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Conserved domains on  [gi|61966781|ref|NP_001013685|]
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putative peptidyl-tRNA hydrolase PTRHD1 [Homo sapiens]

Protein Classification

aminoacyl-tRNA hydrolase( domain architecture ID 141542)

aminoacyl-tRNA hydrolase catalyzes the hydolysis of an N-substituted aminoacyl-tRNA to yield the N-substituted amino acid and tRNA to ensure the recycling of peptidyl-tRNAs produced when translation is aborted

CATH:  3.40.50.1470
EC:  3.1.1.29
Gene Ontology:  GO:0004045|GO:0006412
PubMed:  16849786|24768774
SCOP:  4000577

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTH2_family super family cl19212
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA ...
 25-139 9.68e-48

Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes.


The actual alignment was detected with superfamily member cd02429:

Pssm-ID: 473151  Cd Length: 116  Bit Score: 149.86  E-value: 9.68e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781  25 LVQYLVLRKDLSQApFSWPAGALVAQACHAATAALHTHRDHPHTA--AYLQELGRMRKVVLEAPDETTLKELAETLQQKN 102
Cdd:cd02429   1 LVQYVILRRDLQTK-LSWPLGAVIAQACHAAVAVIHLFRSDPDTKkyAYLSNLDNMHKVVLEVPDEAALKNLSSKLTENS 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 61966781 103 IDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:cd02429  80 IKHKLWIEQPENIPTCIALKPYPKETVASYLKKLKLL 116
 
Name Accession Description Interval E-value
PTH2_like cd02429
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA ...
 25-139 9.68e-48

Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. There is no functional information for this eukaryote-specific subgroup.


Pssm-ID: 239107  Cd Length: 116  Bit Score: 149.86  E-value: 9.68e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781  25 LVQYLVLRKDLSQApFSWPAGALVAQACHAATAALHTHRDHPHTA--AYLQELGRMRKVVLEAPDETTLKELAETLQQKN 102
Cdd:cd02429   1 LVQYVILRRDLQTK-LSWPLGAVIAQACHAAVAVIHLFRSDPDTKkyAYLSNLDNMHKVVLEVPDEAALKNLSSKLTENS 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 61966781 103 IDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:cd02429  80 IKHKLWIEQPENIPTCIALKPYPKETVASYLKKLKLL 116
PTH2 pfam01981
Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from ...
 25-139 4.75e-22

Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.


Pssm-ID: 460403  Cd Length: 115  Bit Score: 84.42  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781    25 LVQYLVLRKDLSqapfsWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNID 104
Cdd:pfam01981   1 LKQVLVVRTDLK-----MSKGKIAAQCAHAAVAAYEKALKPNPELLREWEREGQKKVVLKVPSEEELLELAEKAKSLGLP 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 61966781   105 HMLWLE------QPeNIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:pfam01981  76 HALIRDagrtqiAP-GTPTVLAIGPAPKELVDKITGHLKLL 115
 
Name Accession Description Interval E-value
PTH2_like cd02429
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA ...
 25-139 9.68e-48

Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes. There is no functional information for this eukaryote-specific subgroup.


Pssm-ID: 239107  Cd Length: 116  Bit Score: 149.86  E-value: 9.68e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781  25 LVQYLVLRKDLSQApFSWPAGALVAQACHAATAALHTHRDHPHTA--AYLQELGRMRKVVLEAPDETTLKELAETLQQKN 102
Cdd:cd02429   1 LVQYVILRRDLQTK-LSWPLGAVIAQACHAAVAVIHLFRSDPDTKkyAYLSNLDNMHKVVLEVPDEAALKNLSSKLTENS 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 61966781 103 IDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:cd02429  80 IKHKLWIEQPENIPTCIALKPYPKETVASYLKKLKLL 116
PTH2_family cd02407
Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA ...
 25-139 1.23e-28

Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in bacteria and eukaryotes and Pth2 present in archaea and eukaryotes.


Pssm-ID: 239091  Cd Length: 115  Bit Score: 101.08  E-value: 1.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781  25 LVQYLVLRKDLSqapfsWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNID 104
Cdd:cd02407   1 YKMVIVVRNDLK-----MGKGKIAAQCAHAALAAYKKAMKDPPTLLRAWELEGQKKVVLKVPSEEELLELAKKAKELGLP 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61966781 105 HMLWLE-----QPENIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:cd02407  76 HSLIQDagrtqIPPGTPTVLAIGPAPKEKVDKVTGHLKLL 115
PTH2 pfam01981
Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from ...
 25-139 4.75e-22

Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.


Pssm-ID: 460403  Cd Length: 115  Bit Score: 84.42  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966781    25 LVQYLVLRKDLSqapfsWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNID 104
Cdd:pfam01981   1 LKQVLVVRTDLK-----MSKGKIAAQCAHAAVAAYEKALKPNPELLREWEREGQKKVVLKVPSEEELLELAEKAKSLGLP 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 61966781   105 HMLWLE------QPeNIATCIALRPYPKEEVGQYLKKFRLF 139
Cdd:pfam01981  76 HALIRDagrtqiAP-GTPTVLAIGPAPKELVDKITGHLKLL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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