 [Multi-domain]  Cd Length: 82  Bit Score: 62.05  E-value: 4.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321879      6 KYFYKGENTDLIVFAaSEELVDEYLKNPSIGkLSEVVELFEVFTPQdGRGaegelGAASKAQVENEFGKgKKIEEVIDLI 85
Cdd:pfam01172   1 KVRYKGGGKRFEIAV-DPNKVKKWRKGKSIP-LDEVLQSFKVFTNV-SKG-----DRASKEDLEKEFGT-TDEDEIIKKI 71

                          90
                  ....*....|
gi 6321879     86 LRNGKPNSTT 95
Cdd:pfam01172  72 LEKGELQLTE 81
 
Name Accession Description Interval E-value
SBDS pfam01172
Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ...
 6-95 4.37e-14

Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterized by bone marrow failure and leukemia predisposition. Members of this family play a role in RNA metabolism. In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.


Pssm-ID: 460097 [Multi-domain]  Cd Length: 82  Bit Score: 62.05  E-value: 4.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321879      6 KYFYKGENTDLIVFAaSEELVDEYLKNPSIGkLSEVVELFEVFTPQdGRGaegelGAASKAQVENEFGKgKKIEEVIDLI 85
Cdd:pfam01172   1 KVRYKGGGKRFEIAV-DPNKVKKWRKGKSIP-LDEVLQSFKVFTNV-SKG-----DRASKEDLEKEFGT-TDEDEIIKKI 71

                          90
                  ....*....|
gi 6321879     86 LRNGKPNSTT 95
Cdd:pfam01172  72 LEKGELQLTE 81
 
Name Accession Description Interval E-value
SBDS pfam01172
Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ...
 6-95 4.37e-14

Shwachman-Bodian-Diamond syndrome (SBDS) protein; This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities. It is characterized by bone marrow failure and leukemia predisposition. Members of this family play a role in RNA metabolism. In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.


Pssm-ID: 460097 [Multi-domain]  Cd Length: 82  Bit Score: 62.05  E-value: 4.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321879      6 KYFYKGENTDLIVFAaSEELVDEYLKNPSIGkLSEVVELFEVFTPQdGRGaegelGAASKAQVENEFGKgKKIEEVIDLI 85
Cdd:pfam01172   1 KVRYKGGGKRFEIAV-DPNKVKKWRKGKSIP-LDEVLQSFKVFTNV-SKG-----DRASKEDLEKEFGT-TDEDEIIKKI 71

                          90
                  ....*....|
gi 6321879     86 LRNGKPNSTT 95
Cdd:pfam01172  72 LEKGELQLTE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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