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Conserved domains on  [gi|6319277|ref|NP_009360|]
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cyclin CLN3 [Saccharomyces cerevisiae S288C]

Protein Classification

cyclin family protein( domain architecture ID 11472088)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae S288C G1/S-specific cyclins and G2/mitotic-specific cyclins

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-576 2.17e-78

Cyclin [Cell division and chromosome partitioning];


:

Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 254.31  E-value: 2.17e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   35 CPNLPLLLQKRRAIASAKSKNPNLVKRELQAHHSAISEYNNDQLDHYfRLSHTERPLYNLTNFNSQPQvnpkmrflifdf 114
Cdd:COG5024   3 ESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFL-NQLSTVTRLSNGINFHSSKS------------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  115 imychtrlnlsTSTLFLTFTILDKYSSRFIIKSynyqllsltalwiSSKFWDSKNRMATlkvlqnlcCNQYSIKQFTTme 194
Cdd:COG5024  70 -----------TKLVVGTCLWLAKKTWGIISSG-------------ESNERARIPRLSE--------CNLDSILFIQM-- 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  195 mhlfKSLDWSICQSAtfdSYIDIFLFQSTSPLSPGVVLSAPLEafiQQKLALLNNAAGTAINKssSSQGPSLNINEIklg 274
Cdd:COG5024 116 ----TLNEDSYEPMI---DYILKKDENSLSPYELDENQLALDE---KQAESKRESQSWQDLDA--TDQEDPLMVPEY--- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  275 aimlcelASFNLELSFKYDRSLIALGAInLIKLSLNYYnsNLWENINLALEEncqdLDIKLSEISNTLLDIAMdqnsfps 354
Cdd:COG5024 181 -------ASDIFEYLLKLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVE----VHGKFGLLPETLFLAIN------- 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  355 sFKSKYLNSNKTSLAKSLLDALQNYCIQLKLEEFYRSQelETMYNTIFAQSFDSDSLTCVYSNATTPKSATVSSAATDYF 434
Cdd:COG5024 240 -IIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPS--IKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF 316

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  435 sdhthLRRLTKDSISPPFAFTPTSSSSSPSPFNSPYKTsSSMTTPDsaSHHSHSGSFSSTQNSFKRSLSIPQNSsifWPS 514
Cdd:COG5024 317 -----LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQ-ISPSWCA--AAAMYLSRKILSQNQWDRTLIHYSGN---YTN 385

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319277  515 PltPTTPSLMSNRKLLQNLSVRSKRLFPVRPMATAHPCSAPTQLKKRSTssvdcDFNDSSNL 576
Cdd:COG5024 386 P--DLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKASSPTGEWIRSN-----SSNDSSLL 440
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-576 2.17e-78

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 254.31  E-value: 2.17e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   35 CPNLPLLLQKRRAIASAKSKNPNLVKRELQAHHSAISEYNNDQLDHYfRLSHTERPLYNLTNFNSQPQvnpkmrflifdf 114
Cdd:COG5024   3 ESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFL-NQLSTVTRLSNGINFHSSKS------------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  115 imychtrlnlsTSTLFLTFTILDKYSSRFIIKSynyqllsltalwiSSKFWDSKNRMATlkvlqnlcCNQYSIKQFTTme 194
Cdd:COG5024  70 -----------TKLVVGTCLWLAKKTWGIISSG-------------ESNERARIPRLSE--------CNLDSILFIQM-- 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  195 mhlfKSLDWSICQSAtfdSYIDIFLFQSTSPLSPGVVLSAPLEafiQQKLALLNNAAGTAINKssSSQGPSLNINEIklg 274
Cdd:COG5024 116 ----TLNEDSYEPMI---DYILKKDENSLSPYELDENQLALDE---KQAESKRESQSWQDLDA--TDQEDPLMVPEY--- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  275 aimlcelASFNLELSFKYDRSLIALGAInLIKLSLNYYnsNLWENINLALEEncqdLDIKLSEISNTLLDIAMdqnsfps 354
Cdd:COG5024 181 -------ASDIFEYLLKLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVE----VHGKFGLLPETLFLAIN------- 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  355 sFKSKYLNSNKTSLAKSLLDALQNYCIQLKLEEFYRSQelETMYNTIFAQSFDSDSLTCVYSNATTPKSATVSSAATDYF 434
Cdd:COG5024 240 -IIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPS--IKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF 316

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  435 sdhthLRRLTKDSISPPFAFTPTSSSSSPSPFNSPYKTsSSMTTPDsaSHHSHSGSFSSTQNSFKRSLSIPQNSsifWPS 514
Cdd:COG5024 317 -----LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQ-ISPSWCA--AAAMYLSRKILSQNQWDRTLIHYSGN---YTN 385

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319277  515 PltPTTPSLMSNRKLLQNLSVRSKRLFPVRPMATAHPCSAPTQLKKRSTssvdcDFNDSSNL 576
Cdd:COG5024 386 P--DLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKASSPTGEWIRSN-----SSNDSSLL 440
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 110-204 9.40e-44

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 151.00  E-value: 9.40e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  110 LIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSKNRMATLKVLQNLCCNQYSIKQ 189
Cdd:cd20559   1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEEL 80

                        90
                ....*....|....*
gi 6319277  190 FTTMEMHLFKSLDWS 204
Cdd:cd20559  81 FIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 76-206 2.52e-23

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 95.28  E-value: 2.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277     76 DQLDHYFRLSHTERPLYNLtnFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSL 155
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDY--MDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6319277    156 TALWISSKFwdsKNRMA-TLKVLQNLCCNQYSIKQFTTMEMHLFKSLDWSIC 206
Cdd:pfam00134  79 TCLFIAAKY---EEIYPpTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 113-199 3.06e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 56.83  E-value: 3.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277     113 DFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWdskNRMATLKVLQNLCCNqYSIKQFTT 192
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE---ETPPWTKELVHYTGY-FTEEEILR 76


                   ....*..
gi 6319277     193 MEMHLFK 199
Cdd:smart00385  77 MERLLLE 83
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
35-576 2.17e-78

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 254.31  E-value: 2.17e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   35 CPNLPLLLQKRRAIASAKSKNPNLVKRELQAHHSAISEYNNDQLDHYfRLSHTERPLYNLTNFNSQPQvnpkmrflifdf 114
Cdd:COG5024   3 ESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFL-NQLSTVTRLSNGINFHSSKS------------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  115 imychtrlnlsTSTLFLTFTILDKYSSRFIIKSynyqllsltalwiSSKFWDSKNRMATlkvlqnlcCNQYSIKQFTTme 194
Cdd:COG5024  70 -----------TKLVVGTCLWLAKKTWGIISSG-------------ESNERARIPRLSE--------CNLDSILFIQM-- 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  195 mhlfKSLDWSICQSAtfdSYIDIFLFQSTSPLSPGVVLSAPLEafiQQKLALLNNAAGTAINKssSSQGPSLNINEIklg 274
Cdd:COG5024 116 ----TLNEDSYEPMI---DYILKKDENSLSPYELDENQLALDE---KQAESKRESQSWQDLDA--TDQEDPLMVPEY--- 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  275 aimlcelASFNLELSFKYDRSLIALGAInLIKLSLNYYnsNLWENINLALEEncqdLDIKLSEISNTLLDIAMdqnsfps 354
Cdd:COG5024 181 -------ASDIFEYLLKLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVE----VHGKFGLLPETLFLAIN------- 239

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  355 sFKSKYLNSNKTSLAKSLLDALQNYCIQLKLEEFYRSQelETMYNTIFAQSFDSDSLTCVYSNATTPKSATVSSAATDYF 434
Cdd:COG5024 240 -IIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPS--IKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF 316

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  435 sdhthLRRLTKDSISPPFAFTPTSSSSSPSPFNSPYKTsSSMTTPDsaSHHSHSGSFSSTQNSFKRSLSIPQNSsifWPS 514
Cdd:COG5024 317 -----LRRISKASDYDIFSRTPAKFSSEISPVDYKFIQ-ISPSWCA--AAAMYLSRKILSQNQWDRTLIHYSGN---YTN 385

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319277  515 PltPTTPSLMSNRKLLQNLSVRSKRLFPVRPMATAHPCSAPTQLKKRSTssvdcDFNDSSNL 576
Cdd:COG5024 386 P--DLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKASSPTGEWIRSN-----SSNDSSLL 440
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 110-204 9.40e-44

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 151.00  E-value: 9.40e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  110 LIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSKNRMATLKVLQNLCCNQYSIKQ 189
Cdd:cd20559   1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEEL 80

                        90
                ....*....|....*
gi 6319277  190 FTTMEMHLFKSLDWS 204
Cdd:cd20559  81 FIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 76-206 2.52e-23

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 95.28  E-value: 2.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277     76 DQLDHYFRLSHTERPLYNLtnFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSL 155
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDY--MDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6319277    156 TALWISSKFwdsKNRMA-TLKVLQNLCCNQYSIKQFTTMEMHLFKSLDWSIC 206
Cdd:pfam00134  79 TCLFIAAKY---EEIYPpTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 70-202 8.45e-16

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 74.10  E-value: 8.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   70 ISEYNNDQLDHYFRLSHTERPLYNltNFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYN 149
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPD--YLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKK 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6319277  150 YQLLSLTALWISSKFWDSknRMATLKVLQNLCCNQYSIKQFTTMEMHLFKSLD 202
Cdd:cd20507  79 LQLVGVTALLIASKYEEI--YPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 69-203 5.65e-12

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 63.52  E-value: 5.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   69 AISEYNNDQLDHYFRLSHTER-PLYNLTNfnsQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKS 147
Cdd:cd20567  17 AAVEYVEDIYSFYRKVEPESCvPPYYMSQ---QPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPR 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319277  148 YNYQLLSLTALWISSKF---WdsknrmatLKVLQNLCC---NQYSIKQFTTMEMHLFKSLDW 203
Cdd:cd20567  94 KELQLVGVTAMLIASKYeeiW--------APEVNDFVYisdNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 107-201 3.42e-11

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 59.65  E-value: 3.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  107 MRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFwdSKNRMATLKVLQNLCCNQYS 186
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQ--EEIYPPEVKDLLALCCGAYT 78

                        90
                ....*....|....*
gi 6319277  187 IKQFTTMEMHLFKSL 201
Cdd:cd20536  79 REQICNLECIILTKL 93
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 70-164 7.48e-11

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 60.00  E-value: 7.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   70 ISEYNNDQLDHYFRLSHTERPLYNltNFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYN 149
Cdd:cd20568   5 VAEYVPEIFEYLRELELKTLPNPN--YMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK 82

                        90
                ....*....|....*
gi 6319277  150 YQLLSLTALWISSKF 164
Cdd:cd20568  83 LQLVGISALFIASKY 97
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 113-199 3.06e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 56.83  E-value: 3.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277     113 DFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWdskNRMATLKVLQNLCCNqYSIKQFTT 192
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE---ETPPWTKELVHYTGY-FTEEEILR 76


                   ....*..
gi 6319277     193 MEMHLFK 199
Cdd:smart00385  77 MERLLLE 83
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 108-203 8.29e-10

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 56.07  E-value: 8.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  108 RFLIfDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSKNRMATLKVLQN-LCCNQYS 186
Cdd:cd20528   8 RYLV-DWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRyLCNSVYS 86

                        90
                ....*....|....*..
gi 6319277  187 IKQFTTMEMHLFKSLDW 203
Cdd:cd20528  87 KQEYLQMELLILEFFQW 103
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 70-202 7.65e-09

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 54.57  E-value: 7.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   70 ISEYNNDQLDhYFRlshtERPL-YNLTNF-NSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKS 147
Cdd:cd20508  13 VSEYAKDIFD-YMK----EREEkFVVPDYlEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKK 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6319277  148 YNYQLLSLTALWISSKFWDsknRMA-TLKVLQNLCCNQYSIKQFTTMEMHLFKSLD 202
Cdd:cd20508  88 EKLQLLGATAILIASKFDE---RCPpCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 108-205 1.52e-08

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 52.32  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  108 RFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSknRMATLKVLQNLCCNQYSI 187
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEER--FPPEVATLCYLTDDSYSK 78

                        90
                ....*....|....*...
gi 6319277  188 KQFTTMEMHLFKSLDWSI 205
Cdd:cd20542  79 KQVLRMERRVLRRLRFDL 96
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 111-195 9.18e-08

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 49.72  E-value: 9.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  111 IFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFWDSKnrmATLKVLQNLCcnQYSIKQF 190
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELP---RTLKEIAKVS--GVSEKEL 76


                ....*
gi 6319277  191 TTMEM 195
Cdd:cd00043  77 RKAEK 81
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 102-203 9.27e-07

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 48.32  E-value: 9.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  102 QVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKFwdskNRMATLKV--LQN 179
Cdd:cd20566  34 EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKY----EEMYSPEIgdFVY 109

                        90       100
                ....*....|....*....|....
gi 6319277  180 LCCNQYSIKQFTTMEMHLFKSLDW 203
Cdd:cd20566 110 ITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 72-164 2.02e-05

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 44.16  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   72 EYNNDQLDHyfrLSHTE---RPLYNLTNFnsQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSY 148
Cdd:cd20504   1 EYADDIYEY---LRESElkhRPKPDYMRK--QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRS 75

                        90
                ....*....|....*.
gi 6319277  149 NYQLLSLTALWISSKF 164
Cdd:cd20504  76 KLQLVGTACMFIAAKY 91
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 79-164 2.95e-05

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 43.94  E-value: 2.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   79 DHYFRLSHTE---RPLYNLTNFnSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSL 155
Cdd:cd20562  11 DIYLNLRVAElkrRPLPDYMEK-IQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGV 89


                ....*....
gi 6319277  156 TALWISSKF 164
Cdd:cd20562  90 SCMLIASKY 98
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 71-203 1.63e-04

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 41.79  E-value: 1.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   71 SEYNNDqLDHYFRLSHTERPLYnlTNFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNY 150
Cdd:cd20565   2 SEYVKD-IYAYLRQLEEEQAVR--PKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKML 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6319277  151 QLLSLTALWISSKFWDS-KNRMATLKVLQNlccNQYSIKQFTTMEMHLFKSLDW 203
Cdd:cd20565  79 QLVGVTAMFIASKYEEMyPPEIGDFAFVTD---NTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 97-203 3.40e-04

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 41.02  E-value: 3.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   97 FNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKY--SSRFIIKSyNYQLLSLTALWISSKFWD-SKNRMAT 173
Cdd:cd20579  32 LQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFmaTQENVVKT-RLQLIGISSLFIAAKLEEiYPPKLHQ 110

                        90       100       110
                ....*....|....*....|....*....|
gi 6319277  174 LKVLQNLCCNQYSIkqfTTMEMHLFKSLDW 203
Cdd:cd20579 111 FAYVTDGACTEDEI---LSMELIIMKALKW 137
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 69-201 4.04e-04

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 41.37  E-value: 4.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277   69 AISEYNNDqLDHYFR---LSHTERPLYnltnFNSQPQVNPKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFII 145
Cdd:cd20560  32 AVPEYAED-IHQYLReaeLKHRPKPGY----MRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSV 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6319277  146 KSYNYQLLSLTALWISSKFwdSKNRMATLKVLQNLCCNQYSIKQFTTMEMHLFKSL 201
Cdd:cd20560 107 LRGKLQLVGTAAILLASKY--EEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 108-163 4.50e-04

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 39.85  E-value: 4.50e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6319277  108 RFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSK 163
Cdd:cd20534   2 HFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGK 57
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 105-164 8.84e-04

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 38.84  E-value: 8.84e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319277  105 PKMRFLIFDFIMYCHTRLNLSTSTLFLTFTILDKYSSRFIIKSYNYQLLSLTALWISSKF 164
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRF 60
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 97-163 9.73e-03

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 36.52  E-value: 9.73e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319277   97 FNSQPQVNPKMRFLIFDFIM-YCHT-RLNLSTSTLFLTFtiLDKY--SSRFIIKSyNYQLLSLTALWISSK 163
Cdd:cd20519  26 LNRHPSLQPRMRAILLDWLMeVCEVyRLHRETFYLAVDF--VDRYlsTQTNVPKT-QLQLIGITCLFIAAK 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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