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Conserved domains on  [gi|6166193|sp|Q16595|]
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RecName: Full=Frataxin, mitochondrial; AltName: Full=Friedreich ataxia protein; Short=Fxn; Contains: RecName: Full=Frataxin intermediate form; Short=i-FXN; Contains: RecName: Full=Frataxin(56-210); AltName: Full=m56-FXN; Contains: RecName: Full=Frataxin(78-210); AltName: Full=d-FXN; AltName: Full=m78-FXN; Contains: RecName: Full=Frataxin mature form; AltName: Full=Frataxin(81-210); AltName: Full=m81-FXN; Contains: RecName: Full=Extramitochondrial frataxin; Flags: Precursor

Protein Classification

frataxin( domain architecture ID 10022430)

frataxin is a mitochondrial protein that promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226|GO:0051537|GO:0004322
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 94-192 1.73e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


:

Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.95  E-value: 1.73e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 173
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6166193    174 VYSHDGVSLHELLAAELTK 192
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 94-192 1.73e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.95  E-value: 1.73e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 173
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6166193    174 VYSHDGVSLHELLAAELTK 192
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 90-198 3.95e-52

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 163.08  E-value: 3.95e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     90 LDETTYERLAEETLDSLAEFFEDLADKPytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 169
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 6166193    170 GKN-WVYSHDGVSLHELLAAELTKALKTKL 198
Cdd:pfam01491  77 DAGqWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 90-200 1.77e-45

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 146.26  E-value: 1.77e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193   90 LDETTYERLAEETLDSLAEFFEDLADKpytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWT 169
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV-GGYHFDYK 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6166193  170 GKNWVYSHDGVSLHELLAAELTKALKTKLDL 200
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 90-202 1.28e-19

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 79.84  E-value: 1.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193   90 LDETTYERLAEETLDSLAEFFEDLADkpytfEDYDVSFGSGVLTVKLGGDlGTYVINKQTPNKQIWLSSPsSGPKRYDWT 169
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAK-SGGFHFDYD 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 6166193  170 GKNWVYSHDGVSLHELLAAELTKALKTKLDLSS 202
Cdd:COG1965  74 DGKWIDTRSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 90-201 1.65e-13

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 64.13  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193    90 LDETTYERLAEETLDSLAEFFEDLADKpytfeDYDVSFGSGVLTVKLGGdlGT-YVINKQTPNKQIWLSSPSSGpKRYDW 168
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKSGG-FHFDY 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6166193   169 TGKNWVYSHDGVSLHELLAAELTKALKTKLDLS 201
Cdd:PRK00446  73 KDGEWICDRSGEEFWALLEEAATQQAGEPVSFR 105
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 94-192 1.73e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 168.95  E-value: 1.73e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     94 TYERLAEETLDSLAEFFEDLADKPYTFeDYDVSFGSGVLTVKLGGdLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNW 173
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*....
gi 6166193    174 VYSHDGVSLHELLAAELTK 192
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELSK 97
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 90-198 3.95e-52

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 163.08  E-value: 3.95e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     90 LDETTYERLAEETLDSLAEFFEDLADKPytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 169
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEG---SDADVEYSGGVLTLEFD-NGGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 6166193    170 GKN-WVYSHDGVSLHELLAAELTKALKTKL 198
Cdd:pfam01491  77 DAGqWIYTRDGEELFELLSRELSEQLGEPV 106
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 90-200 1.77e-45

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 146.26  E-value: 1.77e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193   90 LDETTYERLAEETLDSLAEFFEDLADKpytfEDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWT 169
Cdd:cd00503   1 MNESEFHRLADDLLLKIEDTLEEQDDD----ADIDVETQGGVLTLTFG-NGSTIVINRQEPLRQIWLASKV-GGYHFDYK 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 6166193  170 GKNWVYSHDGVSLHELLAAELTKALKTKLDL 200
Cdd:cd00503  75 NGKWICTRSGEELWELLEEECSAQSGEDVEF 105
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 91-200 5.16e-33

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 114.23  E-value: 5.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193     91 DETTYERLAEETLDSLAEFFEDlADKpytfeDYDVSFGSGVLTVKLGgDLGTYVINKQTPNKQIWLSSPSsGPKRYDWTG 170
Cdd:TIGR03421   1 NESEFHQLAEALLDAIEEAIDD-GDA-----DIDCERQGGVLTLTFE-NGSQIIINKQEPLHQIWLAAKS-GGFHFDYDG 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 6166193    171 KNWVYSHDGVSLHELLAAELTKALKTKLDL 200
Cdd:TIGR03421  73 GAWIDTRDGEELWALLARACSEQAGEPVVF 102
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 90-202 1.28e-19

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 79.84  E-value: 1.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193   90 LDETTYERLAEETLDSLAEFFEDLADkpytfEDYDVSFGSGVLTVKLGGDlGTYVINKQTPNKQIWLSSPsSGPKRYDWT 169
Cdd:COG1965   1 MTESEFHQLADALLEAIEEALDRDDD-----ADIDCERSGGVLTLEFDNG-SKIIINRQEPLRQIWLAAK-SGGFHFDYD 73

                        90       100       110
                ....*....|....*....|....*....|...
gi 6166193  170 GKNWVYSHDGVSLHELLAAELTKALKTKLDLSS 202
Cdd:COG1965  74 DGKWIDTRSGEELFALLSRALSEQAGEPVTLAA 106
cyaY PRK00446
frataxin-like protein; Provisional
 90-201 1.65e-13

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 64.13  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193    90 LDETTYERLAEETLDSLAEFFEDLADKpytfeDYDVSFGSGVLTVKLGGdlGT-YVINKQTPNKQIWLSSPSSGpKRYDW 168
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDDGDA-----DIDCERNGGVLTLTFEN--GSkIIINRQEPLHELWLAAKSGG-FHFDY 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 6166193   169 TGKNWVYSHDGVSLHELLAAELTKALKTKLDLS 201
Cdd:PRK00446  73 KDGEWICDRSGEEFWALLEEAATQQAGEPVSFR 105
cyaY PRK01379
iron donor protein CyaY;
90-190 4.96e-11

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 57.25  E-value: 4.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166193    90 LDETTYERLAEETLDSLAEFFEDlADKPYTFedyDVSFGSGVLTvkLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWT 169
Cdd:PRK01379   1 MNNSEFSKIAETTIAYIADKIEE-QDKEASI---DVDLQGDILN--LDTDKGIYVINKQSAAKEIWLSSPVSGPYHFFYE 74

                         90       100
                 ....*....|....*....|.
gi 6166193   170 GKNWvYSHDGVSLHELLAAEL 190
Cdd:PRK01379  75 QGKW-KNRAGLELMAILTEEL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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