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Conserved domains on  [gi|63082033|ref|NP_057259|]
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MRN complex-interacting protein isoform 1 [Homo sapiens]

Protein Classification

MRN complex-interacting protein( domain architecture ID 11239050)

MRN complex-interacting protein (MRNIP/C5orf45) plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRNIP pfam15749
MRN-interacting protein; This family is found in eukaryotes. Family members include MRN ...
 9-107 1.24e-43

MRN-interacting protein; This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP.


:

Pssm-ID: 464843  Cd Length: 100  Bit Score: 145.55  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63082033     9 VLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPL-RSLEETVSASEEENVG 87
Cdd:pfam15749   1 VLRCYSCKMFQVHQVKKSNKWKCKICGEKQSLKKVYGSGSGKDCRLHVQKLNLLRGEIEELADdETLQESDQQEEENENG 80

                          90       100
                  ....*....|....*....|
gi 63082033    88 HQQAGNVKQQEKSQPSESRW 107
Cdd:pfam15749  81 NENDENENNQGDDKKKPSKW 100
 
Name Accession Description Interval E-value
MRNIP pfam15749
MRN-interacting protein; This family is found in eukaryotes. Family members include MRN ...
 9-107 1.24e-43

MRN-interacting protein; This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP.


Pssm-ID: 464843  Cd Length: 100  Bit Score: 145.55  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63082033     9 VLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPL-RSLEETVSASEEENVG 87
Cdd:pfam15749   1 VLRCYSCKMFQVHQVKKSNKWKCKICGEKQSLKKVYGSGSGKDCRLHVQKLNLLRGEIEELADdETLQESDQQEEENENG 80

                          90       100
                  ....*....|....*....|
gi 63082033    88 HQQAGNVKQQEKSQPSESRW 107
Cdd:pfam15749  81 NENDENENNQGDDKKKPSKW 100
 
Name Accession Description Interval E-value
MRNIP pfam15749
MRN-interacting protein; This family is found in eukaryotes. Family members include MRN ...
 9-107 1.24e-43

MRN-interacting protein; This family is found in eukaryotes. Family members include MRN complex-interacting protein (MRNIP), which plays a role in preventing the accumulation of damaged DNA in cells. It associates with the MRE11-RAD50-NBS1 (MRN) damage-sensing complex and is rapidly recruited to sites of DNA damage. Phosphorylation of a serine promotes nuclear localization of MRNIP.


Pssm-ID: 464843  Cd Length: 100  Bit Score: 145.55  E-value: 1.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63082033     9 VLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPL-RSLEETVSASEEENVG 87
Cdd:pfam15749   1 VLRCYSCKMFQVHQVKKSNKWKCKICGEKQSLKKVYGSGSGKDCRLHVQKLNLLRGEIEELADdETLQESDQQEEENENG 80

                          90       100
                  ....*....|....*....|
gi 63082033    88 HQQAGNVKQQEKSQPSESRW 107
Cdd:pfam15749  81 NENDENENNQGDDKKKPSKW 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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