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Conserved domains on  [gi|63099306|gb|AAY32771|]
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solute carrier family 8 member 3, partial [Rheobatrachus silus]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 1000041)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Gene Ontology:  GO:0005432|GO:0006816|GO:0055085
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-377 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 704.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306     1 SIEVITSQEREIIIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFVAGDLGPSTIVGSAAFNMFI 80
Cdd:TIGR00845  99 SIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    81 IIAICVYVIPDGEVRKVKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVVLAWVADRRLLFYKY 160
Cdd:TIGR00845 179 IIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKY 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   161 MHKKYRTDKHRAIMIETEAEHPK---GIEMDGKIMNSH---FLDGNLLnMDGKEVDESRRDMIRILKDLKQKHPEKDLDQ 234
Cdd:TIGR00845 259 VYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARREMIRILKELKQKHPDKDLEQ 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   235 LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQSKRSSSMQDICLDESEE-FVSKIYFDPCSYQCLENCGA 313
Cdd:TIGR00845 338 LEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEENdPVSKIFFEPGHYTCLENCGT 417

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63099306   314 VLLTVVRKGGDISKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIFEED 377
Cdd:TIGR00845 418 VALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-377 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 704.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306     1 SIEVITSQEREIIIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFVAGDLGPSTIVGSAAFNMFI 80
Cdd:TIGR00845  99 SIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    81 IIAICVYVIPDGEVRKVKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVVLAWVADRRLLFYKY 160
Cdd:TIGR00845 179 IIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKY 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   161 MHKKYRTDKHRAIMIETEAEHPK---GIEMDGKIMNSH---FLDGNLLnMDGKEVDESRRDMIRILKDLKQKHPEKDLDQ 234
Cdd:TIGR00845 259 VYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARREMIRILKELKQKHPDKDLEQ 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   235 LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQSKRSSSMQDICLDESEE-FVSKIYFDPCSYQCLENCGA 313
Cdd:TIGR00845 338 LEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEENdPVSKIFFEPGHYTCLENCGT 417

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63099306   314 VLLTVVRKGGDISKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIFEED 377
Cdd:TIGR00845 418 VALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 153-280 2.97e-83

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 249.53  E-value: 2.97e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   153 RRLLFYKYMHKKYRTDKHRAIMIETEAEHPKG----IEMDGKIMNSHF----LDGNLLNMDGKEVDESRRDMIRILKDLK 224
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 63099306   225 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQSKRS 280
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 295-377 4.35e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 102.72  E-value: 4.35e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    295 VSKIYFDPCSYQCLENCGAVLLTVVRKGGDiSKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIF 374
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79


                   ...
gi 63099306    375 EED 377
Cdd:smart00237  80 EKD 82
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
36-154 1.91e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.22  E-value: 1.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306  36 LTLMALGSSAPEILLSLIEVCGHgfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPdgevRKVKHlRVFFVTAAWSIFAYI 115
Cdd:COG0530  24 LTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRP----LAVDR-RVLRRDLPFLLLASL 95

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 63099306 116 WLymiLAVFSPGVVQVWEGLLTLFFFPVCVVLAWVADRR 154
Cdd:COG0530  96 LL---LALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 32-160 9.82e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 41.29  E-value: 9.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   32 TVSNLTLMALGSSAPEILLSLIEVCGHGfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGEVRKVKhlRVFFVTAAWSI 111
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFL 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 63099306  112 FAYIWLYMILAVfspGVVQVWEGLLtlfFFPVCVVLAWVADRRLLFYKY 160
Cdd:PLN03151 254 FTLVSLLVILMV---GKVTVGGAIA---FVSIYVVYAFLVAANEILRKH 296
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-377 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 704.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306     1 SIEVITSQEREIIIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFVAGDLGPSTIVGSAAFNMFI 80
Cdd:TIGR00845  99 SIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    81 IIAICVYVIPDGEVRKVKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVVLAWVADRRLLFYKY 160
Cdd:TIGR00845 179 IIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKY 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   161 MHKKYRTDKHRAIMIETEAEHPK---GIEMDGKIMNSH---FLDGNLLnMDGKEVDESRRDMIRILKDLKQKHPEKDLDQ 234
Cdd:TIGR00845 259 VYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARREMIRILKELKQKHPDKDLEQ 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   235 LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQSKRSSSMQDICLDESEE-FVSKIYFDPCSYQCLENCGA 313
Cdd:TIGR00845 338 LEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEENdPVSKIFFEPGHYTCLENCGT 417

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63099306   314 VLLTVVRKGGDISKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIFEED 377
Cdd:TIGR00845 418 VALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 153-280 2.97e-83

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 249.53  E-value: 2.97e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   153 RRLLFYKYMHKKYRTDKHRAIMIETEAEHPKG----IEMDGKIMNSHF----LDGNLLNMDGKEVDESRRDMIRILKDLK 224
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 63099306   225 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQSKRS 280
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
295-377 3.50e-35

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 124.28  E-value: 3.50e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   295 VSKIYFDPCSYQCLENCGAVLLTVVRKGGDISKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIF 374
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80


                  ...
gi 63099306   375 EED 377
Cdd:pfam03160  81 EGD 83
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 295-377 4.35e-27

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 102.72  E-value: 4.35e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    295 VSKIYFDPCSYQCLENCGAVLLTVVRKGGDiSKTLFVDYKTEDGSANAGADYEFTEGTIVFKSGETLKEFSVGIIDDDIF 374
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79


                   ...
gi 63099306    375 EED 377
Cdd:smart00237  80 EKD 82
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 29-150 1.32e-17

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 78.80  E-value: 1.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    29 WNETVSNLTLMALGSSAPEILLSLIEVCGHGfvaGDLGPSTIVGSAAFNMFIIIAICV---YVIPDGEVRKVkHLRVFFV 105
Cdd:pfam01699  33 ISGTVLGLTILALGTSLPELVSSIIAALRGE---PDLALGNVIGSNIFNILLVLGLSAligPVKVDSLLLKL-DLGVLLL 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 63099306   106 TAAWSIFAYIWLYMILavfsPGVVQVWEGLLTLFFFPVCVVLAWV 150
Cdd:pfam01699 109 VALLLLLLLLLLLLPL----FGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
36-154 1.91e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.22  E-value: 1.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306  36 LTLMALGSSAPEILLSLIEVCGHgfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPdgevRKVKHlRVFFVTAAWSIFAYI 115
Cdd:COG0530  24 LTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRP----LAVDR-RVLRRDLPFLLLASL 95

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 63099306 116 WLymiLAVFSPGVVQVWEGLLTLFFFPVCVVLAWVADRR 154
Cdd:COG0530  96 LL---LALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 30-149 1.41e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 56.54  E-value: 1.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306     30 NETVSNLTLMALGSSAPEILLSLIEVcghgFVA-GDLGPSTIVGSAAFNMFIIIAICVYVipdgeVRKVKHLrvffvtAA 108
Cdd:TIGR00927  493 SEDVAGATFMAAGGSAPELFTSLIGV----FIShSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNL------TW 557

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 63099306    109 WSIFAYIWLY-----MILAVFSPGVVQVWEGLLTLFFFPVCV-VLAW 149
Cdd:TIGR00927  558 WPLFRDVSFYildlmMLILFFLDSLIAWWESLLLLLAYALYVfTMKW 604
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 36-143 1.09e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.55  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    36 LTLMALGSSAPEILLSLIEVCGHgfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPdgevrkvkhlrvfFVTAAWSIF--- 112
Cdd:TIGR00367  41 VTVVAIGTSLPELFTSLIASLMG---QPDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdi 104

                          90       100       110
                  ....*....|....*....|....*....|...
gi 63099306   113 -AYIWLYMILAVFS-PGVVQVWEGLLTLFFFPV 143
Cdd:TIGR00367 105 lFYLLVSILLLFFGlDGQISRIDGVVLLILYIV 137
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
29-147 1.53e-04

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 43.20  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306  29 WNETVSNLTLMALGSSAPEILLSLIEVC-GHGfvagDLGPSTIVGSAAFNMFIIIAICVyVIPDGEVrkvkhLRVFFVTA 107
Cdd:COG0530 184 VSELVIGLTIVAIGTSLPELATSIVAARkGED----DLAVGNIIGSNIFNILLVLGIGA-LITPIPV-----DPAVLSFD 253

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 63099306 108 AWSIFAYIWLYMILAvFSPGVVQVWEGLLTLFFFPVCVVL 147
Cdd:COG0530 254 LPVMLAATLLLLGLL-RTGGRIGRWEGLLLLALYLAYLAL 292
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 32-160 9.82e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 41.29  E-value: 9.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306   32 TVSNLTLMALGSSAPEILLSLIEVCGHGfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGEVRKVKhlRVFFVTAAWSI 111
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFL 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 63099306  112 FAYIWLYMILAVfspGVVQVWEGLLtlfFFPVCVVLAWVADRRLLFYKY 160
Cdd:PLN03151 254 FTLVSLLVILMV---GKVTVGGAIA---FVSIYVVYAFLVAANEILRKH 296
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 31-141 7.27e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 38.07  E-value: 7.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63099306    31 ETVSNLTLMALGSSAPEILLSLIEVCGHgfvAGDLGPSTIVGSAAFNMFIIIAICVYVIPdGEVRKVKHLRVFFVTAAWS 110
Cdd:TIGR00367 204 EKIIGLTLLAIGTSLPELVVSLAAARKG---LGDIAVGNVIGSNIFNILVGLGVPSLFMP-IPVEPLAYNLDAPVMVIVT 279

                          90       100       110
                  ....*....|....*....|....*....|.
gi 63099306   111 IFayiwlYMILAVFSPgVVQVWEGLLTLFFF 141
Cdd:TIGR00367 280 LL-----LMLFFKTSM-KLGRWEGILLLALY 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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