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Conserved domains on  [gi|63146294|gb|AAH95997|]
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Omd protein [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 8.51e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63146294 252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 8.51e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63146294 252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 8.38e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 8.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   68 CPTNFPTSMYCDNRKPKTIP-IIPMHIQQLNLQFNDIEAVTANSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  146 LHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLvnvTMLDLCYNHLsdSMLKEKTLSkmeKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 63146294  226 SMPLGLPSSLMYLSLENNSISSIPDNYfdkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-267 6.74e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 140 LSNLQQLHLEHNNLEEFPF--PLPKsLERLLLGYNEISILptNAMDGLVNVTMLDLCYNHL--SDSMLKE----KTLSKm 211
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENleNLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLppGEKLTFDprslAALSN- 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 63146294 212 eKLMQLNLCNNRLESM-PLGLPSSLMYLSLENNSISSIPD--NYFDKLPKLHALRISHN 267
Cdd:cd21340 121 -SLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
96-153 7.95e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 7.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 63146294    96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 8.51e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 119.65  E-value: 8.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63146294 252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-344 9.98e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.88  E-value: 9.98e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNleefPFPLPKSLERLLLGYNEIS 175
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 176 ILPtNAMDGLVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDNyF 253
Cdd:COG4886 127 DLP-EELANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTDLPeeLGNLTNLKELDLSNNQITDLPEP-L 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 254 DKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPR--NLEHLYLQNNEIESInvtmicpsPDPVHHHH 331
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDL--------PPLANLTN 273

                       250
                ....*....|...
gi 63146294 332 LTYLRVDQNKLKE 344
Cdd:COG4886 274 LKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-344 3.43e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 3.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  95 QLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNei 174
Cdd:COG4886  29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 175 silptNAMDGLVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLCNNRLESMPLGLPS--SLMYLSLENNSISSIPDNy 252
Cdd:COG4886 107 -----EELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE- 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 253 FDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQafyIP------RNLEHLYLQNNEIESInvtmicpsPDP 326
Cdd:COG4886 178 LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD---LPeplanlTNLETLDLSNNQLTDL--------PEL 246

                       250
                ....*....|....*...
gi 63146294 327 VHHHHLTYLRVDQNKLKE 344
Cdd:COG4886 247 GNLTNLEELDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-286 3.50e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 3.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  92 HIQQLNLQFNDIEAVTAnSFINATHLKEINLSHNKIKSQKidyGVFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLL 169
Cdd:COG4886 160 NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDL 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 170 GYNEISILPtnAMDGLVNVTMLDLCYNHLSDSmlkeKTLSKMEKLMQLNLCNNRLESMPL-GLPSSLMYLSLENNSISSI 248
Cdd:COG4886 236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDL----PPLANLTNLKTLDLSNNQLTDLKLkELELLLGLNSLLLLLLLLN 309

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 63146294 249 PDNYFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELN 286
Cdd:COG4886 310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 8.38e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 82.82  E-value: 8.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   68 CPTNFPTSMYCDNRKPKTIP-IIPMHIQQLNLQFNDIEAVTANSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  146 LHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLvnvTMLDLCYNHLsdSMLKEKTLSkmeKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 63146294  226 SMPLGLPSSLMYLSLENNSISSIPDNYfdkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-310 4.04e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 4.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   92 HIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIkSQKIDYGVFAKLSNLQQLHLEHNNleeFPFPLPKS----LERL 167
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNN---FTGSIPRGsipnLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  168 LLG--------YNEISI--------LPTNAMDG-----LVNVTMLD---LCYNHLSDSMLKEktLSKMEKLMQLNLCNNR 223
Cdd:PLN00113 146 DLSnnmlsgeiPNDIGSfsslkvldLGGNVLVGkipnsLTNLTSLEfltLASNQLVGQIPRE--LGQMKSLKWIYLGYNN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  224 LE-SMP--LGLPSSLMYLSL-ENNSISSIPDNyFDKLPKLHALRISHNKLED-IPYDIFNLSNLIELNVGHNKLKQAfyI 298
Cdd:PLN00113 224 LSgEIPyeIGGLTSLNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGE--I 300

                        250
                 ....*....|....*...
gi 63146294  299 P------RNLEHLYLQNN 310
Cdd:PLN00113 301 PelviqlQNLEILHLFSN 318
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-267 6.74e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 6.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 140 LSNLQQLHLEHNNLEEFPF--PLPKsLERLLLGYNEISILptNAMDGLVNVTMLDLCYNHL--SDSMLKE----KTLSKm 211
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENleNLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLppGEKLTFDprslAALSN- 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 63146294 212 eKLMQLNLCNNRLESM-PLGLPSSLMYLSLENNSISSIPD--NYFDKLPKLHALRISHN 267
Cdd:cd21340 121 -SLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
96-153 7.95e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 7.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 63146294    96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-292 6.91e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 6.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   92 HIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIkSQKIDYGvFAKLSNLQQLHLEHNNL----EEFPFPLPkSLERL 167
Cdd:PLN00113 381 NLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SGELPSE-FTKLPLVYFLDISNNNLqgriNSRKWDMP-SLQML 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  168 LLGYNEIS-ILPTNAmdGLVNVTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLES-MPLGLPS--SLMYLSLENN 243
Cdd:PLN00113 458 SLARNKFFgGLPDSF--GSKRLENLDLSRNQFSGAV--PRKLGSLSELMQLKLSENKLSGeIPDELSSckKLVSLDLSHN 533

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 63146294  244 SIS-SIPDNyFDKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNKL 292
Cdd:PLN00113 534 QLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
141-319 8.98e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 8.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  141 SNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMdglVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLc 220
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSI---PATLPDTIQEMELSI- 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  221 nNRLESMPLGLPSSLMYLSLENNSISSIPDNyfdkLPK-LHALRISHNKLEDIPYdifnlsnlielnvghnklkqafYIP 299
Cdd:PRK15370 251 -NRITELPERLPSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTLPA----------------------HLP 303

                        170       180
                 ....*....|....*....|
gi 63146294  300 RNLEHLYLQNNEIESINVTM 319
Cdd:PRK15370 304 SGITHLNVQSNSLTALPETL 323
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-312 6.89e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.85  E-value: 6.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   89 IPMHIQQL-NLQF-----NDIEAVTANSFINATHLKEINLSHNKIKSQKIDygVFAKLSNLQQLHLEHNNLE-EFPFPLp 161
Cdd:PLN00113 252 IPSSLGNLkNLQYlflyqNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLFSNNFTgKIPVAL- 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  162 KSLERLllgynEISILPTNAMDGLV--------NVTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLES-MP--LG 230
Cdd:PLN00113 329 TSLPRL-----QVLQLWSNKFSGEIpknlgkhnNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGeIPksLG 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  231 LPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNK----LKQAFYiPRNLEHL 305
Cdd:PLN00113 402 ACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKffggLPDSFG-SKRLENL 480


                 ....*..
gi 63146294  306 YLQNNEI 312
Cdd:PLN00113 481 DLSRNQF 487
LRR_8 pfam13855
Leucine rich repeat;
213-269 7.11e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 7.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63146294   213 KLMQLNLCNNRLESMP----LGLPSsLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKL 269
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
233-292 1.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63146294   233 SSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDI-PYDIFNLSNLIELNVGHNKL 292
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
141-198 2.13e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63146294   141 SNLQQLHLEHNNLEEFP---FPLPKSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHL 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-342 4.35e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 4.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 136 VFAKLSNLQQLHLEHNNL--EEFPF-----PLPKSLERLLLGYNEISILPTN---AMDGL---VNVTMLDLCYNHLS-DS 201
Cdd:cd00116  18 LLPKLLCLQVLRLEGNTLgeEAAKAlasalRPQPSLKELCLSLNETGRIPRGlqsLLQGLtkgCGLQELDLSDNALGpDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 202 MLKEKTLSKMEKLMQLNLCNNRLESMPL-----GLPSSLMYLS---LENNSISSIP----DNYFDKLPKLHALRISHNKL 269
Cdd:cd00116  98 CGVLESLLRSSSLQELKLNNNGLGDRGLrllakGLKDLPPALEklvLGRNRLEGAScealAKALRANRDLKELNLANNGI 177

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 63146294 270 ED--IPYdifnlsnlielnvghnkLKQAFYIPRNLEHLYLQNNEIESINVTMICPSPDpvHHHHLTYLRVDQNKL 342
Cdd:cd00116 178 GDagIRA-----------------LAEGLKANCNLEVLDLNNNGLTDEGASALAETLA--SLKSLEVLNLGDNNL 233
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
141-348 4.52e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.09  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  141 SNLQQLHLEHNNLEEFPfPLPKSLERLLLGYNEISILPTnAMDGLVNVTMLDLCYNHLSdsmlkektlSKMEKLMQLNLC 220
Cdd:PRK15387 222 AHITTLVIPDNNLTSLP-ALPPELRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLP---------ALPSGLCKLWIF 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  221 NNRLESMPLgLPSSLMYLSLENNSISSIPdnyfdKLP-KLHALRISHNKLEDIPYdifNLSNLIELNVGHNKLKQAFYIP 299
Cdd:PRK15387 291 GNQLTSLPV-LPPGLQELSVSDNQLASLP-----ALPsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLP 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 63146294  300 RNLEHLYLQNNEIESINVTMICPSPDPVHHHHLTYLRVDQNKLKEPISS 348
Cdd:PRK15387 362 SELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVS 410
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-303 5.06e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 5.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  94 QQLNLQFNDIEAVTAnSFINATHLKEINLSHNKIKsqkiDYGVFAKLSNLQQLHLEHNNLEEFPFPLP-KSLERLLLGYN 172
Cdd:COG4886 208 EELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 173 EISILPTNAMDGLVNVTMLDLcYNHLSDSMLKEKTLSKMEKLMQLNLCNNRLESMPLGLPSSLMYLSLENNSISSIPDNY 252
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLL-LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 63146294 253 FDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLE 303
Cdd:COG4886 362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-342 2.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   83 PKTIPIIPMHIQQLNLQFNDIEAVTANSFInaTHLKEINLSHNKIkSQKI--DYGVF---------------------AK 139
Cdd:PLN00113 110 PDDIFTTSSSLRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNML-SGEIpnDIGSFsslkvldlggnvlvgkipnslTN 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  140 LSNLQQLHLEHNNLE-EFPFPLP--KSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDSMlkektlskmeklmq 216
Cdd:PLN00113 187 LTSLEFLTLASNQLVgQIPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPI-------------- 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  217 lnlcnnrleSMPLGLPSSLMYLSLENNSIS-SIPDNYFDkLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNKLKQ 294
Cdd:PLN00113 253 ---------PSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTG 322

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 63146294  295 AfyIPRNLEHL-YLQNNEIESINVTMICPSpDPVHHHHLTYLRVDQNKL 342
Cdd:PLN00113 323 K--IPVALTSLpRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNL 368
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-224 5.12e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 5.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  93 IQQLNLQFNDIEAVTANSFINA----THLKEINLSHNKIKsqkiDYGVFAklsnLQQlHLEHNnleefpfplpKSLERLL 168
Cdd:COG5238 266 VETLYLSGNQIGAEGAIALAKAlqgnTTLTSLDLSVNRIG----DEGAIA----LAE-GLQGN----------KTLHTLN 326

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 63146294 169 LGYNEIS----ILPTNAMDGLVNVTMLDLCYNHLSDSMLKE--KTLSKMEKLMQLNLCNNRL 224
Cdd:COG5238 327 LAYNGIGaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNI 388
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-246 2.60e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 2.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   93 IQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYgvFAKLSNLQQLHLEHNNLE-EFPfplpkslerllLGY 171
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE--LSSCKKLVSLDLSHNQLSgQIP-----------ASF 543

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 63146294  172 NEISILptnamdglvnvTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLESmplGLPSSLMYLSLENNSIS 246
Cdd:PLN00113 544 SEMPVL-----------SQLDLSQNQLSGEI--PKNLGNVESLVQVNISHNHLHG---SLPSTGAFLAINASAVA 602
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 211-315 3.02e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 211 MEKLMQLNLCNNRLESMP-LGLPSSLMYLSLENNSISSIPDnyFDKLPKLHALRISHNKLEDIPydifNLSNLielnvgh 289
Cdd:cd21340   1 LKRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENL------- 67

                        90       100
                ....*....|....*....|....*.
gi 63146294 290 nklkqafyipRNLEHLYLQNNEIESI 315
Cdd:cd21340  68 ----------VNLKKLYLGGNRISVV 83
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 142-302 8.74e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 8.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  142 NLQQLHLEHNNLE-EFPFPLP--KSLERLLLGYNEIS----------------ILPTNAMDGLVN--------VTMLDLC 194
Cdd:PLN00113 381 NLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSgelpseftklplvyflDISNNNLQGRINsrkwdmpsLQMLSLA 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  195 YNHLSDSMlkeKTLSKMEKLMQLNLCNNRL-ESMPLGLP--SSLMYLSLENNSISS-IPDNyFDKLPKLHALRISHNKLE 270
Cdd:PLN00113 461 RNKFFGGL---PDSFGSKRLENLDLSRNQFsGAVPRKLGslSELMQLKLSENKLSGeIPDE-LSSCKKLVSLDLSHNQLS 536

                        170       180       190
                 ....*....|....*....|....*....|...
gi 63146294  271 -DIPYDIFNLSNLIELNVGHNKLKQAfyIPRNL 302
Cdd:PLN00113 537 gQIPASFSEMPVLSQLDLSQNQLSGE--IPKNL 567
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 197-316 9.92e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 9.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 197 HLSdsmLKEKTLSKMEKLMQ------LNLCNNRLESMP-LGLPSSLMYLSLENNSISSIPDnyFDKLPKLHALRISHNKL 269
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcknlkvLYLYDNKITKIEnLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 63146294 270 EDI----------------------------PYDIFNLSN-LIELNVGHNKLK--QAFYIPRNLEHLYLQNNEIESIN 316
Cdd:cd21340  81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDslEPLAPLRNLEQLDASNNQISDLE 158
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
85-251 2.50e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294   85 TIPIIPMHIQQLNLQFNDIEAVTANSfinaTHLKEINLSHNKIKSqkidygVFAKLSNLQQLHLEHNNLEEFPfPLPKSL 164
Cdd:PRK15387 296 SLPVLPPGLQELSVSDNQLASLPALP----SELCKLWAYNNQLTS------LPTLPSGLQELSVSDNQLASLP-TLPSEL 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  165 ERLLLGYNEISILPTNAmdglvnvtmldlcyNHLSDSMLKEKTLSKM----EKLMQLNLCNNRLESMPLgLPSSLMYLSL 240
Cdd:PRK15387 365 YKLWAYNNRLTSLPALP--------------SGLKELIVSGNRLTSLpvlpSELKELMVSGNRLTSLPM-LPSGLLSLSV 429

                        170
                 ....*....|.
gi 63146294  241 ENNSISSIPDN 251
Cdd:PRK15387 430 YRNQLTRLPES 440
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
217-317 6.37e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294  217 LNLCNNRLESMPLGLPSSLMYLSLENNSISSIPdnyfDKLPKLHALRISHNKLEDIPydiFNLSNLIELNVGHNKLKQAF 296
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLP---VLPPGLLELSIFSNPLTHLP 278

                         90       100
                 ....*....|....*....|.
gi 63146294  297 YIPRNLEHLYLQNNEIESINV 317
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTSLPV 299
LRR_8 pfam13855
Leucine rich repeat;
163-224 9.34e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 63146294   163 SLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDsmLKEKTLSKMEKLMQLNLCNNRL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 115-153 1.57e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 63146294   115 THLKEINLSHNKIKsqkiDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam12799   1 PNLEVLDLSNNQIT----DIPPLAKLPNLETLDLSGNNK 35
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-224 8.20e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 8.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63146294 107 TANSFINATHLKEINLSHNKIKSQKIDYGV--FAKLSNLQQLHLEHNNLEE-------FPFPLPKSLERLLLGYNEISIL 177
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIGDAGIRALAegLKANCNLEVLDLNNNGLTDegasalaETLASLKSLEVLNLGDNNLTDA 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 63146294 178 PTNAM-DGL--VNVTM--LDLCYNHLSDS---MLKEkTLSKMEKLMQLNLCNNRL 224
Cdd:cd00116 237 GAAALaSALlsPNISLltLSLSCNDITDDgakDLAE-VLAEKESLLELDLRGNKF 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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