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Conserved domains on  [gi|625943999|gb|KCG90277|]
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ESAT-6 like protein EsxN [Mycobacterium tuberculosis KT-0085]

Protein Classification

WXG100 family type VII secretion target( domain architecture ID 10532566)

WXG100 family type VII secretion target similar to mycobacterial ESAT-6-like protein EsxB, also called CFP-10, which is a secreted protein that acts as a strong host T-cell antigen and is involved in the translocation of bacteria from the host phagolysosome to the host cytoplasm

CATH:  1.10.287.1060
Gene Ontology:  GO:0005576
PubMed:  24586681|11973144

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WXG100 pfam06013
Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental ...
 3-86 9.98e-10

Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.


:

Pssm-ID: 428722  Cd Length: 85  Bit Score: 50.34  E-value: 9.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625943999   3 INYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNM 82
Cdd:pfam06013  2 IKVDPEELRQAAARFQKSAEEIEDELQRLKSTVAALGGGWSGAAADAFQAEFDEWKPAAQKLVDALEEISEALKQAANAY 81


                 ....
gi 625943999  83 AQTD 86
Cdd:pfam06013 82 EDAD 85
 
Name Accession Description Interval E-value
WXG100 pfam06013
Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental ...
 3-86 9.98e-10

Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.


Pssm-ID: 428722  Cd Length: 85  Bit Score: 50.34  E-value: 9.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625943999   3 INYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNM 82
Cdd:pfam06013  2 IKVDPEELRQAAARFQKSAEEIEDELQRLKSTVAALGGGWSGAAADAFQAEFDEWKPAAQKLVDALEEISEALKQAANAY 81


                 ....
gi 625943999  83 AQTD 86
Cdd:pfam06013 82 EDAD 85
 
Name Accession Description Interval E-value
WXG100 pfam06013
Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental ...
 3-86 9.98e-10

Proteins of 100 residues with WXG; ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.


Pssm-ID: 428722  Cd Length: 85  Bit Score: 50.34  E-value: 9.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 625943999   3 INYQFGDVDAHGAMIRAQAASLEAEHQAIVRDVLAAGDFWGGAGSVACQEFITQLGRNFQVIYEQANAHGQKVQAAGNNM 82
Cdd:pfam06013  2 IKVDPEELRQAAARFQKSAEEIEDELQRLKSTVAALGGGWSGAAADAFQAEFDEWKPAAQKLVDALEEISEALKQAANAY 81


                 ....
gi 625943999  83 AQTD 86
Cdd:pfam06013 82 EDAD 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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