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Conserved domains on  [gi|62896561|dbj|BAD96221|]
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hypothetical protein FLJ11848 variant, partial [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
91-391 6.23e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 6.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 250
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 251 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 328
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62896561 329 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 391
Cdd:COG2319 337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
91-391 6.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 6.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 250
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 251 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 328
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62896561 329 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 391
Cdd:COG2319 337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-338 2.35e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 2.35e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 239
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 240 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 302
Cdd:cd00200 166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 62896561 303 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:cd00200 243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 167-204 1.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 62896561    167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-204 4.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62896561   167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
91-391 6.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 6.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 250
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 251 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 328
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62896561 329 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 391
Cdd:COG2319 337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-338 2.35e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 2.35e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 239
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 240 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 302
Cdd:cd00200 166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 62896561 303 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 338
Cdd:cd00200 243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-204 7.82e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 7.82e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  91 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 170
Cdd:cd00200 176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                        90       100       110
                ....*....|....*....|....*....|....
gi 62896561 171 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
89-391 5.84e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 5.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASC 168
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 169 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGV---------AVGAADNSI---NLG 236
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVafspdgkllASGSDDGTVrlwDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 237 SPEQMPS----EREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQ 305
Cdd:COG2319 193 TGKLLRTltghTGAVRSVAfspdgKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPdGRLLASGSADGTVRL 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 306 LDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVA--TWEKQIYTCCR 380
Cdd:COG2319 273 WDLATGE-LLRTLTGHSGGVNSVAFSPDGkLLASGSdDGTVRLWDlATGKLLRTLTGHT-GAVRSVAfsPDGKTLASGSD 350

                       330
                ....*....|.
gi 62896561 381 DGLVRRYQLSD 391
Cdd:COG2319 351 DGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-346 1.01e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 126 LRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 205
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 206 GRSACLGVLADCGSSINGVAVgaadnsinlgspeqMPSERevgteakMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFN 284
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAF--------------SPDGR-------ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVN 139

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62896561 285 CCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG--FIASQGDGSCFI 346
Cdd:cd00200 140 SVAFSpDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
101-391 1.65e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 101 SSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 180
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 181 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSI---NLGSPEQMPSEREVG 248
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspdgktlasGSADGTVrlwDLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 249 TEA---------KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQLDVRSPRaPVQV 317
Cdd:COG2319 163 GAVtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPdGKLLASGSADGTVRLWDLATGK-LLRT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62896561 318 IHRSGAPVLSLLSVRDG-FIAS-QGDGSCFIVQ-QDLDYVTELTGADcDPVYKVAtW---EKQIYTCCRDGLVRRYQLSD 391
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGrLLASgSADGTVRLWDlATGELLRTLTGHS-GGVNSVA-FspdGKLLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-162 1.64e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 1.64e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62896561  89 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:cd00200 216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 167-204 1.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 62896561    167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-162 2.86e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.86e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 62896561    123 NGELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-204 4.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 62896561   167 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 204
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
124-162 2.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 62896561   124 GELRRVLEGHVFDVNSCRFFPSGLVVLSGGMDAQLKIWS 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-119 3.63e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.63e-04
                           10        20
                   ....*....|....*....|....*....
gi 62896561     91 HTKSITCLDISSRGGLGVSSSTDGTMKIW 119
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
91-119 4.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.53e-04
                          10        20
                  ....*....|....*....|....*....
gi 62896561    91 HTKSITCLDISSRGGLGVSSSTDGTMKIW 119
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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