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Conserved domains on  [gi|61966761|ref|NP_001013675|]
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leucine-rich repeat-containing protein 26 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-201 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPPgAFAGAGALQRLDLRENGLHSVHvRAFWGLGALQLLDLSANQLEALaPGTFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 121 SGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61966761 159 ePAALGALPLLRSLSLQDNELAALaPGLLGRLPALDALHLRGN 201
Cdd:COG4886 198 -PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-242 4.15e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 4.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761    174 LQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-201 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPPgAFAGAGALQRLDLRENGLHSVHvRAFWGLGALQLLDLSANQLEALaPGTFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 121 SGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61966761 159 ePAALGALPLLRSLSLQDNELAALaPGLLGRLPALDALHLRGN 201
Cdd:COG4886 198 -PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
97-155 2.08e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 2.08e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761    97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 97-218 1.78e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLR-SLSLQ 175
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRaSFNFT 523

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 61966761  176 DNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPL-----CAWLRR 218
Cdd:PLN03150 524 DNAGLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFLvicamCWWKRR 571
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-202 1.57e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  80 HNRVRALPPgaFAGAGALQRLDLREN------GLHsvhvrafwGLGALQLLDLSaNQleALAPG---TFAP------LRA 144
Cdd:cd21340  55 NNQIEKIEN--LENLVNLKKLYLGGNrisvveGLE--------NLTNLEELHIE-NQ--RLPPGeklTFDPrslaalSNS 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761 145 LRNLSLAGNRLARLEPaaLGALPLLRSLSLQDNELAALAP--GLLGRLPALDALHLRGNP 202
Cdd:cd21340 122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-242 4.15e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 4.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761    174 LQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-201 1.16e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPPgAFAGAGALQRLDLRENGLHSVHvRAFWGLGALQLLDLSANQLEALaPGTFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 121 SGNQLTDLPE-ELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61966761 159 ePAALGALPLLRSLSLQDNELAALaPGLLGRLPALDALHLRGN 201
Cdd:COG4886 198 -PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-201 8.53e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 8.53e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  90 AFAGAGALQRLDLRENGLHSVhVRAFWGLGALQLLDLSANQLEALaPGTFAPLRALRNLSLAGNRLARLePAALGALPLL 169
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNL 184

                        90       100       110
                ....*....|....*....|....*....|..
gi 61966761 170 RSLSLQDNELAALaPGLLGRLPALDALHLRGN 201
Cdd:COG4886 185 KELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-202 4.64e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 4.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  85 ALPPGAFAGAGALQRLDLRENglhsvhvRAFWGLGALQLLDLSANQLEALaPGTFAPLRALRNLSLAGNRLARLePAALG 164
Cdd:COG4886  86 LLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLG 156

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 61966761 165 ALPLLRSLSLQDNELAALaPGLLGRLPALDALHLRGNP 202
Cdd:COG4886 157 NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
97-155 2.08e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 2.08e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761    97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-201 1.84e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 1.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPPgAFAGAGALQRLDLRENGLHSVHvRAFWGLGALQLLDLSANQLEALApgTFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL 265

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61966761 159 EPaaLGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:COG4886 266 PP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
79-131 1.19e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 61966761    79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
121-179 2.71e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 2.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761   121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-188 8.92e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 8.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPPgAFAGAGALQRLDLRENGLHSVhvRAFWGLGALQLLDLSANQLEALAPgtFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 213 SGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL 287

                        90       100       110
                ....*....|....*....|....*....|
gi 61966761 159 EPAALGALPLLRSLSLQDNELAALAPGLLG 188
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILL 317
LRR_8 pfam13855
Leucine rich repeat;
143-202 1.01e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.01e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   143 RALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN03150 PLN03150
hypothetical protein; Provisional
 97-218 1.78e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 58.67  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLR-SLSLQ 175
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRaSFNFT 523

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 61966761  176 DNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPL-----CAWLRR 218
Cdd:PLN03150 524 DNAGLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFLvicamCWWKRR 571
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-201 3.13e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 3.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   91 FAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLR 170
Cdd:PLN00113 471 SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLS 550

                         90       100       110
                 ....*....|....*....|....*....|.
gi 61966761  171 SLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 551 QLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-202 1.57e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  80 HNRVRALPPgaFAGAGALQRLDLREN------GLHsvhvrafwGLGALQLLDLSaNQleALAPG---TFAP------LRA 144
Cdd:cd21340  55 NNQIEKIEN--LENLVNLKKLYLGGNrisvveGLE--------NLTNLEELHIE-NQ--RLPPGeklTFDPrslaalSNS 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761 145 LRNLSLAGNRLARLEPaaLGALPLLRSLSLQDNELAALAP--GLLGRLPALDALHLRGNP 202
Cdd:cd21340 122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-221 3.68e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   80 HNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159
Cdd:PLN00113 484 RNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEI 563

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61966761  160 PAALGALPLLRSLSLQDNELAALAPGlLGRLPALDALHLRGNPWGCG----CALRPlCAWLRRHPL 221
Cdd:PLN00113 564 PKNLGNVESLVQVNISHNHLHGSLPS-TGAFLAINASAVAGNIDLCGgdttSGLPP-CKRVRKTPS 627
PLN03150 PLN03150
hypothetical protein; Provisional
 124-201 1.47e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 1.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61966761  124 LDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-201 3.06e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRaLRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKR-LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         90       100
                 ....*....|....*....|..
gi 61966761  180 AALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHN 533
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-201 1.61e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   86 LPPGAFAGAGALQRLDLRENGLHSVHVRAFwgLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA 165
Cdd:PLN00113 109 IPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTN 186

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 61966761  166 LPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 187 LTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-201 1.87e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDAL 196
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313


                 ....*
gi 61966761  197 HLRGN 201
Cdd:PLN00113 314 HLFSN 318
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-242 4.15e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 45.46  E-value: 4.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61966761    174 LQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPL 70
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-201 4.71e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 4.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   88 PGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALP 167
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLP 332

                         90       100       110
                 ....*....|....*....|....*....|....
gi 61966761  168 LLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 333 RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTN 366
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-201 9.66e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 9.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  114 AFWGLGALQLLDLSANQLEALAPGT-FAPLRALRNLSLAGNRLArlEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSS 165


                 ....*....
gi 61966761  193 LDALHLRGN 201
Cdd:PLN00113 166 LKVLDLGGN 174
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-198 1.12e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD 176
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                         90       100
                 ....*....|....*....|..
gi 61966761  177 NELAALAPGLLGRLPALDALHL 198
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
116-202 1.64e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761 116 WGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRlarlepaALGALPLLRSLSLQDNELAALaPGLLGRLPALDA 195
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKE 140


                ....*..
gi 61966761 196 LHLRGNP 202
Cdd:COG4886 141 LDLSNNQ 147
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 94-157 2.20e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 2.20e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61966761  94 AGALQRLDLRENGLHSVhvRAFWGLGALQLLDLSANQLEALAP--GTFAPLRALRNLSLAGNRLAR 157
Cdd:cd21340 119 SNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK 182
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 88-201 2.24e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  88 PGAFAGAGALQ------RLDLRENGLHSVHVRA----FWGLGALQLLDLSANQL-----EALAPGtFAPLRALRNLSLAG 152
Cdd:COG5238 251 EGVIALAEALKnnttveTLYLSGNQIGAEGAIAlakaLQGNTTLTSLDLSVNRIgdegaIALAEG-LQGNKTLHTLNLAY 329

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61966761 153 NRL----ARLEPAALGALPLLRSLSLQDNEL-----AALAPGLLGRlPALDALHLRGN 201
Cdd:COG5238 330 NGIgaqgAIALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGN-TTLRELNLGKN 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 124-201 2.26e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 2.26e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61966761 124 LDLSANQLEALapGTFAPLRALRNLSLAGNRLARLEpaALGALPLLRSLSLQDNELAALAPglLGRLPALDALHLRGN 201
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
LRR_9 pfam14580
Leucine-rich repeat;
124-202 2.56e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   124 LDLSANQLEALapGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDN---ELAALAPglLGRLPALDALHLRG 200
Cdd:pfam14580  47 IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNnlqELGDLDP--LASLKKLTFLSLLR 122


                  ..
gi 61966761   201 NP 202
Cdd:pfam14580 123 NP 124
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 97-253 8.30e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 8.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  97 LQRLDLRENGLHSVHVRAfwgLG-------ALQLLDLSANQLEALAPGTfaplralrnlslagnrlaRLEPAALGALPLL 169
Cdd:cd00116  25 LQVLRLEGNTLGEEAAKA---LAsalrpqpSLKELCLSLNETGRIPRGL------------------QSLLQGLTKGCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761 170 RSLSLQDNELAALAPGLLGRL---PALDALHLRGNPWGCGcALRPLCAWLRRHPLPASEaetvLCVWPGRLTLSPLTAFS 246
Cdd:cd00116  84 QELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDR-GLRLLAKGLKDLPPALEK----LVLGRNRLEGASCEALA 158


                ....*..
gi 61966761 247 DAAFSHC 253
Cdd:cd00116 159 KALRANR 165
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-188 9.78e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 9.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  79 DHNRVRALPpgAFAGAGALQRLDLRENGLHSVHVRAfwGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARL 158
Cdd:COG4886 236 SNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        90       100       110
                ....*....|....*....|....*....|
gi 61966761 159 EPAALGALPLLRSLSLQDNELAALAPGLLG 188
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 145-177 1.13e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.13e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 61966761   145 LRNLSLAGNRLARLEPaaLGALPLLRSLSLQDN 177
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-183 1.20e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761  89 GAFAGAGALQRLDLRENGLHS----VHVRAFWGLGALQLLDLSANQLE-----ALApGTFAPLRALRNLSLAGNRL---- 155
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLKSLEVLNLGDNNLtdag 237

                        90       100
                ....*....|....*....|....*....
gi 61966761 156 -ARLEPAALGALPLLRSLSLQDNELAALA 183
Cdd:cd00116 238 aAALASALLSPNISLLTLSLSCNDITDDG 266
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-201 1.67e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   97 LQRLDLRENGLHSvHVRAFWG-LGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQ 175
Cdd:PLN00113 166 LKVLDLGGNVLVG-KIPNSLTnLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                         90       100
                 ....*....|....*....|....*.
gi 61966761  176 DNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 245 YNNLTGPIPSSLGNLKNLQYLFLYQN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-201 3.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   88 PGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALP 167
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACR 404

                         90       100       110
                 ....*....|....*....|....*....|....
gi 61966761  168 LLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 405 SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNN 438
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-201 5.86e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 5.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966761   88 PGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALP 167
Cdd:PLN00113 229 PYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQ 308

                         90       100       110
                 ....*....|....*....|....*....|....
gi 61966761  168 LLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
Cdd:PLN00113 309 NLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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