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Conserved domains on  [gi|624388183|gb|KBT47032|]
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glycine betaine transport integral membrane protein BetP, partial [Mycobacterium tuberculosis 2233BH]

Protein Classification

BCCT family transporter( domain architecture ID 10003438)

BCCT (betaine-carnitine-choline transporter) family transporter shares the common functional feature of transporting molecules with a quaternary ammonium group [R-N+(CH3)3]; energized by pmf-driven proton symport; similar to Bacillus subtilis glycine betaine transporter OpuD

CATH:  1.20.5.430
Gene Ontology:  GO:0022857|GO:0071705|GO:0016020
PubMed:  20923416
TCDB:  2.A.15

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
BetT COG1292
Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];
17-491 0e+00

Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440903  Cd Length: 512  Bit Score: 548.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  17 RSIQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPE 96
Cdd:COG1292   11 KKIDPPVFIPSALLILAFVLWGLLFPEAAGAVLNAAFSWITTNFGWFYLLLVLLFVVFCLYLAFSKYGKIRLGGDDAKPE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  97 FSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYR 176
Cdd:COG1292   91 FSTFSWFAMLFSAGMGIGLVFWGVAEPLYHFLSPPP--GVEPGSPEAARWAMAYTFFHWGLHAWAIYALVGLALAYFAYR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 177 RGRPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATAT 256
Cdd:COG1292  169 RGLPLTISSALYPLLGD-RIYGPIGKVIDILAVFATVFGVATSLGLGALQINAGLNYLFGIPNSLTVQIIIIAVITALFT 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 257 ASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWW 336
Cdd:COG1292  248 ISAVSGLDKGIKRLSNLNMVLALLLLLFVLIVGPTLFILNLFVQSLGDYLQNFVPMSLWTDAYGDTGWLGGWTVFYWAWW 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 337 ISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVN-GAVDTNTSLFRLLDGLPIGA 415
Cdd:COG1292  328 IAWAPFVGLFIARISRGRTIREFVLGVLLVPTLFTFLWFSVFGGTAIHLELNGGGDLAEaVAAGVEAALFALLEQLPLGT 407
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 624388183 416 ITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTALRTAAIATAL 491
Cdd:COG1292  408 ILSVLAIILVIIFFVTSADSGSLVLAMLTSGGDEEPPRWQRIFWGVLIGLVAAVLLLAGG---LSALQTASIITAL 480
 
Name Accession Description Interval E-value
BetT COG1292
Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];
17-491 0e+00

Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440903  Cd Length: 512  Bit Score: 548.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  17 RSIQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPE 96
Cdd:COG1292   11 KKIDPPVFIPSALLILAFVLWGLLFPEAAGAVLNAAFSWITTNFGWFYLLLVLLFVVFCLYLAFSKYGKIRLGGDDAKPE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  97 FSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYR 176
Cdd:COG1292   91 FSTFSWFAMLFSAGMGIGLVFWGVAEPLYHFLSPPP--GVEPGSPEAARWAMAYTFFHWGLHAWAIYALVGLALAYFAYR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 177 RGRPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATAT 256
Cdd:COG1292  169 RGLPLTISSALYPLLGD-RIYGPIGKVIDILAVFATVFGVATSLGLGALQINAGLNYLFGIPNSLTVQIIIIAVITALFT 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 257 ASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWW 336
Cdd:COG1292  248 ISAVSGLDKGIKRLSNLNMVLALLLLLFVLIVGPTLFILNLFVQSLGDYLQNFVPMSLWTDAYGDTGWLGGWTVFYWAWW 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 337 ISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVN-GAVDTNTSLFRLLDGLPIGA 415
Cdd:COG1292  328 IAWAPFVGLFIARISRGRTIREFVLGVLLVPTLFTFLWFSVFGGTAIHLELNGGGDLAEaVAAGVEAALFALLEQLPLGT 407
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 624388183 416 ITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTALRTAAIATAL 491
Cdd:COG1292  408 ILSVLAIILVIIFFVTSADSGSLVLAMLTSGGDEEPPRWQRIFWGVLIGLVAAVLLLAGG---LSALQTASIITAL 480
BCCT pfam02028
BCCT, betaine/carnitine/choline family transporter;
23-491 0e+00

BCCT, betaine/carnitine/choline family transporter;


Pssm-ID: 460420  Cd Length: 485  Bit Score: 515.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183   23 VFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAW 102
Cdd:pfam02028   1 VFAVSAGLILAFVLLGLIFPEALSAVVNTALDWITDNFGWFYLLLVLIFLVFALFLAFSRYGNIRLGGDDDKPEFSTFSW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  103 LAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRGRPLS 182
Cdd:pfam02028  81 FAMLFAAGMGIGLVFWGVAEPLSHYLSPPP--GGEPGTPEAAQQAMAYTFFHWGLHAWAIYALVALALAYFAYRKGLPLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  183 VRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSG 262
Cdd:pfam02028 159 ISSALYPLLGD-RIDGPIGKAIDILAIIATVFGVATSLGLGALQINAGLSYLFGIPNTLTTQLAIIAIITALFTISAVSG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  263 VSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDG-WLGDWTIFYWGWWISWAP 341
Cdd:pfam02028 238 LDKGIKRLSNLNMYLAVALLLFVLIAGPTLFILNTFVQSLGDYLQNFVPMSFYTDPFGDTGgWLGGWTIFYWAWWIAWAP 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  342 FVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVN-GAVDTNTSLFRLLDGLPIGAITSVL 420
Cdd:pfam02028 318 FVGMFIARISRGRTIREFILGVLLVPTLFTFLWFSVFGGTAIYLELNGPGDLADaVEAGPPAALFALLEQLPLGTILSVL 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 624388183  421 AVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTALRTAAIATAL 491
Cdd:pfam02028 398 ALLLIIIFFVTSADSGTLVIAMLSSGGDLNPPRWQRVFWGVLLGAVAAVLLLAGG---LEALQSASIIAAL 465
bcct TIGR00842
choline/carnitine/betaine transport; The Betaine/Carnitine/Choline Transporter (BCCT) Family ...
61-491 2.75e-177

choline/carnitine/betaine transport; The Betaine/Carnitine/Choline Transporter (BCCT) Family (TC 2.A.15) Proteins of the BCCT family share the common functional feature of transporting molecules with a quaternary ammonium group [R-N+(CH3)3]. The BCCT family includes transporters for carnitine, choline and glycine betaine. BCCT transporters have 12 putative TMS, and are energized by pmf-driven proton symport. Some of these permeases exhibit osmosensory and osmoregulatory properties inherent to their polypeptide chains. [Transport and binding proteins, Other]


Pssm-ID: 213565  Cd Length: 452  Bit Score: 505.35  E-value: 2.75e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183   61 GWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVPALT 140
Cdd:TIGR00842   1 GWAYILTVTLFLGFVLYIAFSRYGKIRLGRDDEKPEFSTLSWLAMLFAAGMGAGLMFWGVAEPLTYYLTPPFGAGPTSTT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  141 daAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRGRPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSL 220
Cdd:TIGR00842  81 --AQEQALAYTLFHWGIHPWAIYALVGLALAYFHFRKGLPLRLSSALVPLLGE-KVNGPIGKAIDILALVATVFGVATSL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  221 GFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQ 300
Cdd:TIGR00842 158 GLGAPQINAGLSALFGIPDSFWLQALIILCVTALACISVASGVGKGIKILSNINMALAFLLLLFVLIVGPTVFLLNSFVD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  301 NLGGYVQSLPQFMLRTAPF-SHDGWLGDWTIFYWGWWISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFG 379
Cdd:TIGR00842 238 SIGNYLQNFPQMSFRTDPDdGKGGWPGGWTVFYWAWWISWSPFVGMFIARISRGRTIREFIFGVLLGPTAFTWLWFSVFG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  380 DSALLRQRNNGDMLVNGAVDTN--TSLFRLLDGLPIGAITSVLAVLVIVFFFVTSSDSGSLVID-ILSAGGEL--DPPKL 454
Cdd:TIGR00842 318 NSALLLQQNGGFINGPFVVETNgaRALFGLLAALPLGTITMALALILIIIFFITSADSASLVLAnTTSRGGQLgeEPPKW 397
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 624388183  455 TRVYWAVLEGVAAAVLLLIGgaGSLTALRTAAIATAL 491
Cdd:TIGR00842 398 VRVFWAVAIGLIALVLLFSG--GSLAALQTTTIIAAL 432
PRK09928 PRK09928
choline transport protein BetT; Provisional
19-491 4.85e-113

choline transport protein BetT; Provisional


Pssm-ID: 236635  Cd Length: 679  Bit Score: 348.61  E-value: 4.85e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  19 IQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFS 98
Cdd:PRK09928  15 INPVVFYTSAGLILLFSLTTILFTDFSNRWINRTLNWVSKTFGWYYLLAATLYIVFVIFIACSRFGSIKLGPEQSKPEFS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  99 FWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVpalTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRG 178
Cdd:PRK09928  95 LLSWAAMLFAAGIGIDLMFFSVAEPVTQYMQPPEGAGQ---TIEAARQAMVWTLFHYGLTGWSMYALMGMALGYFSYRYN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 179 RPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATAS 258
Cdd:PRK09928 172 LPLTIRSALYPIFGK-RINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPESLAAQAALIALSVIIATIS 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 259 VVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSH-DGWLGDWTIFYWGWWI 337
Cdd:PRK09928 251 VTSGVNKGIRVLSELNVLLALGLILFVLFMGDTSFLLNALVLNVGDYVNRFMGMTLNSFAFDRpTEWMNNWTLFFWAWWV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 338 SWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALlrqrnngDMLVNGAVD--------TNTSLFRLLD 409
Cdd:PRK09928 331 AWSPFVGLFLARISRGRTIRQFVLGTLIIPFTFTLLWLSIFGNSAL-------YEIIHGNAAfaeeamahPERGFYSLLA 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 410 GLPIGAITSVLAVLVIVFFFVTSSDSGSLVI--------DILSaggelDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTA 481
Cdd:PRK09928 404 QYPAFTFSASVATITGLLFYVTSADSGALVLgnftsklkDINS-----DAPNWLRVFWSVAIGLLTLGMLMTNG---ISA 475
                        490
                 ....*....|
gi 624388183 482 LRTAAIATAL 491
Cdd:PRK09928 476 LQNTTVIMGL 485
 
Name Accession Description Interval E-value
BetT COG1292
Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];
17-491 0e+00

Choline-glycine betaine transporter [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440903  Cd Length: 512  Bit Score: 548.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  17 RSIQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPE 96
Cdd:COG1292   11 KKIDPPVFIPSALLILAFVLWGLLFPEAAGAVLNAAFSWITTNFGWFYLLLVLLFVVFCLYLAFSKYGKIRLGGDDAKPE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  97 FSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYR 176
Cdd:COG1292   91 FSTFSWFAMLFSAGMGIGLVFWGVAEPLYHFLSPPP--GVEPGSPEAARWAMAYTFFHWGLHAWAIYALVGLALAYFAYR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 177 RGRPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATAT 256
Cdd:COG1292  169 RGLPLTISSALYPLLGD-RIYGPIGKVIDILAVFATVFGVATSLGLGALQINAGLNYLFGIPNSLTVQIIIIAVITALFT 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 257 ASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWW 336
Cdd:COG1292  248 ISAVSGLDKGIKRLSNLNMVLALLLLLFVLIVGPTLFILNLFVQSLGDYLQNFVPMSLWTDAYGDTGWLGGWTVFYWAWW 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 337 ISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVN-GAVDTNTSLFRLLDGLPIGA 415
Cdd:COG1292  328 IAWAPFVGLFIARISRGRTIREFVLGVLLVPTLFTFLWFSVFGGTAIHLELNGGGDLAEaVAAGVEAALFALLEQLPLGT 407
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 624388183 416 ITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTALRTAAIATAL 491
Cdd:COG1292  408 ILSVLAIILVIIFFVTSADSGSLVLAMLTSGGDEEPPRWQRIFWGVLIGLVAAVLLLAGG---LSALQTASIITAL 480
BCCT pfam02028
BCCT, betaine/carnitine/choline family transporter;
23-491 0e+00

BCCT, betaine/carnitine/choline family transporter;


Pssm-ID: 460420  Cd Length: 485  Bit Score: 515.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183   23 VFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAW 102
Cdd:pfam02028   1 VFAVSAGLILAFVLLGLIFPEALSAVVNTALDWITDNFGWFYLLLVLIFLVFALFLAFSRYGNIRLGGDDDKPEFSTFSW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  103 LAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRGRPLS 182
Cdd:pfam02028  81 FAMLFAAGMGIGLVFWGVAEPLSHYLSPPP--GGEPGTPEAAQQAMAYTFFHWGLHAWAIYALVALALAYFAYRKGLPLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  183 VRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSG 262
Cdd:pfam02028 159 ISSALYPLLGD-RIDGPIGKAIDILAIIATVFGVATSLGLGALQINAGLSYLFGIPNTLTTQLAIIAIITALFTISAVSG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  263 VSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDG-WLGDWTIFYWGWWISWAP 341
Cdd:pfam02028 238 LDKGIKRLSNLNMYLAVALLLFVLIAGPTLFILNTFVQSLGDYLQNFVPMSFYTDPFGDTGgWLGGWTIFYWAWWIAWAP 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  342 FVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVN-GAVDTNTSLFRLLDGLPIGAITSVL 420
Cdd:pfam02028 318 FVGMFIARISRGRTIREFILGVLLVPTLFTFLWFSVFGGTAIYLELNGPGDLADaVEAGPPAALFALLEQLPLGTILSVL 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 624388183  421 AVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTALRTAAIATAL 491
Cdd:pfam02028 398 ALLLIIIFFVTSADSGTLVIAMLSSGGDLNPPRWQRVFWGVLLGAVAAVLLLAGG---LEALQSASIIAAL 465
bcct TIGR00842
choline/carnitine/betaine transport; The Betaine/Carnitine/Choline Transporter (BCCT) Family ...
61-491 2.75e-177

choline/carnitine/betaine transport; The Betaine/Carnitine/Choline Transporter (BCCT) Family (TC 2.A.15) Proteins of the BCCT family share the common functional feature of transporting molecules with a quaternary ammonium group [R-N+(CH3)3]. The BCCT family includes transporters for carnitine, choline and glycine betaine. BCCT transporters have 12 putative TMS, and are energized by pmf-driven proton symport. Some of these permeases exhibit osmosensory and osmoregulatory properties inherent to their polypeptide chains. [Transport and binding proteins, Other]


Pssm-ID: 213565  Cd Length: 452  Bit Score: 505.35  E-value: 2.75e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183   61 GWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVPALT 140
Cdd:TIGR00842   1 GWAYILTVTLFLGFVLYIAFSRYGKIRLGRDDEKPEFSTLSWLAMLFAAGMGAGLMFWGVAEPLTYYLTPPFGAGPTSTT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  141 daAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRGRPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSL 220
Cdd:TIGR00842  81 --AQEQALAYTLFHWGIHPWAIYALVGLALAYFHFRKGLPLRLSSALVPLLGE-KVNGPIGKAIDILALVATVFGVATSL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  221 GFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQ 300
Cdd:TIGR00842 158 GLGAPQINAGLSALFGIPDSFWLQALIILCVTALACISVASGVGKGIKILSNINMALAFLLLLFVLIVGPTVFLLNSFVD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  301 NLGGYVQSLPQFMLRTAPF-SHDGWLGDWTIFYWGWWISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFG 379
Cdd:TIGR00842 238 SIGNYLQNFPQMSFRTDPDdGKGGWPGGWTVFYWAWWISWSPFVGMFIARISRGRTIREFIFGVLLGPTAFTWLWFSVFG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  380 DSALLRQRNNGDMLVNGAVDTN--TSLFRLLDGLPIGAITSVLAVLVIVFFFVTSSDSGSLVID-ILSAGGEL--DPPKL 454
Cdd:TIGR00842 318 NSALLLQQNGGFINGPFVVETNgaRALFGLLAALPLGTITMALALILIIIFFITSADSASLVLAnTTSRGGQLgeEPPKW 397
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 624388183  455 TRVYWAVLEGVAAAVLLLIGgaGSLTALRTAAIATAL 491
Cdd:TIGR00842 398 VRVFWAVAIGLIALVLLFSG--GSLAALQTTTIIAAL 432
PRK09928 PRK09928
choline transport protein BetT; Provisional
19-491 4.85e-113

choline transport protein BetT; Provisional


Pssm-ID: 236635  Cd Length: 679  Bit Score: 348.61  E-value: 4.85e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  19 IQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFS 98
Cdd:PRK09928  15 INPVVFYTSAGLILLFSLTTILFTDFSNRWINRTLNWVSKTFGWYYLLAATLYIVFVIFIACSRFGSIKLGPEQSKPEFS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  99 FWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVpalTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRRG 178
Cdd:PRK09928  95 LLSWAAMLFAAGIGIDLMFFSVAEPVTQYMQPPEGAGQ---TIEAARQAMVWTLFHYGLTGWSMYALMGMALGYFSYRYN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 179 RPLSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATAS 258
Cdd:PRK09928 172 LPLTIRSALYPIFGK-RINGPIGHSVDIAAVIGTIFGIATTLGIGVVQLNYGLSVLFDIPESLAAQAALIALSVIIATIS 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 259 VVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSH-DGWLGDWTIFYWGWWI 337
Cdd:PRK09928 251 VTSGVNKGIRVLSELNVLLALGLILFVLFMGDTSFLLNALVLNVGDYVNRFMGMTLNSFAFDRpTEWMNNWTLFFWAWWV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 338 SWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALlrqrnngDMLVNGAVD--------TNTSLFRLLD 409
Cdd:PRK09928 331 AWSPFVGLFLARISRGRTIRQFVLGTLIIPFTFTLLWLSIFGNSAL-------YEIIHGNAAfaeeamahPERGFYSLLA 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 410 GLPIGAITSVLAVLVIVFFFVTSSDSGSLVI--------DILSaggelDPPKLTRVYWAVLEGVAAAVLLLIGGagsLTA 481
Cdd:PRK09928 404 QYPAFTFSASVATITGLLFYVTSADSGALVLgnftsklkDINS-----DAPNWLRVFWSVAIGLLTLGMLMTNG---ISA 475
                        490
                 ....*....|
gi 624388183 482 LRTAAIATAL 491
Cdd:PRK09928 476 LQNTTVIMGL 485
PRK03356 PRK03356
L-carnitine/gamma-butyrobetaine antiport BCCT transporter;
19-488 2.09e-47

L-carnitine/gamma-butyrobetaine antiport BCCT transporter;


Pssm-ID: 179568  Cd Length: 504  Bit Score: 171.46  E-value: 2.09e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  19 IQPAVFIPaSVVIVAMIVVSVVYSSVAENAFV-RLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGrdDELPEF 97
Cdd:PRK03356  10 IEPKVFFP-PLIIVGILCWLTVRDLDAANVVInAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG--DEKPEF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  98 SFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRsrGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYRR 177
Cdd:PRK03356  87 STASWIFMMFASCTSAAVLFWGSIEIYYYISTPPF--GLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFGYFFFVR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 178 G----RPLSVrwlLEPVVGRGRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWI----RVDNW----WMV 245
Cdd:PRK03356 165 KmdviRPSST---LVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIphtlQLDAIiitcWII 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 246 gmiaaitaTATASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWL 325
Cdd:PRK03356 242 --------LNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVGGTSFIMNYFTDSVGMLLMYLPRMLFYTDPIGKGGFP 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 326 GDWTIFYWGWWISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNgdmLVN-GAVDTNTSL 404
Cdd:PRK03356 314 QGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLMDKN---IINiPNLIEQYGV 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 405 FRLL----DGLPIGAITSVlAVLVIVFF-FVTSSDSGSLVIDILS---AGGELDPPKLTRVYWAVLEGVAAAVLLLIGGa 476
Cdd:PRK03356 391 ARAIietwAALPLSTATMW-GFFILCFIaTVTLINACSYTLAMSTcreVRDGEEPPLLVRIGWSILVGIIGIVLLALGG- 468
                        490
                 ....*....|..
gi 624388183 477 gsLTALRTAAIA 488
Cdd:PRK03356 469 --LKPIQTAIIA 478
PRK09950 PRK09950
putative transporter; Provisional
22-491 1.43e-39

putative transporter; Provisional


Pssm-ID: 236636  Cd Length: 506  Bit Score: 149.94  E-value: 1.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183  22 AVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVvfaLYCGISRIGTIRLGRDDelPEFSFWA 101
Cdd:PRK09950  14 STSLLAVFFIVAALSLFPQQSAAAANTIFQWVTRTFGSPVQLFVLLAMILV---LYLATSKYGNIRLGEGK--PEYSTLS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 102 WLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSrgVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTY-RRGRP 180
Cdd:PRK09950  89 WLFMFICAGLGSSTLYWGVMEWAYYYQTPGLN--IAPRSPKALEYSVSYSFFHWGISAWATYALASLIMAYHFHvRKNKG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 181 LSVRWLLEPVVGRgRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLgwIRVDNWWMVGMIAAITATATASVV 260
Cdd:PRK09950 167 LSLSGIIAAITGV-KPQGPWGRLVDLMFLIATVGALTISLVVTAATFTRGLSAL--TGLPNNFTVQAFVILLSGVIFCLS 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 261 S--GVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWWIS 338
Cdd:PRK09950 244 SyiGIDNGLQRLSKMVGWGAFLFALLVLIVGPTEFITNNIINSIGLTTQNFLQMSLFTDPMGDGSFTRNWTVFYWLWWIS 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 339 WAPFVGMFIARISRGRTIREFIGAVLLVPTViaSLWFtIFGdsalLRQRNNGDMLVNGAVDT---------NTSLFRLLD 409
Cdd:PRK09950 324 YTPGVAMFVTRVSRGRKIKEVIWGLILGSSV--GCWF-FFG----VLESYAIHQFINGVINVpqilntlggETAVQQLLS 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624388183 410 GLPIGAITSVLAVLVIVFFFVTSSDSGSLVIDILSAGG---ELDPPKLTRVYWAVLEGVAAAVLLLIGgaGSLTALRTAA 486
Cdd:PRK09950 397 SLPAGKLFLAAYLGIMIIFLASHMDAVAYTMAATSTRNlreGDDPDRGLRLFWCVVITLIPLSILFTG--ASLDTMKTTV 474

                 ....*
gi 624388183 487 IATAL 491
Cdd:PRK09950 475 VLTAL 479
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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