|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
966-1272 |
2.32e-157 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 477.07 E-value: 2.32e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 966 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1045
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1046 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1125
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1126 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1205
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62088808 1206 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1272
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
746-836 |
2.09e-41 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 146.96 E-value: 2.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 746 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 825
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 62088808 826 LPKCIRVSVQL 836
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
137-1346 |
1.26e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 158.32 E-value: 1.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 137 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 214
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 215 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 279
Cdd:COG2373 449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 280 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 359
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 360 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 434
Cdd:COG2373 592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 435 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 491
Cdd:COG2373 644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 492 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 552
Cdd:COG2373 722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 553 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 619
Cdd:COG2373 796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 620 elsassvynllpekDLTGF--PGPLNdqddedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 697
Cdd:COG2373 868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 698 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 775
Cdd:COG2373 901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 776 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQ---V 852
Cdd:COG2373 964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQtvtL 1040
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 853 PhcicANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpS 931
Cdd:COG2373 1041 A----AGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---A 1097
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 932 GGEvSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPE 1007
Cdd:COG2373 1098 PGE-SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGD 1171
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1008 IKSKAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNG 1086
Cdd:COG2373 1172 KDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1087 cfrssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF---- 1162
Cdd:COG2373 1249 -----------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALspla 1294
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1163 --------ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtse 1234
Cdd:COG2373 1295 kaqlaaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA--- 1356
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1235 dlTSATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLP 1314
Cdd:COG2373 1357 --PLAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAA 1428
|
1290 1300 1310
....*....|....*....|....*....|...
gi 62088808 1315 EL-PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1346
Cdd:COG2373 1429 ELlAGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1382-1472 |
8.79e-34 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 125.37 E-value: 8.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1382 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1460
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 62088808 1461 YETDEFAIAEYN 1472
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
966-1272 |
2.32e-157 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 477.07 E-value: 2.32e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 966 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1045
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1046 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1125
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1126 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1205
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62088808 1206 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1272
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
956-1272 |
6.75e-153 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 466.39 E-value: 6.75e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 956 VSVLGDILGSAMQ----NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDG 1031
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1032 SYSTFGERygrnQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSA 1111
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1112 YITIALLEI-----PLTVTHPVVRNALFCLESAwktaqEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKD 1186
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1187 NSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVAL 1266
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 62088808 1267 HALSKY 1272
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
746-836 |
2.09e-41 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 146.96 E-value: 2.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 746 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 825
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 62088808 826 LPKCIRVSVQL 836
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
137-1346 |
1.26e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 158.32 E-value: 1.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 137 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 214
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 215 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 279
Cdd:COG2373 449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 280 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 359
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 360 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 434
Cdd:COG2373 592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 435 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 491
Cdd:COG2373 644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 492 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 552
Cdd:COG2373 722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 553 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 619
Cdd:COG2373 796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 620 elsassvynllpekDLTGF--PGPLNdqddedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 697
Cdd:COG2373 868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 698 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 775
Cdd:COG2373 901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 776 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQ---V 852
Cdd:COG2373 964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQtvtL 1040
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 853 PhcicANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpS 931
Cdd:COG2373 1041 A----AGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---A 1097
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 932 GGEvSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPE 1007
Cdd:COG2373 1098 PGE-SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGD 1171
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1008 IKSKAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNG 1086
Cdd:COG2373 1172 KDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1087 cfrssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF---- 1162
Cdd:COG2373 1249 -----------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALspla 1294
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1163 --------ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtse 1234
Cdd:COG2373 1295 kaqlaaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA--- 1356
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1235 dlTSATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLP 1314
Cdd:COG2373 1357 --PLAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAA 1428
|
1290 1300 1310
....*....|....*....|....*....|...
gi 62088808 1315 EL-PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1346
Cdd:COG2373 1429 ELlAGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
358-453 |
2.37e-35 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 130.06 E-value: 2.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 358 LSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNvMGTSLTVRVNYKDRS 437
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 62088808 438 PCYGYQWVSEEHEEAH 453
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1382-1472 |
8.79e-34 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 125.37 E-value: 8.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1382 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1460
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 62088808 1461 YETDEFAIAEYN 1472
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
966-1272 |
2.32e-157 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 477.07 E-value: 2.32e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 966 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGrnQG 1045
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1046 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVT 1125
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1126 HPVVRNALFCLESAWKTAqegdhgSHVYTKALLAYAFALAGnQDKRKEVLKSLNEEAVKKDNSVHWERPqkPKAPVGHFY 1205
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62088808 1206 EPQAPSAEVEMTSYVLLAYLTAQPaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1272
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAGG----EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
956-1272 |
6.75e-153 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 466.39 E-value: 6.75e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 956 VSVLGDILGSAMQ----NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDG 1031
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1032 SYSTFGERygrnQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSA 1111
Cdd:pfam07678 81 SYSAFGHS----PGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1112 YITIALLEI-----PLTVTHPVVRNALFCLESAwktaqEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKD 1186
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA-----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1187 NSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVAL 1266
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYL------LLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 62088808 1267 HALSKY 1272
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
966-1272 |
7.94e-107 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 340.52 E-value: 7.94e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 966 AMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQG 1045
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWG---NSDSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1046 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVt 1125
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1126 HPVVRNALFCLESAWktaqegDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERpqkpkapvgHFY 1205
Cdd:cd02891 157 DASIEKALAYLETQL------DGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSL---------SWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62088808 1206 EPQAPSAEVEMTSYVLLAYLTAqpaptsEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1272
Cdd:cd02891 222 GDYGSSLRVEATAYALLALLKL------GDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
969-1272 |
4.47e-71 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 240.25 E-value: 4.47e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 969 NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQ---LTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERygrnQG 1045
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNR----PS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1046 NTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGV---EDEVTLSAYITIALLEIpL 1122
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA-R 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1123 TVTHPVVRNalfcLESAWKTAQE-----GDHGSHVYTKALLAYAFALAgNQDKRKEVLKSLNEEAVKKDNSVHWERPQKP 1197
Cdd:cd02896 159 SICPPEVQN----LDQSIRKAISylenqLPNLQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYWWTIDSP 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62088808 1198 kapvgHFYEPQAPSAEVEMTSYVLLAYLtaqpapTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKY 1272
Cdd:cd02896 234 -----YWPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
966-1272 |
7.08e-61 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 211.26 E-value: 7.08e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 966 AMQNTQNLLQMPYG--------CGEQNMVLFAPNIYVLDYLNETqqltpEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFG 1037
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAAT-----GIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1038 eryGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNaiKGGVEDEVTLSAYITIAL 1117
Cdd:cd00688 76 ---GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1118 LEIPLTVTHPVVRNALFCLESawktAQEGDHG------SHVYTKALLAYAFALAG--NQDKRKEVLKSLNEEAVKKDNSV 1189
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLS----CQNYDGGfgpggeSHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1190 HWERPqkpkapvghfYEPQAPSAEVEMTSYVLLAYLTAqpaptsEDLTSATNIVKWITKQQNAQGGFSS-------TQDT 1262
Cdd:cd00688 227 EGRDR----------TNKLSDSCYTEWAAYALLALGKL------GDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHT 290
|
330
....*....|
gi 62088808 1263 VVALHALSKY 1272
Cdd:cd00688 291 VFALLALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
746-836 |
2.09e-41 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 146.96 E-value: 2.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 746 TWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNY 825
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 62088808 826 LPKCIRVSVQL 836
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
137-1346 |
1.26e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 158.32 E-value: 1.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 137 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELiPL-VYIQDPKGNRIAQwQSFQL-EGGLKQFSFPLSSEPFQGSYKVV 214
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRR-QTLTLnEFGGYSFSFPLPEDAPTGTWRLE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 215 VQ-KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPG-HVTVSICRK------------- 279
Cdd:COG2373 449 LYvDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyr 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 280 YSDASDCHGEDSQAFcekFSGQLNSHGCFyqQVKTKVFQLKRKEYEMKLHTEAQIQEEGtvveltGRqssEITRTITkls 359
Cdd:COG2373 529 FGDPDEEFEPEELDL---GEGTLDADGKA--SLSLPLPDAPDAPGPLRATVEASVFESG------GR---PVTRSAT--- 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 360 fvkvdshfrqgIPFFGQVRLVdgkGVPIPNkvifirgneanyysNATTDEHGLVQFSINTTN-----VMGTSLTVRVNYK 434
Cdd:COG2373 592 -----------VPVHPADFYV---GIRLPL--------------FDGDPEGAPATFEVVAVDpdgkpVAGKGLKVELYRE 643
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 435 DRSpcY--------GYQWVSEEHEEAHHTAYLVFSPSK----SFVHLEPMSHEL----PCGHTQTVQAHYI-------LN 491
Cdd:COG2373 644 EWR--YvwyksddgGWRYESQEKEEPVAEGTLTTGADGpaslSLTPVEWGRYRLevkdPDGGLATSVRFYAggnaswgAE 721
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 492 GGTLLGLK------------KLSFY------YLIMakggIVRTGThgLLVKQEDMK-GHFSISIPVKSDIAPVARLLIYA 552
Cdd:COG2373 722 RPDRLELSldkesykpgetaKLLIQspfagrALVT----VERDGV--LETQWVDVKgGGTTVEIPVTEDWAPNAYVSATL 795
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 553 VLPTGDVIGDSAKY-------DVENcLANKVDLSFSPSQSL-PASHAHLRVTAA-----PQSVcALRAVDQSVLlmkpda 619
Cdd:COG2373 796 VRPGDSTANDMPARaygvaplPVDP-PARRLKVELTAPEKLrPGETLTVTVKVKgaagkAAEV-TLAAVDEGIL------ 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 620 elsassvynllpekDLTGF--PGPLNdqddedcinrhnvYINGITYTPVSSTnekDMYSFLEDmglkaftnskirkpkmc 697
Cdd:COG2373 868 --------------NLTGYktPDPLD-------------FFYGKRALGVETR---DLYGRLIG----------------- 900
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 698 pqlqqyEMHGPEG-LRVGfyesdvmGRGHARLVHVEEPhtetVRKYFPETWIWD-LVVVNSAGVAEVGVTVPDTITEWKA 775
Cdd:COG2373 901 ------AFGGAAGaLRSG-------GDGALGRGGNPKP----PRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRV 963
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 776 GAFCLSEDAgLGiSSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAfLAVPVEKEQ---V 852
Cdd:COG2373 964 MAVAWSDDR-FG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG-LTLEGEATQtvtL 1040
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 853 PhcicANGRQTVSWAVTPKSLGNVNFTVSAEALesqelcgtevpsvpehGRKDTVIKPLLVEP-EGLEKETTFNSLlcpS 931
Cdd:COG2373 1041 A----AGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPaNPLVTRATSGVL---A 1097
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 932 GGEvSEELSLKLPPNVVEESARASVSV----LGDILGSAMQntqnLLQMPYGCGEQNMVLFAPNIYVLDyLNETQQLTPE 1007
Cdd:COG2373 1098 PGE-SWTLPLDLPGGLRPGTGSLTLSLssspPLDLAGLLRY----LLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGD 1171
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1008 IKSKAIGYLNTGYQRQLNYKHYDGSYSTFGeryGRNQGNTWLTAFVLKTFAQARAY-IFIDEAHITQALIWLSQRQKDNG 1086
Cdd:COG2373 1172 KDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPW 1248
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1087 cfrssgsllnnAIKGGVEDEVTLSAYITIALleipltvthpvvrnALfclesawktAQEGDHGSHVYTKALLAYAF---- 1162
Cdd:COG2373 1249 -----------EIEYDDAYRLAVRAYALYVL--------------AR---------AGKADLGDLRYLYDRRKDALspla 1294
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1163 --------ALAGNQDKRKEVLKSLNEEAVKKDNSVHWerpqkpkapvGHFYepqapSAEVEMTSYVLLAYLTAQPAPtse 1234
Cdd:COG2373 1295 kaqlaaalALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALALALLAELGPDA--- 1356
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1235 dlTSATNIVKWITKQQNaQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIqsSGTfssKFQVDNNNRLLLQQVSLP 1314
Cdd:COG2373 1357 --PLAPKLARWLAKALK-SGRWLSTQETAWALLALAAYARAAGASPDFTATLTL--DGK---TLPLTGRGPLARVTLPAA 1428
|
1290 1300 1310
....*....|....*....|....*....|...
gi 62088808 1315 EL-PGEYSMKVTGEGCVYLQTSLKYNILPEKEE 1346
Cdd:COG2373 1429 ELlAGPLTITNTGDGPLYYTLTLSGYPAEGPPP 1461
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
358-453 |
2.37e-35 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 130.06 E-value: 2.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 358 LSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNvMGTSLTVRVNYKDRS 437
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPG-NAASLSITVKTKDPD 79
|
90
....*....|....*.
gi 62088808 438 PCYGYQWVSEEHEEAH 453
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1382-1472 |
8.79e-34 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 125.37 E-value: 8.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 1382 SASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTE-VSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDY 1460
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 62088808 1461 YETDEFAIAEYN 1472
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
467-615 |
9.03e-34 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 127.08 E-value: 9.03e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 467 VHLEPMSHELPCGHTQTVQAHYILNGGTLLGlkklSFYYLIMAKGGIVRTGTHGllvkqedmkGHFSISIPVKSDIAPVA 546
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVGRGG---------VTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62088808 547 RLLIYAV---LPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLM 615
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
231-321 |
9.02e-31 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 116.22 E-value: 9.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 231 EFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHgedsqafcEKFSGQLNSHGCFYQ 310
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCF--------ESFSKELDKDGCGSA 72
|
90
....*....|.
gi 62088808 311 QVKTKVFQLKR 321
Cdd:pfam17791 73 SLSTEEFQLTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
137-229 |
2.71e-25 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 101.24 E-value: 2.71e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62088808 137 VFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQ 216
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 62088808 217 K-KSGGRTEHPFTV 229
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| Big_1 |
pfam02369 |
Bacterial Ig-like domain (group 1); This family consists of bacterial domains with an Ig-like ... |
376-431 |
2.79e-03 |
|
Bacterial Ig-like domain (group 1); This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity.
Pssm-ID: 460541 [Multi-domain] Cd Length: 64 Bit Score: 37.53 E-value: 2.79e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 62088808 376 QVRLVDGKGVPIPNK-VIFIRGNEANYYSNATTDEHGLVQFSInTTNVMGTSlTVRV 431
Cdd:pfam02369 10 TATVTDANGNPVPGAtVTFSASGGTLSASSGTTDANGQATVTL-TSTKAGTV-TVTA 64
|
|
| |
