|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
128-1104 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1327.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 128 KTVPGEKKILVSlddPALKAYNPANVESSWYDWWIKTGVFEPeFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQ 207
Cdd:PTZ00419 11 KDEKKNKKRNIS---SMAASYDPKEVESGWYEWWEKSGFFKP-AEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 208 DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWS 287
Cdd:PTZ00419 87 DSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 288 REAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYP 367
Cdd:PTZ00419 167 REVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 368 VIGSDE-KLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLP-RKIPIITDKEAVDMEFGTGAVKITPAHDQND 445
Cdd:PTZ00419 247 LEDSGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDELVDMEFGTGAVKITPAHDPND 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 446 YNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWW 525
Cdd:PTZ00419 327 YEIAKRHNLPFINIFTLDGKINENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWY 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 526 VSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSMEE 605
Cdd:PTZ00419 406 VNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEEE 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 606 AEKKAAAKYPNSK--FTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTG 683
Cdd:PTZ00419 486 ALEKAKKKFGLSEedFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTD 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 684 SVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAM 763
Cdd:PTZ00419 566 KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDAL 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 764 RFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNE----SLVEKWILHKLTETSKIV 839
Cdd:PTZ00419 646 RFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNveslPWEDKWILHRLNVAIKEV 725
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 840 NEALDKRDFLTSTSSIYEFW-YLICDVYIENSKYLIQEGSAIEKK-SAKDTLYILLDNALKLIHPFMPFISEEMWQRLPK 917
Cdd:PTZ00419 726 TEGFKEYDFSEATQATYNFWlYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPN 805
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 918 RStEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGK--VFVESNHEEYFKTAEDQKDSIVSL 995
Cdd:PTZ00419 806 YL-RKSESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKpdCYVTAKDAELIELIESAENLISTL 884
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 996 IKaIDEVTVVRD---ASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANT 1072
Cdd:PTZ00419 885 AK-IGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPE 963
|
970 980 990
....*....|....*....|....*....|..
gi 6321531 1073 QAKEANKSKLDNTVAEIEGLEATIENLKRLKL 1104
Cdd:PTZ00419 964 DVRKLNDEKIDELNEEIKQLEQAIEELKSLLK 995
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
144-1083 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1238.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 144 ALKAYNPANVESSWYDWWIKTGVFEPEFTADGKVkpegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLF 223
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPP-----FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 224 LPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEE 303
Cdd:TIGR00422 76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 304 AFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSrtllSVPGYDEKVEFGvltsfaypvigSDEKLIIATTRPE 383
Cdd:TIGR00422 155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKG----KLYYIRYPLANG-----------SKDYLVVATTRPE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 384 TIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDD 463
Cdd:TIGR00422 220 TMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIAD-EYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 464 GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQ 543
Cdd:TIGR00422 299 GLLNENAG-KYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 544 ITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEehdridgdYWVAGRSMEEAEKKAaakyPNSKFTLEQ 623
Cdd:TIGR00422 378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGE--------VYVAKEEPLPDDKTN----TGPSVELEQ 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 624 DEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRK 703
Cdd:TIGR00422 446 DTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRK 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 704 MSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGTDAMRFALCAYTTGGRDINLDILR 783
Cdd:TIGR00422 526 MSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKR 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 784 VEGYRKFCNKIYQATKFALMRLGDDyqpPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLI 862
Cdd:TIGR00422 569 VESARNFLNKLWNASRFVLMNLSDD---LELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFiWNDF 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 863 CDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPkrstEKAASIVKASYPVYVSEYDDVK 942
Cdd:TIGR00422 646 CDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----EGADSIMLQSYPVVDAEFVDEE 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 943 SANAYDLVLNITKEARSLLSEYNILKNGKVFVESNHEEYfKTAEDQKDSIVSLIKAID--EVTVVRDASEIPegCVLQSV 1020
Cdd:TIGR00422 722 AEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEA-ETAERLKLNAVDIKGAINfsEVEVVIEKPEVT--EAVVEL 798
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321531 1021 NPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLD 1083
Cdd:TIGR00422 799 VPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
146-1100 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1160.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEPEftADGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:COG0525 5 KTYDPKEVEAKWYQYWEENGYFKAD--PDSDKEP---FTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 226 GFDHAGIATQSVVEKQIwAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:COG0525 80 GTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:COG0525 159 VRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGSGYIVVATTRPETM 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:COG0525 223 LGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIAD-EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGT 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 466 LNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:COG0525 302 INENAG-KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIK 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAgRSMEEAEKKAAAKypnskfTLEQDE 625
Cdd:COG0525 381 FVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCP---------DGEVYVA-RTEPEACAKAGSV------NLTQDE 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 626 DVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMS 705
Cdd:COG0525 445 DVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMS 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 706 KSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVE 785
Cdd:COG0525 525 KSKGNVIDPLDLI------------------------------DKY-------GADALRFTLAALASPGRDIKFDEERVE 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 786 GYRKFCNKIYQATKFALMRLGDdyQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICD 864
Cdd:COG0525 568 GYRNFANKLWNASRFVLMNLEG--FDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFvWNEFCD 645
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 865 VYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKaaSIVKASYPVYVSEYDDVKSA 944
Cdd:COG0525 646 WYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGE--SIMLAPWPEADEELIDEEAE 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 945 NAYDLVLNITKEARSLLSEYNIlKNGK---VFVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVrdASEIPEGCVlQSVN 1021
Cdd:COG0525 724 AEFEWLKEVISAIRNIRAEMNI-PPSKklpLLLKGADEADRARLEENAAYIKRLAR-LEEITIL--VDEKPEGAA-SAVV 798
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531 1022 PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLK 1100
Cdd:COG0525 799 GGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
146-1101 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1130.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEPEftaDGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK05729 7 KTYDPKEVEAKWYQKWEEKGYFKPD---DNSKKP---FSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 226 GFDHAGIATQSVVEKQIwAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:PRK05729 81 GTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:PRK05729 160 VRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVK----------------GKLWHIRYPLADGSDYLVVATTRPETM 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:PRK05729 224 LGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIAD-EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 466 LNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:PRK05729 303 INENPG-EYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEIK 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAgrsmeeaekkAAAKYPNSKFTLEQDE 625
Cdd:PRK05729 382 FVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDE---------DGEVYVG----------REEPEAREKALLTQDE 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 626 DVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMS 705
Cdd:PRK05729 443 DVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMS 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 706 KSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVE 785
Cdd:PRK05729 523 KSKGNVIDPLDLI------------------------------DKY-------GADALRFTLAALASPGRDIRFDEERVE 565
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 786 GYRKFCNKIYQATKFALMRLGDDyqPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICD 864
Cdd:PRK05729 566 GYRNFANKLWNASRFVLMNLEGA--DVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFiWNEFCD 643
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 865 VYIENSKYLIQEGsaiEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKaaSIVKASYPVYVSEYDDvKSA 944
Cdd:PRK05729 644 WYLELAKPVLQEA---AKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEE--SIMLAPWPEADEAIDE-AAE 717
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 945 NAYDLVLNITKEARSLLSEYNIlKNGK---VFVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVRDASEIPEGCVlQSVN 1021
Cdd:PRK05729 718 AEFEWLKELITAIRNIRAEMNI-PPSKklpLLLKGADAEDRARLEANEAYIKRLAR-LESLEILADDEEAPEGAA-SAVV 794
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 1022 PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLKR 1101
Cdd:PRK05729 795 GGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
118-1099 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 1079.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 118 EVEPIPEFIDKTVP-GEKKILVSLddpALKAYNPANVESSWYDWWIKTGVFepefTADGK-VKPEgvFCIPAPPPNVTGA 195
Cdd:PLN02381 72 EDENPEDFIDPDTPfGQKKRLSSQ---MAKQYSPSAVEKSWYAWWEKSGYF----GADAKsSKPP--FVIVLPPPNVTGA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 196 LHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKN 275
Cdd:PLN02381 143 LHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILN 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 276 QIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEK 355
Cdd:PLN02381 223 QLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 356 VEFGVLTSFAYPVIGSDEKLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAV 435
Cdd:PLN02381 303 VEFGVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAILVDPNFGTGAV 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 436 KITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECGPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDI 515
Cdd:PLN02381 383 KITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDV 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 516 IEPLLKPQWWVSQSEMAKDAIKVVRDGQ---ITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRI 592
Cdd:PLN02381 463 VEPMIKPQWFVNCSSMAKQALDAAIDGEnkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKEL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 593 D--GDYWVAGRSMEEAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFW 670
Cdd:PLN02381 543 GsyNDHWVVARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFW 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 671 VTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKES 750
Cdd:PLN02381 623 VARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKD 702
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 751 YPNGIPQCGTDAMRFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNESLVeKWILH 830
Cdd:PLN02381 703 FPNGIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSC-KWILS 781
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 831 KLTET-SKIVNeALDKRDFLTSTSSIYEFW-YLICDVYIENSK-YLIQEGS--AIEKKSAKDTLYILLDNALKLIHPFMP 905
Cdd:PLN02381 782 VLNKAiSKTVS-SLDAYEFSDAASTVYSWWqYQFCDVFIEAIKpYFAGDNPefASERAAAQDTLWICLDTGLRLLHPFMP 860
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 906 FISEEMWQRLPK-RSTEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSE-YNILKNGKV--FVESNHEEY 981
Cdd:PLN02381 861 FVTEELWQRLPQpKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEvLEKQKNERLpaFALCRNQEI 940
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 982 FKTAEDQKDSIVSLIKAIDEVTVVRDASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTI 1061
Cdd:PLN02381 941 AAIIKSHQLEILTLANLSSLKVLLSENDAPPAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKM 1020
|
970 980 990
....*....|....*....|....*....|....*...
gi 6321531 1062 NSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENL 1099
Cdd:PLN02381 1021 NASGYKEKVPANIQEEDARKLTKLLQELEFFEKESKRL 1058
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
146-1094 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 838.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEPEfTADGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK14900 17 KGYEHREVEARWYPFWQERGYFHGD-EHDRTRPP---FSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 226 GFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:PRK14900 93 GTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:PRK14900 173 VRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLADGSGEIVVATTRPETM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:PRK14900 238 LGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 466 LNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:PRK14900 318 MTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAGRSmeeaekkaaakyPNS-----KFT 620
Cdd:PRK14900 397 FIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCP---------DGHVTVARET------------PEAcstcgKAE 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 621 LEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQ 700
Cdd:PRK14900 456 LRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEK 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 701 GRKMSKSLGNVIDPLDVitgiklddlhakllqgnldprevekakigqkesypngIPQCGTDAMRFALCAYTTGGRDINLD 780
Cdd:PRK14900 536 GQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLA 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 781 ILRVEGYRKFCNKIYQATKFALMRLGD---DYQPPATEGLsgneSLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE 857
Cdd:PRK14900 579 KERIEGYRAFANKLWNASRFALMNLSGyqeRGEDPARLAR----TPADRWILARLQRAVNETVEALEAFRFNDAANAVYA 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 858 F-WYLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLP--KRSTEKAASIVKASYPvY 934
Cdd:PRK14900 655 FvWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqVGASAWADSVLAAEYP-R 733
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 935 VSEYDDVKSAnAYDLVLNITKEARSLLSEYNI------LKNGKVFVESNHEEYFKTAEDQKDSIVSLIKAIDEVTVVRDA 1008
Cdd:PRK14900 734 KGEADEAAEA-AFRPVLGIIDAVRNIRGEMGIpwkvklGAQAPVEIAVADPALRDLLQAGELARVHRVAGVEGSRLVVAA 812
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 1009 SEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEAN---------- 1078
Cdd:PRK14900 813 ATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDraraeelrek 892
|
970
....*....|....*.
gi 6321531 1079 KSKLDNTVAEIEGLEA 1094
Cdd:PRK14900 893 RGKLEAHRAMLSGSEA 908
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
156-780 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 837.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 156 SWYDWWIKTGVFEPEFTADgKVKPEgvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQ 235
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKR-KGKPS--FTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 236 SVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:pfam00133 78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 316 RASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDE-KLIIATTRPETIFGDTAVAVH 394
Cdd:pfam00133 158 RGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVN 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 395 PD-------------------------------DDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQ 443
Cdd:pfam00133 222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITD-DYVDMEFGTGAVHIAPAHGE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 444 NDYNTGKRHNLEFINILTDDGLLNEECgPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQ 523
Cdd:pfam00133 301 NDYEVGQRHNLEVINPVDDDGTFTEEA-PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQ 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 524 WWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSM 603
Cdd:pfam00133 380 WFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFE 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 604 EEAEKKAAAKYPNSKF-----TLEQDEDVLDTWFSSGLWPFSTLGWPEK-TKDMETFYPFSMLETGWDILFFWVTRMILL 677
Cdd:pfam00133 458 EEGSIKWLHREAKDKLgygkgTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMIML 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 678 GLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQ 757
Cdd:pfam00133 538 STALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID-------------------------------------K 580
|
650 660
....*....|....*....|...
gi 6321531 758 CGTDAMRFALCaYTTGGRDINLD 780
Cdd:pfam00133 581 YGADALRLWLA-NSDYGRDINLS 602
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
154-1095 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 720.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 154 ESSWYDWWIKTGVFEPEFTADGKvkPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIA 233
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGD--P---FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 234 TQSVVEKQIWAKDRKtRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGV 313
Cdd:PLN02943 141 TQLVVEKMLASEGIK-RTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 314 IYRASRLVNWSVKLNTAISNLEVEnkdvksrtllsvpgYDEkvEFGVLTSFAYPVIG-SDEKLIIATTRPETIFGDTAVA 392
Cdd:PLN02943 220 IYQGSYMVNWSPNLQTAVSDLEVE--------------YSE--EPGTLYYIKYRVAGgSEDFLTIATTRPETLFGDVAIA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 393 VHPDDDRYKHLHGKFIQHPF-LPRKIPIITDKEaVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECG 471
Cdd:PLN02943 284 VNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRY-VDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAG 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 472 PEWqgmkrFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSS 551
Cdd:PLN02943 363 LYW-----FEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 552 EAEYFHWLGNIQDWCISRQLWWGHRCPVYFinIEGEEHDRidgDYWVAgRSMEEAEKKAAAKYPNSkFTLEQDEDVLDTW 631
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWY--IVGKDCEE---DYIVA-RSAEEALEKAREKYGKD-VEIYQDPDVLDTW 510
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 632 FSSGLWPFSTLGWPE-KTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGN 710
Cdd:PLN02943 511 FSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGN 590
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 711 VIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALcAYTTGGRDINLDILRVEGYRKF 790
Cdd:PLN02943 591 VIDPLDTI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAF 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 791 CNKIYQATKFALMRLGDDYQPPATEGLSGNE----------SLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE-FW 859
Cdd:PLN02943 633 TNKLWNAGKFVLQNLPSQSDTSAWEHILACKfdkeesllslPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDfFW 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 860 YLICDVYIENSKY-LIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRsteKAASIVkASYPvYVSEY 938
Cdd:PLN02943 713 SDFADWYIEASKTrLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYR---KEALIV-SPWP-QTSLP 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 939 DDVKSANAYDLVLNITKEARSLLSEYNILKNGKV---FVESNHEEYFKTAEDQkdsIVSLIKAIDEVTVvrDASEIPEGC 1015
Cdd:PLN02943 788 KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRIsasIVASAEVIEYISKEKE---VLALLSRLDLQNV--HFTDSPPGD 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 1016 VLQSVN----PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKA--------NTQAKEANKsKLD 1083
Cdd:PLN02943 863 ANQSVHlvasEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKApedvvrgvREKAAEAEE-KIK 941
|
970
....*....|..
gi 6321531 1084 NTVAEIEGLEAT 1095
Cdd:PLN02943 942 LTKNRLAFLKST 953
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
181-779 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 589.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 181 GVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVG 260
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 261 KVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVenkd 340
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 341 vksrtllsvpgydekvefgvltsfaypvigsdekliiattrpetifgdtavavhpdddrykhlhgkfiqhpflprkipii 420
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 421 tdkeavdmefgtgavkitpahdqndyntgkrhnlefiniltddgllneecgpewqgmkrfdarkkvieqlkeknlyvgqe 500
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 501 dnemtiptCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVY 580
Cdd:cd00817 156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 581 FINiegeehdriDGDYWVAGRSME--EAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFS 658
Cdd:cd00817 228 YCK---------DGGHWVVAREEDeaIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTS 298
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 659 MLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIklddlhakllqgnldpr 738
Cdd:cd00817 299 LLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY----------------- 361
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 6321531 739 evekakigqkesypngipqcGTDAMRFALCAYTTGGRDINL 779
Cdd:cd00817 362 --------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
146-1011 |
6.22e-154 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 478.15 E-value: 6.22e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEpeFTADGKvKPegVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK13208 8 KKYDPEELEEKWQKIWEEEGTYK--FDPDER-KP--VYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 226 GFDHAGIATQSVVEKQ--IwakdrkTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEE 303
Cdd:PRK13208 83 GWDDNGLPTERKVEKYygI------RKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 304 AFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPViGSDEKLIIATTRPE 383
Cdd:PRK13208 157 SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE----------------GKLNYIKFPV-EDGEEIEIATTRPE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 384 TIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDD 463
Cdd:PRK13208 220 LLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILAD-PLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDED 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 464 GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRdgQ 543
Cdd:PRK13208 299 GRMTEAAG-KLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK--E 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 544 ITITPKSSEAEYFHWLGNIQ-DWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSmeeaekKAAAKYPNSK---F 619
Cdd:PRK13208 376 INWYPEHMRVRLENWIEGLNwDWCISRQRYFGTPIPVWYCKDCGHPILPDEEDLPVDPTK------DEPPGYKCPQcgsP 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 620 TLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDA 699
Cdd:PRK13208 450 GFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDP 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 700 QGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALcAYTTGGRDINL 779
Cdd:PRK13208 530 DGKKMSKSKGNVVTPEELL------------------------------EKY-------GADAVRYWA-ASARLGSDTPF 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 780 DILRVEGYRKFCNKIYQATKFALMrLGDDYQPPATEGLsgneSLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF- 858
Cdd:PRK13208 572 DEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAEVL----EPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFf 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 859 WYLICDVYIENSKY-LIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRstekaaSIVKASYPVYVSE 937
Cdd:PRK13208 647 WHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG------SVHRASWPEPDEE 720
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321531 938 YDDVKSANAYDLVLNITKEARSLLSEYNILKNGKV-FVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVRDASEI 1011
Cdd:PRK13208 721 LIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLkKVEVYGPADLELLEAAEEDLKAAGN-IEELELVEGDPEL 794
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
148-1031 |
2.48e-107 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 357.85 E-value: 2.48e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 148 YNPANVESSWYDWWIKTGVFE---------PEFT-ADGkvkpegvfcipapPPNVTGALHIGHALTIAIQDSLIRYNRMK 217
Cdd:COG0060 16 ANLPKREPEILKFWEENDIYEksrearagrPKFVlHDG-------------PPYANGDIHIGHALNKILKDIIVRYKTMR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 218 GKTVLFLPGFD-HaG--IATQsvVEKQIwAKDRKTRHDYGREAFVGK----VWEWKEEYhsriKNQIQKLGASYDWSREA 290
Cdd:COG0060 83 GFDVPYVPGWDcH-GlpIELK--VEKEL-GIKKKDIEKVGIAEFREKcreyALKYVDEQ----REDFKRLGVWGDWDNPY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 291 FTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLlsvpgYdekVEFGVLTSFAyPVIG 370
Cdd:COG0060 155 LTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSI-----Y---VKFPVKDEKA-LLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 371 SDEKLIIATTRPETIFGDTAVAVHPD----------DDRY---------------------------KHLHGKFIQHPFL 413
Cdd:COG0060 226 EDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 414 -----PRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEEcGPEWQGMKRFDARKKVIE 488
Cdd:COG0060 306 yvvgyDRAHPVILG-DYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEE-APLFAGLFVKDANPAIIE 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 489 QLKEKNLYVGQEdnemTI----PTCSRSGdiiEPLL---KPQWWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGN 561
Cdd:COG0060 384 DLKERGALLARE----KIthsyPHCWRCK---TPLIyraTPQWFISMDKLRDRALEAIE--KVNWIPEWGEGRFGNMLEN 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 562 IQDWCISRQLWWG-------HRCP--------VYF-----INIEGEE-------HDR-IDGDYwvagrsmeeaekkaaaK 613
Cdd:COG0060 455 RPDWCISRQRYWGvpipiwvCEDCgelhrteeVIGsvaelLEEEGADawfeldlHRPfLDETL----------------K 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 614 YPNSKFTLEQDEDVLDTWFSSGLWPFSTLgwpeKTKDmETFYPFSM-LE-----TGWdilfFWVtrMILLGLKLTGSVPF 687
Cdd:COG0060 519 CPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENRE-ELHFPADFyLEgsdqtRGW----FYS--SLLTSTALFGRAPY 587
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 688 KEVFCHSLVRDAQGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFAL 767
Cdd:COG0060 588 KNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI------------------------------DKY-------GADILRLWV 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 768 CAYTTGGrDINL--DILR--VEGYRKfcnkIYQATKFALMRLgDDYQPpATEGLSGNE-SLVEKWILHKLTETSKIVNEA 842
Cdd:COG0060 631 ASSDYWG-DLRFsdEILKevRDVYRR----LRNTYRFLLANL-DDFDP-AEDAVPYEDlPELDRWILSRLNELIKEVTEA 703
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 843 LDKRDFLTSTSSIYEF-------WYLicDV-----YIEnskyliqEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEE 910
Cdd:COG0060 704 YDNYDFHRAYRALHNFcvedlsnWYL--DIskdrlYTE-------AADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEE 774
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 911 MWQRLPKrstEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEY---NILKN--GKVFVESNHEEYFKTA 985
Cdd:COG0060 775 IWQNLPG---EAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEAArkeKLIRQplEAAVVLYADEELAAAL 851
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|.
gi 6321531 986 EDQKD-----SIVSlikaidEVTVVRDASEIPEGCVLQSVNPEVNVHLLVK 1031
Cdd:COG0060 852 ESLGDllaeeLNVS------EVELVDDAEDLGKDALKALDVEGISVTVEVE 896
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
182-718 |
7.35e-59 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 204.96 E-value: 7.35e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 182 VFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKqIWAKDRKTRHdygREAFVGK 261
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAER-KGGRKKKTIW---IEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 262 VWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVnwsvklntaisnlevenkdv 341
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV-------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 342 ksrtllsvpgydekvefgvltsfaypvigsdekliiattrpetifgdtavavhpdddrykhlhgkfiqhpflprkipIIT 421
Cdd:cd00668 137 -----------------------------------------------------------------------------RIT 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 422 DKEAVDMefgtgavkitpahdqndyntgkrhnlefiniltddgllneecgPEWqgmkrfdaRKKVIEQLKEKNlyvgqed 501
Cdd:cd00668 140 EQWFFDM-------------------------------------------PKF--------KEKLLKALRRGK------- 161
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 502 nemtiptcsrsgdiieplLKPQWWvsqsemakdaikvvrdgqititpkssEAEYFHWLGNIQDWCISRQLWWGHRCPvyf 581
Cdd:cd00668 162 ------------------IVPEHV--------------------------KNRMEAWLESLLDWAISRQRYWGTPLP--- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 582 iniegeehdridgdywvagrsmeeaekkaaakypnskftleqdEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLE 661
Cdd:cd00668 195 -------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHL 231
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 6321531 662 TGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00668 232 IGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
160-961 |
1.63e-54 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 206.55 E-value: 1.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 160 WWIKTGVFEPEFT-ADGkvkpeGVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVV 238
Cdd:PLN02843 15 LWEENQVYKRVSDrNNG-----ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 239 EKQIwakDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRAS 318
Cdd:PLN02843 90 LQSL---DQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 319 RLVNWSVKLNTAISNLEVEnkdvksrtllsvpgYDEKvefGVLTSF--AYPVIGSDEK-------------LIIATTRPE 383
Cdd:PLN02843 167 KPVHWSPSSRTALAEAELE--------------YPEG---HVSKSIyvAFPVVSPSETspeeleeflpglsLAIWTTTPW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 384 TIFGDTAVAVHPDDD--------------------------RYKHLHGKFI----------------------------- 408
Cdd:PLN02843 230 TMPANAAVAVNDKLQysvvevqsfsedestsggnkkkrpgnVLKEQQKLFLivatdlvpaleakwgvklvvlktfpgsdl 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 409 -----QHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRF-DA 482
Cdd:PLN02843 310 egcryIHPLYNRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLgEG 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 483 RKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGdiiepllKP-------QWWVSQSEMAKDAIKVVRdgQITITPKSSEAEY 555
Cdd:PLN02843 389 NAAVVEALDEAGSLLMEEAYGHKYPYDWRTK-------KPtifrateQWFASVEGFRQAALDAID--KVKWIPAQGENRI 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 556 FHWLGNIQDWCISRQLWWGHRCPVyFINIEGEE----HDRID----------GDYWvagRSMeEAEKKAAAKYPNSKFTL 621
Cdd:PLN02843 460 RAMVSGRSDWCISRQRTWGVPIPV-FYHVETKEplmnEETIAhvksivaqkgSDAW---WYM-DVEDLLPEKYRDKASDY 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 622 EQDEDVLDTWFSSGlwpfSTLGWPEKTKDmETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQG 701
Cdd:PLN02843 535 EKGTDTMDVWFDSG----SSWAGVLGSRE-GLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 702 RKMSKSLGNVIDPLDVITGIKlddlhakllqgnldprevekakiGQKESypngiPQCGTDAMRF--ALCAYtTGGRDINL 779
Cdd:PLN02843 610 FKMSKSLGNVVDPRLVIEGGK-----------------------NQKQE-----PAYGADVLRLwvASVDY-TGDVLIGP 660
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 780 DILR--VEGYRKFCNKIyqatKFALMRLGdDYQPpaTEGLSgNESL--VEKWILHKLTETSKIVNEALDKRDFLTSTSSI 855
Cdd:PLN02843 661 QILKqmSDIYRKLRGTL----RYLLGNLH-DWKP--DNAVP-YEDLpsIDKYALFQLENVVNEIEESYDNYQFFKIFQIL 732
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 856 YEFWYL-ICDVYIENSK---YlIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLP-KRSTEKAASIVKAS 930
Cdd:PLN02843 733 QRFTIVdLSNFYLDVAKdrlY-VGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPfQEDGSAAESVFEAG 811
|
890 900 910
....*....|....*....|....*....|...
gi 6321531 931 YPVYVSEYDDVKSANA--YDLVLNITKEARSLL 961
Cdd:PLN02843 812 WPTPNEEWLSFPAEDVdfWSLLLEVRDEVNKVL 844
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
779-915 |
8.56e-54 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 183.91 E-value: 8.56e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 779 LDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGlsgNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF 858
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE---SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 6321531 859 -WYLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:cd07962 78 fWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
148-935 |
2.43e-44 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 173.78 E-value: 2.43e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 148 YNPANVESSWYDWWIKTGVFEpeFTADGKVKPEGVFCI-PAPppnvTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPG 226
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMfPYP----SGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 227 FDHAGI-ATQSVVEKQIWAKDrktrhdygreafvgkvweWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:TIGR00396 75 WDAFGLpAENAAIKRGIHPAK------------------WTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIF 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFA-------------------- 365
Cdd:TIGR00396 137 LELFEKGLAYVKEADVNWCPNDGTVLANEQVDSDGRSWRGDTPVEKKELKQWFLKITAYAeellndleeldhwpesvkem 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 366 --------------YPVIGSDEKLIIATTRPETIFGDTAVAVHPDDDRYKHLH------GKFIQ---------------- 409
Cdd:TIGR00396 217 qrnwigksegveitFKIADHDEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAennpkvAAFIKkilnktvaertkatke 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 410 -----------HPFLPRKIPIITDKEAVdMEFGTGAVKITPAHDQNDYNTGKRHNLEFIN-ILTDDGLLNEECGP----- 472
Cdd:TIGR00396 297 kkgvdtgikaiHPLTGEKIPIWVANYVL-MEYGTGAVMGVPAHDERDFEFAQKYGLPIKPvIDPAEKDLSLTAAYtedgv 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 473 -----EWQGMKRFDARKKVIEQLKEKNLyvgqednemtiptcsrsgdiiepllkpqwwvsqsemakdaikvvrdGQITIT 547
Cdd:TIGR00396 376 lvnsgEFNGLNSSEARNAIIDMLEKEGK----------------------------------------------GKRKVN 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 548 PKsseaeyfhwlgnIQDWCISRQLWWGHRCPVYFIN-------------IEGEEHDRIDGDywvAGRSMEEAEKKAAAKY 614
Cdd:TIGR00396 410 YR------------LRDWGFSRQRYWGEPIPIIHCEdggvvpvpeedlpVILPEDVVYDGD---GGSPLSRIPEWVNVTC 474
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 615 PNSKFTLEQDEDVLDTWFSSGlWPFSTLGWPEKTKDM------ETFYPFSMLETGWD-----ILF--FWVTRMILLGLkL 681
Cdd:TIGR00396 475 PSCGKPALRETDTMDTFAGSS-WYYLRYLDPKNTDGPfdkekaEYWLPVDLYIGGIEhailhLLYarFFHKFLRDIGY-V 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 682 TGSVPFKEVFCHSLV-----------------------RDAQGR--------KMSKSLGNVIDPLDVItgiklddlhakl 730
Cdd:TIGR00396 553 NTKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIV------------ 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 731 lqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVEGYRKFCNKIYqatkfalmRLGDDYQ 810
Cdd:TIGR00396 621 ------------------ESY-------GADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVW--------NLVYEIT 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 811 PPATEGLSGNESL--VEKWILHKLTETSKIVNEALDKR-DFLTSTSSIYEFwylICDVYIENSKYLIQEGsaiekksakd 887
Cdd:TIGR00396 668 GELDAASLTVTALeeAQKELRRDVHKFLKKVTEDLEKReSFNTAISAMMEL---LNKLYKAKKEALMLEY---------- 734
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 6321531 888 tlyilLDNALKLIHPFMPFISEEMWQRL-PKRSTEKAASIVKASYPVYV 935
Cdd:TIGR00396 735 -----LKGFVTVLSPFAPHLAEELWEKLgSEPFIIDNAKWPVVDETALV 778
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
146-934 |
3.36e-39 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 157.52 E-value: 3.36e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEPEfTADGKVKpegVFCI---PAPppnvTGALHIGHALTIAIQDSLIRYNRMKGKTVL 222
Cdd:COG0495 3 ERYNPKEIEKKWQKYWEENGTFKAD-EDSSKPK---YYVLdmfPYP----SGRLHMGHVRNYTIGDVVARYKRMQGYNVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 223 FlP-GFD-------HAGIATQSvvekqiwakdrktrHDYgreafvgkvwEWKEEYHSRIKNQIQKLGASYDWSREAFTLS 294
Cdd:COG0495 75 H-PmGWDafglpaeNAAIKNGV--------------HPA----------EWTYENIANMRRQLKRLGLSYDWSREIATCD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 295 PELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENK-------DVKSR---------T-----LLS----V 349
Cdd:COG0495 130 PEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVIDGrcwrcgaPVEKKelpqwflkiTdyadeLLDdldkL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 350 PGYDEKV----------EFGVltSFAYPVIGSDEKLIIATTRPETIFGDTAVAV---HP--------------------- 395
Cdd:COG0495 210 DGWPEKVktmqrnwigrSEGA--EVDFPVEGSDEKITVFTTRPDTLFGATFMVLapeHPlvkelatpeqnaavaafieea 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 396 ---------DDDRYKH--LHGKFIQHPFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL--- 460
Cdd:COG0495 288 kkkseiertSETKEKTgvFTGLYAINPLTGEKIPIwIAD--YVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIape 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 461 ------------TDDG-LLNEEcgpEWQGMKRFDARKKVIEQLKEKNLyvgqednemtiptcsrsgdiiepllkpqwwvs 527
Cdd:COG0495 366 dgddpdileeayTGDGvLINSG---EFDGLDSEEAKEAIIEWLEEKGL-------------------------------- 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 528 qsemakdaikvvrdGQITITPKsseaeyfhwlgnIQDWCISRQLWWGhrCPVYFINIE--GE-------------EHDRI 592
Cdd:COG0495 411 --------------GKRKVNYR------------LRDWLISRQRYWG--EPIPIIHCEdcGVvpvpedqlpvelpEDVDF 462
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 593 DGDywvaGRSmeeaekkaaakyPnskftLEQDE------------------DVLDTWF-SSglW-------------PFS 640
Cdd:COG0495 463 DPT----GGS------------P-----LARAPewvnvtcpkcggparretDTMDTFVdSS--WyylrytdphndeaPFD 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 641 tlgwPEKTKDmetfypfsmletgW---D---------IL------FFwvTR-MILLGLkLTGSVPFKEVFCHSLVRD--- 698
Cdd:COG0495 520 ----PEAANY-------------WlpvDqyiggiehaILhllyarFF--TKvLRDLGL-VSFDEPFKRLLTQGMVLEvgk 579
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 699 -----AQGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMR-FALCA--- 769
Cdd:COG0495 580 dgvviGGIEKMSKSKGNVVDPDEII------------------------------EKY-------GADTLRlFEMFAgpp 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 770 -----YTTGGrdinldilrVEGYRKFCNKIYqatkfalmRLGDDYQ---PPATEGLSGNESLVEKwILHKlteTSKIVNE 841
Cdd:COG0495 623 erdleWSDSG---------VEGAYRFLNRVW--------RLVVDEAealKLDVADLSEADKELRR-ALHK---TIKKVTE 681
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 842 ALDKRDFLTSTSSIYEFwylicdVyieNSKYLIQEGSAIEKKSAKDTLYILldnaLKLIHPFMPFISEEMWQRLpkrstE 921
Cdd:COG0495 682 DIERLRFNTAIAALMEL------V---NALYKAKDSGEADRAVLREALETL----VLLLAPFAPHIAEELWERL-----G 743
|
970
....*....|...
gi 6321531 922 KAASIVKASYPVY 934
Cdd:COG0495 744 HEGSVADAPWPEA 756
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
146-934 |
2.07e-38 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 156.04 E-value: 2.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 146 KAYNPANVESSWYDWWIKTGVFEPEFTADgKVKPEGVFCipAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PLN02882 6 KDFSFPKQEEKILSLWSEIDAFKTQLKRT-EGLPEYIFY--DGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 226 GFDHAGIATQSVVEKQIWAKDRKTRHDYG----REAFVGKVWEWKEEYHSRIKnqiqKLGASYDWSREAFTLSPELTKSV 301
Cdd:PLN02882 83 GWDCHGLPVEYEIDKKLGIKRRDDVLKMGidkyNEECRSIVTRYSKEWEKTVT----RTGRWIDFENDYKTMDPKFMESV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 302 EEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEV--ENKDVKSrtllsvpgydekveFGVLTSFayPVIGSDEK--LII 377
Cdd:PLN02882 159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSD--------------PAVMVSF--PIVGDPDNasFVA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 378 ATTRPETIFGDTAVAVHPDDDrYKHLHGKFIQHPFL---PR--KIPIITDK-----------------------EAVD-- 427
Cdd:PLN02882 223 WTTTPWTLPSNLALCVNPNFT-YVKVRNKYTGKVYIvaeSRlsALPTAKPKskkgskpenaaegyevlakvpgsSLVGkk 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 428 --------MEF-----------------GTGAVKITPAHDQNDYNTGKRHNL-----EFINILTDDGLLNEECgPEWQGM 477
Cdd:PLN02882 302 yeplfdyfSEFsdtafrvvaddyvtddsGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKV-TDFSGR 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 478 KRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGdiiEPLLK---PQWWVSQSEMaKDAIkVVRDGQITITPKSSEAE 554
Cdd:PLN02882 381 YVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSD---TPLIYravPSWFVKVEEI-KDRL-LENNKQTYWVPDYVKEK 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 555 YFH-WLGNIQDWCISRQLWWGHRCPVYfINIEGEEHDRIDGDYWVAGRSMEEAE-----KKAAAKYPNSK---FT-LEQD 624
Cdd:PLN02882 456 RFHnWLENARDWAVSRSRFWGTPLPIW-ISDDGEEVVVIGSIAELEKLSGVKVTdlhrhFIDHITIPSSRgpeFGvLRRV 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 625 EDVLDTWFSSGLWPFSTLGWPEKTKDM-ETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRK 703
Cdd:PLN02882 535 DDVFDCWFESGSMPYAYIHYPFENKELfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKK 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 704 MSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGTDAMRFALcayttggrdINLDILR 783
Cdd:PLN02882 615 MSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL---------INSPVVR 648
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 784 VEGYRkFCNK------------IYQATKFALM---RL----GDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALD 844
Cdd:PLN02882 649 AEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQnakRLevegGAPFVPLDLAKLQNSANVLDRWINSATQSLVKFVREEMG 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 845 KRDFLTSTSSIYEFWYLICDVYIE-NSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKA 923
Cdd:PLN02882 728 AYRLYTVVPYLVKFIDNLTNIYVRfNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGSE 807
|
890
....*....|.
gi 6321531 924 ASIVKASYPVY 934
Cdd:PLN02882 808 ESIHYCSFPQV 818
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
196-999 |
4.33e-37 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 151.17 E-value: 4.33e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 196 LHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFdHA------GIAtqsvveKQIWAKDRKTRHDYGREAFVGKVWEWK--- 266
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAF-HVtgtpilGIA------ERIARGDPETIELYKSLYGIPEEELEKfkd 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 267 -----EEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAisnleVENKDV 341
Cdd:PRK12300 74 peyivEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP-----VGDHDL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 342 KsrtllsvpgYDEKVEFG--VLTSFaypvIGSDEKLII-ATTRPETIFGDTAVAVHPD--------DDRY---------- 400
Cdd:PRK12300 149 L---------DGEEPEIVeyTLIKF----EESEDLILPaATLRPETIFGVTNLWVNPDatyvkaevDGEKwivskeaaek 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 401 ----------------KHLHGKFIQHPFLPRKIPIItdkEA--VDMEFGTGAVKITPAHDQNDY--------NTGKRHNL 454
Cdd:PRK12300 216 lsfqdrdveiieeikgSELIGKKVKNPVTGKEVPIL---PAdfVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 455 EFINILT---------------------DD-----------------GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLY 496
Cdd:PRK12300 293 EPIPLIEvegygefpakevveklgiksqEDpeleeatkevyraefhkGVLKENTG-EYAGKPVREAREKITKDLIEKGIA 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 497 -VGQEdnEMTIPTCSRSG-DIIEPLLKPQWWVSQS-----EMAKDAIKvvrdgQITITPKSSEAEYFHWLGNIQDWCISR 569
Cdd:PRK12300 372 dIMYE--FSNRPVYCRCGtECVVKVVKDQWFIDYSdpewkELAHKALD-----NMEIIPEEYRKEFENTIDWLKDRACAR 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 570 QLWWGHRCP-----------------VYFINIEGEEHDRIDG--------DYWVAGrsmeeaekkaaakypnsKFTLEQD 624
Cdd:PRK12300 445 RRGLGTRLPwdeewiieslsdstiymAYYTIAHKIREYGIKPeqltpeffDYVFLG-----------------KGDPEEV 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 625 EDVldtwfssglwpfstLGWPEKT-----KDMETFYPFSMLETGWD-----ILFF------------WVTRMILLGLKLT 682
Cdd:PRK12300 508 SKK--------------TGIPKEIleemrEEFLYWYPVDWRHSGKDlipnhLTFFifnhvaifpeekWPRGIVVNGFVLL 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 683 GsvpfkevfchslvrdaqGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDA 762
Cdd:PRK12300 574 E-----------------GKKMSKSKGNVIPLRKAI------------------------------EEY-------GADV 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 763 MRFALCAYTTGGRDINLDILRVEGYRKFCNKIYQatkfaLMRLGDDYqppateGLSGNESLVEKWILHKLTETSKIVNEA 842
Cdd:PRK12300 600 VRLYLTSSAELLQDADWREKEVESVRRQLERFYE-----LAKELIEI------GGEEELRFIDKWLLSRLNRIIKETTEA 668
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 843 LDK---RDFLtsTSSIYEF-----WYLicdvyienskyliqegsAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQR 914
Cdd:PRK12300 669 MESfqtRDAV--QEAFYELlndlrWYL-----------------RRVGEANNKVLREVLEIWIRLLAPFTPHLAEELWHK 729
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 915 LpkrstEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNIlKNGKVFVESNHEEYFKTAEDQKDSIV- 993
Cdd:PRK12300 730 L-----GGEGFVSLEKWPEPDESKIDEEAELAEEYVKRLIEDIREILKVAKI-KPKKVYIYVAPDWKYEVLEIAAENGDv 803
|
....*..
gi 6321531 994 -SLIKAI 999
Cdd:PRK12300 804 kEAIKEL 810
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
189-718 |
1.89e-33 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 132.36 E-value: 1.89e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 189 PPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE 268
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 269 YHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWsvklntaisnlevenkdvksrtlls 348
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 349 vpgydekvefgvltsfayPVIgsdeklIIATtrpetifgdtavavhpdddrykhlhgkfiqhpflprkipiitdkeavdm 428
Cdd:cd00818 144 ------------------PLI------YRAT------------------------------------------------- 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 429 efgtgavkitpahdqndyntgkrhnlefiniltddgllneecgpewqgmkrfdarkkvieqlkeknlyvgqednemtipt 508
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 509 csrsgdiiepllkPQWWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEE 588
Cdd:cd00818 151 -------------PQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEV 215
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 589 HDRidgdywvagrsmeeaekkaaakypnskftleQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILF 668
Cdd:cd00818 216 LVR-------------------------------RVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTR 264
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 6321531 669 FWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00818 265 GWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
189-915 |
9.61e-33 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 138.18 E-value: 9.61e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 189 PPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE 268
Cdd:PTZ00427 110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLK 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 269 YHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVE--NKD------ 340
Cdd:PTZ00427 190 YSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDtpdpsi 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 341 VKSRTLLS----------------------VPGYDEKVEFG------------------------------------VLT 362
Cdd:PTZ00427 270 IISFVLCSdfpkveeecnieedkqllgekySVLYNNKRENSnngnnnstnnvcyaqhseilawtttpwtlpsnlalcVNE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 363 SFAYPVI---GSDEKLIIATTRPETIFGDTAVAV------------HPDDDRYKHLHGKFIQ-HPFLPRKIPIITDKEAV 426
Cdd:PTZ00427 350 HFTYLRIhhvKSNRVVIVGECRLEWIMKELKWNVedlkivnrfkgkELKGLRYKPLFTNFYEkYNFKERAYKILADDFVT 429
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 427 DmEFGTGAVKITPAHDQNDYNTGKRHNLE------FINILTDDGLLNEECgPEWQGMKRFDARKKVIEQLKEKNLYVGQE 500
Cdd:PTZ00427 430 D-DAGTGIVHCAPTYGEDDFRVCKKNGVIdpekniFIDPLDANGYFTNEV-EEVQNLYIKEADNVIKKKLKNENRLLSNN 507
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 501 DNEMTIPTCSRSGdiiEPLLK---PQWWVSQSEMAKdaiKVVRDGQIT--ITPKSSEAEYFHWLGNIQDWCISRQLWWGH 575
Cdd:PTZ00427 508 TIVHSYPFCWRSD---TPLIYraiPAWFIRVSNSTN---ELVKNNETTywIPAHIKEKKFHNWIKDAKDWCISRNRYWGT 581
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 576 RCPVY-------FINIEGEEH-DRIDG-----DYWVAGRSMEEAEKKAAAKYPNskftLEQDEDVLDTWFSSGLWPFSTL 642
Cdd:PTZ00427 582 PIPIWadekmetVICVESIKHlEELSGvkninDLHRHFIDHIEIKNPKGKTYPK----LKRIPEVFDCWFESGSMPYAKV 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 643 GWP--EKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITG 720
Cdd:PTZ00427 658 HYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDK 737
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 721 IKLDDLHAKLLqgNLDPREVEKAKIGQKesypnGIPQCgtdAMRFALCAYTTggrdinldilrvegYRKFCNKI--YQAT 798
Cdd:PTZ00427 738 YGADSLRLYLI--NSVAVRAENLKFQEK-----GVNEV---VKSFILPFYHS--------------FRFFSQEVtrYECL 793
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 799 KFALMRLGDDYqppategLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEFWYLICDVYIENSKYLIQeGS 878
Cdd:PTZ00427 794 NKKQFLFNTDY-------IYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMR-GS 865
|
810 820 830
....*....|....*....|....*....|....*....
gi 6321531 879 AIEKKS--AKDTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:PTZ00427 866 LGEENClqSLCTTYRTLHLFTVLMAPFTPFITEYIYQQL 904
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
825-975 |
1.85e-31 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 120.20 E-value: 1.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 825 EKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICDVYIENSKYLIQEGSAIEKksAKDTLYILLDNALKLIHPF 903
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFfWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321531 904 MPFISEEMWQRLpkrstekaaSIVKASYPVyVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGKVFVE 975
Cdd:pfam08264 79 MPFITEELWQKE---------SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
143-587 |
9.82e-28 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 121.47 E-value: 9.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 143 PALKAYNPANVESSWYDWWIKTGVFE-PEFTADGKVKPEGVFCIPAPppnvTGA-LHIGHALTIAIQDSLIRYNRMKGKT 220
Cdd:PLN02563 75 AAKRAYPFHEIEPKWQRYWEENRTFRtPDDVDTSKPKFYVLDMFPYP----SGAgLHVGHPEGYTATDILARYKRMQGYN 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 221 VLFLPGFDHAGI-ATQSVVEKQIWAKDRKTRHDygreafvgkvwewkeeyhSRIKNQIQKLGASYDWSREAFTLSPELTK 299
Cdd:PLN02563 151 VLHPMGWDAFGLpAEQYAIETGTHPKITTLKNI------------------ARFRSQLKSLGFSYDWDREISTTEPEYYK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 300 SVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENkDVKSRT------------LLSVPGYDEK------------ 355
Cdd:PLN02563 213 WTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVD-GLSERGghpvirkpmrqwMLKITAYADRlledlddldwpe 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 356 -----------------VEFGVLtsfAYPVIGSDEKLIIATTRPETIFGDTAVAVHPD---------DDRYKHLH----- 404
Cdd:PLN02563 292 sikemqrnwigrsegaeLDFSVL---DGEGKERDEKITVYTTRPDTLFGATYLVVAPEhpllsslttAEQKEAVEeyvda 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 405 ---------------------GKFIQHPFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL-- 460
Cdd:PLN02563 369 asrksdlertelqkektgvftGSYAINPATGEAIPIwVAD--YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVkp 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 461 ------------TDDG-LLNEEC-GPEWQGMKRFDARKKVIEQLKEKNlyvgqednemtiptcsrsgdiiepllkpqwwv 526
Cdd:PLN02563 447 adgneddaekayTGEGvIVNSSSsGLDINGLSSKEAAKKVIEWLEETG-------------------------------- 494
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321531 527 sqsemakdaikvvrDGQITITPKsseaeyfhwlgnIQDWCISRQLWWGHRCPVYFINIEGE 587
Cdd:PLN02563 495 --------------NGKKKVNYK------------LRDWLFARQRYWGEPIPVVFLEDSGE 529
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
185-328 |
1.20e-19 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 91.16 E-value: 1.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 185 IPAPPPNvtGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAG-----IATQSVVEKQIWAKDRKtrhdygreafv 259
Cdd:cd00812 6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGlpaenAAIKIGRDPEDWTEYNI----------- 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531 260 gkvwewkeeyhSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLN 328
Cdd:cd00812 73 -----------KKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCKLLD 130
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
788-958 |
2.22e-17 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 81.06 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 788 RKFCNKIYQATKFAL--MRLgDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF------W 859
Cdd:cd07961 11 RKVLLPLWNAYRFFVtyANL-DGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFideltnW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 860 YlicdvyIE-NSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKAASIVKASYPVYVSEY 938
Cdd:cd07961 90 Y------IRrNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESL 163
|
170 180
....*....|....*....|
gi 6321531 939 DDVKSANAYDLVLNITKEAR 958
Cdd:cd07961 164 IDEELEEAMELVREIVELGR 183
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
780-956 |
1.03e-15 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 76.41 E-value: 1.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 780 DILR--VEGYRKFCNKIyqatKFALMRLgDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE 857
Cdd:cd07960 4 EILKqvAEAYRKIRNTF----RFLLGNL-NDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 858 F-------WYLicDV-----YIE--NSKyliqegsaiEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKa 923
Cdd:cd07960 79 FctvdlsaFYL--DIikdrlYCDakDSL---------ERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEE- 146
|
170 180 190
....*....|....*....|....*....|...
gi 6321531 924 aSIVKASYPVYVSEYDDVKSANAYDLVLNITKE 956
Cdd:cd07960 147 -SVFLEDWPELPEEWKDEELEEKWEKLLALRDE 178
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
364-490 |
4.74e-15 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 74.51 E-value: 4.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 364 FAYPVIGSDEKLIIATTRPETIFGDTAVAVHPDDD------RYKHLHGKFIQ---------------------------H 410
Cdd:pfam13603 12 ITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPlveklaEKNPEVAAFIEeckntseiertsetkekegvftglyaiH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 411 PFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL----------------TDDGLL-NEEcgp 472
Cdd:pfam13603 92 PITGEKIPIwIAN--FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIqpedgdldldimteayTEEGILvNSG--- 166
|
170
....*....|....*...
gi 6321531 473 EWQGMKRFDARKKVIEQL 490
Cdd:pfam13603 167 EFDGLDSEEAKEAIIKKL 184
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
183-915 |
1.40e-12 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 71.68 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 183 FCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFD-HaGIATQSVVEKQiwakdrktrhdyGR--EAFV 259
Cdd:COG0143 3 FLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeH-GTKIELAAEKE------------GItpQELV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 260 gkvwewkEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYRAsrlvnwsvklntaisnleven 338
Cdd:COG0143 70 -------DRIHAEFKELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKG--------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 339 kdvksrtllSVPG-YDEKVEfgvltSFaYPvigsdekliiattrpetifgdtavavhpddDRYkhLHGkfiqhpflprKI 417
Cdd:COG0143 119 ---------EYEGwYCPECE-----RF-LP------------------------------DRY--VEG----------TC 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 418 PIITDKEAvdmefgtgavkitpAHDQNDYNTGKRHNLEFINILTDDgllneeCG--PEWqgmkrfdarkkvieqLKEKNL 495
Cdd:COG0143 142 PKCGAEDA--------------YGDQCENCGATLEPTELINPRSAI------SGapPEL---------------REEEHY 186
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 496 YVgqednemtiptcsRSGDIIEPLLK-----PQWwvsQSEMAKDAIKVVRDGqititpksseaeyfhwlgnIQDWCISRQ 570
Cdd:COG0143 187 FF-------------RLSKYQDRLLEwieenPDI---QPEVRNEVLSWLKEG-------------------LQDLSISRD 231
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 571 LWWGhrcpvyfinIEgeehdridgdywvagrsmeeaekkaaakYPNskftleqDED-VLDTWF-------SsglwpfSTL 642
Cdd:COG0143 232 FDWG---------IP----------------------------VPG-------DPGkVFYVWFdaligyiS------ATK 261
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 643 GWPEKTK---DMETFYPFSMLET----GWDILFF----WVTrmILLGLKLTgsVPfKEVFCHS--LVRdaqGRKMSKSLG 709
Cdd:COG0143 262 GYADDRGlpeDFEKYWPAPDTELvhfiGKDIIRFhaiiWPA--MLMAAGLP--LP-KKVFAHGflTVE---GEKMSKSRG 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 710 NVIDPLDVitgikLDDLHAkllqgnldprevekakigqkesypngipqcgtDAMRFALCAYTTGGRDINLD----ILRVE 785
Cdd:COG0143 334 NVIDPDDL-----LDRYGP--------------------------------DALRYYLLREVPFGQDGDFSwedfVARVN 376
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 786 G----------YR--KFCNKiyqatKFalmrlgdDYQPPAteglSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTS 853
Cdd:COG0143 377 SdlandlgnlaSRtlSMIHK-----YF-------DGKVPE----PGELTEADEELLAEAEAALEEVAEAMEAFEFRKALE 440
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321531 854 SIYEFWYLiCDVYIENSK--YLIQEGsaiEKKSAKDTLYILLdNALK----LIHPFMPFISEEMWQRL 915
Cdd:COG0143 441 EIMALARA-ANKYIDETApwKLAKDE---DPERLATVLYTLL-EALRilaiLLKPFLPETAEKILEQL 503
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
185-318 |
8.86e-11 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 65.00 E-value: 8.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 185 IPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATqsvvekQIWAKDRKTrhdyGREAFVgkvwe 264
Cdd:pfam09334 3 VTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPI------ELKAEKEGI----TPEELV----- 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 6321531 265 wkEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYRAS 318
Cdd:pfam09334 68 --DRYHEIHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKE 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
188-315 |
1.03e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 65.67 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 188 PPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFD-HagiatQSVVEKQiwAKDRktrhdyGREAFvgkvwEWK 266
Cdd:PRK11893 8 PIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRK--AEEA------GISPQ-----ELA 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 6321531 267 EEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:PRK11893 70 DRNSAAFKRLWEALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIY 116
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
185-315 |
1.46e-10 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 63.70 E-value: 1.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 185 IPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQiwakdrktrhdyGREafvgkVWE 264
Cdd:cd00814 4 ITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE------------GVT-----PQE 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 6321531 265 WKEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:cd00814 67 LCDKYHEIFKDLFKWLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
192-315 |
3.99e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 60.58 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 192 VTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGiatQSVVEKqiwAKDR-KTRHdygreafvgkvwEWKEEYH 270
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQA---AEKAgKTPQ------------EYVDEIS 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 6321531 271 SRIKNQIQKLGASYDwsreAF--TLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:PRK12267 77 AGFKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIY 119
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
813-915 |
6.96e-09 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 54.90 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 813 ATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSI-YEF-----WYLicdvyienskyliqegSAIEKKSAK 886
Cdd:cd07959 25 ETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGlYELqndldWYR----------------ERGGAGMNK 88
|
90 100
....*....|....*....|....*....
gi 6321531 887 DTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:cd07959 89 DLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
784-915 |
2.04e-08 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 53.38 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 784 VEGYRKFCNKIYqatkfalmRLGDDYQP-PATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEFwyli 862
Cdd:cd07958 6 VEGAYRFLNRVW--------RLVTELAEaLAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMEL---- 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 6321531 863 cdVyieNSKYLIQEGSAIEKKSAKDTLYILLdnalKLIHPFMPFISEEMWQRL 915
Cdd:cd07958 74 --V---NALYKYKKKDAQHAAVLREALETLV----LLLAPFAPHIAEELWEEL 117
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
640-718 |
5.27e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 53.65 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 640 STLGWPEKTKDM-ETFYPFSMLETGWDILFF----WVTRMILLGLKLtgsvpFKEVFCHS-LVRDaqGRKMSKSLGNVID 713
Cdd:PRK12267 237 TALGYGSDDDELfKKFWPADVHLVGKDILRFhaiyWPIMLMALGLPL-----PKKVFAHGwWLMK--DGKMSKSKGNVVD 309
|
....*
gi 6321531 714 PLDVI 718
Cdd:PRK12267 310 PEELV 314
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
783-904 |
8.51e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 49.04 E-value: 8.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 783 RVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGneslVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYL 861
Cdd:cd07375 3 RLKQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEE----ADRELLARLQEFIKRTTNALEALDPTTAVQELFKFtNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6321531 862 icDVYIENSKYLIQEGSAIEKKSAkdTLYILLDNALKLIHPFM 904
Cdd:cd07375 79 --NWYLDELKPALQTEELREAVLA--VLRAALVVLTKLLAPFT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
663-718 |
1.40e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 52.19 E-value: 1.40e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321531 663 GWDILFF----WVTRMILLGLKLtgsvpFKEVFCHS-LVRDaqGRKMSKSLGNVIDPLDVI 718
Cdd:PRK11893 261 GKDILRFhavyWPAFLMAAGLPL-----PKRVFAHGfLTLD--GEKMSKSLGNVIDPFDLV 314
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
190-316 |
4.76e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 47.45 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 190 PNVTGALHIGHALTiAIQ-DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQiwakdrktrhdyGR--EAFVgkvwewk 266
Cdd:PRK00133 11 PYANGPIHLGHLVE-YIQaDIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE------------GItpEELI------- 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 6321531 267 EEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYR 316
Cdd:PRK00133 71 ARYHAEHKRDFAGFGISFDnYGS---THSEENRELAQEIYLKLKENGYIYE 118
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
160-240 |
1.90e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 45.83 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 160 WWIKTGVFEPEFTADGKvKPEGVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVE 239
Cdd:PLN02959 25 WWEEEKVFEAEAGDEPP-KPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGMPIKASAD 103
|
.
gi 6321531 240 K 240
Cdd:PLN02959 104 K 104
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
819-915 |
1.99e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 42.48 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 819 GNESLVEKWILHKLTETSKIVNEALDKRDFltsTSSIYEFWYLI--CDVYIENSKY--LIQEGsaiEKKSAKDTLYILLd 894
Cdd:cd07957 32 GGLTEEDEELLEEAEELLEEVAEAMEELEF---RKALEEIMELAraANKYIDETAPwkLAKEE---DPERLATVLYVLL- 104
|
90 100
....*....|....*....|....*
gi 6321531 895 NALK----LIHPFMPFISEEMWQRL 915
Cdd:cd07957 105 ELLRilaiLLSPFMPETAEKILDQL 129
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
622-741 |
2.75e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 45.09 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 622 EQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETF----YPFSMLETGWDILFF----WVTRMILLGLKLTgsvpfKEVFCH 693
Cdd:PLN02224 283 DDDKQTIYVWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELP-----KMVFGH 357
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 6321531 694 S-LVRDaqGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLqgnldpREVE 741
Cdd:PLN02224 358 GfLTKD--GMKMGKSLGNTLEPFELVQKFGPDAVRYFFL------REVE 398
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
183-317 |
3.62e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 41.24 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 183 FCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAG--IATQSVVEkqiwakdrktrhdyGREAfvg 260
Cdd:PLN02224 71 FVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAAN--------------GRNP--- 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531 261 kvwewkEEYHSRIKNQIQKLGASYDWSREAF--TLSPELTKSVEEAFVRLHDEGVIYRA 317
Cdd:PLN02224 134 ------PEHCDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRA 186
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
188-265 |
4.76e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 38.61 E-value: 4.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 188 PPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGiatqsvvEKQIWAKDRKTR-HDYGREAFVGKV---W 263
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG-------GLIGDPANKKGEnAKAFVERWIERIkedV 76
|
..
gi 6321531 264 EW 265
Cdd:cd00802 77 EY 78
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
663-718 |
9.84e-03 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 39.44 E-value: 9.84e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531 663 GWDILFF----WVTrmILLGLKLTgsvPFKEVFCHSLVRdAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00814 242 GKDIIRFhaiyWPA--MLLGAGLP---LPTRIVAHGYLT-VEGKKMSKSRGNVVDPDDLL 295
|
|
| |
