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Conserved domains on  [gi|625944012|gb|KCG90290|]
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PE family protein PE20 [Mycobacterium tuberculosis KT-0085]

Protein Classification

PE family protein( domain architecture ID 10469594)

PE family protein similar to various Mycobacterium tuberculosis PE and PE-PGRS (polymorphic GC-rich sequences) virulence/immunogenicity factors

CATH:  1.10.287.850
Gene Ontology:  GO:0009986|GO:0005576
PubMed:  27483162|28842489|33324577
SCOP:  4001232

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PE pfam00934
PE family; This family named after a PE motif near to the amino terminus of the domain. The PE ...
 4-94 5.12e-11

PE family; This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis. The C-terminus of this domain contains the type VII secretion signal that has a YXXXD/E motif.


:

Pssm-ID: 425952  Cd Length: 91  Bit Score: 54.04  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625944012   4 VLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAADEVSALTATQFNFHAAMYQAVGAQAIAMNEAFVAMLGAS 83
Cdd:pfam00934  1 VIVAPEALAAAAADLAGIGSALSAANAAAAAPTTAVLAAGADEVSAAIAALFSAHAQEYQALSAQAAAFHDQFVQALAAA 80

                         90
                 ....*....|.
gi 625944012  84 ADSYAATEAAN 94
Cdd:pfam00934 81 AGAYAAAEAAN 91
 
Name Accession Description Interval E-value
PE pfam00934
PE family; This family named after a PE motif near to the amino terminus of the domain. The PE ...
 4-94 5.12e-11

PE family; This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis. The C-terminus of this domain contains the type VII secretion signal that has a YXXXD/E motif.


Pssm-ID: 425952  Cd Length: 91  Bit Score: 54.04  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625944012   4 VLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAADEVSALTATQFNFHAAMYQAVGAQAIAMNEAFVAMLGAS 83
Cdd:pfam00934  1 VIVAPEALAAAAADLAGIGSALSAANAAAAAPTTAVLAAGADEVSAAIAALFSAHAQEYQALSAQAAAFHDQFVQALAAA 80

                         90
                 ....*....|.
gi 625944012  84 ADSYAATEAAN 94
Cdd:pfam00934 81 AGAYAAAEAAN 91
 
Name Accession Description Interval E-value
PE pfam00934
PE family; This family named after a PE motif near to the amino terminus of the domain. The PE ...
 4-94 5.12e-11

PE family; This family named after a PE motif near to the amino terminus of the domain. The PE family of proteins all contain an amino-terminal region of about 110 amino acids. The carboxyl terminus of this family are variable and fall into several classes. The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis. The C-terminus of this domain contains the type VII secretion signal that has a YXXXD/E motif.


Pssm-ID: 425952  Cd Length: 91  Bit Score: 54.04  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625944012   4 VLVCPDALAIAAGQLRHVGSVIAARNAVAAPATAELAPAAADEVSALTATQFNFHAAMYQAVGAQAIAMNEAFVAMLGAS 83
Cdd:pfam00934  1 VIVAPEALAAAAADLAGIGSALSAANAAAAAPTTAVLAAGADEVSAAIAALFSAHAQEYQALSAQAAAFHDQFVQALAAA 80

                         90
                 ....*....|.
gi 625944012  84 ADSYAATEAAN 94
Cdd:pfam00934 81 AGAYAAAEAAN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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