Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 61743930   603 YECDECGKTFIRHDHLTKHKKIH 625
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930    83 KQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNP---STDVVTLDHVTHSVFQHLLEFLYTSEfFVYKYEIPLVL 159
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQEsesSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLL 84

                          90
                  ....*....|....
gi 61743930   160 EAAKFLDIIDAVKL 173
Cdd:pfam00651  85 AAADKLQIPSLVDK 98

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 61743930   603 YECDECGKTFIRHDHLTKHKKIH 625
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  87 FCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAK 163
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSsgmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                ..
gi 61743930 164 FL 165
Cdd:cd18186  81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  71 KNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFV 150
Cdd:cd18221   3 KVMLDRLNEQRE-LDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMV 81

                        90       100
                ....*....|....*....|....*....
gi 61743930 151 Y-KYEIPLVLEAAKFLDIIDAVKLLNNEN 178
Cdd:cd18221  82 QgEEEANDVWKAAEYLQMQEAIKALEFRN 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930     89 DLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPS---TDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKFL 165
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 61743930    166 DIIDAVKL 173
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  72 NLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYF-HACLSKNPSTDVVTL-DHVTHSVFQHLLEFLYTSEFF 149
Cdd:cd18278  17 NILLCLNDQR-KQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTENDLVVSLpEEVTARGFGPLLQFAYTAKLL 95

                        90
                ....*....|....*.
gi 61743930 150 VYKYEIPLVLEAAKFL 165
Cdd:cd18278  96 LSRENIQEVIRCAEFL 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLY 144
Cdd:cd18256   2 KHASLILAQLNKLR-GQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDIFHILLDFIY 80

                        90       100
                ....*....|....*....|....*....
gi 61743930 145 TSEFFVYKYEIPLVLEAAKFLDIIDAVKL 173
Cdd:cd18256  81 TGVVEVTVSNVQELLVAADMLQLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  88 CDLLIIVEGKEFSAHKVVVAVGSSYFHACLS-KNPSTDVVTL-DHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKFL 165
Cdd:cd18955   2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFL 81

                ..
gi 61743930 166 DI 167
Cdd:cd18955  82 GV 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  88 CDLLIIVEGKEFSAHKVVVAVGSSYFHACL---SKNPSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLVLEAAKF 164
Cdd:cd18264  29 CDVVLEAEGNEFPAHRSLLACSSDYFRALFkdyTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASY 108

                        90       100
                ....*....|....*....|
gi 61743930 165 LDIIDAVKLLNN---ENVAP 181
Cdd:cd18264 109 LQVTEAIGLCSQyliNNLAP 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTD---VVTLDHVTHSVFQHLLEFLY 144
Cdd:cd18326   7 DHSSDILSSLNEQRT-QGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDqqnVYEIDFVSAEALTALLDFAY 85

                        90       100
                ....*....|....*....|...
gi 61743930 145 TSEFFVYKYEIPLVLEAAKFLDI 167
Cdd:cd18326  86 TATLTVSTSNVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRqKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPS---TDVVTLDHVTHSVFQHLLEFLY 144
Cdd:cd18235   3 QHTQKAFDVMNELR-KQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSesrANRVTLQDVDGKALLLLIDYVY 81

                        90       100
                ....*....|....*....|....*
gi 61743930 145 TSEFFVYKYEIPLVLEAAKFLDIID 169
Cdd:cd18235  82 TAEIQVTEENVQVLLPAANLLQLTD 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  73 LLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEFF 149
Cdd:cd18255   5 LLQGLNALRAKG-QLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTggmRESSQDEIELKGVSAKGLKHILDFAYTSELT 83

                        90       100
                ....*....|....*....|....
gi 61743930 150 VYKYEIPLVLEAAKFLDIIDAVKL 173
Cdd:cd18255  84 LDLDCIQDVLGAAVHLQMLPVVEL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  72 NLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSK--NPSTDVVTLDHVTHSVFQHLLEFLYTSEFF 149
Cdd:cd18209   4 SLLSALNEERLKG-QLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEkeNESQSVFQLDFCEPDAFENVLNYIYSSSLF 82

                        90
                ....*....|....*...
gi 61743930 150 VYKYEIPLVLEAAKFLDI 167
Cdd:cd18209  83 VEKSSLAAVQELGYSLGI 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  82 QKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKN---PSTDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIPLV 158
Cdd:cd18237  16 RKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmteSKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSL 95

                ....*....
gi 61743930 159 LEAAKFLDI 167
Cdd:cd18237  96 LDAANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  77 LNDDRQKQPSFCDL-LIIVEGKE-FSAHKVVVAVGSSYFHACLSKNPSTDVV--TLDHVTHSVFQHLLEFLYTSEFFVYK 152
Cdd:cd18231   4 LNEQRLFQPDLCDVdIVLVRQRStFPAHKGVLAAYSQFFHSLFTQNKQLQRVelSLEALTSQGLQQILNFIYTSKLLVNS 83

                        90
                ....*....|....*..
gi 61743930 153 YEIPLVLEAAKFLDIID 169
Cdd:cd18231  84 CNVQDVLNAAAVLQMND 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61743930  75 KYLNDdrqkqPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYT 145
Cdd:cd18297   5 HYVNN-----PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSsgsTEAQTPVIEIPDIRYDIFQLMMQYLYT 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  69 YNKNLLKYLNddRQKQPSF-CDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSE 147
Cdd:cd18260   1 YGANLLEGLN--RMRQERFlCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVELNDISPLGLATVITYAYTGK 78

                        90       100
                ....*....|....*....|....*.
gi 61743930 148 FFVYKYEIPLVLEAAKFLDIIDAVKL 173
Cdd:cd18260  79 LTLSLYTIGSTISAASYLQIHALVKM 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  72 NLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTSEF 148
Cdd:cd18250   7 HLLRGLSELRAER-KFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAgelRESRADRVVLHGVSAEILGLLLDFSYTGRV 85

                        90
                ....*....|....*..
gi 61743930 149 FVYKYEIPLVLEAAKFL 165
Cdd:cd18250  86 TVTQDNVEALLRAADLF 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRQKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHS----VFQHLLEFL 143
Cdd:cd18207   8 QHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTisskVFGDILDFA 87

                        90       100
                ....*....|....*....|..
gi 61743930 144 YTSEFFVYKYEIPLVLEAAKFL 165
Cdd:cd18207  88 YTSRIVVRLESFPELMTAAKFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  69 YNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYF-HACLSKNpSTDVVTLDHVTHSVFQHLLEFLYTSE 147
Cdd:cd18227   8 FSSTILQKLNQQRQ-QGQLCDISVVVQGHLFRAHKAVLAASSPYFcDQVLLKN-SRRIVLPDVMNPRVFENILLSCYTGR 85

                        90       100
                ....*....|....*....|
gi 61743930 148 FFVYKYEIPLVLEAAKFLDI 167
Cdd:cd18227  86 LVLPAPEIVSYLTAASFLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  69 YNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSEF 148
Cdd:cd18290  10 FGNSILECLNEQRL-QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILSFCYTGRL 88

                        90
                ....*....|....*....
gi 61743930 149 FVYKYEIPLVLEAAKFLDI 167
Cdd:cd18290  89 SMNVGDQFLLMYTAGFLQI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61743930  76 YLNDDrqkqpsFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLS---KNPSTDVVTLDHVTHSVFQHLLEFLYTS 146
Cdd:cd18287  17 FLNEE------YSDVTFVVEEKRFPAHRVILAARSEYFRALLYggmRESQQSEIELKDTNAEAFKALLKYIYTG 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  73 LLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNP--STDVVTLDHVTHSVFQHLLEFLYTSEFFV 150
Cdd:cd18204   5 FLKTLNEQRL-EGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEvdSSSVIEIDFLRSDIFEEVLNYMYTAKISV 83

                        90
                ....*....|....*..
gi 61743930 151 YKYEIPLVLEAAKFLDI 167
Cdd:cd18204  84 KKEDVNLMMSSGQILGI 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNPSTDVVTLDHVTHSVFQHLLEFLYTSE 147
Cdd:cd18222   7 DFSNSVLSHLNQLRM-QGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSFCYTGR 85

                        90       100
                ....*....|....*....|
gi 61743930 148 FFVYKYEIPLVLEAAKFLDI 167
Cdd:cd18222  86 ICLQLADIISYLTAASFLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  79 DDRQKQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNP--STDVVTLDHVTHSVFQHLLEFLYTSEFFVYKYEIP 156
Cdd:cd18212  15 EEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGevGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKSLE 94

                        90
                ....*....|....*.
gi 61743930 157 LVLEAAKFLDIIDAVK 172
Cdd:cd18212  95 QILATAQFLKVNDLVK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRQKQpSFCDLLIIVEGKEFSAHKVVVAVGSSYF----------HACLSKNPSTDVVTLDHVTHSVFQ 137
Cdd:cd18327   7 EHSSELLSCLNEQRRAG-LLCDLTIKTRGLEYRTHRAVLAACSLYFrklftgggggSGDLGAGGGQDVCELDFVGPEALG 85

                        90       100       110
                ....*....|....*....|....*....|
gi 61743930 138 HLLEFLYTSEFFVYKYEIPLVLEAAKFLDI 167
Cdd:cd18327  86 ALLEFAYTATLTISSSNMREVLRAARLLEI 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743930  68 QYNKNLLKYLNDDRQkQPSFCDLLIIVEGKEFSAHKVVVAVGSSYFHACLSKNP-STDVVTL--DHVTHSVFQHLLEFLY 144
Cdd:cd18194   5 EHSRQLLQCLREQRS-QGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLdKRDLVRLnsDIVTAPAFGLLLDFMY 83

                        90       100       110
                ....*....|....*....|....*....|
gi 61743930 145 TSEFFVYKYEIPLVLEAAKFLDIIDAVKLL 174
Cdd:cd18194  84 EGRLALRDLPVEDVLAAASYLHMYDIVKVC 113