N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 62087622  26 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGY 37

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 62087622  26 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGY 37

Superfamily II DNA and RNA helicase [Replication, recombination and repair];

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 62087622  25 NFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:COG0513   3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGR 40

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 62087622  26 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGY 37

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*
gi 62087622  28 DMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:cd17939   1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGR 35

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|...
gi 62087622  23 VDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAI 55
Cdd:cd18048  17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENAL 49

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20
                ....*....|....*....|....*
gi 62087622  31 LKESLLRGIYAYGFEKPSAIQQRAI 55
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETAL 25

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|
gi 62087622  26 FDDMNLKESLLRGIYAYGFEKPSAIQQRAI 55
Cdd:cd18047   3 FEELRLKPQLLQGVYAMGFNRPSKIQENAL 32

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 62087622  25 NFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGK 62
Cdd:cd17959   2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGR 39

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.

                        10        20        30
                ....*....|....*....|....*....|
gi 62087622  35 LLRGIYAYGFEKPSAIQQRAiIPCIKGKRN 64
Cdd:cd00268   1 LLKALKKLGFEKPTPIQAQA-IPLILSGRD 29

ATP-dependent RNA helicase DeaD; Provisional

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 62087622   21 EIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAI 55
Cdd:PRK11634   3 EFETTFADLGLKAPILEALNDLGYEKPSPIQAECI 37