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Conserved domains on  [gi|620597362|ref|NP_001278736|]
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prolyl endopeptidase FAP isoform 2 [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 12012129)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 89-448 1.33e-116

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 355.09  E-value: 1.33e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362   89 ILSNRTMLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGrENKIF 168
Cdd:pfam00930   9 LATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITSDG-SDGIF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  169 NGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRIFIIDTTYP 247
Cdd:pfam00930  88 NGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVELFVYDLASG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  248 AYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRTGWAggFFV 327
Cdd:pfam00930 168 KTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSDGWV--ELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  328 STPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRRNIYRISI 404
Cdd:pfam00930 236 QDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTERHLYSVSL 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 620597362  405 GSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 448
Cdd:pfam00930 313 DS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
528-731 9.72e-65

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 9.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  528 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 607
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  608 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 682
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 620597362  683 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 731
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 89-448 1.33e-116

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 355.09  E-value: 1.33e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362   89 ILSNRTMLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGrENKIF 168
Cdd:pfam00930   9 LATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITSDG-SDGIF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  169 NGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRIFIIDTTYP 247
Cdd:pfam00930  88 NGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVELFVYDLASG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  248 AYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRTGWAggFFV 327
Cdd:pfam00930 168 KTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSDGWV--ELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  328 STPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRRNIYRISI 404
Cdd:pfam00930 236 QDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTERHLYSVSL 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 620597362  405 GSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 448
Cdd:pfam00930 313 DS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
528-731 9.72e-65

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 9.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  528 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 607
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  608 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 682
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 620597362  683 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 731
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
489-731 1.07e-52

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.14  E-value: 1.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 489 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 568
Cdd:COG1506    6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 569 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 645
Cdd:COG1506   71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 646 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 725
Cdd:COG1506  149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                 ....*.
gi 620597362 726 FLKQCF 731
Cdd:COG1506  228 FLDRHL 233
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 106-203 3.53e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 106 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 181
Cdd:COG0823   14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                         90       100
                 ....*....|....*....|..
gi 620597362 182 atkYALWWSPNGKFLAYAEFND 203
Cdd:COG0823   78 ---ASPSWSPDGKRLAFVSRSD 96
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 89-448 1.33e-116

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 355.09  E-value: 1.33e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362   89 ILSNRTMLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGrENKIF 168
Cdd:pfam00930   9 LATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITSDG-SDGIF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  169 NGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRIFIIDTTYP 247
Cdd:pfam00930  88 NGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVELFVYDLASG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  248 AYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRTGWAggFFV 327
Cdd:pfam00930 168 KTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSDGWV--ELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  328 STPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRRNIYRISI 404
Cdd:pfam00930 236 QDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTERHLYSVSL 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 620597362  405 GSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 448
Cdd:pfam00930 313 DS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
528-731 9.72e-65

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 9.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  528 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 607
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  608 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 682
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 620597362  683 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 731
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
489-731 1.07e-52

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.14  E-value: 1.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 489 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 568
Cdd:COG1506    6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 569 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 645
Cdd:COG1506   71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 646 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 725
Cdd:COG1506  149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                 ....*.
gi 620597362 726 FLKQCF 731
Cdd:COG1506  228 FLDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
536-710 2.13e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 52.28  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 536 LAsKEGMVIALVD--GRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFI-EMGFIDEKRIAIWGWSYGGYVsSLALASG 612
Cdd:COG0412   52 LA-AAGYVVLAPDlyGRGGPGDDPDEARALMGALDPELLAADLRAALDWLkAQPEVDAGRVGVVGFCFGGGL-ALLAAAR 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 613 TGLFKCGIAvapvssweyyasvyterFMGLPTKDDNLEHYKNSTvmaraeyfrnVDYLLIHGTADDNVHFQNSAQIAKAL 692
Cdd:COG0412  130 GPDLAAAVS-----------------FYGGLPADDLLDLAARIK----------APVLLLYGEKDPLVPPEQVAALEAAL 182

                        170
                 ....*....|....*...
gi 620597362 693 VNAQVDFQAMWYSDQNHG 710
Cdd:COG0412  183 AAAGVDVELHVYPGAGHG 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 489-691 2.52e-07

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 52.61  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 489 DEITL---WYkmiLPPqfDRSKKYPLLIQVYGGPCSQSVRSVFAvnwiSYLAsKEGMVIALVDGRGT-AFQGDkllyavY 564
Cdd:COG1073   19 DGIKLagdLY---LPA--GASKKYPAVVVAHGNGGVKEQRALYA----QRLA-ELGFNVLAFDYRGYgESEGE------P 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 565 RKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGlFKCGIAVAPVSSWEYYASVYTERFMGLPT 644
Cdd:COG1073   83 REEGSPERRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPFTSLEDLAAQRAKEARGAYL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 620597362 645 KDDNLeHYKNSTVMARAEYFRNVDY--------LLIHGTADDNVHFQNSAQIAKA 691
Cdd:COG1073  162 PGVPY-LPNVRLASLLNDEFDPLAKiekisrplLFIHGEKDEAVPFYMSEDLYEA 215
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 486-695 1.52e-06

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 50.39  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 486 LEVDEITLWYKMILPPQFDRSKKYPLLIQVYGgpCSQSVRSVFAV-NWISyLASKEGMVIALVDGRGTA-------FQGD 557
Cdd:COG3509   30 FTVGGGTRTYRLYVPAGYDGGAPLPLVVALHG--CGGSAADFAAGtGLNA-LADREGFIVVYPEGTGRApgrcwnwFDGR 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 558 KllyavyRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSsweyyasvyte 637
Cdd:COG3509  107 D------QRRGRDDVAFIAALVDDLAARYGIDPKRVYVTGLSAGGAMAYRLACEYPDVFA---AVAPVA----------- 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 620597362 638 rfmGLPTKDDNlehyknstvMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA 695
Cdd:COG3509  167 ---GLPYGAAS---------DAACAPGRPVPVLVIHGTADPTVPYAGAEETLAQWAAL 212
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 106-203 3.53e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 106 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 181
Cdd:COG0823   14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                         90       100
                 ....*....|....*....|..
gi 620597362 182 atkYALWWSPNGKFLAYAEFND 203
Cdd:COG0823   78 ---ASPSWSPDGKRLAFVSRSD 96
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
504-732 3.71e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 45.25  E-value: 3.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 504 DRSKKYPLLIQVYGG-PCSQSVRSVFAVnwISYLASKEGMVIALVDgrgtafqgdkllyavYRKL-------GVYEVEDQ 575
Cdd:COG0657    8 GAKGPLPVVVYFHGGgWVSGSKDTHDPL--ARRLAARAGAAVVSVD---------------YRLApehpfpaALEDAYAA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 576 ITAVRKFIEMGFIDEKRIAIWGWSYGGY-VSSLALA---SGTGLFKCGIAVAPVSSWEyyASVYTERFMGL-PTkddnle 650
Cdd:COG0657   71 LRWLRANAAELGIDPDRIAVAGDSAGGHlAAALALRardRGGPRPAAQVLIYPVLDLT--ASPLRADLAGLpPT------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 651 hyknstvmaraeyfrnvdyLLIHGTADDNVhfQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLS----TNHLYTHMTHF 726
Cdd:COG0657  143 -------------------LIVTGEADPLV--DESEALAAALRAAGVPVELHVYPGGGHGFGLLAglpeARAALAEIAAF 201


                 ....*.
gi 620597362 727 LKQCFS 732
Cdd:COG0657  202 LRRALA 207
YpfH COG0400
Predicted esterase [General function prediction only];
561-712 9.20e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.13  E-value: 9.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 561 YAVYRKLGVYEVEDQITAVRKFIEmgFIDE---------KRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPvssweyy 631
Cdd:COG0400   52 FDLSFLEGREDEEGLAAAAEALAA--FIDElearygidpERIVLAGFSQGAAMALSLALRRPELLAGVVALSG------- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 632 asvyterfmGLPTKDDnlehyknstVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYsDQNHGL 711
Cdd:COG0400  123 ---------YLPGEEA---------LPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREY-PGGHEI 183


                 .
gi 620597362 712 S 712
Cdd:COG0400  184 S 184
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
504-631 1.74e-04

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 43.87  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362  504 DRSKKYPLL--IQVYGGPCSQSVRSVFAVNWISYLASkeGMVIALVDGRGTAFQGdkllyavyrklGVYEVE--DQITAV 579
Cdd:pfam02129  14 KTGGPVPALltRSPYGARRDGASDLALAHPEWEFAAR--GYAVVYQDVRGTGGSE-----------GVFTVGgpQEAADG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 620597362  580 RKFIEmgFIDEK-----RIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYY 631
Cdd:pfam02129  81 KDVID--WLAGQpwcngKVGMTGISYLGTTQLAAAATGPPGLKAIAPESGISDLYDY 135
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
499-700 8.60e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 42.15  E-value: 8.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 499 LPPQFD-RSKKYPLLIQVYGGPCSQS--VRSVFAVNWI-SYLASKEG--MVIALVDGRGTAFQGdkllyAVYRKLGVYE- 571
Cdd:COG2382  101 LPPGYDnPGKKYPVLYLLDGGGGDEQdwFDQGRLPTILdNLIAAGKIppMIVVMPDGGDGGDRG-----TEGPGNDAFEr 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 572 --VEDQITAVRKfiEMGFIDE-KRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSSweyyasvyterfmGLPTKDDN 648
Cdd:COG2382  176 flAEELIPFVEK--NYRVSADpEHRAIAGLSMGGLAALYAALRHPDLFG---YVGSFSG-------------SFWWPPGD 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 620597362 649 LEHYKNSTVMARAEYFRNVDYLLIHGTADDNVhfQNSAQIAKALVNAQVDFQ 700
Cdd:COG2382  238 ADRGGWAELLAAGAPKKPLRFYLDVGTEDDLL--EANRALAAALKAKGYDVE 287
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 570-697 2.70e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 620597362 570 YEVEDQITAVRKFIEmgFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVssWEYYASVYTERFMGLPTKDDNL 649
Cdd:COG0596   70 YTLDDLADDLAALLD--ALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV--LAALAEPLRRPGLAPEALAALL 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 620597362 650 EHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQV 697
Cdd:COG0596  146 RALARTDLRERLARIT-VPTLVIWGEKDPIVPPALARRLAELLPNAEL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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