NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|624384297|gb|KBT43182|]
View 

6-phosphogluconolactonase DevB (6PGL) [Mycobacterium tuberculosis 2233BH]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10471859)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-235 9.34e-92

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


:

Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 269.49  E-value: 9.34e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297    9 PDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQAR 88
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   89 RALLNHVDIPSNQVHPMAASdgdfGGDLDAAALAYEQVLAAsAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTR 168
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPAS----AADPEEAAAAYEAELRE-LLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 624384297  169 MVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGaDPVSVPAAGA-VGRQNTLW 235
Cdd:pfam01182 156 LVVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVrPGAGETVW 222
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-235 9.34e-92

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 269.49  E-value: 9.34e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297    9 PDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQAR 88
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   89 RALLNHVDIPSNQVHPMAASdgdfGGDLDAAALAYEQVLAAsAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTR 168
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPAS----AADPEEAAAAYEAELRE-LLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 624384297  169 MVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGaDPVSVPAAGA-VGRQNTLW 235
Cdd:pfam01182 156 LVVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVrPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 7-245 5.93e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 267.70  E-value: 5.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297    7 IFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQaqQIEWSKVHLFWGDERYVPEDDDERNLKQ 86
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   87 ARRALLNHVDIPSNQVHPMAASDGDfggdLDAAALAYEQVLAASAAPgDPAPNFDVHLLGMGPEGHINSLFPHSPAVLES 166
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELSD----IEEAAELYEQELAAAFQP-IVFPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  167 TRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAI-GGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:TIGR01198 154 ERLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALaVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 5-246 2.17e-87

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 259.32  E-value: 2.17e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   5 IEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYL--SAQAQQIEWSKVHLFWGDERY-VPEDDDE 81
Cdd:COG0363    4 VIIFPDAEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELarLHKEGGLDWSRVHVFNLDEYVgLPPDHPQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  82 RNLKQARRALLNHVDIPSNQVHPMAASDGDfggdLDAAALAYEQVLAAsaapgdpAPNFDVHLLGMGPEGHINSLFPHSP 161
Cdd:COG0363   84 SNRRFMREALLDHVDIPPENIHIPDGEAED----PEAAAARYEALIAE-------AGGIDLQLLGIGEDGHIAFNFPGSP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 162 AVLESTRmVVAVDDS------------PKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVG 229
Cdd:COG0363  153 FLSETDR-VVTLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQG 231

                        250
                 ....*....|....*..
gi 624384297 230 RQNTLWLLDRDAAAKLP 246
Cdd:COG0363  232 HPNVTWFLDEAAASLLT 248
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-237 2.57e-83

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 247.86  E-value: 2.57e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  14 LVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQqIEWSKVHLFWGDERYVPEDDDERNLKQARRALLN 93
Cdd:cd01400    3 LAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAAPA-LDWSKVHVFLGDERCVPPDDPDSNYRLAREALLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  94 HVDIPSNQVHPMAASDGdfggdLDAAALAYEQVLAASAapgDPAPNFDVHLLGMGPEGHINSLFPHSPAVL-ESTRMVVA 172
Cdd:cd01400   82 HVAIPAANIHPIPTELG-----PEDAAAAYEKELRALF---GGVPPFDLVLLGMGPDGHTASLFPGHPALLeETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 624384297 173 VDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQ-NTLWLL 237
Cdd:cd01400  154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPgEVLWFL 219
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 33-245 2.35e-38

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 134.60  E-value: 2.35e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  33 RGQALIVLTGGgNGIALLRYL--SAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASdg 110
Cdd:PLN02360  41 RGVFAIALSGG-SLISFMGKLceAPYNKTVDWAKWYIFWADERVVAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDT-- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 111 dfgGDLDAAALAYE-------QVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSPKPPPRR 183
Cdd:PLN02360 118 ---VTAEEAATDYEfairqlvKTRTIGVSDISDCPKFDLILLGMGSDGHVASLFPNHPALEEKDDWVTFITDSPKPPPER 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 624384297 184 ITLTLPAIQRSREVWLLVSGPGKADAVAAAIG----GADPVSVPAAGAVGRQNTL-WLLDRDAAAKL 245
Cdd:PLN02360 195 ITFTLPVINSASNVAVVATGESKANAVHLAIDdvteGPDAPSLPARMVQPTKGKLvWFLDKPAASKL 261
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-235 9.34e-92

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 269.49  E-value: 9.34e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297    9 PDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQAR 88
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   89 RALLNHVDIPSNQVHPMAASdgdfGGDLDAAALAYEQVLAAsAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTR 168
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPAS----AADPEEAAAAYEAELRE-LLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 624384297  169 MVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGaDPVSVPAAGA-VGRQNTLW 235
Cdd:pfam01182 156 LVVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVrPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 7-245 5.93e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 267.70  E-value: 5.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297    7 IFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQaqQIEWSKVHLFWGDERYVPEDDDERNLKQ 86
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   87 ARRALLNHVDIPSNQVHPMAASDGDfggdLDAAALAYEQVLAASAAPgDPAPNFDVHLLGMGPEGHINSLFPHSPAVLES 166
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELSD----IEEAAELYEQELAAAFQP-IVFPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  167 TRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAI-GGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:TIGR01198 154 ERLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALaVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 5-246 2.17e-87

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 259.32  E-value: 2.17e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   5 IEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYL--SAQAQQIEWSKVHLFWGDERY-VPEDDDE 81
Cdd:COG0363    4 VIIFPDAEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELarLHKEGGLDWSRVHVFNLDEYVgLPPDHPQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  82 RNLKQARRALLNHVDIPSNQVHPMAASDGDfggdLDAAALAYEQVLAAsaapgdpAPNFDVHLLGMGPEGHINSLFPHSP 161
Cdd:COG0363   84 SNRRFMREALLDHVDIPPENIHIPDGEAED----PEAAAARYEALIAE-------AGGIDLQLLGIGEDGHIAFNFPGSP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 162 AVLESTRmVVAVDDS------------PKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVG 229
Cdd:COG0363  153 FLSETDR-VVTLDEStrqanarffgsiPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQG 231

                        250
                 ....*....|....*..
gi 624384297 230 RQNTLWLLDRDAAAKLP 246
Cdd:COG0363  232 HPNVTWFLDEAAASLLT 248
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-237 2.57e-83

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 247.86  E-value: 2.57e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  14 LVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQqIEWSKVHLFWGDERYVPEDDDERNLKQARRALLN 93
Cdd:cd01400    3 LAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAAPA-LDWSKVHVFLGDERCVPPDDPDSNYRLAREALLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  94 HVDIPSNQVHPMAASDGdfggdLDAAALAYEQVLAASAapgDPAPNFDVHLLGMGPEGHINSLFPHSPAVL-ESTRMVVA 172
Cdd:cd01400   82 HVAIPAANIHPIPTELG-----PEDAAAAYEKELRALF---GGVPPFDLVLLGMGPDGHTASLFPGHPALLeETDRLVVA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 624384297 173 VDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQ-NTLWLL 237
Cdd:cd01400  154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPgEVLWFL 219
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 33-245 2.35e-38

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 134.60  E-value: 2.35e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  33 RGQALIVLTGGgNGIALLRYL--SAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASdg 110
Cdd:PLN02360  41 RGVFAIALSGG-SLISFMGKLceAPYNKTVDWAKWYIFWADERVVAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDT-- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 111 dfgGDLDAAALAYE-------QVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSPKPPPRR 183
Cdd:PLN02360 118 ---VTAEEAATDYEfairqlvKTRTIGVSDISDCPKFDLILLGMGSDGHVASLFPNHPALEEKDDWVTFITDSPKPPPER 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 624384297 184 ITLTLPAIQRSREVWLLVSGPGKADAVAAAIG----GADPVSVPAAGAVGRQNTL-WLLDRDAAAKL 245
Cdd:PLN02360 195 ITFTLPVINSASNVAVVATGESKANAVHLAIDdvteGPDAPSLPARMVQPTKGKLvWFLDKPAASKL 261
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 36-245 1.41e-26

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 102.56  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  36 ALIVLTGGGNGIALLRYL--SAQAQQIEWSKVHLFWGDErYV--PEDDDERNLKQARRALLNHVDIPSNQVHPMaasDGD 111
Cdd:cd01399   21 AVLGLATGSTPLGVYEELieLHKEGGLSFSNVTTFNLDE-YVglPPDHPQSYHYFMRENLFDHIDIKPENIHIP---DGN 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 112 fGGDLDAAALAYEQVLAAsaapgdpAPNFDVHLLGMGPEGHI--N----SLFPHSPAVL--ESTR--MVVAVDDSPKPPP 181
Cdd:cd01399   97 -AADLEAECRRYEALIAE-------AGGIDLQLLGIGENGHIgfNepgsSLDSRTRVVTldESTRqaNARFFDGDEDVPT 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 624384297 182 RRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:cd01399  169 QAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 5-245 1.10e-23

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 95.67  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297   5 IEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIV-LTGGGNGIALLRYLSA--QAQQIEWSKVHLFWGDErYV--PEDD 79
Cdd:PRK00443   3 LIILKTAEEVGKWAARHIANRINAFLPTKERPFVLgLATGSSPLETYKALIElhKAGKVDFSRVTTFNLDE-YVglPADH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  80 DERNLKQARRALLNHVDIPSNQVHpmaASDGDfGGDLDAAALAYEQVLAASAAPgdpapnfDVHLLGMGPEGHINslFPH 159
Cdd:PRK00443  82 PESYRYFMRENFFDHVDIPPENIN---LLNGN-APDPEAECRRYEEKIKSAGGI-------DLQILGIGENGHIA--FNE 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 160 SPAVLESTRMVVAV----------------DDSPKpppRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGadPVS-- 221
Cdd:PRK00443 149 PGSSFASRTRIKTLtedtriansrffdgdiEQVPK---YALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEG--PVNhm 223

                        250       260
                 ....*....|....*....|....*.
gi 624384297 222 VPAagAVGRQ--NTLWLLDRDAAAKL 245
Cdd:PRK00443 224 WPA--SILQLhpKATLVLDEAAASEL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 63-245 4.00e-16

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 77.38  E-value: 4.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  63 SKVHLFWGDERY-VPEDDDERNLKQARRALLNHVDIPSNQVHpmaASDGDFGGD-LDAAALAYEQVLAAsaapgdpAPNF 140
Cdd:PRK02122  90 KNVITFNLDEYYpMQPDSLQSYHRFMKENLFDHVDIPPENIH---IPDGTIPKEeIDEYCRDYEEKIEA-------AGGI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 141 DVHLLGMGPEGHINSLFPHSpAVLESTRMVV--------AVDD---SPKPPPRRITLTLPAIQRSREVWLLVSGPGKADA 209
Cdd:PRK02122 160 DFQLLGIGRTGHIGFNEPGS-GRNSRTRLVTldhitrrdAASDffgEENVPRKAITMGVGTILKARRIVLLAWGEHKAPI 238

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 624384297 210 VAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:PRK02122 239 IKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 56-245 1.00e-11

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 62.85  E-value: 1.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  56 QAQQIEWSKVHLFWGDErYV--PEDDDERNLKQARRALLNHVDIPSNQVHPMAASdgdfGGDLDAAALAYEQVLAASAAp 133
Cdd:PTZ00285  57 REGRVSFSNVVTFNMDE-YVglPRDHPQSYHYFMKENFFDHVDIKEENRHILNGT----APDLEEECRRYEEKIRAVGG- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 134 gdpapnFDVHLLGMGPEGHINSLFPHSPavLESTRMVVAV-------------DDSPKPPPRRITLTLPAIQRSREVWLL 200
Cdd:PTZ00285 131 ------IDLFLAGIGTDGHIAFNEPGSS--LDSRTRVKSLnqetidanarffgNDISKVPTMALTVGIRTIMEAREVLLL 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 624384297 201 VSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:PTZ00285 203 ATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLDEDATLEL 247
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 37-148 7.40e-11

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 59.29  E-value: 7.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  37 LIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASdgdfGGDL 116
Cdd:cd00458   23 VIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTS----LPIE 98

                         90       100       110
                 ....*....|....*....|....*....|..
gi 624384297 117 DAAALAYEQVLAASAApgdpapnFDVHLLGMG 148
Cdd:cd00458   99 KACEKYEREILDQVDA-------IDLAVDGAG 123
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 141-239 4.44e-07

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 49.44  E-value: 4.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 141 DVHLLGMGPEGHI------NSLFP--HSPAVLESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAA 212
Cdd:PRK09762 126 DLCVLGLGKNGHLglnepgESLQPacHISQLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATER 205

                         90       100
                 ....*....|....*....|....*..
gi 624384297 213 AIGGADPVSVPAAGAVGRQNTLWLLDR 239
Cdd:PRK09762 206 FLTAKVSTAIPASFLWLHSNFICLIDR 232
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
40-245 1.69e-06

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 47.82  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297  40 LTGGGNGIALLRYLSAQAQQIEW-SKVHLFWGDEryVPEDDDER---NLKQARRALLNHVDIPSNQVHPMAASDgdfggd 115
Cdd:PRK12358  34 ITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTIDN------ 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 624384297 116 ldaaALAYEQVLAAsaapgdpAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSP-------------KPPPR 182
Cdd:PRK12358 106 ----YREHDQKLAR-------DGGLDLVVLGLGADGHFCGNLPGTTHFHDETVEVPIQGEMVdivahgelggdfsLVPDS 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 624384297 183 RITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKL 245
Cdd:PRK12358 175 YVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEAAAAEL 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH