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Conserved domains on  [gi|61806717|ref|NP_001013588|]
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osteoglycin, paralog a precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-244 2.61e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 118 YLYARYNKIKKITAkDFGDIVTLKRIDFTGNIISEIEDgAFAKLTMLEELSLAENQLAKLPM----LPaKLTAFNANHNK 193
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEplanLT-NLETLDLSNNQ 239

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61806717 194 LKTkgvkANAFKKLNKLLHLYLAHNELEAVPLIPE--TVRTLHLQNNNISTVS 244
Cdd:COG4886 240 LTD----LPELGNLTNLEELDLSNNQLTDLPPLANltNLKTLDLSNNQLTDLK 288
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-244 2.61e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 118 YLYARYNKIKKITAkDFGDIVTLKRIDFTGNIISEIEDgAFAKLTMLEELSLAENQLAKLPM----LPaKLTAFNANHNK 193
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEplanLT-NLETLDLSNNQ 239

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61806717 194 LKTkgvkANAFKKLNKLLHLYLAHNELEAVPLIPE--TVRTLHLQNNNISTVS 244
Cdd:COG4886 240 LTD----LPELGNLTNLEELDLSNNQLTDLPPLANltNLKTLDLSNNQLTDLK 288
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
103-272 9.49e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.24  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  103 DPDMTSVPTLPKETNYLYARYNKIKKITAKDFGdivtlkridftgniiseiedgafakltmLEELSLAENQLAKLPMLPA 182
Cdd:PRK15387 311 DNQLASLPALPSELCKLWAYNNQLTSLPTLPSG----------------------------LQELSVSDNQLASLPTLPS 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  183 KLTAFNANHNKLKTKGVKANAFKKL--------------NKLLHLYLAHNELEAVPLIPETVRTLHLQNNNISTVSTDTF 248
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLI 442

                        170       180
                 ....*....|....*....|....
gi 61806717  249 CKSNDTyyirpnmnEIRMDGNPIN 272
Cdd:PRK15387 443 HLSSET--------TVNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
139-220 1.92e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717   139 TLKRIDFTGNIISEIEDGAFAKLTMLEELSLAENQLaklpmlpakltafnanhnklktKGVKANAFKKLNKLLHLYLAHN 218
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 61806717   219 EL 220
Cdd:pfam13855  60 RL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 156-249 1.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 156 GAFAKLTMLEELSLAENQL------AKLPMLPA--KLTAFNANHNKLKTKGVK--ANAFKKLNKLLHLYLAHNEL----- 220
Cdd:cd00116 159 KALRANRDLKELNLANNGIgdagirALAEGLKAncNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLtdaga 238

                        90       100       110
                ....*....|....*....|....*....|...
gi 61806717 221 ----EAVPLIPETVRTLHLQNNNISTVSTDTFC 249
Cdd:cd00116 239 aalaSALLSPNISLLTLSLSCNDITDDGAKDLA 271
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-244 2.61e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 118 YLYARYNKIKKITAkDFGDIVTLKRIDFTGNIISEIEDgAFAKLTMLEELSLAENQLAKLPM----LPaKLTAFNANHNK 193
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEplanLT-NLETLDLSNNQ 239

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61806717 194 LKTkgvkANAFKKLNKLLHLYLAHNELEAVPLIPE--TVRTLHLQNNNISTVS 244
Cdd:COG4886 240 LTD----LPELGNLTNLEELDLSNNQLTDLPPLANltNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-243 3.95e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 3.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 118 YLYARYNKIKKItAKDFGDIVTLKRIDFTGNIISEIEDgAFAKLTMLEELSLAENQLAKLPMLPAKLTA---FNANHNKL 194
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNlkeLDLSNNQI 194

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 61806717 195 KTKGvkaNAFKKLNKLLHLYLAHNELEAvplIPETV------RTLHLQNNNISTV 243
Cdd:COG4886 195 TDLP---EPLGNLTNLEELDLSGNQLTD---LPEPLanltnlETLDLSNNQLTDL 243
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
103-272 9.49e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.24  E-value: 9.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  103 DPDMTSVPTLPKETNYLYARYNKIKKITAKDFGdivtlkridftgniiseiedgafakltmLEELSLAENQLAKLPMLPA 182
Cdd:PRK15387 311 DNQLASLPALPSELCKLWAYNNQLTSLPTLPSG----------------------------LQELSVSDNQLASLPTLPS 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  183 KLTAFNANHNKLKTKGVKANAFKKL--------------NKLLHLYLAHNELEAVPLIPETVRTLHLQNNNISTVSTDTF 248
Cdd:PRK15387 363 ELYKLWAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLI 442

                        170       180
                 ....*....|....*....|....
gi 61806717  249 CKSNDTyyirpnmnEIRMDGNPIN 272
Cdd:PRK15387 443 HLSSET--------TVNLEGNPLS 458
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
118-275 6.99e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 6.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 118 YLYARYNKIKKITAkDFGDIVTLKRIDFTGNIISEIEDgaFAKLTMLEELSLAENQLAKLPMLP--AKLTAFNANHNKLK 195
Cdd:COG4886 209 ELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLT 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 196 TKGVKANAFKKLNKLLHLYLAHNELEAVPLIPETVRTLHLQNNNISTVSTDTFCKSNDTYYIRPNMNEIRMDGNPINLGQ 275
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-244 1.77e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 123 YNKIKKITAKDFGDIVTLKRIDFTGNiiseiedGAFAKLTMLEELSLAENQLAKLPMLPA---KLTAFNANHNKLKTKGv 199
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnltNLKELDLSNNQLTDLP- 152

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61806717 200 kaNAFKKLNKLLHLYLAHNELEAVP--LIP-ETVRTLHLQNNNISTVS 244
Cdd:COG4886 153 --EPLGNLTNLKSLDLSNNQLTDLPeeLGNlTNLKELDLSNNQITDLP 198
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
82-243 2.84e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.62  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717   82 SDLPTCLLCVCLTGSVyceeVDPDMTSVPTLPKETNYLYARYNKIKKITAKDFGdivtLKRIDFTGNIISEIE--DGAFA 159
Cdd:PRK15387 214 TTLPDCLPAHITTLVI----PDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPG----LLELSIFSNPLTHLPalPSGLC 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  160 KLTM--------------LEELSLAENQLAKLPMLPAKLTAFNANHNKLKTKGVKANAFKKLNkllhlyLAHNELEAVPL 225
Cdd:PRK15387 286 KLWIfgnqltslpvlppgLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQELS------VSDNQLASLPT 359

                        170
                 ....*....|....*...
gi 61806717  226 IPETVRTLHLQNNNISTV 243
Cdd:PRK15387 360 LPSELYKLWAYNNRLTSL 377
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
103-233 1.43e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 46.31  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717  103 DPDMTSVPTLPKETNYLYARYNKIKKITAKDFGdivtLKRIDFTGNIISEIEdgafAKLTMLEELSLAENQLAKLPMLPA 182
Cdd:PRK15387 351 DNQLASLPTLPSELYKLWAYNNRLTSLPALPSG----LKELIVSGNRLTSLP----VLPSELKELMVSGNRLTSLPMLPS 422

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 61806717  183 KLTAFNANHNKLKtkgvkanafKKLNKLLHLYLAHN-ELEAVPLIPETVRTL 233
Cdd:PRK15387 423 GLLSLSVYRNQLT---------RLPESLIHLSSETTvNLEGNPLSERTLQAL 465
LRR_8 pfam13855
Leucine rich repeat;
139-220 1.92e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717   139 TLKRIDFTGNIISEIEDGAFAKLTMLEELSLAENQLaklpmlpakltafnanhnklktKGVKANAFKKLNKLLHLYLAHN 218
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 61806717   219 EL 220
Cdd:pfam13855  60 RL 61
LRR_8 pfam13855
Leucine rich repeat;
118-174 2.04e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 61806717   118 YLYARYNKIKKITAKDFGDIVTLKRIDFTGNIISEIEDGAFAKLTMLEELSLAENQL 174
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 156-249 1.94e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 156 GAFAKLTMLEELSLAENQL------AKLPMLPA--KLTAFNANHNKLKTKGVK--ANAFKKLNKLLHLYLAHNEL----- 220
Cdd:cd00116 159 KALRANRDLKELNLANNGIgdagirALAEGLKAncNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLtdaga 238

                        90       100       110
                ....*....|....*....|....*....|...
gi 61806717 221 ----EAVPLIPETVRTLHLQNNNISTVSTDTFC 249
Cdd:cd00116 239 aalaSALLSPNISLLTLSLSCNDITDDGAKDLA 271
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 139-241 5.07e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.23  E-value: 5.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806717 139 TLKRIDFTGNIISEIEDGAFAKL----TMLEELSLAENQ--------LAKLPMLPAKLTAFNANHNKLKTKGVK--ANAF 204
Cdd:COG5238 265 TVETLYLSGNQIGAEGAIALAKAlqgnTTLTSLDLSVNRigdegaiaLAEGLQGNKTLHTLNLAYNGIGAQGAIalAKAL 344

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61806717 205 KKLNKLLHLYLAHNELE---AVPLI-----PETVRTLHLQNNNIS 241
Cdd:COG5238 345 QENTTLHSLDLSDNQIGdegAIALAkylegNTTLRELNLGKNNIG 389
LRR_8 pfam13855
Leucine rich repeat;
183-240 6.93e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61806717   183 KLTAFNANHNKLKtkGVKANAFKKLNKLLHLYLAHNELEAVPliPET------VRTLHLQNNNI 240
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLS--PGAfsglpsLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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